10 Best over counter cold and flu medicines of 2025

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1

Vicks
VICKS DayQuil & NyQuil SEVERE Co-Pack, Cold & Flu Medicine, Powerful Relief for Headache, Fever, Sore Throat, Minor Aches & Pains, Congestion, Sinus Pressure, Stuffy Nose, and Cough, 48 LiquiCaps
Main highlights

Powerful 9-Symptom Relief
Vicks DayQuil and NyQuil Severe provide maximum strength relief for 9 common cold and flu symptoms.

Day and Night Use
Ideal for daytime use with DayQuil's non-drowsy formula and nighttime relief with NyQuil for restful sleep.

Quick Symptom Relief
Customers praise the fast-acting nature, clearing congestion in 10-15 minutes.
9.7

Exceptional

Our Rating

8.9
Flavor

8.7
simple to consume

8.2
worth the money
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Value for Money

2

Vicks
VICKS DayQuil & NyQuil SEVERE Honey Flavor Co-Pack, Cold & Flu Medicine, Relieves Headache, Fever, Sore Throat, Minor Aches & Pains, Nasal Congestion, Sinus Pressure, Stuffy Nose, and Cough, 2x12oz
Main highlights

Maximum Strength Relief
Provides powerful relief for 9 cold and flu symptoms with real honey flavor.

Day and Night Use
Ideal for treating symptoms any time with non-drowsy DayQuil and restful NyQuil.

Honey Flavor Praised
Most users appreciate the honey flavor for better taste compared to traditional options.
9.6

Exceptional

Our Rating

8.0
worth the money

8.0
Flavor
3

Contac
Contac Non-Drowsy Day & Multi-Symptom Night Cold & Flu Medicine, Maximum Strength Relief for Fever, Sore Throat, Nasal Congestion, Head & Body Aches, Runny Nose, 28 Count, 16 Day, 12 Night Caplets
Main highlights

Maximum Strength Relief
Provides maximum strength relief for cold and flu symptoms.

Day and Night Use
Ideal for continuous relief with separate day and night formulas.

Customer Praised Effectiveness
Highly praised for relieving nasal congestion and body aches.
9.4

Excellent

Our Rating
4

Vicks
VICKS NyQuil Cold & Flu Relief Over-the-Counter Medicine, Powerful Multi-Symptom Nighttime Relief for Headache, Fever, Sore Throat, Minor Aches & Pains, Sneezing, Runny Nose, and Cough, 48 LiquiCaps
Main highlights

Powerful Multi-Symptom Relief
NyQuil provides fast relief for headache, fever, sore throat, sneezing, and cough.

Ideal for Nighttime Use
Perfect for nighttime use to alleviate cold and flu symptoms and ensure restful sleep.

Cost-Effective and Convenient
Highly praised for its cost-effectiveness and convenience, especially with Subscribe and Save.
9.3

Excellent

Our Rating

9.1
worth the money

9.1
Flavor

8.9
simple to consume
5

Mucinex
Mucinex Maximum Strength Fast-Max Cold & Flu and Nightshift, All-in-One Multi Symptom Relief Liquid, 6 Fl Oz - 2 Count (Pack of 1)

18% Off
Main highlights

Powerful Multi-Symptom Relief
Provides maximum strength relief for cold and flu symptoms, including sore throat, cough, and congestion.

Ideal for Severe Cold and Flu
Perfect for adults experiencing severe cold and flu symptoms, day or night.

Highly Effective Liquid Formula
Customers praise the liquid formula for its fast-acting relief and pleasant grape flavor.
9.2

Excellent

Our Rating

8.7
Flavor

8.7
worth the money

8.0
Simple to use
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6

Mucinex

Mucinex Fast-Max Maximum Strength Cold and Flu Medicine for Adults, Powerful Over-The-Counter Medication for 6 Different Cold & Flu Symptoms, Fast Release Caplets, 20 Count
9.1

Excellent

Our Rating
7

HealthA2Z
HealthA2Z® Daytime and Nighttime | Cold & Flu Medicine | Powerful Multi-Symptom Daytime and Nighttime Relief (24 Daytime & 12 Nighttime Softgels) (Daytime & Nighttime Combo (36 Count Pack of 1))
Main highlights

Powerful Multi-Symptom Relief
HealthA2Z Daytime and Nighttime Cold & Flu Medicine offers effective relief for various symptoms, similar to leading brands, at a great value.

Convenient Day and Night Use
Includes both daytime and nighttime formulas in one package, perfect for around-the-clock symptom management.

