10 Best nyquil severe colds of 2025

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1

Vicks

NyQuil Ultra Concentrated Cold and Flu Medicine, Nighttime, Relief for Cough, Sore Throat, Fever, Congestion, Easy to Swallow, Easy to Open Bottle, 48 LiquiCaps
9.6

Exceptional

Our Rating
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Value for Money

2

Vicks
Vicks NyQuil SEVERE Cold, Flu, and Congestion Medicine, 2x12 fl oz Twin Pack, Berry Flavor, Maximum Strength, Nighttime Relief
Main highlights

Maximum Strength 9-Symptom Relief
NyQuil SEVERE provides fast relief for 9 cold and flu symptoms, including cough, fever, and congestion.

Ideal for Nighttime Cold Relief
Designed to help you sleep by alleviating symptoms that keep you awake.

Praised for Effective Symptom Relief
Customers love NyQuil SEVERE for its reliable and quick symptom relief.
9.4

Excellent

Our Rating

9.3
worth the money

9.1
Flavor
3

Vicks
VICKS DayQuil & NyQuil SEVERE Co-Pack, Cold & Flu Medicine, Powerful Relief for Headache, Fever, Sore Throat, Minor Aches & Pains, Congestion, Sinus Pressure, Stuffy Nose, and Cough, 48 LiquiCaps
Main highlights

Powerful 9-Symptom Relief
Vicks DayQuil and NyQuil Severe provide maximum strength relief for 9 common cold and flu symptoms.

Day and Night Use
Ideal for daytime use with DayQuil's non-drowsy formula and nighttime relief with NyQuil for restful sleep.

Quick Symptom Relief
Customers praise the fast-acting nature, clearing congestion in 10-15 minutes.
9.2

Excellent

Our Rating

8.9
Flavor

8.7
simple to consume

8.2
worth the money
4

Vicks
Vicks NyQuil Severe Cold, Flu, & Congestion Medicine, 24 Liquicaps, Maximum Strength, 24Count
Main highlights

Comprehensive Symptom Relief
Provides maximum strength relief for cough, headache, fever, sore throat, aches, nasal congestion, and more.

Ideal for Severe Cold and Flu
Best suited for tackling severe cold, flu, and congestion symptoms effectively.

Highly Effective for Symptom Management
Customers frequently praise its effectiveness in alleviating multiple symptoms quickly.
9.0

Excellent

Our Rating
5

Amazon Basic Care
Amazon Basic Care Nighttime Severe Cold and Flu Syrup, Max Strength Liquid Medicine, Multi-Symptom Relief, for Adults and Children 12 Years and Older, Mixed Berry Flavor, 12 fl oz (Pack of 1)
Main highlights

Maximum Strength Relief
Provides comprehensive relief for headache, fever, sore throat, sinus congestion, and cough with maximum strength ingredients.

Nighttime Use for Restful Sleep
Ideal for nighttime use to ensure restful sleep while managing severe cold and flu symptoms.

Effective Sleep Aid
Frequently praised for its quick and effective sleep-inducing properties, helping users rest better.
Key specs
- form:liquid
- symptom relief:cold and flu
- flavor:mixed berry
- dosage:N/A
- active ingredient:acetaminophen 650 mg
8.9

Very Good

Our Rating

9.1
worth the money

8.7
Comfort

8.2
Flavor
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6

Vicks
Vicks NyQuil SEVERE Cold and Flu Relief Liquid Medicine, Maximum Strength, 9-Symptom Nighttime Relief For Headache, Fever, Sore Throat, Nasal Congestion, Sinus Pressure, Runny Nose, Cough, 8 FL OZ
Main highlights

Powerful 9-Symptom Relief
NyQuil SEVERE offers maximum strength relief for 9 cold and flu symptoms, including headache, fever, and sore throat.

Ideal Nighttime Use
Best used at night for fast relief, allowing uninterrupted sleep despite cold or flu symptoms.

Customer Praised Fast Relief
Customers frequently praise its rapid onset, providing effective relief to help manage severe cold and flu symptoms.
Key specs
- form:Liquid
- symptom relief:Cold & flu symptoms
- flavor:N/A
- dosage:One dose
- active ingredient:N/A
8.7

Very Good

Our Rating
7

Vicks
Vicks DayQuil & NyQuil SEVERE Cold & Flu Medicine, Relief for Headache, Fever, Sore Throat, Minor Aches & Pains, Nasal Congestion, Sinus Pressure, Stuffy Nose, and Cough, Co-Pack, 2 x 12 OZ
Main highlights

Key Features
Maximum strength relief for cold & flu symptoms, both day and night, with fast-acting results to take you from 9 to none.

