10 Best nyquil severe colds of 2025

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Best Choice

1

Vicks

NyQuil Ultra Concentrated Cold and Flu Medicine, Nighttime, Relief for Cough, Sore Throat, Fever, Congestion, Easy to Swallow, Easy to Open Bottle, 48 LiquiCaps
9.6

Exceptional

Our Rating
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Value for Money

2

Vicks
Vicks NyQuil SEVERE Cold, Flu, and Congestion Medicine, 2x12 fl oz Twin Pack, Berry Flavor, Maximum Strength, Nighttime Relief
Main highlights

Maximum Strength 9-Symptom Relief
NyQuil SEVERE provides fast relief for 9 cold and flu symptoms, including cough, fever, and congestion.

Ideal for Nighttime Cold Relief
Designed to help you sleep by alleviating symptoms that keep you awake.

Praised for Effective Symptom Relief
Customers love NyQuil SEVERE for its reliable and quick symptom relief.
9.4

Excellent

Our Rating

9.3
worth the money

9.1
Flavor
3

Vicks
Vicks DayQuil & Nyquil Severe Cold, Flu & Congestion Medicine, 24 Count

16% Off
Main highlights

Powerful and Fast Acting Relief
DayQuil and NyQuil SEVERE provide maximum strength relief for 9 symptoms, working quickly to alleviate discomfort.

Day and Night Usage
Ideal for continuous relief, DayQuil for daytime and NyQuil for nighttime use, ensuring you can stay active and rest well.

Trusted Brand Endorsement
Praised for its effectiveness, Vicks is the world's #1 selling OTC cough and cold brand, trusted for over 125 years.
9.3

Excellent

Our Rating
4

Vicks
VICKS DayQuil & NyQuil SEVERE Co-Pack, Cold & Flu Medicine, Powerful Relief for Headache, Fever, Sore Throat, Minor Aches & Pains, Congestion, Sinus Pressure, Stuffy Nose, and Cough, 48 LiquiCaps
Main highlights

Powerful 9-Symptom Relief
Vicks DayQuil and NyQuil Severe provide maximum strength relief for 9 common cold and flu symptoms.

Day and Night Use
Ideal for daytime use with DayQuil's non-drowsy formula and nighttime relief with NyQuil for restful sleep.

Quick Symptom Relief
Customers praise the fast-acting nature, clearing congestion in 10-15 minutes.
9.1

Excellent

Our Rating

8.9
Flavor

8.7
simple to consume

8.2
worth the money
5

Vicks
Vicks DayQuil & NyQuil SEVERE Cold & Flu Medicine, Relief for Headache, Fever, Sore Throat, Minor Aches & Pains, Nasal Congestion, Sinus Pressure, Stuffy Nose, and Cough, Co-Pack, 2 x 12 OZ
Main highlights

Key Features
Maximum strength relief for cold & flu symptoms, both day and night, with fast-acting results to take you from 9 to none.

Ideal Use Cases
Perfect for those needing non-drowsy relief during the day and restful relief at night for severe cold and flu symptoms.

Customer Praise
Most reviews highlight Vicks` longstanding trust and effectiveness, emphasizing how quickly and reliably it alleviates the worst cold and flu symptoms.
9.0

Excellent

Our Rating

9.3
Comfort

9.1
worth the money

8.7
Flavor
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6

Amazon Basic Care
Amazon Basic Care Nighttime Severe Cold and Flu Syrup, Max Strength Liquid Medicine, Multi-Symptom Relief, for Adults and Children 12 Years and Older, Mixed Berry Flavor, 12 fl oz (Pack of 1)
Main highlights

Maximum Strength Relief
Provides comprehensive relief for headache, fever, sore throat, sinus congestion, and cough with maximum strength ingredients.

Nighttime Use for Restful Sleep
Ideal for nighttime use to ensure restful sleep while managing severe cold and flu symptoms.

Effective Sleep Aid
Frequently praised for its quick and effective sleep-inducing properties, helping users rest better.
Key specs
- form:liquid
- symptom relief:cold and flu
- flavor:mixed berry
- active ingredient:acetaminophen 650 mg
- package type:N/A
8.9

Very Good

Our Rating

9.1
worth the money

8.7
Comfort

8.2
Flavor
7

Amazon Basic Care

Amazon Basic Care Daytime and Nighttime Max Strength Severe Cold and Flu Relief Medicine, Combo Pack, Liquid Medication for Day and Night, Original and Berry, 24 fl oz (Pack of 1)
8.7

Very Good

Our Rating

9.1
worth the money

9.1
Comfort

8.4
Flavor
8

Vicks
VICKS DayQuil & NyQuil SEVERE Honey Flavor Co-Pack, Cold & Flu Medicine, RelievesHeadache, Fever, Sore Throat, Minor Aches & Pains, Nasal Congestion, Sinus Pressure, Stuffy Nose, and Cough, 2x12oz
Main highlights

Maximum Strength Relief
Provides powerful relief for 9 cold and flu symptoms with real honey flavor.

