10 Best phlegm expectorants of 2025

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1

Curist
Curist Guaifenesin 600 mg Extended Release Tablets (300 Dye-Free Tablets) - Expectorant Mucus Relief, Generic Guaifenesin 600 mg, (Bulk Pack)
Main highlights

Extended Release Relief
Provides 12-hour relief from congestion and sinus pressure.

Ideal for Cold and Allergy
Best for relieving cold and allergy-induced mucus and congestion.

Customer Praised Value
Praised for effectiveness and affordability compared to name brands.
Key specs
- form:Tablets
- active ingredient:Guaifenesin 600 mg
- symptom relief:Mucus relief
- dosage:600 mg
- target age:12 & up
9.8

Exceptional

Our Rating
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Value for Money

2

Mucinex
Mucinex 12 Hour 600 mg Guaifenesin Extended-Release Tablets for Excess Mucus Relief, Expectorant Aids Excess Mucus Removal, Chest Congestion Relief, 100 Bi-Layer Tablets
Main highlights

Extended Relief and Mucus Control
Mucinex 12 Hour Tablets offer long-lasting chest congestion relief by thinning and loosening mucus for a productive cough.

Chronic Congestion and Flu Season
Perfect for managing chest congestion during flu season and for those with chronic respiratory conditions like COPD.

Long-lasting Effectiveness
Customers appreciate its continuous 12-hour relief, minimizing the need for frequent doses.
9.5

Excellent

Our Rating

9.7
quality of ingredients

9.5
worth the money

9.3
simple to consume
3

Amazon Basic Care
Amazon Basic Care Guaifenesin Cough and Mucus Relief Extended-Release Tablets, 600 mg, 12 Hour Expectorant, 20 Count
Main highlights

Effective 12-Hour Relief
Amazon Basic Care Guaifenesin Tablets provide up to 12 hours of chest congestion relief, helping to thin and loosen mucus effectively.

Best for Chest Congestion
Ideal for adults and children 12+ needing long-lasting relief from chest congestion due to mucus.

Praised for Cost Efficiency
Customers appreciate the cost-effectiveness, noting it's cheaper than pharmacy options and name brands.
Key specs
- form:Extended-Release Tablets
- active ingredient:Guaifenesin 600 mg
- symptom relief:Chest congestion relief
- dosage:600 mg
- target age:12 years and older
9.4

Excellent

Our Rating

9.7
quality of ingredients

9.5
simple to consume

9.3
worth the money
4

Mucinex
Mucinex Chest Congestion Maximum Strength 12 Hour Extended Release Tablets Relieves Chest Congestion Caused by Excess Mucus(#1 Doctor Recommended OTC expectorant), 1200mg, 42 Count (Pack of 1)
Main highlights

Long-lasting Relief
Mucinex provides 12-hour maximum strength chest congestion and mucus relief.

Ideal for Cold Season
Perfect for adults needing effective mucus removal during cold seasons.

Highly Effective Dosage
Users praise its effectiveness, preferring it over taking multiple doses.
9.3

Excellent

Our Rating

9.5
Comfort

9.3
worth the money

8.7
simple to consume
5

Amazon Basic Care
Amazon Basic Care Maximum Strength Mucus DM, Expectorant and Cough Suppressant, 14 Tablets
Main highlights

Powerful Cough and Congestion Relief
Combines 1200 mg guaifenesin and 60 mg dextromethorphan HBr for maximum strength relief.

Best for Severe Cold and Allergies
Perfect for managing tough cold symptoms and allergy-related coughing.

Customer Praised Effectiveness
Highly rated for alleviating cough and congestion, comparable to Mucinex.
Key specs
- active ingredient:dextromethorphan HBr, guaifenesin
- formulation:tablets
- flavor:N/A
- pack size:N/A
- sugar free:N/A
9.2

Excellent

Our Rating

9.1
worth the money

8.4
simple to consume

8.2
Flavor
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6

GenCare
GenCare Mucus Relief Expectorant Guaifenesin 400 mg 200 Tablets Value Pack - Fast Acting Thinning of Mucus for Colds, Chest Congestion, Flu, Coughing and Allergies

23% Off
Main highlights

Fast Relief with Guaifenesin
GenCare Mucus Relief contains 400mg Guaifenesin to thin mucus, easing breathing and expelling phlegm.

Effective for Colds and Flu
Ideal for combatting chest congestion, mucus, and bronchial secretions caused by colds and flu.

