10 Best migraine relief medications of 2025

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Best Choice

1

Excedrin
Excedrin Migraine Relief Caplets to Alleviate Migraine Symptoms - 200 Count
Main highlights

Triple Action Formula
Combines acetaminophen, aspirin, and caffeine for powerful migraine relief.

Ideal for Migraine Sufferers
Best for alleviating migraine symptoms like headache, light sensitivity, and nausea.

Quick Relief Praised by Users
Users appreciate its fast-acting relief, often within 20 minutes.
Key specs
- Light Sensitivity:Relieves sensitivity
- Form:Caplets
- Use:Migraine relief
- Active Ingredient:Acetaminophen, aspirin, caffeine
- Features:Triple action formula
9.6

Exceptional

Our Rating

9.9
pain management

9.3
simple to consume

8.7
worth the money
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Value for Money

2

Excedrin
Excedrin Extra Strength Pain Relief Caplets for Headache Relief, Acetaminophen 250mg, Aspirin 250mg, Caffeine 65mg, Pain Reliever, 200 Count
Main highlights

Fast Acting Pain Relief
Excedrin Extra Strength provides quick relief for headaches and minor aches with a combination of pain relievers and caffeine.

Versatile Pain Management
Ideal for adults seeking temporary relief from headaches, colds, menstrual cramps, toothaches, muscular aches, and arthritis.

Highly Praised Effectiveness
Customers appreciate its consistent effectiveness in alleviating headaches and pain, even with long-term use.
Key specs
- form:Caplets
- pain relief:Headaches, cramps, toothaches
- active ingredient:N/A
- dosing instructions:N/A
- age suitability:Adults
9.5

Excellent

Our Rating

9.9
pain management

8.7
worth the money

8.0
simple to consume
3

GlaxoSmithKline

Excedrin Migraine Relief Caplets for Migraine Symptoms, Acetaminophen 250mg, Aspirin 250mg, Caffeine 65mg, Pain Reliever, 100 Count

19% Off
9.4

Excellent

Our Rating
4

Excedrin
Excedrin Migraine Relief Caplets for Migraine Symptoms, Acetaminophen 250mg, Aspirin 250mg, Caffeine 65mg, Pain Reliever, 24 Count

39% Off
Main highlights

Triple Action Formula
Combines acetaminophen, aspirin, and caffeine for powerful relief.

Ideal for Quick Migraine Relief
Effective migraine relief in 30 minutes for many users.

Customer Praised Fast Acting
Users appreciate quick headache relief, even with regular strength.
Key specs
- form:Caplet
- pain relief:Migraine headache relief
- active ingredient:Acetaminophen, aspirin, caffeine
- dosing instructions:N/A
- age suitability:N/A
9.3

Excellent

Our Rating

9.7
pain management

9.3
worth the money
5

Amazon Basic Care
Amazon Basic Care Migraine Relief, Acetaminophen, Aspirin (NSAID) and Caffeine Tablets, Headache Pain Reliever/Pain Reliever Aid, 200 Count
Main highlights

Effective_Migraine_Relief
Combines acetaminophen, aspirin, and caffeine to effectively relieve migraine pain.

Ideal_for_Adult_Use
Designed for adults who need fast-acting migraine relief.

Affordable_Alternative
Praised for being a cost-effective alternative to Excedrin Migraine.
Key specs
- form:Coated caplets
- pain relief:Migraine pain relief
- active ingredient:acetaminophen, aspirin, caffeine
- dosing instructions:2-caplet dose
- age suitability:For adults
9.2

Excellent

Our Rating

9.5
simple to consume

9.5
worth the money

9.3
pain management
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6

Amazon Basic Care
Amazon Basic Care Migraine Relief Geltabs to Alleviate Migraine Symptoms, Acetaminophen, Aspirin (NSAID) and Caffeine, 80 Count
Main highlights

Effective Migraine Relief
Combines acetaminophen, aspirin, and caffeine for fast headache relief.

Ideal for Migraine Onset
Best used at the onset of migraine symptoms for quick relief.

Praised Gel Tab Formulation
Customers appreciate the fast-acting gel tabs for their effectiveness.
8.9

Very Good

Our Rating
7

GenCare
GenCare - Headache Relief Acetaminophen with Aspirin (NSAID) & Caffeine (300 Caplets) Value Pack | Head Pain, Muscle Aches, Back Pain & Body | Generic ExcedrEn Extra Strength

20% Off
Main highlights

Fast_Effective_Headache_Relief
Contains 250mg Acetaminophen, 250mg Aspirin, 65mg Caffeine for quick, extended pain relief.

