10 Best otc cold and flu medicines of 2025

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1

Vicks
VICKS DayQuil & NyQuil SEVERE Co-Pack, Cold & Flu Medicine, Powerful Relief for Headache, Fever, Sore Throat, Minor Aches & Pains, Congestion, Sinus Pressure, Stuffy Nose, and Cough, 48 LiquiCaps
Main highlights

Powerful 9-Symptom Relief
Vicks DayQuil and NyQuil Severe provide maximum strength relief for 9 common cold and flu symptoms.

Day and Night Use
Ideal for daytime use with DayQuil's non-drowsy formula and nighttime relief with NyQuil for restful sleep.

Quick Symptom Relief
Customers praise the fast-acting nature, clearing congestion in 10-15 minutes.
9.7

Exceptional

Our Rating

8.9
Flavor

8.7
simple to consume

8.2
worth the money
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Value for Money

2

Vicks
Vicks NyQuil SEVERE Cold, Flu, and Congestion Medicine, 2x12 fl oz Twin Pack, Berry Flavor, Maximum Strength, Nighttime Relief
Main highlights

Maximum Strength 9-Symptom Relief
NyQuil SEVERE provides fast relief for 9 cold and flu symptoms, including cough, fever, and congestion.

Ideal for Nighttime Cold Relief
Designed to help you sleep by alleviating symptoms that keep you awake.

Praised for Effective Symptom Relief
Customers love NyQuil SEVERE for its reliable and quick symptom relief.
9.5

Excellent

Our Rating

9.3
worth the money

9.1
Flavor
3

Tylenol
Tylenol Cold + Flu Severe Day & Night Caplets for Fever, Pain, Cough & Congestion Relief, 24 Count

27% Off
Main highlights

Comprehensive Cold Flu Relief
24-count pack offers multi-symptom relief for cold and flu.

Day Night Usage
Ideal for day and night relief with separate formulas.

Highly Praised Value
Customers appreciate the value and effectiveness of the product.
Key specs
- features:Cold & flu relief
- product dimensions:4.52 x 0.78 x 2.95 inches
- active ingredients:Acetaminophen, Phenylephrine HCl
- decongestant:Phenylephrine HCl
- saline solution:N/A
9.4

Excellent

Our Rating
4

Mucinex
Mucinex Fast-Max Liquid Gels for Day/Night Cold and Flu, 24 Count

25% Off
Main highlights

Multi-Symptom Relief Efficiency
Provides fast, powerful relief for 9 cold and flu symptoms.

Ideal for Day and Night Use
Designed for comprehensive symptom management, both day and night.

Quick Symptom Relief Praised
Customers appreciate the fast-acting relief, often within two doses.
Key specs
- dosage:1 dose
- symptom relief:Cold & flu symptoms
- form:Liquid gel
- active ingredient:Acetaminophen, Dextromethorphan, Guaifenesin
- flavor:N/A
9.3

Excellent

Our Rating

9.7
quality of ingredients

9.5
pain management

8.0
simple to consume
5

Vicks
VICKS DayQuil & NyQuil High Blood Pressure Cold & Flu Relief Liquid Medicine Co-Pack, Powerful Multi-Symptom Daytime & Nighttime Relief for Cold, Cough, and Flu Symptoms, Sugar & Alcohol Free, 2x8oz
Main highlights

Specially Formulated for High Blood Pressure
Decongestant-free cold and flu relief suitable for those with high blood pressure.

Ideal for Day and Night Use
Provides effective symptom relief both during the day and at night.

Effective Multi-Symptom Relief
Praised for easing fever, aches, cough, and providing restful sleep.
Key specs
- dosage:One dose
- symptom relief:Headache, fever, sore throat
- form:N/A
- active ingredient:N/A
- flavor:N/A
9.2

Excellent

Our Rating

9.9
simple to consume

9.3
pain management

9.3
Flavor
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6

Contac
Contac Non-Drowsy Day & Multi-Symptom Night Cold & Flu Medicine, Maximum Strength Relief for Fever, Sore Throat, Nasal Congestion, Head & Body Aches, Runny Nose, 28 Count, 16 Day, 12 Night Caplets
Main highlights

Maximum Strength Relief
Provides maximum strength relief for cold and flu symptoms.

Day and Night Use
Ideal for continuous relief with separate day and night formulas.

Customer Praised Effectiveness
Highly praised for relieving nasal congestion and body aches.
9.0

Excellent

Our Rating
7

HealthA2Z
HealthA2Z® Daytime and Nighttime | Cold & Flu Medicine | Powerful Multi-Symptom Daytime and Nighttime Relief (24 Daytime & 12 Nighttime Softgels) (Daytime & Nighttime Combo (36 Count Pack of 1))
Main highlights

Powerful Multi-Symptom Relief
HealthA2Z Daytime and Nighttime Cold & Flu Medicine offers effective relief for various symptoms, similar to leading brands, at a great value.

