10 Best psoriasis topicals of 2025

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Best Choice

1

PSODEX
PSODEX Psoriasis Cream – 3.4fl oz Topical Psoriasis Treatment with Coal Tar, Salicylic Acid, Tea Tree Oil, Aloe Vera – All-Natural Ingredients – Soothing and Moisturizing Coal Tar Psoriasis Cream
Main highlights

Natural and Medicated Relief
Psodex Psoriasis Cream provides safe, effective relief with natural ingredients, free from harsh chemicals, ensuring optimal skin care.

Comprehensive Treatment Plan
Ideal for all psoriasis types; use 2-4 times daily based on severity for best results.

Praised Skin Protection
Customers appreciate its protective barrier, preventing further issues and aiding healing.
9.8

Exceptional

Our Rating
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Value for Money

2

Amélie Monnier
Clinically Tested DermaCalm SOS Therapy - Eczema Psoriasis Dermatitis Prone, Dry Skin - Urea 8%, Probiotics w/Best Natural Ingredients - Itchy, Severely Dry, Scaly Skin. Adults & Kids, Eczema Cream
Main highlights

Moisture Sealing Formula
Seals in moisture and repairs dry skin barrier for relief.

Ideal for Travel
Includes five individual sachets for easy travel use.

Highly Soothing
Customers praise its calming effect on itchy, dry skin.
9.7

Exceptional

Our Rating

9.5
Moisturizing

9.3
Aroma

8.7
worth the money
3

Gold Bond
Gold Bond Multi-Symptom Psoriasis Relief Cream, 4 oz., for Itchy, Irritated & Scaling Skin

16% Off
Main highlights

Effective Psoriasis Relief
Gold Bond cream alleviates itching, irritation, and flaking, offering steroid-free relief for psoriasis and seborrheic dermatitis.

Daily Use for Sensitive Skin
Ideal for daily application on sensitive skin areas, ensuring consistent symptom management without irritation.

Instant Skin Soothing
Customers praise its immediate soothing effect, providing quick relief from discomfort and visible skin improvements.
9.6

Exceptional

Our Rating

9.3
Comfort

9.1
Moisturizing

8.9
Aroma
4

CeraVe
CeraVe Moisturizing Cream for Psoriasis Treatment, With Salicylic Acid for Dry Skin Itch Relief & Urea for Moisturizing, Fragrance Free & Allergy Tested, 8 Oz
Main highlights

Moisturizing and Exfoliating Benefits
Formulated with salicylic acid and urea to relieve dry, itchy skin.

Ideal for Psoriasis Treatment
Best for use on psoriasis-prone skin, hands, and face.

Customer Praised Skin Softening
Highly praised for smoothing rough, bumpy skin effectively.
9.5

Excellent

Our Rating

8.9
Moisturizing

8.0
worth the money

8.0
Long life
5

Nizoral
Nizoral Psoriasis Relief Cream- Relieves Itching, Irritation & Redness and Controls Flaking and Scaling with Maximum Strength Medicine (Salicylic Acid 3%), 4 Fl Oz
Main highlights

Maximum Strength Relief
Contains 3% Salicylic Acid to relieve itching and redness.

Effective for Psoriasis
Ideal for controlling flaking and scaling of psoriasis symptoms.

Customer Praised Absorption
Absorbs well when massaged, leaving skin smooth and soft.
9.4

Excellent

Our Rating
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6

MG217
MG217 Multi Symptom Relief 2% Coal Tar Medicated Psoriasis Ointment oz Jar, 4 Oz
Main highlights

Effective Psoriasis Treatment
MG217 ointment helps slow cell overgrowth and prevents symptom recurrence, offering relief from itching, redness, and flaky skin.

Best for Persistent Psoriasis
Ideal for individuals seeking relief from chronic psoriasis symptoms, including seborrheic dermatitis.

Praised Healing Effect
Customers appreciate its ability to heal redness and flaking long-term, outperforming many over-the-counter alternatives.
9.3

Excellent

Our Rating

8.7
Moisturizing

8.7
worth the money

8.0
Aroma
7

MG217
MG217 Medicated Moisturizing Psoriasis Cream With 3% Salicylic Acid, Multi-symptom, Fragrance Free, 3.5 Fl Oz, (5604)

10% Off
Main highlights

Moisturizing Treatment with Salicylic Acid
Combines salicylic acid with moisturizing agents to control flaking and prevent symptom recurrence.