Versatile_Pain_Relief_Use
Ideal for headaches, muscle aches, toothaches, menstrual cramps, and arthritis.

Cost-Effective_Generic_Option
Praised for effectiveness matching brand names like Tylenol, at a lower cost.
Key specs
- form:Caplet
- pain relief:Headaches, muscle aches
- active ingredient:Acetaminophen, Aspirin, Caffeine
- dosing instructions:2 caplets every 6 hours
- age suitability:12 years and older
8.8

Very Good

Our Rating

8.9
worth the money

8.0
Flavor
8

TIME-CAP LABS, INC.
TIME-CAP LABS, INC. Timely Extra Strength Headache Relief - Acetaminophen with Aspirin & Caffeine (200 Caplets) - Headache, Migraine & Back and Body Pain & Muscle Aches - Extra Strength - Made in USA
Main highlights

Triple-Action Synergy
Combines Acetaminophen, Aspirin, and Caffeine for effective headache relief.

Ideal for Fast Relief
Perfect for those needing quick relief from headaches and pain.

Comparable to Excedrin
Praised for effectiveness similar to Excedrin by users.
Key specs
- form:Caplets
- pain relief:Effective for headaches
- active ingredient:Acetaminophen, Aspirin, Caffeine
- dosing instructions:200 caplets per bottle
- age suitability:N/A
8.7

Very Good

Our Rating
9

Excedrin
Excedrin Tension Headache Relief Caplets, Acetaminophen 500mg, Caffeine 65mg, Pain Reliever, Aspirin-Free, 100 Count

19% Off
Main highlights

Fast-Acting Pain Relief
Combines acetaminophen and caffeine for quick headache and muscle ache relief.

Ideal for Stress-Related Pain
Perfect for tension headaches and neck, shoulder pain from stress.

Aspirin-Free Formula
Praised for its effective, non-NSAID, aspirin-free pain relief.
8.6

Very Good

Our Rating

9.5
pain management

9.1
worth the money
10

GenCare

GenCare - Tension Headache Relief Pain Reliever with Acetaminophen 500 mg & Caffeine 65 mg (200 Caplets) Best Value Bulk Extra Strength for Head, Migraine, Joint Pain & Body Ache Relief Medicine

16% Off
8.4

Good

Our Rating

10 Best migraine relief medications of 2025

1

Excedrin Migraine Relief Caplets to Alleviate Migraine Symptoms - 200 Count

9.9

9.3

8.7

How do we rank?

How do we rank?

Analyzing top stores

2

Excedrin Extra Strength Pain Relief Caplets for Headache Relief, Acetaminophen 250mg, Aspirin 250mg, Caffeine 65mg, Pain Reliever, 200 Count

9.9

8.7

8.0

3

Excedrin Migraine Relief Caplets for Migraine Symptoms, Acetaminophen 250mg, Aspirin 250mg, Caffeine 65mg, Pain Reliever, 100 Count

4

Excedrin Migraine Relief Caplets for Migraine Symptoms, Acetaminophen 250mg, Aspirin 250mg, Caffeine 65mg, Pain Reliever, 24 Count

9.7

9.3

5

Amazon Basic Care Migraine Relief, Acetaminophen, Aspirin (NSAID) and Caffeine Tablets, Headache Pain Reliever/Pain Reliever Aid, 200 Count

9.5

9.5

9.3

6

Amazon Basic Care Migraine Relief Geltabs to Alleviate Migraine Symptoms, Acetaminophen, Aspirin (NSAID) and Caffeine, 80 Count

7

GenCare - Headache Relief Acetaminophen with Aspirin (NSAID) & Caffeine (300 Caplets) Value Pack | Head Pain, Muscle Aches, Back Pain & Body | Generic ExcedrEn Extra Strength

8.9

8.0

8

TIME-CAP LABS, INC. Timely Extra Strength Headache Relief - Acetaminophen with Aspirin & Caffeine (200 Caplets) - Headache, Migraine & Back and Body Pain & Muscle Aches - Extra Strength - Made in USA

9

Excedrin Tension Headache Relief Caplets, Acetaminophen 500mg, Caffeine 65mg, Pain Reliever, Aspirin-Free, 100 Count

9.5

9.1

10

GenCare - Tension Headache Relief Pain Reliever with Acetaminophen 500 mg & Caffeine 65 mg (200 Caplets) Best Value Bulk Extra Strength for Head, Migraine, Joint Pain & Body Ache Relief Medicine

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