Day and Night Use
Ideal for treating symptoms any time with non-drowsy DayQuil and restful NyQuil.

Honey Flavor Praised
Most users appreciate the honey flavor for better taste compared to traditional options.
8.5

Good

Our Rating

8.0
worth the money

8.0
Flavor
9

Vicks
Vicks NyQuil SEVERE Cold and Flu Relief Liquid Medicine, Maximum Strength, 9-Symptom Nighttime Relief For Headache, Fever, Sore Throat, Nasal Congestion, Sinus Pressure, Runny Nose, Cough, 8 FL OZ

11% Off
Main highlights

Powerful 9-Symptom Relief
NyQuil SEVERE offers maximum strength relief for 9 cold and flu symptoms, including headache, fever, and sore throat.

Ideal Nighttime Use
Best used at night for fast relief, allowing uninterrupted sleep despite cold or flu symptoms.

Customer Praised Fast Relief
Customers frequently praise its rapid onset, providing effective relief to help manage severe cold and flu symptoms.
Key specs
- form:Liquid
- symptom relief:Cold & flu symptoms
- flavor:N/A
- active ingredient:N/A
- package type:Bottle
8.3

Good

Our Rating
10

Amazon Basic Care
Amazon Basic Care Vapor Ice Day and Night Severe Cold and Flu Relief Caplets, Maximum Strength Medicine, Combo Pack, 48 Count
Main highlights

Maximum Strength Multi-Symptom Relief
Provides around-the-clock relief for cold and flu symptoms with a combination of daytime and nighttime caplets.

Ideal for Families and Busy Individuals
Perfect for those needing effective relief during the day and restful sleep at night.

Highly Praised Nighttime Formula
Customers appreciate the nighttime caplets for aiding sleep and symptom relief.
Key specs
- form:Coated caplets
- symptom relief:Cold and flu symptoms
- flavor:Vapor Ice
- active ingredient:Compare to Vicks DayQuil/NyQuil
- package type:Combination pack
8.1

Good

Our Rating

9.3
simple to consume

9.1
worth the money

8.7
Flavor

10 Best nyquil severe colds of 2025

1

NyQuil Ultra Concentrated Cold and Flu Medicine, Nighttime, Relief for Cough, Sore Throat, Fever, Congestion, Easy to Swallow, Easy to Open Bottle, 48 LiquiCaps

How do we rank?

How do we rank?

Analyzing top stores

2

Vicks NyQuil SEVERE Cold, Flu, and Congestion Medicine, 2x12 fl oz Twin Pack, Berry Flavor, Maximum Strength, Nighttime Relief

9.3

9.1

3

Vicks DayQuil & Nyquil Severe Cold, Flu & Congestion Medicine, 24 Count

4

VICKS DayQuil & NyQuil SEVERE Co-Pack, Cold & Flu Medicine, Powerful Relief for Headache, Fever, Sore Throat, Minor Aches & Pains, Congestion, Sinus Pressure, Stuffy Nose, and Cough, 48 LiquiCaps

8.9

8.7

8.2

5

Vicks DayQuil & NyQuil SEVERE Cold & Flu Medicine, Relief for Headache, Fever, Sore Throat, Minor Aches & Pains, Nasal Congestion, Sinus Pressure, Stuffy Nose, and Cough, Co-Pack, 2 x 12 OZ

9.3

9.1

8.7

6

Amazon Basic Care Nighttime Severe Cold and Flu Syrup, Max Strength Liquid Medicine, Multi-Symptom Relief, for Adults and Children 12 Years and Older, Mixed Berry Flavor, 12 fl oz (Pack of 1)

9.1

8.7

8.2

7

Amazon Basic Care Daytime and Nighttime Max Strength Severe Cold and Flu Relief Medicine, Combo Pack, Liquid Medication for Day and Night, Original and Berry, 24 fl oz (Pack of 1)

9.1

9.1

8.4

8

VICKS DayQuil & NyQuil SEVERE Honey Flavor Co-Pack, Cold & Flu Medicine, RelievesHeadache, Fever, Sore Throat, Minor Aches & Pains, Nasal Congestion, Sinus Pressure, Stuffy Nose, and Cough, 2x12oz

8.0

8.0

9

Vicks NyQuil SEVERE Cold and Flu Relief Liquid Medicine, Maximum Strength, 9-Symptom Nighttime Relief For Headache, Fever, Sore Throat, Nasal Congestion, Sinus Pressure, Runny Nose, Cough, 8 FL OZ

10

Amazon Basic Care Vapor Ice Day and Night Severe Cold and Flu Relief Caplets, Maximum Strength Medicine, Combo Pack, 48 Count

9.3

9.1

8.7

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