10 Best nasal spray for sinusitis of 2025

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Best Choice

1

Flonase
Flonase Allergy Relief Nasal Spray, 24-Hour Non-Drowsy Multi-Symptom Relief - 72 Sprays plus Bonus Pack of Tissues
Main highlights

24-Hour Non-Drowsy Relief
Flonase provides long-lasting, non-drowsy relief from multiple allergy symptoms.

Year-Round Allergy Solution
Ideal for seasonal and year-round allergies caused by pollen, mold, dust mites, and pet dander.

Effective Ear Relief
Customers praise its effectiveness in alleviating ear congestion linked to sinus issues.
9.8

Exceptional

Our Rating

8.2
Gentle

8.0
worth the money
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Value for Money

2

Afrin
Afrin No Drip Severe Congestion Nasal Mist Twin Pack, Non-Drowsy, Fast-Acting Decongestant for Nasal Congestion and Sinus Pressure Relief, Adults and Children 6 and Older, .5 fl oz (Pack of 2)
Main highlights

Maximum Strength Relief
Afrin No Drip provides instant, long-lasting relief for severe nasal congestion.

Ideal for Allergy Season
Perfect for allergy sufferers needing effective nasal congestion relief.

Long-Lasting Effect
Customers praise its 12-hour effectiveness and non-drip formulation.
9.7

Exceptional

Our Rating

9.5
Simple to use

9.1
worth the money

8.9
Moisturizing
3

Vicks
Vicks Sinex SEVERE Nasal Spray, Original Ultra Fine Mist, Decongestant Medicine, Relief from Stuffy Nose due to Cold or Allergy, & Nasal Congestion, Sinus Pressure Relief, 265 Sprays x 2

14% Off
Main highlights

12-Hour Relief from Congestion
Provides instant, long-lasting relief from nasal congestion and sinus pressure for up to 12 hours.

Ideal for Cold and Allergy Season
Perfect for treating severe sinus congestion and pressure from colds or allergies.

Instant Effectiveness Praised by Users
Highly rated for its immediate effectiveness in clearing nasal passages.
9.5

Excellent

Our Rating

9.5
Simple to use

9.3
Moisturizing

9.1
worth the money
4

Afrin
Afrin No Drip Extra Moisturizing 12 Hour Nasal Congestion Relief Pump Mist, Sinus Spray Decongestant - 15 mL
Main highlights

12 Hour Relief and Moisture
Afrin No Drip Extra Moisturizing provides up to 12 hours of congestion relief while soothing dry nasal passages.

Ideal for Nighttime and Travel
Perfect for nighttime congestion relief and reducing in-flight discomfort from sinus pressure.

Instant and Effective Congestion Relief
Praised for its fast-acting relief of nasal and sinus congestion, especially during sleep and travel.
9.3

Excellent

Our Rating

9.9
sweat control

9.3
pain management

8.7
Simple to use
5

Mucinex
Mucinex Sinus-Max Oxymetazoline Nasal Spray Decongestant,12 Hour Over-The-Counter Medication Nose Spray for Sinus Relief, Nasal Decongestants For Adults, Allergy Congestion Relief, 0.75 Fl Oz

17% Off
Main highlights

Fast Acting Relief
Mucinex Sinus-Max provides quick relief from nasal and sinus congestion.

Ideal for Allergies
Perfect for allergy season, offering targeted congestion relief.

Customer Praised Effectiveness
Users love its fast action and long-lasting congestion relief.
9.2

Excellent

Our Rating
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6

Vicks
Vicks Sinex Severe Nasal Spray with Moisturizing Ultra Fine Mist, Decongestant for Stuffy Nose Relief from Cold, Allergy, Sinus Pressure - 265 Sprays
Main highlights

Instant Relief and Long-Lasting Effect
Provides instant, 12-hour relief from nasal congestion and sinus pressure.

Effective for Cold and Allergy Relief
Ideal for severe congestion and sinus pressure from colds or allergies.

User Praise for Comfort and Efficacy
Praised for its effective relief without side effects or irritation.
9.1

Excellent

Our Rating

9.7
worth the money

9.7
Simple to use

9.5
Moisturizing
7

Xlear
Xlear Nasal Spray with Xylitol, 1.5 fl oz (Pack of 1)
Main highlights

Natural Decongestant and Moisturizer
Xlear Nasal Spray gently cleans, moisturizes, and decongests sinuses naturally with xylitol.