Cost-Effective Alternative
Praised for being more affordable than Mucinex, with similar active ingredients and effectiveness.
Key specs
- form:Tablets
- active ingredient:Guaifenesin
- symptom relief:Mucus and phlegm
- dosage:N/A
- target age:12 years and up
9.1

Excellent

Our Rating

8.9
worth the money

8.7
simple to consume

8.0
Flavor
7

Buckley's
BUCKLEY'S Original 'EXPECTORANT' Syrup for COUGH, MUCUS & PHLEGM 150 ml Size
Main highlights

Effective Mucus Relief
Buckley's Original Expectorant Syrup effectively loosens and thins mucus, aiding in its removal from the lungs.

Ideal for Persistent Coughs
Best used for stubborn coughs and colds resistant to other treatments.

Highly Praised Effectiveness
Customers consistently praise its ability to quickly alleviate cough symptoms despite its unpleasant taste.
8.9

Very Good

Our Rating
8

Safrel
Safrel Pharma Mucus Relief Guaifenesin 400 mg - Fast Acting Expectorant, Thins and Loosens Mucus, Relieves Chest Congestion, Cough, Cold and Flu | Compare to Mucinex Tablets (200 Count (Pack of 1))

22% Off
Main highlights

Fast Acting Expectorant
Safrel Pharma Mucus Relief Guaifenesin 400 mg quickly thins mucus, easing chest congestion and cough.

Ideal for Mild Congestion
Best used for mild congestion, providing effective relief without excessive drying.

Easier Swallowing Experience
Customers appreciate the easier swallowing and less aftertaste compared to other brands.
8.8

Very Good

Our Rating
9

NUVICARE
NUVICARE Expectorant Mucus Relief 400mg - Guaifenesin 400mg Tablets - Fast Chest Congestion Relief for Adults - Compare to Mucinex Tablets - Generic Mucus Clear for Phlegm and Congestion (100 Count)

38% Off
Main highlights

Powerful Chest Congestion Relief
Nuvicare tablets provide fast-acting, effective support to clear airways and ease breathing with 400mg guaifenesin.

Ideal for Respiratory Conditions
Perfect for adults dealing with chest congestion and mucus buildup, similar to Mucinex.

Fast-Acting Formula Praised
Customers love the quick relief from congestion and heavy breathing.
Key specs
- form:Tablets
- active ingredient:Guaifenesin 400 mg
- symptom relief:Mucus congestion
- dosage:400 mg
- target age:N/A
8.7

Very Good

Our Rating
10

HealthA2Z

HealthA2Z® Mucus Relief | Guaifenesin 600 mg | 12 Hour | No Benzene | Expectorant | Relieves Chest Congestion | Thins and Loosens Mucus | Extended Release (75 Counts)
8.6

Very Good

Our Rating

10 Best phlegm expectorants of 2025

1

Curist Guaifenesin 600 mg Extended Release Tablets (300 Dye-Free Tablets) - Expectorant Mucus Relief, Generic Guaifenesin 600 mg, (Bulk Pack)

How do we rank?

How do we rank?

Analyzing top stores

2

Mucinex 12 Hour 600 mg Guaifenesin Extended-Release Tablets for Excess Mucus Relief, Expectorant Aids Excess Mucus Removal, Chest Congestion Relief, 100 Bi-Layer Tablets

9.7

9.5

9.3

3

Amazon Basic Care Guaifenesin Cough and Mucus Relief Extended-Release Tablets, 600 mg, 12 Hour Expectorant, 20 Count

9.7

9.5

9.3

4

Mucinex Chest Congestion Maximum Strength 12 Hour Extended Release Tablets Relieves Chest Congestion Caused by Excess Mucus(#1 Doctor Recommended OTC expectorant), 1200mg, 42 Count (Pack of 1)

9.5

9.3

8.7

5

Amazon Basic Care Maximum Strength Mucus DM, Expectorant and Cough Suppressant, 14 Tablets

9.1

8.4

8.2

6

GenCare Mucus Relief Expectorant Guaifenesin 400 mg 200 Tablets Value Pack - Fast Acting Thinning of Mucus for Colds, Chest Congestion, Flu, Coughing and Allergies

8.9

8.7

8.0

7

BUCKLEY'S Original 'EXPECTORANT' Syrup for COUGH, MUCUS & PHLEGM 150 ml Size

8

Safrel Pharma Mucus Relief Guaifenesin 400 mg - Fast Acting Expectorant, Thins and Loosens Mucus, Relieves Chest Congestion, Cough, Cold and Flu | Compare to Mucinex Tablets (200 Count (Pack of 1))

9

NUVICARE Expectorant Mucus Relief 400mg - Guaifenesin 400mg Tablets - Fast Chest Congestion Relief for Adults - Compare to Mucinex Tablets - Generic Mucus Clear for Phlegm and Congestion (100 Count)

10

HealthA2Z® Mucus Relief | Guaifenesin 600 mg | 12 Hour | No Benzene | Expectorant | Relieves Chest Congestion | Thins and Loosens Mucus | Extended Release (75 Counts)

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