June 28, 2025

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10 Best otc sinus medicines of 2025

Save up to 41% off

Best Choice

1

Advil
Advil Sinus Congestion and Pain, Sinus Relief Medicine, Pain Reliever and Fever Reducer with Ibuprofen and Phenylephrine HCl - 50 Coated Tablets

27% Off
Main highlights

Sinus Relief with Ibuprofen
Advil Sinus Congestion and Pain provides effective relief with ibuprofen for pain and phenylephrine for congestion.

Ideal for Allergies and Colds
Perfect for adults and children over 12 experiencing sinus pressure, headaches, and allergy symptoms.

Convenient Packaging
Customers praise the portability and convenience of single-dose packets, ideal for travel and on-the-go use.
9.6

Exceptional

Our Rating

9.7
movability

9.7
For traveling

9.3
worth the money
How do we rank?

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Based on millions of stores and reviews

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Value for Money

2

Vicks
VICKS DayQuil & NyQuil SEVERE Co-Pack, Cold & Flu Medicine, Powerful Relief for Headache, Fever, Sore Throat, Minor Aches & Pains, Congestion, Sinus Pressure, Stuffy Nose, and Cough, 48 LiquiCaps

15% Off
Main highlights

Powerful 9-Symptom Relief
Vicks DayQuil and NyQuil Severe provide maximum strength relief for 9 common cold and flu symptoms.

Day and Night Use
Ideal for daytime use with DayQuil's non-drowsy formula and nighttime relief with NyQuil for restful sleep.

Quick Symptom Relief
Customers praise the fast-acting nature, clearing congestion in 10-15 minutes.
9.4

Excellent

Our Rating

8.9
Flavor

8.7
simple to consume

8.2
worth the money
3

Sudafed
Sudafed PE Sinus Pressure + Pain Relief Tablets, Maximum Strength, Non-Drowsy, OTC Sinus Relief Medicine with Acetaminophen Pain Reliever & Phenylephrine HCl Nasal Decongestant, 24 ct
Main highlights

Fast Powerful Relief
Provides maximum strength, non-drowsy relief for sinus congestion and pain.

Ideal for Allergy Season
Perfect for relieving nasal congestion from allergies and colds.

Customer Praised Effectiveness
Highly rated for its effective relief during allergy season.
9.3

Excellent

Our Rating

9.1
simple to consume

8.4
worth the money

8.0
Comfort
4

Rite Aid

Rite Aid Maximum Strength Daytime and Nighttime Sinus Relief Caplets - 20 Count | Sinus & Cold Medicine | Cough & Cold Medicine | Cold Medicine for Adults | Sinus Pressure & Tension Headache Relief
9.2

Excellent

Our Rating
5

Advil
Advil Sinus Congestion and Pain, Sinus Relief Medicine, Pain Reliever and Fever Reducer with Ibuprofen and Phenylephrine HCl - 20 Coated Tablets
Main highlights

Comprehensive Sinus Relief
Combines ibuprofen and phenylephrine for pain, fever, and sinus congestion relief.

Portable and Convenient
Ideal for on-the-go relief; easily fits in bags or pockets.

Quick and Effective Performance
Praised for rapid relief of sinus congestion and headaches.
9.0

Excellent

Our Rating

9.7
pain management

9.3
simple to consume

8.0
Packaging materials
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6

Contac
Contac Cold & Flu Medicine, Non-Drowsy, Powerful Multi-Symptom Daytime Relief for Nasal Congestion, Sinus Pressure, Headache, Fever, Sore Throat, Minor Aches and Pains, 24 Caplets
Main highlights

Maximum Strength Symptom Relief
Provides relief for nasal congestion, sinus pressure, aches, and fever.

Ideal for Daytime Cold and Flu
Perfect for managing symptoms without drowsiness during the day.

Highly Praised by Customers
Users appreciate its effectiveness and availability through online retailers.
8.8

Very Good

Our Rating

9.7
pain management

8.9
worth the money

8.4
For traveling
7

Vicks
Vicks Sinex SEVERE Nasal Spray, Original Ultra Fine Mist, Decongestant Medicine, Relief from Stuffy Nose due to Cold or Allergy, & Nasal Congestion, Sinus Pressure Relief, 265 Sprays x 2

14% Off
Main highlights

12-Hour Relief from Congestion
Provides instant, long-lasting relief from nasal congestion and sinus pressure for up to 12 hours.

Ideal for Cold and Allergy Season
Perfect for treating severe sinus congestion and pressure from colds or allergies.