Ideal for Chronic Sinus Issues
Perfect for individuals with recurring sinus infections and allergies.

Highly Effective for Sinus Relief
Users praise its immediate relief from congestion and improved breathing.
9.0

Excellent

Our Rating

9.7
Simple to use

9.7
For traveling

9.3
worth the money
8

Amazon Basic Care
Amazon Basic Care Maximum Strength 12 Hour Nasal Spray, Oxymetazoline HCl Solution, Congestion Relief, Cold and Allergy Medicine, Decongestant, 1 fl oz (Pack of 1)
Main highlights

12 Hour Relief
Provides fast, powerful congestion relief for up to 12 hours.

Ideal for Cold and Allergy Relief
Perfect for relieving nasal and sinus congestion due to colds and allergies.

Fast-Acting Relief
Customers praise its quick effectiveness in alleviating stuffy noses.
8.9

Very Good

Our Rating

8.0
worth the money

8.0
Simple to use

8.0
Comfort
9

Nasonex
Nasonex 24Hr Allergy Nasal Spray - 60 Spray
Main highlights

24HR Allergy Relief
Nasonex 24HR Allergy Nasal Spray provides full-day relief from allergy symptoms with non-drowsy formula.

Ideal for Daily Use
Perfect for managing indoor, outdoor, and seasonal allergies without a prescription.

Scent-Free Advantage
Customers praise the scent-free formula that doesn't leave a lingering smell.
8.7

Very Good

Our Rating

9.9
Aroma

9.5
Simple to use

9.1
worth the money
10

Beekeeper's Naturals
Beekeeper's Naturals Nasal Spray for Adults with Propolis, Xylitol & Saline, Clears Nasal Congestion, Moisturizes Sinus Canal, & Decongest Sinus Cavities, 1 fl oz
Main highlights

Natural Ingredients and Benefits
Formulated with sea salt, propolis, and xylitol for sinus relief.

Ideal for Sinus Congestion
Perfect for relieving congestion caused by pollutants and allergens.

Customer Praised Natural Formula
Highly rated for its natural, chemical-free composition.
8.5

Good

Our Rating

10 Best nasal spray for sinusitis of 2025

1

Flonase Allergy Relief Nasal Spray, 24-Hour Non-Drowsy Multi-Symptom Relief - 72 Sprays plus Bonus Pack of Tissues

8.2

8.0

How do we rank?

How do we rank?

Analyzing top stores

2

Afrin No Drip Severe Congestion Nasal Mist Twin Pack, Non-Drowsy, Fast-Acting Decongestant for Nasal Congestion and Sinus Pressure Relief, Adults and Children 6 and Older, .5 fl oz (Pack of 2)

9.5

9.1

8.9

3

Vicks Sinex SEVERE Nasal Spray, Original Ultra Fine Mist, Decongestant Medicine, Relief from Stuffy Nose due to Cold or Allergy, & Nasal Congestion, Sinus Pressure Relief, 265 Sprays x 2

9.5

9.3

9.1

4

Afrin No Drip Extra Moisturizing 12 Hour Nasal Congestion Relief Pump Mist, Sinus Spray Decongestant - 15 mL

9.9

9.3

8.7

5

Mucinex Sinus-Max Oxymetazoline Nasal Spray Decongestant,12 Hour Over-The-Counter Medication Nose Spray for Sinus Relief, Nasal Decongestants For Adults, Allergy Congestion Relief, 0.75 Fl Oz

6

Vicks Sinex Severe Nasal Spray with Moisturizing Ultra Fine Mist, Decongestant for Stuffy Nose Relief from Cold, Allergy, Sinus Pressure - 265 Sprays

9.7

9.7

9.5

7

Xlear Nasal Spray with Xylitol, 1.5 fl oz (Pack of 1)

9.7

9.7

9.3

8

Amazon Basic Care Maximum Strength 12 Hour Nasal Spray, Oxymetazoline HCl Solution, Congestion Relief, Cold and Allergy Medicine, Decongestant, 1 fl oz (Pack of 1)

8.0

8.0

8.0

9

Nasonex 24Hr Allergy Nasal Spray - 60 Spray

9.9

9.5

9.1

10

Beekeeper's Naturals Nasal Spray for Adults with Propolis, Xylitol & Saline, Clears Nasal Congestion, Moisturizes Sinus Canal, & Decongest Sinus Cavities, 1 fl oz

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