10 Best congestion medicines of 2025

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1

Mucinex
Mucinex Fast-Max Severe Congestion & Cough Medicine, Maximum Strength Symptom Relief, Over-The-Counter Medication, Cold Medicine, Cough Suppressant, Expectorant, Nasal Decongestant, FSA/HSA, 6 FL OZ

22% Off
Main highlights

Powerful Multi-Symptom Relief
Maximum Strength Mucinex Fast-Max provides relief for cough, chest congestion, and nasal congestion with a triple-action formula.

Ideal for Severe Cold Symptoms
Best used for severe congestion, persistent cough, and excess mucus for adults 12+ years.

Highly Effective Cough Suppressant
Praised for its ability to provide quick relief from persistent coughing, enabling restful sleep.
9.9

Exceptional

Our Rating

9.3
quality of sleep

9.1
worth the money

8.9
Flavor
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Value for Money

2

Sudafed
Sudafed PE Sinus Congestion Day + Night Maximum Strength Decongestant & Antihistamine Tablets with Phenylephrine HCl & Diphenhydramine HCl, Helps Nasal & Sinus Pressure & Congestion, 20 ct
Main highlights

Powerful Sinus Relief
20-count of maximum strength tablets for day and night sinus congestion relief.

Best for All-Day Use
Ideal for relieving sinus pressure and congestion both day and night.

Fast Symptom Relief
Customers praise quick relief from sinus congestion and pressure.
9.8

Exceptional

Our Rating

9.5
simple to consume

8.7
worth the money

8.4
pain management
3

Mucinex
Mucinex Sinus Max Severe Congestion & Pain Relief, Maximum Strength Nasal & Sinus Relief, Decongestant for Adults, Acetaminophen Pain Reliever, Guaifenesin Expectorant and Mucus Removal, 20 Caplets

21% Off
Main highlights

Maximum Strength Relief
Provides relief from pain, headache, nasal, sinus, and chest congestion.

Ideal for Severe Congestion
Best for adults experiencing severe sinus and nasal congestion.

Praised for Effectiveness
Customers appreciate the product's good results despite small packaging.
9.7

Exceptional

Our Rating
4

Sudafed
Sudafed PE Head Congestion + Mucus Tablets for Sinus Pressure, Pain & Congestion, 24 ct

20% Off
Main highlights

Comprehensive Relief
Provides non-drowsy relief from sinus pain, pressure, and congestion with acetaminophen, phenylephrine HCl, and guaifenesin.

Ideal for Cold and Allergy Symptoms
Perfect for alleviating symptoms of hay fever, upper respiratory allergies, and the common cold.

Highly Effective for Stuffy Nose
Praised for its effectiveness in relieving stuffy noses, according to customer reviews.
9.6

Exceptional

Our Rating

9.9
simple to consume

9.7
pain management

8.0
For Gentle skin
5

Sudafed
Sudafed PE Sinus Pressure + Pain Relief Tablets, Maximum Strength, Non-Drowsy, OTC Sinus Relief Medicine with Acetaminophen Pain Reliever & Phenylephrine HCl Nasal Decongestant, 24 ct

12% Off
Main highlights

Fast Powerful Relief
Provides maximum strength, non-drowsy relief for sinus congestion and pain.

Ideal for Allergy Season
Perfect for relieving nasal congestion from allergies and colds.

Customer Praised Effectiveness
Highly rated for its effective relief during allergy season.
9.5

Excellent

Our Rating

9.1
simple to consume

8.4
worth the money

8.0
Comfort
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6

Benadryl
Benadryl Allergy Plus Congestion Ultratabs with Diphenhydramine HCl Antihistamine & Phenylephrine HCl Nasal Decongestant, Allergy & Sinus Congestion Relief Tablets, 24 ct

35% Off
Main highlights

Comprehensive Allergy and Congestion Relief
Combines diphenhydramine and phenylephrine for effective allergy and congestion relief in one tablet.

Ideal for Allergy and Cold Symptoms
Perfect for relieving symptoms from hay fever, indoor/outdoor allergies, and common cold.

Praised for Itch Relief
Highly recommended for its effectiveness in alleviating itching.
9.3

Excellent

Our Rating
7

Vicks
Vicks Sinex SEVERE LiquiCaps, All-In-One Sinus Relief, Non-Drowsy, Nasal Decongestant, Maximum Strength Relief of Sinus Headache, Pain, Pressure, & Congestion, 24 LiquiCaps

11% Off
Main highlights

Fast Relief from Nasal Congestion
Experience fast, powerful relief from nasal congestion and sinus pain.

Ideal for Sinus Symptoms from Allergies
Best for treating sinus symptoms caused by colds and allergies.

