10 Best acetaminophens of 2025

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1

Amazon Basic Care
Amazon Basic Care Acetaminophen Extended-Release Tablets, 650 mg, Arthritis Pain, 400 Count
Main highlights

Extended-Release Pain Relief
Provides 650 mg acetaminophen for up to 8-hour relief.

Ideal for Arthritis and Aches
Perfect for arthritis, backache, cramps, and other minor pains.

Value and Effectiveness
Praised for great value and effective pain relief.
9.7

Exceptional

Our Rating

9.5
simple to consume

9.5
worth the money

9.3
pain management
How do we rank?

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Thousands of users trust our site daily

Based on millions of stores and reviews

Shoppers influence our rankings
Analyzing top stores
Value for Money

2

Amazon Basic Care
Amazon Basic Care Rapid Release Acetaminophen Caplets 500 mg, Extra Strength Pain Reliever and Fever Reducer, 400 Count
Main highlights

Rapid Pain Relief and Fever Reduction
Contains 500 mg of acetaminophen for quick relief of pain and fever.

Ideal for Headaches and Muscle Aches
Perfect for headaches, muscle aches, arthritis, and menstrual pain.

Highly Praised for Effectiveness
Customers appreciate its quick and reliable pain relief.
9.5

Excellent

Our Rating
3

Amazon Basic Care
Amazon Basic Care Extra Strength Pain Relief, Acetaminophen Caplets, 500 mg, 200 Count (Packaging may vary)

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Main highlights

Effective Pain Relief
Contains 500 mg of acetaminophen, comparable to Tylenol, for pain and fever relief.

Versatile Use Cases
Ideal for minor aches, headaches, arthritis, and reducing fever.

Value for Money
Praised for being cost-effective and as effective as name brands.
9.4

Excellent

Our Rating

9.7
simple to consume

9.7
worth the money

9.7
quality of ingredients
4

Amazon Basic Care
Amazon Basic Care Extra Strength Pain Relief, Acetaminophen Caplets, 500 mg, Pain Reliever/Fever Reducer, 500 Count (Packaging may vary)
Main highlights

Effective Pain and Fever Relief
Contains 500 mg of Acetaminophen, similar to Tylenol, for relieving minor aches and reducing fever.

Ideal for Everyday Aches
Perfect for headaches, arthritis, colds, and menstrual cramps in adults and children over 12.

Great Value for Money
Customers appreciate the cost-effectiveness and comparable performance to name brands.
9.2

Excellent

Our Rating
5

Amazon Basic Care
Amazon Basic Care Extra Strength Pain Relief, Acetaminophen Caplets, 500 mg, 1000 Count (Packaging may vary)
Main highlights

Effective Pain Relief and Fever Reduction
Contains 500 mg of Acetaminophen, comparable to Extra Strength Tylenol, for temporary relief from various minor aches and pains.

Versatile Use for Adults and Teens
Ideal for adults and children 12+ for pain relief and fever reduction due to colds, headaches, and more.

Cost-Effective Alternative to Brand Names
Praised for providing the same effectiveness as Tylenol at a lower price, making it a preferred choice for budget-conscious consumers.
Key specs
- dosing instructions:Adults and children 12+
- age suitability:12 years and over
- form:Caplets
- active ingredient:Acetaminophen, 500 mg
- fever reduction:Temporarily reduces fever
8.9

Very Good

Our Rating

9.9
worth the money

9.7
simple to consume

9.7
pain management
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6

Amazon Basic Care
Amazon Basic Care Extra Strength Pain Relief, Acetaminophen Caplets, 500 mg, Pain Reliever/Fever Reducer, 100 Count (Packaging may vary)
Main highlights

Fast-Acting Pain Relief
Contains acetaminophen 500 mg for quick relief from minor aches and fever.

Versatile Use Cases
Ideal for relieving headaches, backaches, menstrual cramps, and minor arthritis pain.

Highly Praised Affordability
Customers appreciate its cost-effectiveness and performance comparable to brand-name products.
Key specs
- dosing instructions:adults and children 12+
- age suitability:12 years and over
- form:caplets
- active ingredient:acetaminophen 500 mg
- fever reduction:fever reducer
8.7

Very Good

Our Rating
7

GoodSense
GoodSense Extra Strength Pain Relief, Acetaminophen Caplets, 500 mg, 500 Count
Main highlights

Effective Pain Relief and Fever Reduction
Contains 500 mg of Acetaminophen to relieve pain and reduce fever.