Convenient Day and Night Use
Includes both daytime and nighttime formulas in one package, perfect for around-the-clock symptom management.

Easy to Swallow Softgels
Customers appreciate the easy-to-swallow softgel capsules with no aftertaste, enhancing user experience.
8.7

Very Good

Our Rating
8

Vicks
Vicks DayQuil Cold & Flu Medicine, Non-Drowsy Powerful Multi-Symptom Daytime Relief for Headache, Fever, Sore Throat, Minor Aches and Pains, Nasal Congestion, Sinus Pressure and Cough, 48 Liquicaps
Main highlights

Powerful Multi-Symptom Relief
Combines acetaminophen, dextromethorphan, and phenylephrine for comprehensive cold and flu relief.

Daytime Use for Busy Schedules
Ideal for daytime relief without drowsiness, keeping you productive.

Customer Praised Effectiveness
Works fast and effectively, as noted by numerous satisfied users.
8.6

Very Good

Our Rating
9

Nature's Way
Nature's Way Cold+Flu Relief, Umcka, Shortens Duration and Reduces Severity, Multi-Symptom Relief, Homeopathic, Phenylephrine Free, Non-Drowsy, Berry Flavored, 20 Chewable Tablets (Packaging May Vary)

39% Off
Main highlights

Symptom Relief Formula
Natures Way Umcka Cold & Flu Relief offers multi-symptom relief for body aches, congestion, cough, fever, runny nose, and sore throat.

Effective for Quick Recovery
Ideal for reducing cold and flu duration and severity, even when taken after symptoms start.

Great Taste and Easy Use
Customers praise its delicious berry flavor and convenient chewable form.
8.5

Good

Our Rating

9.7
Flavor

8.9
worth the money
10

Vicks

VICKS DayQuil & NyQuil Elderberry Flavor Cold & Flu Liquid Medicine Co-Pack, Multi-Symptom Relief of Headache, Fever, Sore Throat, Minor Aches & Pains, Sneezing, Runny Nose, and Cough, 2x12oz
8.4

Good

Our Rating

10 Best otc cold and flu medicines of 2025

1

VICKS DayQuil & NyQuil SEVERE Co-Pack, Cold & Flu Medicine, Powerful Relief for Headache, Fever, Sore Throat, Minor Aches & Pains, Congestion, Sinus Pressure, Stuffy Nose, and Cough, 48 LiquiCaps

8.9

8.7

8.2

How do we rank?

How do we rank?

Analyzing top stores

2

Vicks NyQuil SEVERE Cold, Flu, and Congestion Medicine, 2x12 fl oz Twin Pack, Berry Flavor, Maximum Strength, Nighttime Relief

9.3

9.1

3

Tylenol Cold + Flu Severe Day & Night Caplets for Fever, Pain, Cough & Congestion Relief, 24 Count

4

Mucinex Fast-Max Liquid Gels for Day/Night Cold and Flu, 24 Count

9.7

9.5

8.0

5

VICKS DayQuil & NyQuil High Blood Pressure Cold & Flu Relief Liquid Medicine Co-Pack, Powerful Multi-Symptom Daytime & Nighttime Relief for Cold, Cough, and Flu Symptoms, Sugar & Alcohol Free, 2x8oz

9.9

9.3

9.3

6

Contac Non-Drowsy Day & Multi-Symptom Night Cold & Flu Medicine, Maximum Strength Relief for Fever, Sore Throat, Nasal Congestion, Head & Body Aches, Runny Nose, 28 Count, 16 Day, 12 Night Caplets

7

HealthA2Z® Daytime and Nighttime | Cold & Flu Medicine | Powerful Multi-Symptom Daytime and Nighttime Relief (24 Daytime & 12 Nighttime Softgels) (Daytime & Nighttime Combo (36 Count Pack of 1))

8

Vicks DayQuil Cold & Flu Medicine, Non-Drowsy Powerful Multi-Symptom Daytime Relief for Headache, Fever, Sore Throat, Minor Aches and Pains, Nasal Congestion, Sinus Pressure and Cough, 48 Liquicaps

9

Nature's Way Cold+Flu Relief, Umcka, Shortens Duration and Reduces Severity, Multi-Symptom Relief, Homeopathic, Phenylephrine Free, Non-Drowsy, Berry Flavored, 20 Chewable Tablets (Packaging May Vary)

9.7

8.9

10

VICKS DayQuil & NyQuil Elderberry Flavor Cold & Flu Liquid Medicine Co-Pack, Multi-Symptom Relief of Headache, Fever, Sore Throat, Minor Aches & Pains, Sneezing, Runny Nose, and Cough, 2x12oz

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