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10 Best sinus medicines of 2026
Save up to 28% off
1
AdvilAdvil Sinus Congestion and Pain, Sinus Relief Medicine, Pain Reliever and Fever Reducer with Ibuprofen and Phenylephrine HCl - 20 Coated Tablets
9.7Exceptional
Our Rating
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2
AdvilAdvil Sinus Congestion and Pain, Sinus Relief Medicine, Pain Reliever and Fever Reducer with Ibuprofen and Phenylephrine HCl - 20 Coated Tablets
9.5Excellent
Our Rating
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3
TylenolTylenol Sinus + Headache Daytime Non-Drowsy Relief Caplets, Acetaminophen 325mg, Nasal Decongestant for Sinus Pressure, Headache & Nasal Congestion Relief, 24 ct
20% OffKey specs-
features:Non-drowsy, sinus relief
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product dimensions:4.5 x 0.75 x 3 inches
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active ingredients:325 mg acetaminophen
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usage instructions:Adults and children 12+
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decongestant:5 mg phenylephrine HCl
9.2Excellent
Our Rating
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4
TylenolTylenol Sinus + Headache Daytime Non-Drowsy Relief Caplets, Acetaminophen 325mg, Nasal Decongestant for Sinus Pressure, Headache & Nasal Congestion Relief, 24 ct
24% OffKey specs-
features:Non-drowsy, sinus relief
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product dimensions:4.5 x 0.75 x 3 inches
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active ingredients:325 mg acetaminophen
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usage instructions:Adults and children 12+
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decongestant:5 mg phenylephrine HCl
8.9Very Good
Our Rating
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5
SudafedSudafed PE Sinus Pressure + Pain Relief Tablets, Maximum Strength, Non-Drowsy, OTC Sinus Relief Medicine with Acetaminophen Pain Reliever & Phenylephrine HCl Nasal Decongestant, 24 ct
12% Off8.8Very Good
Our Rating
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6
SudafedSudafed PE Sinus Pressure + Pain Relief Tablets, Maximum Strength, Non-Drowsy, OTC Sinus Relief Medicine with Acetaminophen Pain Reliever & Phenylephrine HCl Nasal Decongestant, 24 ct
16% Off8.7Very Good
Our Rating
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7
TylenolTylenol Sinus Severe Daytime Cold & Flu Relief Medicine Caplets, Non-Drowsy Pain Reliever, Fever Reducer Expectorant & Decongestant, Acetaminophen, Guaifenesin & Phenylephrine HCl, 24 ct
24% Off8.4Good
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8
TylenolTylenol Sinus Severe Daytime Cold & Flu Relief Medicine Caplets, Non-Drowsy Pain Reliever, Fever Reducer Expectorant & Decongestant, Acetaminophen, Guaifenesin & Phenylephrine HCl, 24 ct
28% Off8.1Good
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9
ValuMedsValuMeds Nasal Decongestant PE Phenylephrine HCl 10mg Tablets (Bulk 300 Count) Non-Drowsy Sinus Pressure Relief & Nasal Congestion Relief, Stuffy Nose Decongestants for Adults | Compare to Sudafed PE
8.0Good
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10
ValuMedsValuMeds Nasal Decongestant PE Phenylephrine HCl 10mg Tablets (Bulk 300 Count) Non-Drowsy Sinus Pressure Relief & Nasal Congestion Relief, Stuffy Nose Decongestants for Adults | Compare to Sudafed PE
10% Off7.9Good
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