Instant Effectiveness Praised by Users
Highly rated for its immediate effectiveness in clearing nasal passages.
8.6

Very Good

Our Rating

9.5
Simple to use

9.3
Moisturizing

9.1
worth the money
8

Advil
Advil Sinus Congestion and Pain, Sinus Relief Medicine, Pain Reliever and Fever Reducer with Ibuprofen and Phenylephrine HCl - 10 Coated Tablets

41% Off
Main highlights

Fast Relief for Sinus and Pain
Advil Sinus Congestion and Pain offers rapid relief for sinus pressure, nasal congestion, headaches, and minor body aches.

Daytime and Nighttime Use
Ideal for adults and children 12+ for both daytime and nighttime sinus and pain relief.

Non-Drowsy Formula Praised
Customers appreciate the non-drowsy formula, allowing them to remain active and alert.
8.3

Good

Our Rating
9

Rite Aid
Rite Aid Daytime Severe Sinus Congestion & Pain Relief - Acetaminophen, 325 mg - 24 Caplets | Multi-Symptom Non-Drowsy | Relief | Cold and Flu | Cold & Sinus Medicine for Adults
Main highlights

Comprehensive Multi-Symptom Relief
Rite Aid provides relief from cold and flu symptoms, including fever, headache, and congestion.

Ideal for Daytime Use
Non-drowsy formula allows you to stay active and alert while treating symptoms.

Praised for Cost Effectiveness
Customers appreciate the affordability compared to similar products like Tylenol and Mucinex.
8.1

Good

Our Rating

9.9
pain management

9.7
worth the money

9.3
simple to consume
10

Rite Aid
Rite Aid Severe Sinus Medicine and Nasal Decongestant, Maximum Strength - 20 Caplets | Sinus Relief | Pain Relief | Multi-Symptom Cold and Flu Medicine | Severe Cold & Sinus Medicine for Adults
Main highlights

Comprehensive Relief
Provides 325mg Acetaminophen for pain, expectorant for mucus, and decongestant for congestion relief.

Ideal for Severe Symptoms
Perfect for tackling severe sinus congestion, pressure, and headaches.

Highly Effective
Praised for being more effective than expensive brands in relieving sinus pressure.
7.9

Good

Our Rating

9.5
worth the money

9.3
pain management

8.7
quality of ingredients

10 Best otc sinus medicines of 2025

1

Advil Sinus Congestion and Pain, Sinus Relief Medicine, Pain Reliever and Fever Reducer with Ibuprofen and Phenylephrine HCl - 50 Coated Tablets

9.7

9.7

9.3

How do we rank?

How do we rank?

Analyzing top stores

2

VICKS DayQuil & NyQuil SEVERE Co-Pack, Cold & Flu Medicine, Powerful Relief for Headache, Fever, Sore Throat, Minor Aches & Pains, Congestion, Sinus Pressure, Stuffy Nose, and Cough, 48 LiquiCaps

8.9

8.7

8.2

3

Sudafed PE Sinus Pressure + Pain Relief Tablets, Maximum Strength, Non-Drowsy, OTC Sinus Relief Medicine with Acetaminophen Pain Reliever & Phenylephrine HCl Nasal Decongestant, 24 ct

9.1

8.4

8.0

4

Rite Aid Maximum Strength Daytime and Nighttime Sinus Relief Caplets - 20 Count | Sinus & Cold Medicine | Cough & Cold Medicine | Cold Medicine for Adults | Sinus Pressure & Tension Headache Relief

5

Advil Sinus Congestion and Pain, Sinus Relief Medicine, Pain Reliever and Fever Reducer with Ibuprofen and Phenylephrine HCl - 20 Coated Tablets

9.7

9.3

8.0

6

Contac Cold & Flu Medicine, Non-Drowsy, Powerful Multi-Symptom Daytime Relief for Nasal Congestion, Sinus Pressure, Headache, Fever, Sore Throat, Minor Aches and Pains, 24 Caplets

9.7

8.9

8.4

7

Vicks Sinex SEVERE Nasal Spray, Original Ultra Fine Mist, Decongestant Medicine, Relief from Stuffy Nose due to Cold or Allergy, & Nasal Congestion, Sinus Pressure Relief, 265 Sprays x 2

9.5

9.3

9.1

8

Advil Sinus Congestion and Pain, Sinus Relief Medicine, Pain Reliever and Fever Reducer with Ibuprofen and Phenylephrine HCl - 10 Coated Tablets

9

Rite Aid Daytime Severe Sinus Congestion & Pain Relief - Acetaminophen, 325 mg - 24 Caplets | Multi-Symptom Non-Drowsy | Relief | Cold and Flu | Cold & Sinus Medicine for Adults

9.9

9.7

9.3

10

Rite Aid Severe Sinus Medicine and Nasal Decongestant, Maximum Strength - 20 Caplets | Sinus Relief | Pain Relief | Multi-Symptom Cold and Flu Medicine | Severe Cold & Sinus Medicine for Adults

9.5

9.3

8.7

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