10 Best migraine medicines of 2025

Save up to 41% off

Best Choice

1

MigreLief
MigreLief Original Triple Therapy with Puracol - Nutritional Support for Migraine Sufferers - 60 Caplets/1 Month Supply
Main highlights

Effective Nutritional Support
MigreLief provides dual patented nutritional support for migraine sufferers with a unique combination of Magnesium, Riboflavin, and Puracol Feverfew.

Recommended for Migraine Prevention
Ideal for adults and teens seeking consistent migraine prevention with a safe, non-GMO, vegetarian formula.

Improved Quality of Life
Users report significant reduction in migraine frequency and severity, enhancing daily life quality.
9.7

Exceptional

Our Rating

8.9
worth the money

8.4
simple to consume

8.2
Flavor
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Real users impact

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Based on millions of stores and reviews

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Value for Money

2

Excedrin
Excedrin Migraine Relief Caplets for Migraine Symptoms, Acetaminophen 500mg, Aspirin 250mg, Caffeine 65mg, Pain Reliever, 200 count
Main highlights

Triple Action Formula
Combines acetaminophen, aspirin, and caffeine for powerful migraine relief.

Ideal for Migraine Sufferers
Best for alleviating migraine symptoms like headache, light sensitivity, and nausea.

Quick Relief Praised by Users
Users appreciate its fast-acting relief, often within 20 minutes.
Key specs
- Light Sensitivity:Relieves sensitivity
- Form:Caplets
- Use:Migraine relief
- Active Ingredient:Acetaminophen, aspirin, caffeine
- Features:Triple action formula
9.6

Exceptional

Our Rating

9.9
pain management

9.3
simple to consume

8.7
worth the money
3

Amazon Basic Care
Amazon Basic Care Migraine Relief, Acetaminophen, Aspirin (NSAID) and Caffeine Tablets, Headache Pain Reliever/Pain Reliever Aid, 200 Count
Main highlights

Effective_Migraine_Relief
Combines acetaminophen, aspirin, and caffeine to effectively relieve migraine pain.

Ideal_for_Adult_Use
Designed for adults who need fast-acting migraine relief.

Affordable_Alternative
Praised for being a cost-effective alternative to Excedrin Migraine.
Key specs
- form:Coated caplets
- active ingredient:acetaminophen, aspirin, caffeine
- pain relief:Migraine pain relief
- dosing instructions:2-caplet dose
- age suitability:For adults
9.5

Excellent

Our Rating

9.5
simple to consume

9.5
worth the money

9.3
pain management
4

Amazon Basic Care
Amazon Basic Care Migraine Relief Geltabs, Acetaminophen, Aspirin (NSAID) and Caffeine, 80 Count
Main highlights

Effective Migraine Relief
Combines acetaminophen, aspirin, and caffeine for fast headache relief.

Ideal for Migraine Onset
Best used at the onset of migraine symptoms for quick relief.

Praised Gel Tab Formulation
Customers appreciate the fast-acting gel tabs for their effectiveness.
9.4

Excellent

Our Rating
5

Excedrin
Excedrin Migraine Relief Caplets for Migraine Symptoms, Acetaminophen 500mg, Aspirin 250mg, Caffeine 65mg, Pain Reliever, 24 Count

29% Off
Main highlights

Triple Action Formula
Combines acetaminophen, aspirin, and caffeine for powerful relief.

Ideal for Quick Migraine Relief
Effective migraine relief in 30 minutes for many users.

Customer Praised Fast Acting
Users appreciate quick headache relief, even with regular strength.
Key specs
- form:Caplet
- active ingredient:Acetaminophen, aspirin, caffeine
- pain relief:Migraine headache relief
- dosing instructions:N/A
- age suitability:N/A
9.3

Excellent

Our Rating

9.7
pain management

9.3
worth the money
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6

GlaxoSmithKline

Excedrin Migraine Relief Caplets for Migraine Symptoms, Acetaminophen 500mg, Aspirin 250mg, Caffeine 65mg, Pain Reliever, 100 Count

22% Off
9.2

Excellent

Our Rating
7

GenCare
GenCare - Headache Relief Acetaminophen with Aspirin (NSAID) & Caffeine (300 Caplets) Value Pack | Head Pain, Muscle Aches, Back Pain & Body | Generic ExcedrEn Extra Strength

17% Off
Main highlights

Fast_Effective_Headache_Relief
Contains 250mg Acetaminophen, 250mg Aspirin, 65mg Caffeine for quick, extended pain relief.

