10 Best otc drugs of 2025

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1

VOLTAREN
Voltaren Arthritis Pain Gel for Powerful Topical Arthritis Pain Relief with Diclofenac - NEW Easy Open Cap - 100 g x 2

25% Off
Main highlights

Powerful Topical Relief
Voltaren Arthritis Pain Gel offers prescription-strength relief for arthritis, improving mobility and reducing stiffness with a non-greasy formula.

Ideal for Arthritis Pain
Perfect for hand, wrist, elbow, ankle, foot, and knee pain relief when used up to four times daily.

Doctor Recommended Effectiveness
Customers praise its effectiveness, often noting significant relief and satisfaction with results.
9.7

Exceptional

Our Rating
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Real users impact

Thousands of users trust our site daily

Based on millions of stores and reviews

Shoppers influence our rankings
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Value for Money

2

Pepcid
Pepcid AC Maximum Strength Heartburn Relief Tablets, OTC Medicine Prevents & Relieves Heartburn Due to Acid Indigestion & Sour Stomach, 20mg Famotidine Acid Reducer, Fast-Acting, 50 ct

33% Off
Main highlights

Fast-Acting and Long-Lasting Relief
Pepcid AC provides up to 12-hour relief from heartburn and acid indigestion.

Ideal for Preventative Use
Take 60 minutes before meals to prevent heartburn.

Highly Praised Effectiveness
Customers appreciate the reliable relief from GERD symptoms.
9.6

Exceptional

Our Rating

9.9
simple to consume

9.1
worth the money
3

Tylenol
Tylenol 8HR Arthritis Pain Relief Caplets, 650 mg Acetaminophen Pain Relief Pills for Minor Arthritis Pain & Joint Pain, Fever Reducer, Oral Pain Reliever for Joint Pain 100 ct.Pack of 1
Main highlights

Fast-Acting Extended Relief
Tylenol 8HR provides fast, temporary relief for minor arthritis pain with 650 mg acetaminophen.

Ideal for Arthritis Sufferers
Best suited for those needing relief from joint pain in hands, knees, and more.

Highly Praised for Pain Management
Customers appreciate its effectiveness in controlling pain without narcotics.
9.4

Excellent

Our Rating

9.3
worth the money

9.3
Long life

9.3
pain management
4

Tylenol
Tylenol Extra Strength Acetaminophen Rapid Release Gels, Extra Strength Pain Reliever & Fever Reducer, Gelcaps with Laser-Drilled Holes, 500 mg Acetaminophen, 100 ct

24% Off
Main highlights

Fast Acting Relief
100-count Tylenol Extra Strength Rapid Release Gels work quickly to relieve pain and reduce fever with 500 mg acetaminophen.

Ideal for Adults and Teens
Suitable for adults and children 12 years and older, making it versatile for family use.

Highly Praised Effectiveness
Customers appreciate the fast action and effectiveness, noting the rapid relief and long-lasting results.
9.3

Excellent

Our Rating

9.7
simple to consume

9.5
worth the money

9.5
pain management
5

Amazon Basic Care
Amazon Basic Care Loperamide Hydrochloride Tablets, 2 mg, Anti-Diarrheal, 24 Count (Pack of 1) (Packaging may vary)
Main highlights

Key Features
Effective anti-diarrheal with 2 mg Loperamide HCl per tablet, gluten-free, capsule-shaped for easy intake. Comparable to Imodium A-D.

Ideal Use Cases
Optimal for controlling symptoms of diarrhea, including Travelers Diarrhea, suitable for adults and children over 6 years.

Customer Praise
Highly praised for its fast-acting relief of diarrhea, affordability, and comparable effectiveness to brand names.
9.2

Excellent

Our Rating

9.5
simple to consume

8.4
For traveling

8.4
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6

Mosby

Mosby's Otc Drugs: An Over-The-counter Drug Resource for Health Professionals

69% Off
9.0

Excellent

Our Rating
7

HealthA2Z
HealthA2Z® Allergy Relief | Loratadine 10mg | Antihistamine | Non-Drowsy | Relief from Itchy Throat, Sneezing, Runny Noses | 24-Hours Allergy Medicine (300 Tablets)

14% Off
Main highlights

24-Hour Non-Drowsy Relief
Provides effective, non-drowsy allergy relief for 24 hours.

