10 Best non prescription medications of 2025

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Best Choice

1

Amazon Basic Care
Amazon Basic Care 24-Hour Allergy Relief Nasal Spray, Fluticasone Propionate (Glucocorticoid) 50 mcg, Full Prescription Strength, Non-Drowsy, 0.62 fl oz (Pack of 3)
Main highlights

24-Hour Allergy Relief
Provides relief from allergy symptoms such as itchy eyes, nasal congestion, and sneezing for up to 24 hours with Fluticasone Propionate.

Daily Allergy Management
Ideal for individuals with persistent allergies, offering non-drowsy, full prescription strength relief without needing a prescription.

Cost-Effective Alternative
Customers frequently praise the product for its effectiveness and affordability compared to the name brand Flonase.
Key specs
- dosage:50 mcg per spray
- form:nasal spray
- active ingredient:Fluticasone Propionate 50 mcg
- usage instructions:once per day
- symptom relief:allergy symptoms
9.9

Exceptional

Our Rating
How do we rank?

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Thousands of users trust our site daily

Based on millions of stores and reviews

Shoppers influence our rankings
Analyzing top stores
Value for Money

2

Wiley-Blackwell

Paramedic Pocketbook of Prescription Medications
9.8

Exceptional

Our Rating
3

HealthCareAisle
HealthCareAisle Allergy Relief - Fexofenadine Hydrochloride Tablets USP, 180 mg, 90 Tablets, Allergy Medication, Non-Drowsy 24-Hour Relief
Main highlights

Non-Drowsy Long-Lasting Relief
Fexofenadine provides 24-hour non-drowsy relief from indoor and outdoor allergies.

Ideal for Persistent Allergy Sufferers
Perfect for those needing consistent relief from hay fever and upper respiratory allergies.

Cost-Effective Alternative
Customers praise its effectiveness comparable to name brands at a lower cost.
9.7

Exceptional

Our Rating
4

Bantam

The Pill Book Guide to Over-the-Counter Medications: The Illustrated Guide to the Most Commonly Used Non-Prescription Medications
9.6

Exceptional

Our Rating
5

GenCare
GenCare - Cetirizine HCL 10 mg (200 Caplets) - 24 Hour Allergy Relief Pills - Non Drowsy Generic OTC Allergy Medication - Antihistamine Medicine for Sneezing, Runny Nose & Itchy Eyes - Generic Zyrtec

18% Off
Main highlights

24 Hour Non Drowsy Relief
Provides full-day relief from allergies without causing drowsiness.

Effective for Indoor and Outdoor Allergies
Ideal for hay fever, pollen, dust, pet dander, and seasonal allergies.

Comparable to Brand Name Effectiveness
Praised for being as effective as brand-name allergy medications.
Key specs
- dosage:10mg
- form:Tablets
- active ingredient:Cetirizine HCL
- usage instructions:Adults and children 6+
- symptom relief:Allergy, itching, congestion
9.5

Excellent

Our Rating

9.7
simple to consume

9.5
worth the money
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6

Atria Books

Are Your Prescriptions Killing You?: How to Prevent Dangerous Interactions, Avoid Deadly Side Effects, and Be Healthier with Fewer Drugs

35% Off
9.3

Excellent

Our Rating
7

Body Press

Complete Guide to Prescription and Non-Prescription Drugs
9.0

Excellent

Our Rating
8

Amazon Basic Care
Amazon Basic Care 24-Hour Allergy Relief Nasal Spray, Fluticasone Propionate (Glucocorticoid), 50 mcg, Full Prescription Strength, Non-Drowsy, 0.62 fl oz (Pack of 1)
Main highlights

24-Hour Non-Drowsy Relief
Provides effective allergy symptom relief for up to 24 hours without causing drowsiness.

Ideal for Various Allergens
Perfect for combating indoor, outdoor, and pet allergens with ease.

Comparable to Flonase Quality
Customers praise its effectiveness and quality, comparable to Flonase.
Key specs
- dosage:50 mcg per spray
- form:Nasal spray
- active ingredient:Fluticasone Propionate, 50 mcg
- usage instructions:Use once per day
- symptom relief:Allergy symptoms
8.9

Very Good

Our Rating

9.5
Simple to use

9.1
worth the money

8.2
Flavor
9

WELMATE
WELMATE - Levocetirizine Dihydrochloride 5mg (180 ct) - Non Drowsy Allergy Medicine - 24 Hours - Antihistamine - Generic Allergy Pills - Over-The-Counter Medication
Main highlights

Key Features and Benefits
Fast-acting, 24-hour relief from indoor and outdoor allergens, with the efficacy of a prescription medication in an OTC form.

Ideal Use Cases
Perfect for those suffering from seasonal allergies or pet-related allergies, needing quick and long-lasting relief from symptoms.

Customer Reviews Summary
Most praised for its rapid effectiveness and comprehensive relief from a wide range of allergy symptoms.
8.8

Very Good

Our Rating
10

Ohm

Ohm 24 Hour Loratadine Allergy Relief Tablets, 10mg - 300 Count | Non-Drowsy Allergy Pills, Medicine Original Prescription Strenght

30% Off
8.7

Very Good

Our Rating

10 Best non prescription medications of 2025

1

Amazon Basic Care 24-Hour Allergy Relief Nasal Spray, Fluticasone Propionate (Glucocorticoid) 50 mcg, Full Prescription Strength, Non-Drowsy, 0.62 fl oz (Pack of 3)

How do we rank?

How do we rank?

Analyzing top stores

2

Paramedic Pocketbook of Prescription Medications

3

HealthCareAisle Allergy Relief - Fexofenadine Hydrochloride Tablets USP, 180 mg, 90 Tablets, Allergy Medication, Non-Drowsy 24-Hour Relief

4

The Pill Book Guide to Over-the-Counter Medications: The Illustrated Guide to the Most Commonly Used Non-Prescription Medications

5

GenCare - Cetirizine HCL 10 mg (200 Caplets) - 24 Hour Allergy Relief Pills - Non Drowsy Generic OTC Allergy Medication - Antihistamine Medicine for Sneezing, Runny Nose & Itchy Eyes - Generic Zyrtec

9.7

9.5

6

Are Your Prescriptions Killing You?: How to Prevent Dangerous Interactions, Avoid Deadly Side Effects, and Be Healthier with Fewer Drugs

7

Complete Guide to Prescription and Non-Prescription Drugs

8

Amazon Basic Care 24-Hour Allergy Relief Nasal Spray, Fluticasone Propionate (Glucocorticoid), 50 mcg, Full Prescription Strength, Non-Drowsy, 0.62 fl oz (Pack of 1)

9.5

9.1

8.2

9

WELMATE - Levocetirizine Dihydrochloride 5mg (180 ct) - Non Drowsy Allergy Medicine - 24 Hours - Antihistamine - Generic Allergy Pills - Over-The-Counter Medication

10

Ohm 24 Hour Loratadine Allergy Relief Tablets, 10mg - 300 Count | Non-Drowsy Allergy Pills, Medicine Original Prescription Strenght

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