Highly Effective for Sinus Headaches
Commonly praised for quickly alleviating sinus pressure headaches.
9.2

Excellent

Our Rating

9.3
simple to consume

9.3
worth the money

8.9
pain management
8

Boiron
Boiron SinusCalm Tablets for Sinus Pain Relief, Runny Nose, Congestion, Sinus Pressure, Headache - 60 Count

21% Off
Main highlights

Homeopathic Sinus Relief
Targets sinus pain with a stuffy or runny nose, non-drowsy, and non-habit forming.

Convenient for All Ages
Sweet pellets melt under the tongue, suitable for ages 6 and up.

Effective Symptom Relief
Praised for effectively stopping constant runny nose and congestion.
9.1

Excellent

Our Rating

9.3
simple to consume

8.2
Flavor

8.0
worth the money
9

Advil
Advil Sinus Congestion and Pain, Sinus Relief Medicine, Pain Reliever and Fever Reducer with Ibuprofen and Phenylephrine HCl - 10 Coated Tablets

41% Off
Main highlights

Fast Relief for Sinus and Pain
Advil Sinus Congestion and Pain offers rapid relief for sinus pressure, nasal congestion, headaches, and minor body aches.

Daytime and Nighttime Use
Ideal for adults and children 12+ for both daytime and nighttime sinus and pain relief.

Non-Drowsy Formula Praised
Customers appreciate the non-drowsy formula, allowing them to remain active and alert.
8.8

Very Good

Our Rating
10

Tylenol
Tylenol Sinus Severe Daytime Cold & Flu Relief Medicine Caplets, Non-Drowsy Pain Reliever, Fever Reducer Expectorant & Decongestant, Acetaminophen, Guaifenesin & Phenylephrine HCl, 24 ct

28% Off
Main highlights

Non-Drowsy Symptom Relief
Provides non-drowsy relief from sinus headache, nasal congestion, and chest congestion.

Daytime Use for Adults and Teens
Ideal for adults and children 12+ needing daytime sinus relief.

Quick Decongestion Effect
Customers praise its fast-acting decongestion for stuffy head relief.
8.5

Good

Our Rating

10 Best congestion medicines of 2025

1

Mucinex Fast-Max Severe Congestion & Cough Medicine, Maximum Strength Symptom Relief, Over-The-Counter Medication, Cold Medicine, Cough Suppressant, Expectorant, Nasal Decongestant, FSA/HSA, 6 FL OZ

9.3

9.1

8.9

How do we rank?

How do we rank?

Analyzing top stores

2

Sudafed PE Sinus Congestion Day + Night Maximum Strength Decongestant & Antihistamine Tablets with Phenylephrine HCl & Diphenhydramine HCl, Helps Nasal & Sinus Pressure & Congestion, 20 ct

9.5

8.7

8.4

3

Mucinex Sinus Max Severe Congestion & Pain Relief, Maximum Strength Nasal & Sinus Relief, Decongestant for Adults, Acetaminophen Pain Reliever, Guaifenesin Expectorant and Mucus Removal, 20 Caplets

4

Sudafed PE Head Congestion + Mucus Tablets for Sinus Pressure, Pain & Congestion, 24 ct

9.9

9.7

8.0

5

Sudafed PE Sinus Pressure + Pain Relief Tablets, Maximum Strength, Non-Drowsy, OTC Sinus Relief Medicine with Acetaminophen Pain Reliever & Phenylephrine HCl Nasal Decongestant, 24 ct

9.1

8.4

8.0

6

Benadryl Allergy Plus Congestion Ultratabs with Diphenhydramine HCl Antihistamine & Phenylephrine HCl Nasal Decongestant, Allergy & Sinus Congestion Relief Tablets, 24 ct

7

Vicks Sinex SEVERE LiquiCaps, All-In-One Sinus Relief, Non-Drowsy, Nasal Decongestant, Maximum Strength Relief of Sinus Headache, Pain, Pressure, & Congestion, 24 LiquiCaps

9.3

9.3

8.9

8

Boiron SinusCalm Tablets for Sinus Pain Relief, Runny Nose, Congestion, Sinus Pressure, Headache - 60 Count

9.3

8.2

8.0

9

Advil Sinus Congestion and Pain, Sinus Relief Medicine, Pain Reliever and Fever Reducer with Ibuprofen and Phenylephrine HCl - 10 Coated Tablets

10

Tylenol Sinus Severe Daytime Cold & Flu Relief Medicine Caplets, Non-Drowsy Pain Reliever, Fever Reducer Expectorant & Decongestant, Acetaminophen, Guaifenesin & Phenylephrine HCl, 24 ct

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