Ideal for Daily Allergy Management
Perfect for managing symptoms from pollen, dust, and pets.

Value for Money
Praised for its affordability and quantity compared to brands.
8.9

Very Good

Our Rating
8

Percogesic
Percogesic Backache Relief Pain Reliever, Maximum Strength, 48 Tablets

19% Off
Main highlights

Fast Acting Formula
Percogesic Backache Relief offers quick relief for backaches and muscular pain with its maximum strength formula.

Ideal for Back and Muscle Pain
Best used for relieving backaches, muscle pain, and sciatic discomfort effectively.

Customer Praised Effectiveness
Praised for its fast action and long-lasting relief, similar to other popular brands.
8.8

Very Good

Our Rating

8.4
worth the money

8.0
pain management
9

Imodium
Imodium A-D Diarrhea Relief Caplets with Loperamide Hydrochloride, Anti-Diarrheal Medicine to Help Control Symptoms of Diarrhea Due to Acute, Active & Traveler's Diarrhea, 6 ct.
Main highlights

Fast Acting Relief
Imodium A-D Caplets provide quick relief from diarrhea symptoms, helping restore natural body rhythm and balance.

Perfect for Travel
Convenient tear-away packaging makes it ideal for travel and on-the-go use.

Highly Effective
Praised by users for quickly stopping diarrhea, often within 30 minutes to an hour.
8.6

Very Good

Our Rating

9.7
worth the money

8.0
Simple to use

8.0
Packaging materials
10

Salonpas
Salonpas Lidocaine 4% Pain Relieving Gel-Patch, 6 Count, for Back, Neck, Shoulder, Knee & Elbow Pain

20% Off
Main highlights

Numbing Relief with Lidocaine
Utilizes 4% Lidocaine for effective numbing relief of pain.

Versatile Pain Relief
Ideal for back, neck, shoulder, and knee pain relief.

User-Friendly Application
Praised for ease of use and staying power.
8.3

Good

Our Rating

8.2
Attachment

8.0
Simple to use

8.0
Long life

10 Best otc drugs of 2025

1

Voltaren Arthritis Pain Gel for Powerful Topical Arthritis Pain Relief with Diclofenac - NEW Easy Open Cap - 100 g x 2

How do we rank?

How do we rank?

Analyzing top stores

2

Pepcid AC Maximum Strength Heartburn Relief Tablets, OTC Medicine Prevents & Relieves Heartburn Due to Acid Indigestion & Sour Stomach, 20mg Famotidine Acid Reducer, Fast-Acting, 50 ct

9.9

9.1

3

Tylenol 8HR Arthritis Pain Relief Caplets, 650 mg Acetaminophen Pain Relief Pills for Minor Arthritis Pain & Joint Pain, Fever Reducer, Oral Pain Reliever for Joint Pain 100 ct.Pack of 1

9.3

9.3

9.3

4

Tylenol Extra Strength Acetaminophen Rapid Release Gels, Extra Strength Pain Reliever & Fever Reducer, Gelcaps with Laser-Drilled Holes, 500 mg Acetaminophen, 100 ct

9.7

9.5

9.5

5

Amazon Basic Care Loperamide Hydrochloride Tablets, 2 mg, Anti-Diarrheal, 24 Count (Pack of 1) (Packaging may vary)

9.5

8.4

8.4

6

Mosby's Otc Drugs: An Over-The-counter Drug Resource for Health Professionals

7

HealthA2Z® Allergy Relief | Loratadine 10mg | Antihistamine | Non-Drowsy | Relief from Itchy Throat, Sneezing, Runny Noses | 24-Hours Allergy Medicine (300 Tablets)

8

Percogesic Backache Relief Pain Reliever, Maximum Strength, 48 Tablets

8.4

8.0

9

Imodium A-D Diarrhea Relief Caplets with Loperamide Hydrochloride, Anti-Diarrheal Medicine to Help Control Symptoms of Diarrhea Due to Acute, Active & Traveler's Diarrhea, 6 ct.

9.7

8.0

8.0

10

Salonpas Lidocaine 4% Pain Relieving Gel-Patch, 6 Count, for Back, Neck, Shoulder, Knee & Elbow Pain

8.2

8.0

8.0

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