10 Best equate acetaminophens 500 of 2025

Save up to 37% off

Best Choice

1

Generic

Acetaminophen 500 mg, Extra Strength Rapid Release, 400 Gelcaps (Pack of 01)
9.7

Exceptional

Our Rating
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Value for Money

2

Generic

Acetaminophen 500mg Caplets, Extra-Strength, 250 Count (Pack of 2)
9.5

Excellent

Our Rating
3

Amazon Basic Care
Amazon Basic Care Extra Strength Pain Relief, Acetaminophen Caplets, 500 mg, Pain Reliever/Fever Reducer, 500 Count (Packaging may vary)
Main highlights

Effective Pain and Fever Relief
Contains 500 mg of Acetaminophen, similar to Tylenol, for relieving minor aches and reducing fever.

Ideal for Everyday Aches
Perfect for headaches, arthritis, colds, and menstrual cramps in adults and children over 12.

Great Value for Money
Customers appreciate the cost-effectiveness and comparable performance to name brands.
9.3

Excellent

Our Rating
4

GoodSense
GoodSense Extra Strength Pain Relief, Acetaminophen Caplets, 500 mg, 500 Count
Main highlights

Effective Pain Relief and Fever Reduction
Contains 500 mg of Acetaminophen to relieve pain and reduce fever.

Ideal for Families and Frequent Users
Perfect for households with high demand for pain relief.

High Value for Money
Praised for large quantity and cost-effectiveness by customers.
Key specs
- dosing instructions:Adults and children 12+
- form:Caplets
- active ingredient:Acetaminophen, 500 mg
- pain relief:Minor aches and pains
- age suitability:12 years and over
9.2

Excellent

Our Rating

9.9
worth the money

9.7
simple to consume

9.7
pain management
5

Generic

Extra Strength Acetaminophen 500mg, 225 Gelcaps (Pack of 1)
8.9

Very Good

Our Rating
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6

Generic

Extra Strength Acetaminophen 500 mg, 100 Tablets by Equate (Pack of 01)
8.8

Very Good

Our Rating
7

Amazon Basic Care
Amazon Basic Care Rapid Release Acetaminophen Caplets 500 mg, Extra Strength Pain Reliever and Fever Reducer, 400 Count
Main highlights

Rapid Pain Relief and Fever Reduction
Contains 500 mg of acetaminophen for quick relief of pain and fever.

Ideal for Headaches and Muscle Aches
Perfect for headaches, muscle aches, arthritis, and menstrual pain.

Highly Praised for Effectiveness
Customers appreciate its quick and reliable pain relief.
8.6

Very Good

Our Rating
8

Rite Aid
Rite Aid Extra Strength Pain Relief Acetaminophen PM Caplets, 500mg Acetaminophen / 25mg Diphenhydramine - 300 Count - Nighttime Pain Reliever + Sleep Aid

37% Off
Main highlights

Non-Habit Forming Pain Relief and Sleep Aid
Rite Aid Acetaminophen PM offers non-habit forming pain relief and sleep aid, combining acetaminophen 500mg and diphenhydramine HCI 25mg to help you sleep better.

Effective for Nighttime Pain and Sleep Issues
Ideal for those experiencing nighttime pain, headaches, muscle aches, or joint pain, and who need a sleep aid to fall asleep and stay asleep.

Affordable Alternative to Name Brands
Customers frequently praise the product for being as effective as leading brands but at a significantly lower price, providing the same relief and sleep benefits.
8.5

Good

Our Rating

9.9
worth the money

9.9
pain management

9.7
quality of sleep
9

GenCare
GenCare Extra Strength Acetaminophen PM 500 mg (375 Tablets) | Ultimate Pain Relief & Sleep Support for Adults | Quick Acting & Non Habit Forming Headache Relief | Eases Aches & Joint Discomfort
Main highlights

Fast Acting Pain Relief and Sleep Support
Combines 500 mg Acetaminophen with 25 mg Diphenhydramine for quick pain relief and better sleep.

Ideal for Nighttime Use
Perfect for headaches, muscle aches, and cold symptoms that disrupt sleep.

Highly Praised for Effectiveness
Customers appreciate its fast action in relieving pain and aiding sleep.
Key specs
- dosing instructions:1 pill contains 500mg Acetaminophen
- form:Tablet
- active ingredient:Acetaminophen, Diphenhydramine
- pain relief:Headaches, migraines, sore muscles
- age suitability:N/A
8.3

Good

Our Rating
10

Rite Aid

Rite Aid Extra Strength PM Pain Relief Gelcaps, 500 mg Acetaminophen / 25 mg Diphenhydramine - 80 Count | Nighttime PM Pain Reliever + Sleep Aid | Arthritis Pain Relief | Menstrual Pain Relief

30% Off
8.2

Good

Our Rating

10 Best equate acetaminophens 500 of 2025

1

Acetaminophen 500 mg, Extra Strength Rapid Release, 400 Gelcaps (Pack of 01)

How do we rank?

How do we rank?

Analyzing top stores

2

Acetaminophen 500mg Caplets, Extra-Strength, 250 Count (Pack of 2)

3

Amazon Basic Care Extra Strength Pain Relief, Acetaminophen Caplets, 500 mg, Pain Reliever/Fever Reducer, 500 Count (Packaging may vary)

4

GoodSense Extra Strength Pain Relief, Acetaminophen Caplets, 500 mg, 500 Count

9.9

9.7

9.7

5

Extra Strength Acetaminophen 500mg, 225 Gelcaps (Pack of 1)

6

Extra Strength Acetaminophen 500 mg, 100 Tablets by Equate (Pack of 01)

7

Amazon Basic Care Rapid Release Acetaminophen Caplets 500 mg, Extra Strength Pain Reliever and Fever Reducer, 400 Count

8

Rite Aid Extra Strength Pain Relief Acetaminophen PM Caplets, 500mg Acetaminophen / 25mg Diphenhydramine - 300 Count - Nighttime Pain Reliever + Sleep Aid

9.9

9.9

9.7

9

GenCare Extra Strength Acetaminophen PM 500 mg (375 Tablets) | Ultimate Pain Relief & Sleep Support for Adults | Quick Acting & Non Habit Forming Headache Relief | Eases Aches & Joint Discomfort

10

Rite Aid Extra Strength PM Pain Relief Gelcaps, 500 mg Acetaminophen / 25 mg Diphenhydramine - 80 Count | Nighttime PM Pain Reliever + Sleep Aid | Arthritis Pain Relief | Menstrual Pain Relief

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