Versatile_Pain_Relief_Use
Ideal for headaches, muscle aches, toothaches, menstrual cramps, and arthritis.

Cost-Effective_Generic_Option
Praised for effectiveness matching brand names like Tylenol, at a lower cost.
Key specs
- form:Caplet
- active ingredient:Acetaminophen, Aspirin, Caffeine
- pain relief:Headaches, muscle aches
- dosing instructions:2 caplets every 6 hours
- age suitability:12 years and older
9.1

Excellent

Our Rating

8.9
worth the money

8.0
Flavor
8

GenCare

GenCare - Tension Headache Relief Pain Reliever with Acetaminophen 500 mg & Caffeine 65 mg (200 Caplets) Best Value Bulk Extra Strength for Head, Migraine, Joint Pain & Body Ache Relief Medicine

23% Off
8.9

Very Good

Our Rating
9

Hyland's
Hyland's Migraine Headache Natural Pain Relief Tablets, Pack of 1, 100 Count (Packaging May Vary)

13% Off
Main highlights

Natural Relief for Migraines
Provides relief for migraines and headaches with natural ingredients, avoiding common painkillers.

Ideal for Migraine Management
Best used at migraine onset or with prescription medications for enhanced relief.

Praised for Quick Dissolution
Customers appreciate its quick-dissolving tablets, making it easy to use without water.
8.8

Very Good

Our Rating

8.0
Flavor

8.0
worth the money

8.0
pain management
10

Motrin
Motrin IB Migraine Relief Liquid Gel Capsules with 200 mg Ibuprofen per Capsule, Fast & Effective Migraine Headache Medicine with NSAID Pain Reliever Ibuprofen, Caffeine-Free, 80 ct

41% Off
Main highlights

Key Features and Benefits
Fast, effective migraine relief with 200mg ibuprofen per liquid gel. Caffeine-free and dye-free for adults 18+. Safe when used as directed.

Ideal Use Cases
Best for adults seeking relief from migraine headaches, including symptoms of nausea, photophobia, and phonophobia, without the use of caffeine or dyes.

Customer Reviews Highlight
Most praised for its rapid relief from severe migraine pain, making it a go-to choice for sufferers needing quick, effective symptom management.
Key specs
- dosage:200 mg per capsule
- pack size:80-count bottle
- active ingredient:Ibuprofen
- formulation:Liquid Gel Capsules
- safety features:Caffeine-free & dye-free
8.7

Very Good

Our Rating

10 Best migraine medicines of 2025

1

MigreLief Original Triple Therapy with Puracol - Nutritional Support for Migraine Sufferers - 60 Caplets/1 Month Supply

8.9

8.4

8.2

How do we rank?

How do we rank?

Analyzing top stores

2

Excedrin Migraine Relief Caplets for Migraine Symptoms, Acetaminophen 500mg, Aspirin 250mg, Caffeine 65mg, Pain Reliever, 200 count

9.9

9.3

8.7

3

Amazon Basic Care Migraine Relief, Acetaminophen, Aspirin (NSAID) and Caffeine Tablets, Headache Pain Reliever/Pain Reliever Aid, 200 Count

9.5

9.5

9.3

4

Amazon Basic Care Migraine Relief Geltabs, Acetaminophen, Aspirin (NSAID) and Caffeine, 80 Count

5

Excedrin Migraine Relief Caplets for Migraine Symptoms, Acetaminophen 500mg, Aspirin 250mg, Caffeine 65mg, Pain Reliever, 24 Count

9.7

9.3

6

Excedrin Migraine Relief Caplets for Migraine Symptoms, Acetaminophen 500mg, Aspirin 250mg, Caffeine 65mg, Pain Reliever, 100 Count

7

GenCare - Headache Relief Acetaminophen with Aspirin (NSAID) & Caffeine (300 Caplets) Value Pack | Head Pain, Muscle Aches, Back Pain & Body | Generic ExcedrEn Extra Strength

8.9

8.0

8

GenCare - Tension Headache Relief Pain Reliever with Acetaminophen 500 mg & Caffeine 65 mg (200 Caplets) Best Value Bulk Extra Strength for Head, Migraine, Joint Pain & Body Ache Relief Medicine

9

Hyland's Migraine Headache Natural Pain Relief Tablets, Pack of 1, 100 Count (Packaging May Vary)

8.0

8.0

8.0

10

Motrin IB Migraine Relief Liquid Gel Capsules with 200 mg Ibuprofen per Capsule, Fast & Effective Migraine Headache Medicine with NSAID Pain Reliever Ibuprofen, Caffeine-Free, 80 ct

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