10 Best otc drugs of 2025

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Voltaren
Voltaren Arthritis Pain Gel for Powerful Topical Arthritis Pain Relief with Diclofenac - NEW Easy Open Cap - 100 g x 2
Main highlights

Powerful Topical Relief
Voltaren Arthritis Pain Gel offers prescription-strength relief for arthritis, improving mobility and reducing stiffness with a non-greasy formula.

Ideal for Arthritis Pain
Perfect for hand, wrist, elbow, ankle, foot, and knee pain relief when used up to four times daily.

Doctor Recommended Effectiveness
Customers praise its effectiveness, often noting significant relief and satisfaction with results.
9.7

Exceptional

Our Rating
How do we rank?

Powerful technology We scan thousands of products and stores, analyzing reviews to find what matters most to users like you

Careful review Our team ensures quality, value, and fit based on real user feedback

Trusted insights AI and human analysis guide your decisions, reflecting real user priorities
Real users impact

Thousands of users trust our site daily

Based on millions of stores and reviews

Shoppers influence our rankings
Analyzing top stores
Value for Money

2

Independently published

Common OTC Drugs: What everyone should know about commonly encountered over-the-counter drugs (What everyone should know about their health)
9.6

Exceptional

Our Rating
3

Mosby

Mosby's Otc Drugs: An Over-The-counter Drug Resource for Health Professionals

83% Off
9.4

Excellent

Our Rating
4

Tylenol
Tylenol Extra Strength Acetaminophen Rapid Release Gels, Extra Strength Pain Reliever & Fever Reducer, Gelcaps with Laser-Drilled Holes, 500 mg Acetaminophen, 100 ct

24% Off
Main highlights

Fast Acting Relief
100-count Tylenol Extra Strength Rapid Release Gels work quickly to relieve pain and reduce fever with 500 mg acetaminophen.

Ideal for Adults and Teens
Suitable for adults and children 12 years and older, making it versatile for family use.

Highly Praised Effectiveness
Customers appreciate the fast action and effectiveness, noting the rapid relief and long-lasting results.
Key specs
- dosing instructions:Adults and children 12+
- age suitability:12 years and older
- form:Rapid release gels
- active ingredient:Acetaminophen 500mg
- fever reduction:Helps reduce fever
9.3

Excellent

Our Rating

9.7
simple to consume

9.5
worth the money

9.5
pain management
5

Pepcid
Pepcid AC Maximum Strength Heartburn Relief Tablets, OTC Medicine Prevents & Relieves Heartburn Due to Acid Indigestion & Sour Stomach, 20mg Famotidine Acid Reducer, Fast-Acting, 50 ct

43% Off
Main highlights

Fast-Acting and Long-Lasting Relief
Pepcid AC provides up to 12-hour relief from heartburn and acid indigestion.

Ideal for Preventative Use
Take 60 minutes before meals to prevent heartburn.

Highly Praised Effectiveness
Customers appreciate the reliable relief from GERD symptoms.
9.2

Excellent

Our Rating

9.9
simple to consume

9.1
worth the money
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6

Pepto Bismol
Pepto Bismol Chewable Tablets for Nausea, Heartburn, Indigestion, Upset Stomach, and Diarrhea - 5 Symptom Fast Relief, Original Flavor, 48 ct
Main highlights

Five Symptom Relief
Provides fast relief for nausea, heartburn, indigestion, upset stomach, and diarrhea.

Ideal for Travel
Perfect for on-the-go relief, making it travel-friendly.

Praised for Convenience
Customers appreciate its portability and ease of use.
Key specs
- dosage form:Chewables
- country of origin:USA
- package dimensions:4.09 x 2.76 x 1.46 inches
- symptoms relief:Nausea, Heartburn, Indigestion
- active ingredients:N/A
9.1

Excellent

Our Rating

9.9
movability

9.7
Simple to use

9.3
simple to consume
7

Amazon Basic Care
Amazon Basic Care Ibuprofen Tablets, 200 mg, Pain Reliever and Fever Reducer, For Headache, Muscular Aches, Arthritis, Backache and More, 100 Count (Pack of 1)
Main highlights

Effective Pain Relief
Contains 200 mg of ibuprofen, a proven NSAID for pain and fever relief.

Convenient for On-the-Go
Ideal for travel, pocketbooks, cars, and first aid kits.

