10 Best equate acetaminophens 500 of 2026

Save up to 21% off

1

Generic

Extra Strength Acetaminophen 500mg Gelcaps - 225 Count (Pack of 1)
9.7

Exceptional

Our Rating
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2

Amazon Basic Care
Amazon Basic Care Rapid Release Acetaminophen Caplets 500 mg, Extra Strength Pain Reliever and Fever Reducer, 400 Count
Main highlights

Rapid Pain Relief and Fever Reduction
Contains 500 mg of acetaminophen for quick relief of pain and fever.

Ideal for Headaches and Muscle Aches
Perfect for headaches, muscle aches, arthritis, and menstrual pain.

Highly Praised for Effectiveness
Customers appreciate its quick and reliable pain relief.
9.5

Excellent

Our Rating
3

Amazon Basic Care
Amazon Basic Care Extra Strength Pain Relief, Acetaminophen Caplets, 500 mg, Pain Reliever/Fever Reducer, 500 Count (Packaging may vary)
Main highlights

Effective Pain and Fever Relief
Contains 500 mg of Acetaminophen, similar to Tylenol, for relieving minor aches and reducing fever.

Ideal for Everyday Aches
Perfect for headaches, arthritis, colds, and menstrual cramps in adults and children over 12.

Great Value for Money
Customers appreciate the cost-effectiveness and comparable performance to name brands.
9.3

Excellent

Our Rating
4

Amazon Basic Care
Amazon Basic Care Extra Strength Pain Relief, Acetaminophen Caplets, 500 mg, Pain Reliever/Fever Reducer, 500 Count (Packaging may vary)
Main highlights

Effective Pain and Fever Relief
Contains 500 mg of Acetaminophen, similar to Tylenol, for relieving minor aches and reducing fever.

Ideal for Everyday Aches
Perfect for headaches, arthritis, colds, and menstrual cramps in adults and children over 12.

Great Value for Money
Customers appreciate the cost-effectiveness and comparable performance to name brands.
9.1

Excellent

Our Rating
5

Amazon Basic Care
Amazon Basic Care Extra Strength Pain Relief, Acetaminophen Caplets, 500 mg, 200 Count (Packaging may vary)
Main highlights

Effective Pain Relief
Contains 500 mg of acetaminophen, comparable to Tylenol, for pain and fever relief.

Versatile Use Cases
Ideal for minor aches, headaches, arthritis, and reducing fever.

Value for Money
Praised for being cost-effective and as effective as name brands.
9.0

Excellent

Our Rating

9.7
simple to consume

9.7
worth the money

9.7
quality of ingredients
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6

Amazon Basic Care
Amazon Basic Care Extra Strength Pain Relief, Acetaminophen Caplets, 500 mg, 200 Count (Packaging may vary)
Main highlights

Effective Pain Relief
Contains 500 mg of acetaminophen, comparable to Tylenol, for pain and fever relief.

Versatile Use Cases
Ideal for minor aches, headaches, arthritis, and reducing fever.

Value for Money
Praised for being cost-effective and as effective as name brands.
8.9

Very Good

Our Rating

9.7
simple to consume

9.7
worth the money

9.7
quality of ingredients
7

GenCare
GenCare Extra Strength Acetaminophen PM 500 mg (375 Tablets) | Ultimate Pain Relief & Sleep Support for Adults | Quick Acting & Non Habit Forming Headache Relief | Eases Aches & Joint Discomfort

17% Off
Main highlights

Fast Acting Pain Relief and Sleep Support
Combines 500 mg Acetaminophen with 25 mg Diphenhydramine for quick pain relief and better sleep.

Ideal for Nighttime Use
Perfect for headaches, muscle aches, and cold symptoms that disrupt sleep.

Highly Praised for Effectiveness
Customers appreciate its fast action in relieving pain and aiding sleep.
Key specs
- dosing instructions:1 pill contains 500mg Acetaminophen
- form:Tablet
- active ingredient:Acetaminophen, Diphenhydramine
- pain relief:Headaches, migraines, sore muscles
- age suitability:N/A
8.7

Very Good

Our Rating
8

GenCare
GenCare Extra Strength Acetaminophen PM 500 mg (375 Tablets) | Ultimate Pain Relief & Sleep Support for Adults | Quick Acting & Non Habit Forming Headache Relief | Eases Aches & Joint Discomfort

21% Off
Main highlights

Fast Acting Pain Relief and Sleep Support
Combines 500 mg Acetaminophen with 25 mg Diphenhydramine for quick pain relief and better sleep.