Ideal for Psoriasis and Dermatitis
Best used for managing psoriasis and seborrheic dermatitis symptoms on dry skin.

Fragrance-Free and Non-Greasy
Praised for being fragrance-free and absorbing without leaving a greasy residue.
9.1

Excellent

Our Rating

9.1
quality of ingredients

8.4
Fashion

8.4
Moisturizing
8

Cortizone 10
Cortizone 10 Anti-Itch Lotion for Psoriasis 3.4 oz (96g) , Maximum Strength 1% Hydrocortisone
Main highlights

Maximum Strength Relief
Contains maximum strength hydrocortisone for effective itch relief.

Ideal for Psoriasis
Designed to soothe itching and irritation from psoriasis.

Non-Sticky Texture
Praised for its non-sticky and pleasant application.
8.9

Very Good

Our Rating

9.7
Moisturizing

9.3
worth the money

8.7
For Gentle skin
9

MG217

MG217 2% Coal Tar Ointment for Psoriasis, Extra Strength Multi Symptom Relief, Effectively Relieves Itching, Scaling, Redness, Vitamin A, D and E, 4 oz Jar
8.8

Very Good

Our Rating
10

CalmScalp
CalmScalp Topical Scalp Solution | Calms Irritated Scalp | Controls Dry Scalp & Flakes | Reduces Scales & Redness | Clinically Proven | Non Shampoo Leave-On Scalp Treatment | Made in The USA | 4 oz.
Main highlights

Clinically Proven Relief
Reduces redness, scales, flakes, and dry patches on irritated scalp.

Ideal for Psoriasis and Dermatitis
Perfect for those with mild to moderate psoriasis and seborrheic dermatitis.

Non-Greasy and Fast-Drying
Praised for its easy application and non-dripping formula.
8.7

Very Good

Our Rating

9.5
Simple to use

9.1
Moisturizing

8.0
Aroma

10 Best psoriasis topicals of 2025

1

PSODEX Psoriasis Cream – 3.4fl oz Topical Psoriasis Treatment with Coal Tar, Salicylic Acid, Tea Tree Oil, Aloe Vera – All-Natural Ingredients – Soothing and Moisturizing Coal Tar Psoriasis Cream

How do we rank?

How do we rank?

Analyzing top stores

2

Clinically Tested DermaCalm SOS Therapy - Eczema Psoriasis Dermatitis Prone, Dry Skin - Urea 8%, Probiotics w/Best Natural Ingredients - Itchy, Severely Dry, Scaly Skin. Adults & Kids, Eczema Cream

9.5

9.3

8.7

3

Gold Bond Multi-Symptom Psoriasis Relief Cream, 4 oz., for Itchy, Irritated & Scaling Skin

9.3

9.1

8.9

4

CeraVe Moisturizing Cream for Psoriasis Treatment, With Salicylic Acid for Dry Skin Itch Relief & Urea for Moisturizing, Fragrance Free & Allergy Tested, 8 Oz

8.9

8.0

8.0

5

Nizoral Psoriasis Relief Cream- Relieves Itching, Irritation & Redness and Controls Flaking and Scaling with Maximum Strength Medicine (Salicylic Acid 3%), 4 Fl Oz

6

MG217 Multi Symptom Relief 2% Coal Tar Medicated Psoriasis Ointment oz Jar, 4 Oz

8.7

8.7

8.0

7

MG217 Medicated Moisturizing Psoriasis Cream With 3% Salicylic Acid, Multi-symptom, Fragrance Free, 3.5 Fl Oz, (5604)

9.1

8.4

8.4

8

Cortizone 10 Anti-Itch Lotion for Psoriasis 3.4 oz (96g) , Maximum Strength 1% Hydrocortisone

9.7

9.3

8.7

9

MG217 2% Coal Tar Ointment for Psoriasis, Extra Strength Multi Symptom Relief, Effectively Relieves Itching, Scaling, Redness, Vitamin A, D and E, 4 oz Jar

10

CalmScalp Topical Scalp Solution | Calms Irritated Scalp | Controls Dry Scalp & Flakes | Reduces Scales & Redness | Clinically Proven | Non Shampoo Leave-On Scalp Treatment | Made in The USA | 4 oz.

9.5

9.1

8.0

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