10 Best over counter allergy medicines of 2025

Save up to 34% off

Best Choice

1

Xyzal

Xyzal 24 Hour Allergy Relief Medicine with Bonus Tissue Pack, Original Prescription Strength Antihistamine Pill, Levocetirizine Dihydrochloride Tablets, 5 mg, 80 Count
9.8

Exceptional

Our Rating
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Value for Money

2

Xyzal
Xyzal 24 Hour Allergy Relief Medicine, Original Prescription Strength Antihistamine, Levocetirizine Dihydrochloride Tablets, 5 mg, 80 Count
Main highlights

24-Hour Allergy Relief
Xyzal provides effective 24-hour relief from allergy symptoms.

Ideal for Nighttime Use
Best taken at night to prevent morning allergy symptoms.

Highly Effective for Most Allergies
Praised for clearing allergies, especially in winter and spring.
9.7

Exceptional

Our Rating

9.9
simple to consume

9.3
Flavor

9.3
worth the money
3

Benadryl
Benadryl Ultratabs Allergy Relief Medicine, 25 mg Diphenhydramine HCl Antihistamine Tablets For Relief of Cold & Allergy Symptoms Like Sneezing, Runny Nose, & Itchy Eyes & Throat, 100 ct

24% Off
Main highlights

Powerful Allergy Relief
Benadryl Ultratabs provide fast relief from sneezing, runny nose, itchy eyes, and throat.

Ideal for Seasonal Allergies
Perfect for managing symptoms from pollen, dust, mold, and pet dander.

Highly Effective
Customers praise its effectiveness in relieving allergy symptoms quickly.
9.4

Excellent

Our Rating

9.7
simple to consume

9.5
worth the money
4

GenCare
GenCare - Cetirizine HCL 10 mg (200 Caplets) - 24 Hour Allergy Relief Pills - Non Drowsy Generic OTC Allergy Medication - Antihistamine Medicine for Sneezing, Runny Nose & Itchy Eyes - Generic Zyrtec

23% Off
Main highlights

24 Hour Non Drowsy Relief
Provides full-day relief from allergies without causing drowsiness.

Effective for Indoor and Outdoor Allergies
Ideal for hay fever, pollen, dust, pet dander, and seasonal allergies.

Comparable to Brand Name Effectiveness
Praised for being as effective as brand-name allergy medications.
Key specs
- pack size:200 pills
- form:Tablets
- active ingredient:Cetirizine HCL
- usage instructions:Adults and children 6+
- symptom relief:Allergy, itching, congestion
9.3

Excellent

Our Rating

9.7
simple to consume

9.5
worth the money
5

WELMATE
WELMATE - Levocetirizine Dihydrochloride 5mg (180 ct) - Non Drowsy Allergy Medicine - 24 Hours - Antihistamine - Generic Allergy Pills - Over-The-Counter Medication - HSA Eligible & FSA Eligible
Main highlights

Key Features and Benefits
Fast-acting, 24-hour relief from indoor and outdoor allergens, with the efficacy of a prescription medication in an OTC form.

Ideal Use Cases
Perfect for those suffering from seasonal allergies or pet-related allergies, needing quick and long-lasting relief from symptoms.

Customer Reviews Summary
Most praised for its rapid effectiveness and comprehensive relief from a wide range of allergy symptoms.
9.0

Excellent

Our Rating
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6

Benadryl
Benadryl Extra Strength Allergy Relief Medicine, 50 mg Diphenhydramine HCl Antihistamine Tablets for Relief of Allergy Symptoms Due to Hay Fever or Other Upper Respiratory Allergies, 24 ct

34% Off
Main highlights

Effective Allergy Relief
Contains 50 mg Diphenhydramine HCl for fast relief from allergy symptoms.

Versatile Use Cases
Ideal for relieving indoor and outdoor allergies, hay fever, and cold symptoms.

Fast Acting
Customers praise its quick action in alleviating symptoms.
Key specs
- pack size:24-count
- form:Tablets
- active ingredient:Diphenhydramine HCl
- usage instructions:1 tablet every 4-6 hours
- symptom relief:Allergy, hay fever, cold
8.9

Very Good

Our Rating
7

Xyzal
Xyzal 24 Hour Allergy Relief Medicine, Original Prescription Strength Antihistamine, Levocetirizine Dihydrochloride Tablets, 5 mg, 35 Count

27% Off
Main highlights

Key Features
Rapid relief in one hour, 24-hour allergy symptom control, full prescription strength without a prescription.

Ideal Use Cases
Effective for nighttime use, providing relief from severe pollen allergies and preventing morning discomfort.

