10 Best topical anesthetics of 2025

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Best Choice

1

Curist
Curist 5% Lidocaine Cream Maximum Strength Topical Pain Relief - 6 oz (170 g) XL Tube - Numb Quickly & Effectively Numbing Formulation - (1 Pack - 6 oz Tube)
Main highlights

Maximum Strength Relief
Experience deep pain relief with 5% lidocaine, the strongest OTC formulation.

Versatile Use Cases
Ideal for hemorrhoids, bug bites, rashes, bruises, and more.

Highly Recommended Application
Customers praise its non-greasy, quick-absorbing formula and long-lasting effect.
9.8

Exceptional

Our Rating

8.2
pain management

8.0
worth the money
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Value for Money

2

Treatonic

Treatonic Maximum Strength Numbing Cream: Numbing Cream for Discomfort, Burn, Itch & Pain Relief - Fast-Acting, Soothing Topical Anesthetic with Menthol & Emu Oil for Hemorrhoid Treatment – 1.7oz
9.6

Exceptional

Our Rating
3

Ebanel
Ebanel 5% Lidocaine Numbing Cream, Pain Relief Burn Itch Numb Cream, Maximum Strength Topical Anesthetic with Allantoin, Vitamin E for Local and Anorectal Uses, Hemorrhoid Treatment, 1.35 Oz
Main highlights

Fast-Acting Long-Lasting Relief
Ebanel 5 Lidocaine Cream provides quick, enduring numbing for pain relief and itch reduction.

Ideal for Skin Procedures
Perfect for tattoos, microneedling, waxing, and injections, enhancing comfort during sessions.

Highly Praised Numbing Effect
Customers commend its ability to significantly reduce discomfort and improve treatment experience.
9.5

Excellent

Our Rating

8.9
Simple to use

8.0
Absorbency

8.0
Gentle
4

HealthWise

HealthWise Maximum OTC Strength Lidocaine Cream | Numbs Away Pain | Long-Lasting Relief | Non-Greasy | 2.7 Oz | Unscented Formula | Topical Anesthetic
9.4

Excellent

Our Rating
5

Bactine MAX
Bactine MAX First Aid Spray - Cleansing Spray with 4% Lidocaine - Relief for Minor Cuts, Burns & Bug Bites - 5oz
Main highlights

Max Relief and Germ Protection
Bactine MAX provides pain and itch relief while killing 99% of germs.

Ideal for Minor Injuries
Perfect for cuts, scrapes, burns, bug bites, and sunburns.

No-Sting Application Praised
Customers appreciate the sting-free application, even on sensitive skin.
9.3

Excellent

Our Rating

9.7
Simple to use

9.3
pain management

8.7
Easy to grip
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6

EBANEL LABORATORIES
Ebanel 5% Lidocaine Spray Pain Relief Numb520 Burn Itch Relief Numbing Spray for Skin, Topical Anesthetic Postpartum Hemorrhoid Treatment with Phenylephrine for Local and Anorectal Uses
Main highlights

Fast-Acting Pain Relief
Ebanel 5 Lidocaine Spray offers immediate relief from pain, itching, and discomfort with its enhanced lidocaine and phenylephrine formula.

Versatile Use Cases
Ideal for tattoos, waxing, and minor skin irritations, providing temporary relief and comfort in sensitive areas.

Effective Numbing Experience
Customers praise its ability to significantly reduce pain during long tattoo sessions and other procedures.
Key specs
- active ingredients:Lidocaine, Phenylephrine HCl
- application method:Spray on skin
- usage:Numbing, itch relief
- formulation:Spray
- pain relief:Immediate, 1 hour duration
9.0

Excellent

Our Rating

8.0
Simple to use

8.0
worth the money

8.0
pain management
7

Americaine

Americaine Hospital Formula, Maximum Strength Benzocaine Topical Anesthetic Spray, For Minor Cuts, Scrapes, Burns & Sunburn, 2 oz Can (Packaging may vary)
8.9

Very Good

Our Rating
8

HealthWise
HealthWise Lidocaine Plus+ Cream | Numbs Away Pain | | Non-Greasy | 3.0 Oz | 4% OTC Lidocaine + 10% Benzyl Alcohol | Topical Anesthetic
Main highlights

Powerful Pain Relief
Combines 4% lidocaine and 10% benzyl alcohol for effective pain numbing.