Ideal for Families and Frequent Users
Perfect for households with high demand for pain relief.

High Value for Money
Praised for large quantity and cost-effectiveness by customers.
Key specs
- dosing instructions:Adults and children 12+
- age suitability:12 years and over
- form:Caplets
- active ingredient:Acetaminophen, 500 mg
- fever reduction:Temporarily reduces fever
8.6

Very Good

Our Rating

9.9
worth the money

9.7
simple to consume

9.7
pain management
8

Amazon Basic Care
Amazon Basic Care Acetaminophen Extended-Release Tablets, 650 mg, 100 Count (Packaging may vary)
Main highlights

Extended Relief Benefit
Provides up to 8 hours of pain and fever relief.

Versatile Use Cases
Ideal for minor aches, backache, arthritis, cramps, and fever.

Customer Praises Quality
Praised for being comparable to name brands in effectiveness.
8.5

Good

Our Rating

9.9
worth the money

9.7
pain management

9.3
safety
9

Tylenol
Tylenol Regular Strength Tablets with 325 mg of Acetaminophen, Fever Reducer & Pain Reliever for Headache, Backache, Muscle Aches, Joint Pain & Menstrual Cramps, 100 ct
Main highlights

Effective Pain and Fever Relief
Tylenol Regular Strength Tablets provide 325 mg of acetaminophen for temporary relief of minor aches and fever reduction.

Versatile Use for Common Ailments
Ideal for headaches, backaches, toothaches, menstrual cramps, and cold-related pain for adults and children 6 years and older.

Trusted Safety and Reliability
Praised for its reliable pain relief and safety profile, as noted in customer reviews.
Key specs
- dosing instructions:Adults and children 6+
- age suitability:6 years and older
- form:Tablets
- active ingredient:acetaminophen
- fever reduction:Yes
8.3

Good

Our Rating
10

TIME-CAP LABS, INC.

TIME-CAP LABS, INC. Timely Acetaminophen 325 MG Tablets 1000 Count - Regular Strength Pain Relief - Menstrual Cramps, Fever Reducer, Minor Pain of Arthritis
8.2

Good

Our Rating

10 Best acetaminophens of 2025

1

Amazon Basic Care Acetaminophen Extended-Release Tablets, 650 mg, Arthritis Pain, 400 Count

9.5

9.5

9.3

How do we rank?

How do we rank?

Analyzing top stores

2

Amazon Basic Care Rapid Release Acetaminophen Caplets 500 mg, Extra Strength Pain Reliever and Fever Reducer, 400 Count

3

Amazon Basic Care Extra Strength Pain Relief, Acetaminophen Caplets, 500 mg, 200 Count (Packaging may vary)

9.7

9.7

9.7

4

Amazon Basic Care Extra Strength Pain Relief, Acetaminophen Caplets, 500 mg, Pain Reliever/Fever Reducer, 500 Count (Packaging may vary)

5

Amazon Basic Care Extra Strength Pain Relief, Acetaminophen Caplets, 500 mg, 1000 Count (Packaging may vary)

9.9

9.7

9.7

6

Amazon Basic Care Extra Strength Pain Relief, Acetaminophen Caplets, 500 mg, Pain Reliever/Fever Reducer, 100 Count (Packaging may vary)

7

GoodSense Extra Strength Pain Relief, Acetaminophen Caplets, 500 mg, 500 Count

9.9

9.7

9.7

8

Amazon Basic Care Acetaminophen Extended-Release Tablets, 650 mg, 100 Count (Packaging may vary)

9.9

9.7

9.3

9

Tylenol Regular Strength Tablets with 325 mg of Acetaminophen, Fever Reducer & Pain Reliever for Headache, Backache, Muscle Aches, Joint Pain & Menstrual Cramps, 100 ct

10

TIME-CAP LABS, INC. Timely Acetaminophen 325 MG Tablets 1000 Count - Regular Strength Pain Relief - Menstrual Cramps, Fever Reducer, Minor Pain of Arthritis

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