July 1, 2025

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10 Best upset stomach medicines of 2025

Save up to 34% off

Best Choice

1

Imodium
Imodium Multi-Symptom Relief Caplets with Loperamide Hydrochloride & Simethicone, Anti-Diarrheal Medicine for Treatment of Diarrhea, Gas, Bloating, Cramps & Pressure, Easier to Open, 24 ct

34% Off
Main highlights

Comprehensive Symptom Relief
Combines loperamide HCl and simethicone for diarrhea and abdominal discomfort relief.

Versatile Use Cases
Suitable for adults and children 12+, perfect for home and on-the-go.

Highly Effective Performance
Praised for ease of use and effectiveness in customer reviews.
9.8

Exceptional

Our Rating

9.1
worth the money

8.2
Flavor
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Value for Money

2

Boiron
Boiron NauseaCalm Relief for Upset Stomach, Nausea, and Vomiting Due to Stomach Flu, Overindulgence, or Motion Sickness - Non-Drowsy - 60 Count
Main highlights

Convenient Relief
Meltaway tablets dissolve without water, ideal for travel and quick relief.

Versatile Use
Effective for nausea from stomach flu, overindulgence, and motion sickness.

Customer Praise
Quick dissolving action and pleasant taste frequently praised by users.
9.5

Excellent

Our Rating

9.9
simple to consume

9.7
For traveling

9.3
Flavor
3

Nauzene
Nauzene Non-drowsy Upset Stomach & Nausea Relief Chewable Tablets - Fast-Acting Relief in 4 Minutes - Doctor Recommended - Wild Cherry Flavor, 42 ct
Main highlights

Fast Relief from Discomfort
The 4 Minute Formula quickly relieves stomach discomfort from overindulgence.

Ideal for Chronic Nausea
Perfect for those suffering from chronic nausea and acid reflux.

Highly Effective Nausea Relief
Praised for its effectiveness in alleviating nausea quickly.
9.4

Excellent

Our Rating

9.9
Simple to use

8.9
worth the money

8.2
Flavor
4

Pepto Bismol
Pepto Bismol Liquid for Nausea, Heartburn, Indigestion, Upset Stomach, and Diarrhea - Fast Relief for 5 Symptoms, Original Flavor, 2x12 oz
Main highlights

Fast Relief for Multiple Symptoms
Pepto Bismol provides quick relief for nausea, heartburn, indigestion, upset stomach, and diarrhea.

Ideal for Quick Stomach Relief
Perfect for anyone needing fast, effective relief from common digestive discomforts.

Trusted Family Classic
Customers appreciate Pepto Bismol's reliability as a classic, effective stomach remedy.
9.3

Excellent

Our Rating

9.3
Flavor

9.3
worth the money
5

Pepto Bismol
Pepto Bismol Caplets Ultra for Nausea, Heartburn, Indigestion, Upset Stomach, and Diarrhea - 5 Symptom Fast Relief, 24 ct

16% Off
Main highlights

Fast Relief for Five Symptoms
Pepto Bismol Caplets Ultra provide quick relief for nausea, heartburn, indigestion, upset stomach, and diarrhea with a 2X concentrated formula.

Ideal for Travel and Busy Lifestyles
Compact caplets are perfect for travelers and those needing quick relief without carrying liquid bottles.

Highly Praised for Effectiveness
Customers frequently commend the caplets for their fast and effective relief, especially in diverse food environments.
9.2

Excellent

Our Rating

9.3
For traveling

8.7
simple to consume

8.7
worth the money
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6

Pepto Bismol
Pepto Bismol Chewable Tablets for Nausea, Heartburn, Indigestion, Upset Stomach, and Diarrhea - 5 Symptom Fast Relief, Original Flavor, 48 ct
Main highlights

Five Symptom Relief
Provides fast relief for nausea, heartburn, indigestion, upset stomach, and diarrhea.

Ideal for Travel
Perfect for on-the-go relief, making it travel-friendly.

Praised for Convenience
Customers appreciate its portability and ease of use.
9.1

Excellent

Our Rating

9.9
movability

9.7
Simple to use

9.3
simple to consume
7

UpSpring
UpSpring Stomach Settle Drops for Occasional Nausea Relief/Upset Stomach with Ginger, Lemon, Spearmint, and B6. Mint Flavor Drops, 28 Ct(Packaging May Vary)
Main highlights

Soothing Herbal Relief
Combines ginger, spearmint, lemon, and B6 for upset stomach relief.