Ideal for Muscle and Joint Aches
Perfect for arthritis, backaches, strains, sprains, and bruises.

Non-Greasy Formula Praised
Customers love the smooth, non-greasy application.
Key specs
- Package Type:Tube
- Active Ingredients:Lidocaine, Benzyl Alcohol
- Application Method:Apply directly to skin
- Formulation:Non-greasy cream
- Target Area:Muscles and joints
8.7

Very Good

Our Rating
9

HealthWise

HealthWise 4% Lidocaine Roll-On | OTC Strength | Pain Relief Liquid | 2.5 oz. 73 mL | Non-Greasy, Unscented Formula | Topical Anesthetic
8.5

Good

Our Rating
10

Aspercreme
Aspercreme Lidocaine Pain Relief Cream Soothes Aggravated Nerves, Numbing Topical Analgesic with Max-Strength 4% Lidocaine & Moisturizing Aloe, 4.3 Oz.

34% Off
Main highlights

Fast-Acting Numbing Relief
Contains 4% lidocaine for quick, effective pain relief.

Ideal for Joint and Muscle Pain
Perfect for arthritis, backaches, sprains, and strains.

Praised for Ease of Use
Customers love its ease of application and effectiveness.
Key specs
- Package Type:Bottle
- Active Ingredients:4% Lidocaine
- Application Method:Topical
- Formulation:Cream
- Target Area:Joints & Muscles
8.2

Good

Our Rating

8.4
worth the money

8.4
pain management

10 Best topical anesthetics of 2025

1

Curist 5% Lidocaine Cream Maximum Strength Topical Pain Relief - 6 oz (170 g) XL Tube - Numb Quickly & Effectively Numbing Formulation - (1 Pack - 6 oz Tube)

8.2

8.0

How do we rank?

How do we rank?

Analyzing top stores

2

Treatonic Maximum Strength Numbing Cream: Numbing Cream for Discomfort, Burn, Itch & Pain Relief - Fast-Acting, Soothing Topical Anesthetic with Menthol & Emu Oil for Hemorrhoid Treatment – 1.7oz

3

Ebanel 5% Lidocaine Numbing Cream, Pain Relief Burn Itch Numb Cream, Maximum Strength Topical Anesthetic with Allantoin, Vitamin E for Local and Anorectal Uses, Hemorrhoid Treatment, 1.35 Oz

8.9

8.0

8.0

4

HealthWise Maximum OTC Strength Lidocaine Cream | Numbs Away Pain | Long-Lasting Relief | Non-Greasy | 2.7 Oz | Unscented Formula | Topical Anesthetic

5

Bactine MAX First Aid Spray - Cleansing Spray with 4% Lidocaine - Relief for Minor Cuts, Burns & Bug Bites - 5oz

9.7

9.3

8.7

6

Ebanel 5% Lidocaine Spray Pain Relief Numb520 Burn Itch Relief Numbing Spray for Skin, Topical Anesthetic Postpartum Hemorrhoid Treatment with Phenylephrine for Local and Anorectal Uses

8.0

8.0

8.0

7

Americaine Hospital Formula, Maximum Strength Benzocaine Topical Anesthetic Spray, For Minor Cuts, Scrapes, Burns & Sunburn, 2 oz Can (Packaging may vary)

8

HealthWise Lidocaine Plus+ Cream | Numbs Away Pain | | Non-Greasy | 3.0 Oz | 4% OTC Lidocaine + 10% Benzyl Alcohol | Topical Anesthetic

9

HealthWise 4% Lidocaine Roll-On | OTC Strength | Pain Relief Liquid | 2.5 oz. 73 mL | Non-Greasy, Unscented Formula | Topical Anesthetic

10

Aspercreme Lidocaine Pain Relief Cream Soothes Aggravated Nerves, Numbing Topical Analgesic with Max-Strength 4% Lidocaine & Moisturizing Aloe, 4.3 Oz.

8.4

8.4

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