Easy to Swallow Softgels
Customers appreciate the easy-to-swallow softgel capsules with no aftertaste, enhancing user experience.
8.8

Very Good

Our Rating
8

Vicks
Vicks DayQuil & Nyquil Severe Cold, Flu & Congestion Medicine, 24 Count

16% Off
Main highlights

Powerful and Fast Acting Relief
DayQuil and NyQuil SEVERE provide maximum strength relief for 9 symptoms, working quickly to alleviate discomfort.

Day and Night Usage
Ideal for continuous relief, DayQuil for daytime and NyQuil for nighttime use, ensuring you can stay active and rest well.

Trusted Brand Endorsement
Praised for its effectiveness, Vicks is the world's #1 selling OTC cough and cold brand, trusted for over 125 years.
8.7

Very Good

Our Rating
9

Advil
Advil Multi Symptom Cold and Flu Medicine, Cold Medicine for Adults with Ibuprofen, Phenylephrine HCL and Chlorpheniramine Maleate - 20 Coated Tablets
Main highlights

Multi-Symptom Relief
Combines Ibuprofen, Phenylephrine, and Chlorpheniramine for comprehensive cold and flu symptom relief.

Ideal for Home Use
Best used when resting at home due to drowsiness.

Customer Favorite
Praised for its effectiveness in relieving multiple cold symptoms.
Key specs
- dosage:One tablet every 4 hours
- form:Coated tablets
- active ingredient:Ibuprofen, Phenylephrine HCL
- target age:12 years and older
- package type:Bottle
8.6

Very Good

Our Rating
10

Vicks

Vicks NyQuil Cold & Flu Relief Over-the-Counter Medicine, Powerful Multi-Symptom Nighttime Relief for Headache, Fever, Sore Throat, Minor Aches and Pains, Sneezing, Runny Nose, and Cough, 24 Liquicaps
8.5

Good

Our Rating

10 Best over counter cold and flu medicines of 2025

1

VICKS DayQuil & NyQuil SEVERE Co-Pack, Cold & Flu Medicine, Powerful Relief for Headache, Fever, Sore Throat, Minor Aches & Pains, Congestion, Sinus Pressure, Stuffy Nose, and Cough, 48 LiquiCaps

8.9

8.7

8.2

How do we rank?

How do we rank?

Analyzing top stores

2

VICKS DayQuil & NyQuil SEVERE Honey Flavor Co-Pack, Cold & Flu Medicine, Relieves Headache, Fever, Sore Throat, Minor Aches & Pains, Nasal Congestion, Sinus Pressure, Stuffy Nose, and Cough, 2x12oz

8.0

8.0

3

Contac Non-Drowsy Day & Multi-Symptom Night Cold & Flu Medicine, Maximum Strength Relief for Fever, Sore Throat, Nasal Congestion, Head & Body Aches, Runny Nose, 28 Count, 16 Day, 12 Night Caplets

4

VICKS NyQuil Cold & Flu Relief Over-the-Counter Medicine, Powerful Multi-Symptom Nighttime Relief for Headache, Fever, Sore Throat, Minor Aches & Pains, Sneezing, Runny Nose, and Cough, 48 LiquiCaps

9.1

9.1

8.9

5

Mucinex Maximum Strength Fast-Max Cold & Flu and Nightshift, All-in-One Multi Symptom Relief Liquid, 6 Fl Oz - 2 Count (Pack of 1)

8.7

8.7

8.0

6

Mucinex Fast-Max Maximum Strength Cold and Flu Medicine for Adults, Powerful Over-The-Counter Medication for 6 Different Cold & Flu Symptoms, Fast Release Caplets, 20 Count

7

HealthA2Z® Daytime and Nighttime | Cold & Flu Medicine | Powerful Multi-Symptom Daytime and Nighttime Relief (24 Daytime & 12 Nighttime Softgels) (Daytime & Nighttime Combo (36 Count Pack of 1))

8

Vicks DayQuil & Nyquil Severe Cold, Flu & Congestion Medicine, 24 Count

9

Advil Multi Symptom Cold and Flu Medicine, Cold Medicine for Adults with Ibuprofen, Phenylephrine HCL and Chlorpheniramine Maleate - 20 Coated Tablets

10

Vicks NyQuil Cold & Flu Relief Over-the-Counter Medicine, Powerful Multi-Symptom Nighttime Relief for Headache, Fever, Sore Throat, Minor Aches and Pains, Sneezing, Runny Nose, and Cough, 24 Liquicaps

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