Customer Praise
Most reviews highlight its quick effectiveness and all-day relief, significantly improving quality of life during allergy season.
8.8

Very Good

Our Rating

9.7
simple to consume

8.7
worth the money
8

GenCare
GenCare - Allergy Relief Medicine | Antihistamine Diphenhydramine 25mg (600 Tablets Per Bottle) Value Pack | Relieve for Itchy Eyes, Sneezing, Runny Nose | Seasonal or Indoor & Outdoor Allergies

23% Off
Main highlights

Bulk Savings Bottle
600 count bottle ideal for families or chronic allergy sufferers.

Versatile Use Cases
Perfect for allergy relief, sleep aid, and pet care.

Value and Quantity
Praised for affordability and large quantity in customer reviews.
Key specs
- pack size:600 count
- form:Tablet
- active ingredient:Diphenhydramine HCL
- usage instructions:Evening or before bed
- symptom relief:Itchy eyes, congestion
8.6

Very Good

Our Rating

9.9
worth the money

9.3
quality of sleep

8.7
simple to consume
9

Benadryl
Benadryl Ultratabs Allergy Relief Medicine, 25 mg Diphenhydramine HCl Antihistamine Tablets For Relief of Cold & Allergy Symptoms Like Sneezing, Runny Nose, & Itchy Eyes & Throat, 24 ct

24% Off
Main highlights

Powerful Allergy and Cold Relief
Benadryl Ultratabs provide effective relief for allergies and cold symptoms like sneezing, runny nose, and itchy, watery eyes.

Perfect for On-the-Go Use
Compact, easy-to-swallow tablets ideal for travel, fitting easily into purses, carry-ons, or glove compartments.

Highly Praised Portability
Customers appreciate the convenient packaging that makes it easy to carry and access the tablets whenever needed.
8.4

Good

Our Rating
10

TIME-CAP LABS, INC.

TIME-CAP LABS, INC. Timely Cetirizine 10mg + Ibuprofen 200mg Bundle - Generic Allergy Relief & Pain Killer Over The Counter Medicine - (500 + 365 Tablets)
8.3

Good

Our Rating

10 Best over counter allergy medicines of 2025

1

Xyzal 24 Hour Allergy Relief Medicine with Bonus Tissue Pack, Original Prescription Strength Antihistamine Pill, Levocetirizine Dihydrochloride Tablets, 5 mg, 80 Count

How do we rank?

How do we rank?

Analyzing top stores

2

Xyzal 24 Hour Allergy Relief Medicine, Original Prescription Strength Antihistamine, Levocetirizine Dihydrochloride Tablets, 5 mg, 80 Count

9.9

9.3

9.3

3

Benadryl Ultratabs Allergy Relief Medicine, 25 mg Diphenhydramine HCl Antihistamine Tablets For Relief of Cold & Allergy Symptoms Like Sneezing, Runny Nose, & Itchy Eyes & Throat, 100 ct

9.7

9.5

4

GenCare - Cetirizine HCL 10 mg (200 Caplets) - 24 Hour Allergy Relief Pills - Non Drowsy Generic OTC Allergy Medication - Antihistamine Medicine for Sneezing, Runny Nose & Itchy Eyes - Generic Zyrtec

9.7

9.5

5

WELMATE - Levocetirizine Dihydrochloride 5mg (180 ct) - Non Drowsy Allergy Medicine - 24 Hours - Antihistamine - Generic Allergy Pills - Over-The-Counter Medication - HSA Eligible & FSA Eligible

6

Benadryl Extra Strength Allergy Relief Medicine, 50 mg Diphenhydramine HCl Antihistamine Tablets for Relief of Allergy Symptoms Due to Hay Fever or Other Upper Respiratory Allergies, 24 ct

7

Xyzal 24 Hour Allergy Relief Medicine, Original Prescription Strength Antihistamine, Levocetirizine Dihydrochloride Tablets, 5 mg, 35 Count

9.7

8.7

8

GenCare - Allergy Relief Medicine | Antihistamine Diphenhydramine 25mg (600 Tablets Per Bottle) Value Pack | Relieve for Itchy Eyes, Sneezing, Runny Nose | Seasonal or Indoor & Outdoor Allergies

9.9

9.3

8.7

9

Benadryl Ultratabs Allergy Relief Medicine, 25 mg Diphenhydramine HCl Antihistamine Tablets For Relief of Cold & Allergy Symptoms Like Sneezing, Runny Nose, & Itchy Eyes & Throat, 24 ct

10

TIME-CAP LABS, INC. Timely Cetirizine 10mg + Ibuprofen 200mg Bundle - Generic Allergy Relief & Pain Killer Over The Counter Medicine - (500 + 365 Tablets)

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