Ideal Use Cases
Perfect for those needing non-drowsy relief during the day and restful relief at night for severe cold and flu symptoms.

Customer Praise
Most reviews highlight Vicks` longstanding trust and effectiveness, emphasizing how quickly and reliably it alleviates the worst cold and flu symptoms.
8.6

Very Good

Our Rating

9.3
Comfort

9.1
worth the money

8.7
Flavor
8

Vicks
Vicks DayQuil & Nyquil Severe Cold, Flu & Congestion Medicine, 24 Count

16% Off
Main highlights

Powerful and Fast Acting Relief
DayQuil and NyQuil SEVERE provide maximum strength relief for 9 symptoms, working quickly to alleviate discomfort.

Day and Night Usage
Ideal for continuous relief, DayQuil for daytime and NyQuil for nighttime use, ensuring you can stay active and rest well.

Trusted Brand Endorsement
Praised for its effectiveness, Vicks is the world's #1 selling OTC cough and cold brand, trusted for over 125 years.
8.5

Good

Our Rating
9

Vicks

Vicks NyQuil Severe Honey Cold and Flu Medicine, Maximum Strength, Relieves Cough, Sore Throat, Fever, Congestion, 12 Oz
8.4

Good

Our Rating
10

Vicks
VICKS NyQuil Cold & Flu Relief Over-the-Counter Medicine, Powerful Multi-Symptom Nighttime Relief for Headache, Fever, Sore Throat, Minor Aches & Pains, Sneezing, Runny Nose, and Cough, 48 LiquiCaps
Main highlights

Powerful Multi-Symptom Relief
NyQuil provides fast relief for headache, fever, sore throat, sneezing, and cough.

Ideal for Nighttime Use
Perfect for nighttime use to alleviate cold and flu symptoms and ensure restful sleep.

Cost-Effective and Convenient
Highly praised for its cost-effectiveness and convenience, especially with Subscribe and Save.
8.3

Good

Our Rating

9.1
worth the money

9.1
Flavor

8.9
simple to consume

10 Best nyquil severe colds of 2025

1

NyQuil Ultra Concentrated Cold and Flu Medicine, Nighttime, Relief for Cough, Sore Throat, Fever, Congestion, Easy to Swallow, Easy to Open Bottle, 48 LiquiCaps

How do we rank?

How do we rank?

Analyzing top stores

2

Vicks NyQuil SEVERE Cold, Flu, and Congestion Medicine, 2x12 fl oz Twin Pack, Berry Flavor, Maximum Strength, Nighttime Relief

9.3

9.1

3

VICKS DayQuil & NyQuil SEVERE Co-Pack, Cold & Flu Medicine, Powerful Relief for Headache, Fever, Sore Throat, Minor Aches & Pains, Congestion, Sinus Pressure, Stuffy Nose, and Cough, 48 LiquiCaps

8.9

8.7

8.2

4

Vicks NyQuil Severe Cold, Flu, & Congestion Medicine, 24 Liquicaps, Maximum Strength, 24Count

5

Amazon Basic Care Nighttime Severe Cold and Flu Syrup, Max Strength Liquid Medicine, Multi-Symptom Relief, for Adults and Children 12 Years and Older, Mixed Berry Flavor, 12 fl oz (Pack of 1)

9.1

8.7

8.2

6

Vicks NyQuil SEVERE Cold and Flu Relief Liquid Medicine, Maximum Strength, 9-Symptom Nighttime Relief For Headache, Fever, Sore Throat, Nasal Congestion, Sinus Pressure, Runny Nose, Cough, 8 FL OZ

7

Vicks DayQuil & NyQuil SEVERE Cold & Flu Medicine, Relief for Headache, Fever, Sore Throat, Minor Aches & Pains, Nasal Congestion, Sinus Pressure, Stuffy Nose, and Cough, Co-Pack, 2 x 12 OZ

9.3

9.1

8.7

8

Vicks DayQuil & Nyquil Severe Cold, Flu & Congestion Medicine, 24 Count

9

Vicks NyQuil Severe Honey Cold and Flu Medicine, Maximum Strength, Relieves Cough, Sore Throat, Fever, Congestion, 12 Oz

10

VICKS NyQuil Cold & Flu Relief Over-the-Counter Medicine, Powerful Multi-Symptom Nighttime Relief for Headache, Fever, Sore Throat, Minor Aches & Pains, Sneezing, Runny Nose, and Cough, 48 LiquiCaps

9.1

9.1

8.9

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