Praised Portability
Customers love the individual packets for easy sharing and tracking.
8.8

Very Good

Our Rating

9.9
pain management

9.7
movability

9.5
dispense easily
8

Amazon Basic Care
Amazon Basic Care Naproxen Sodium Tablets 220 mg, Pain Reliever/Fever Reducer (NSAID), Muscular Aches, Backache, Headache, Toothache, Minor Arthritis Pain Relief & More, 300 Count (Packaging may vary)

22% Off
Main highlights

Long-Lasting Relief
Provides pain relief and fever reduction for up to 12 hours.

Versatile Pain Management
Ideal for minor arthritis, muscular aches, headaches, and more.

Great Value
Praised for cost-effectiveness compared to similar brands like Aleve.
8.7

Very Good

Our Rating

9.7
simple to consume

9.5
worth the money

9.5
pain management
9

HealthA2Z
HealthA2Z® Allergy Relief | Loratadine 10mg | Antihistamine | Relief from Itchy Throat, Sneezing, Runny Noses | 24-Hours Allergy Medicine (300 Tablets)

32% Off
Main highlights

24-Hour Non-Drowsy Relief
Provides effective, non-drowsy allergy relief for 24 hours.

Ideal for Daily Allergy Management
Perfect for managing symptoms from pollen, dust, and pets.

Value for Money
Praised for its affordability and quantity compared to brands.
8.4

Good

Our Rating
10

Amazon Basic Care
Amazon Basic Care Loperamide Hydrochloride Tablets, 2 mg, Anti-Diarrheal, 24 Count (Pack of 1) (Packaging may vary)
Main highlights

Key Features
Effective anti-diarrheal with 2 mg Loperamide HCl per tablet, gluten-free, capsule-shaped for easy intake. Comparable to Imodium A-D.

Ideal Use Cases
Optimal for controlling symptoms of diarrhea, including Travelers Diarrhea, suitable for adults and children over 6 years.

Customer Praise
Highly praised for its fast-acting relief of diarrhea, affordability, and comparable effectiveness to brand names.
8.3

Good

Our Rating

9.5
simple to consume

8.4
For traveling

8.4
Flavor

10 Best otc drugs of 2025

1

Voltaren Arthritis Pain Gel for Powerful Topical Arthritis Pain Relief with Diclofenac - NEW Easy Open Cap - 100 g x 2

How do we rank?

How do we rank?

Analyzing top stores

2

Common OTC Drugs: What everyone should know about commonly encountered over-the-counter drugs (What everyone should know about their health)

3

Mosby's Otc Drugs: An Over-The-counter Drug Resource for Health Professionals

4

Tylenol Extra Strength Acetaminophen Rapid Release Gels, Extra Strength Pain Reliever & Fever Reducer, Gelcaps with Laser-Drilled Holes, 500 mg Acetaminophen, 100 ct

9.7

9.5

9.5

5

Pepcid AC Maximum Strength Heartburn Relief Tablets, OTC Medicine Prevents & Relieves Heartburn Due to Acid Indigestion & Sour Stomach, 20mg Famotidine Acid Reducer, Fast-Acting, 50 ct

9.9

9.1

6

Pepto Bismol Chewable Tablets for Nausea, Heartburn, Indigestion, Upset Stomach, and Diarrhea - 5 Symptom Fast Relief, Original Flavor, 48 ct

9.9

9.7

9.3

7

Amazon Basic Care Ibuprofen Tablets, 200 mg, Pain Reliever and Fever Reducer, For Headache, Muscular Aches, Arthritis, Backache and More, 100 Count (Pack of 1)

9.9

9.7

9.5

8

Amazon Basic Care Naproxen Sodium Tablets 220 mg, Pain Reliever/Fever Reducer (NSAID), Muscular Aches, Backache, Headache, Toothache, Minor Arthritis Pain Relief & More, 300 Count (Packaging may vary)

9.7

9.5

9.5

9

HealthA2Z® Allergy Relief | Loratadine 10mg | Antihistamine | Relief from Itchy Throat, Sneezing, Runny Noses | 24-Hours Allergy Medicine (300 Tablets)

10

Amazon Basic Care Loperamide Hydrochloride Tablets, 2 mg, Anti-Diarrheal, 24 Count (Pack of 1) (Packaging may vary)

9.5

8.4

8.4

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