Ideal for Nighttime Use
Perfect for headaches, muscle aches, and cold symptoms that disrupt sleep.

Highly Praised for Effectiveness
Customers appreciate its fast action in relieving pain and aiding sleep.
Key specs
- dosing instructions:1 pill contains 500mg Acetaminophen
- form:Tablet
- active ingredient:Acetaminophen, Diphenhydramine
- pain relief:Headaches, migraines, sore muscles
- age suitability:N/A
8.5

Good

Our Rating
9

GoodSense
GoodSense Extra Strength Pain Relief, Acetaminophen Caplets, 500 mg, 500 Count

17% Off
Main highlights

Effective Pain Relief and Fever Reduction
Contains 500 mg of Acetaminophen to relieve pain and reduce fever.

Ideal for Families and Frequent Users
Perfect for households with high demand for pain relief.

High Value for Money
Praised for large quantity and cost-effectiveness by customers.
Key specs
- dosing instructions:Adults and children 12+
- form:Caplets
- active ingredient:Acetaminophen, 500 mg
- pain relief:Minor aches and pains
- age suitability:12 years and over
8.4

Good

Our Rating

9.9
worth the money

9.7
simple to consume

9.7
pain management
10

GoodSense
GoodSense Extra Strength Pain Relief, Acetaminophen Caplets, 500 mg, 500 Count

21% Off
Main highlights

Effective Pain Relief and Fever Reduction
Contains 500 mg of Acetaminophen to relieve pain and reduce fever.

Ideal for Families and Frequent Users
Perfect for households with high demand for pain relief.

High Value for Money
Praised for large quantity and cost-effectiveness by customers.
Key specs
- dosing instructions:Adults and children 12+
- form:Caplets
- active ingredient:Acetaminophen, 500 mg
- pain relief:Minor aches and pains
- age suitability:12 years and over
8.3

Good

Our Rating

9.9
worth the money

9.7
simple to consume

9.7
pain management

10 Best equate acetaminophens 500 of 2026

1

Extra Strength Acetaminophen 500mg Gelcaps - 225 Count (Pack of 1)

How do we rank?

How do we rank?

Analyzing top stores

2

Amazon Basic Care Rapid Release Acetaminophen Caplets 500 mg, Extra Strength Pain Reliever and Fever Reducer, 400 Count

3

Amazon Basic Care Extra Strength Pain Relief, Acetaminophen Caplets, 500 mg, Pain Reliever/Fever Reducer, 500 Count (Packaging may vary)

4

Amazon Basic Care Extra Strength Pain Relief, Acetaminophen Caplets, 500 mg, Pain Reliever/Fever Reducer, 500 Count (Packaging may vary)

5

Amazon Basic Care Extra Strength Pain Relief, Acetaminophen Caplets, 500 mg, 200 Count (Packaging may vary)

9.7

9.7

9.7

6

Amazon Basic Care Extra Strength Pain Relief, Acetaminophen Caplets, 500 mg, 200 Count (Packaging may vary)

9.7

9.7

9.7

7

GenCare Extra Strength Acetaminophen PM 500 mg (375 Tablets) | Ultimate Pain Relief & Sleep Support for Adults | Quick Acting & Non Habit Forming Headache Relief | Eases Aches & Joint Discomfort

8

GenCare Extra Strength Acetaminophen PM 500 mg (375 Tablets) | Ultimate Pain Relief & Sleep Support for Adults | Quick Acting & Non Habit Forming Headache Relief | Eases Aches & Joint Discomfort

9

GoodSense Extra Strength Pain Relief, Acetaminophen Caplets, 500 mg, 500 Count

9.9

9.7

9.7

10

GoodSense Extra Strength Pain Relief, Acetaminophen Caplets, 500 mg, 500 Count

9.9

9.7

9.7

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