Perfect for Travelers
Individually wrapped drops ideal for on-the-go nausea relief.

Popular Flavor Combination
Distinctive lemon, ginger, and mint flavors praised by users.
9.0

Excellent

Our Rating

9.5
For traveling

8.9
Flavor

8.7
worth the money
8

Kaopectate
Kaopectate Multi-Symptom Anti-Diarrheal& Upset Stomach Reliever, 42 Caplets

28% Off
Main highlights

Multi-Symptom Relief
Provides relief from diarrhea, nausea, indigestion, gas, and more with trusted Bismuth subsalicylate.

Travel-Friendly Solution
Convenient caplets are ideal for on-the-go relief from stomach discomfort.

Highly Praised Portability
Customers appreciate its effectiveness and convenience for travel and daily use.
8.7

Very Good

Our Rating

9.1
simple to consume

8.9
worth the money

8.7
Flavor
9

Nauzene
Nauzene Non-drowsy Upset Stomach & Nausea Relief Chewable Tablets - Fast-Acting Relief in 4 Minutes - Doctor Recommended - Wild Cherry Flavor, 56 ct

25% Off
Main highlights

Quick Relief Formula
The 4-minute formula quickly alleviates stomach discomfort from overindulgence.

Ideal for Overindulgence
Perfect for relieving nausea and discomfort after heavy meals or drinks.

Fast-Acting and Effective
Praised for quick action and effectiveness in user reviews.
8.6

Very Good

Our Rating

9.3
worth the money

8.4
Flavor
10

Pepto Bismol
Pepto Bismol Original Liquid 5 Symptom Medicine - Including Upset Stomach and Diarrhea Relief 8 oz (Packaging May Vary)
Main highlights

5 Symptom Relief
Provides relief from nausea, heartburn, indigestion, upset stomach, and diarrhea.

Ideal for Quick Relief
Perfect for those needing fast, effective stomach relief anytime.

Customer Praised Effectiveness
Highly praised for its fast-acting and reliable relief.
8.4

Good

Our Rating

9.7
quality of ingredients

9.3
worth the money

8.2
Flavor

10 Best upset stomach medicines of 2025

1

Imodium Multi-Symptom Relief Caplets with Loperamide Hydrochloride & Simethicone, Anti-Diarrheal Medicine for Treatment of Diarrhea, Gas, Bloating, Cramps & Pressure, Easier to Open, 24 ct

9.1

8.2

How do we rank?

How do we rank?

Analyzing top stores

2

Boiron NauseaCalm Relief for Upset Stomach, Nausea, and Vomiting Due to Stomach Flu, Overindulgence, or Motion Sickness - Non-Drowsy - 60 Count

9.9

9.7

9.3

3

Nauzene Non-drowsy Upset Stomach & Nausea Relief Chewable Tablets - Fast-Acting Relief in 4 Minutes - Doctor Recommended - Wild Cherry Flavor, 42 ct

9.9

8.9

8.2

4

Pepto Bismol Liquid for Nausea, Heartburn, Indigestion, Upset Stomach, and Diarrhea - Fast Relief for 5 Symptoms, Original Flavor, 2x12 oz

9.3

9.3

5

Pepto Bismol Caplets Ultra for Nausea, Heartburn, Indigestion, Upset Stomach, and Diarrhea - 5 Symptom Fast Relief, 24 ct

9.3

8.7

8.7

6

Pepto Bismol Chewable Tablets for Nausea, Heartburn, Indigestion, Upset Stomach, and Diarrhea - 5 Symptom Fast Relief, Original Flavor, 48 ct

9.9

9.7

9.3

7

UpSpring Stomach Settle Drops for Occasional Nausea Relief/Upset Stomach with Ginger, Lemon, Spearmint, and B6. Mint Flavor Drops, 28 Ct(Packaging May Vary)

9.5

8.9

8.7

8

Kaopectate Multi-Symptom Anti-Diarrheal& Upset Stomach Reliever, 42 Caplets

9.1

8.9

8.7

9

Nauzene Non-drowsy Upset Stomach & Nausea Relief Chewable Tablets - Fast-Acting Relief in 4 Minutes - Doctor Recommended - Wild Cherry Flavor, 56 ct

9.3

8.4

10

Pepto Bismol Original Liquid 5 Symptom Medicine - Including Upset Stomach and Diarrhea Relief 8 oz (Packaging May Vary)

9.7

9.3

8.2

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