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8 Best sinus medicines of 2026

Save up to 21% off
  • Best Choice

    1

    Tylenol Sinus + Headache Daytime Non-Drowsy Relief Caplets, 24 Ct
    Tylenol
    9.8
    Exceptional

    Tylenol Sinus + Headache Daytime Non-Drowsy Relief Caplets, 24 Ct

    16% Off
    • is discontinued by manufacturer:No
    • asin:B00DZG46T2
    • product dimensions:4.5 x 0.75 x 3 inches; 1.12 ounces
    • date first available:July 10, 2014
    • item model number:JJ-2320
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  • Value for Money

    2

    Sudafed PE Sinus Pressure + Pain Relief Tablets, Non-Drowsy, 24 Ct
    Sudafed
    9.6
    Exceptional

    Sudafed PE Sinus Pressure + Pain Relief Tablets, Non-Drowsy, 24 Ct

  • 3

    Vicks Sinex SEVERE, All-In-One Sinus + Mucus Relief, Non-Drowsy, Loosens Mucus, Maximum Strength Relief of Pain, Pressure, Congestion, & Headache Relief, 24 LiquiCaps
    Vicks
    9.5
    Excellent

    Vicks Sinex SEVERE, All-In-One Sinus + Mucus Relief, Non-Drowsy, Loosens Mucus, Maximum Strength Relief of Pain, Pressure, Congestion, & Headache Relief, 24 LiquiCaps

    • is discontinued by manufacturer:N/A
    • asin:B07GD4WGGH
    • product dimensions:1.1 x 3.31 x 4.31 inches 1.6 ounces
    • date first available:May 3, 2018
    • item model number:233331

  • 4

    ValuMeds Nasal Decongestant PE Non-Drowsy for Adults | Maximum Strength Phenylephrine HCl 10mg to Relieve Sinus Pressure from Cold or Allergies | Comparable to Sudafed PE Congestion | 100 Tablets
    ValuMeds
    9.2
    Excellent

    ValuMeds Nasal Decongestant PE Non-Drowsy for Adults | Maximum Strength Phenylephrine HCl 10mg to Relieve Sinus Pressure from Cold or Allergies | Comparable to Sudafed PE Congestion | 100 Tablets

  • 5

    Advil Sinus Congestion and Pain, Sinus Relief Medicine, Pain Reliever and Fever Reducer with Ibuprofen and Phenylephrine HCl - 20 Coated Tablets
    Advil
    9.0
    Excellent

    Advil Sinus Congestion and Pain, Sinus Relief Medicine, Pain Reliever and Fever Reducer with Ibuprofen and Phenylephrine HCl - 20 Coated Tablets

    • is discontinued by manufacturer:No
    • asin:B015QMLYY2
    • product dimensions:4.5 x 4 x 4.5 inches; 0.63 ounces
    • date first available:September 23, 2015
    • item model number:305730199216
  • See Today’s Deals & Prices

  • 6

    Mucinex Rapid Clear Maximum Strength Cold Medicine & Expectorant, Fever, Pain, Headache, & Excess Mucus Relief with Acetaminophen & Guaifenesin, Rapid Release Caplets for Adults, 20 Count
    Mucinex
    8.8
    Very Good

    Mucinex Rapid Clear Maximum Strength Cold Medicine & Expectorant, Fever, Pain, Headache, & Excess Mucus Relief with Acetaminophen & Guaifenesin, Rapid Release Caplets for Adults, 20 Count

    • Active Ingredients:Acetaminophen, Guaifenesin
    • Type:Cold Medicine & Expectorant
    • Count:20
    • Form:Rapid Release Caplets
    • Strength:Maximum Strength

  • 7

    Sinus Infection Treatment & Symptoms | Request prescription for sinus medication like nasal spray, antibiotics for sinus headache & pain symptom relief from an online doctor, NP, or PA
    Amazon One Medical
    8.7
    Very Good

    Sinus Infection Treatment & Symptoms | Request prescription for sinus medication like nasal spray, antibiotics for sinus headache & pain symptom relief from an online doctor, NP, or PA

  • 8

    Sudafed PE Head Congestion + Mucus Relief Tablets, Non-Drowsy, 24 Ct
    Sudafed
    8.5
    Good

    Sudafed PE Head Congestion + Mucus Relief Tablets, Non-Drowsy, 24 Ct

    21% Off