10 Best migraine medicines of 2025

Save up to 39% off

Best Choice

1

Excedrin
Excedrin Migraine Relief Caplets to Alleviate Migraine Symptoms - 200 Count
Main highlights

Triple Action Formula
Combines acetaminophen, aspirin, and caffeine for powerful migraine relief.

Ideal for Migraine Sufferers
Best for alleviating migraine symptoms like headache, light sensitivity, and nausea.

Quick Relief Praised by Users
Users appreciate its fast-acting relief, often within 20 minutes.
Key specs
- Light Sensitivity:Relieves sensitivity
- Form:Caplets
- Use:Migraine relief
- Active Ingredient:Acetaminophen, aspirin, caffeine
- Features:Triple action formula
9.6

Exceptional

Our Rating

9.9
pain management

9.3
simple to consume

8.7
worth the money
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Value for Money

2

Amazon Basic Care
Amazon Basic Care Migraine Relief, Acetaminophen, Aspirin (NSAID) and Caffeine Tablets, Headache Pain Reliever/Pain Reliever Aid, 200 Count
Main highlights

Effective_Migraine_Relief
Combines acetaminophen, aspirin, and caffeine to effectively relieve migraine pain.

Ideal_for_Adult_Use
Designed for adults who need fast-acting migraine relief.

Affordable_Alternative
Praised for being a cost-effective alternative to Excedrin Migraine.
Key specs
- form:Coated caplets
- active ingredient:acetaminophen, aspirin, caffeine
- pain relief:Migraine pain relief
- dosing instructions:2-caplet dose
- age suitability:For adults
9.5

Excellent

Our Rating

9.5
simple to consume

9.5
worth the money

9.3
pain management
3

Excedrin
Excedrin Migraine Relief Caplets for Migraine Symptoms, Acetaminophen 250mg, Aspirin 250mg, Caffeine 65mg, Pain Reliever, 24 Count

39% Off
Main highlights

Triple Action Formula
Combines acetaminophen, aspirin, and caffeine for powerful relief.

Ideal for Quick Migraine Relief
Effective migraine relief in 30 minutes for many users.

Customer Praised Fast Acting
Users appreciate quick headache relief, even with regular strength.
Key specs
- form:Caplet
- active ingredient:Acetaminophen, aspirin, caffeine
- pain relief:Migraine headache relief
- dosing instructions:N/A
- age suitability:N/A
9.4

Excellent

Our Rating

9.7
pain management

9.3
worth the money
4

GlaxoSmithKline

Excedrin Migraine Relief Caplets for Migraine Symptoms, Acetaminophen 250mg, Aspirin 250mg, Caffeine 65mg, Pain Reliever, 100 Count

19% Off
9.3

Excellent

Our Rating
5

Amazon Basic Care
Amazon Basic Care Migraine Relief Geltabs to Alleviate Migraine Symptoms, Acetaminophen, Aspirin (NSAID) and Caffeine, 80 Count
Main highlights

Effective Migraine Relief
Combines acetaminophen, aspirin, and caffeine for fast headache relief.

Ideal for Migraine Onset
Best used at the onset of migraine symptoms for quick relief.

Praised Gel Tab Formulation
Customers appreciate the fast-acting gel tabs for their effectiveness.
9.0

Excellent

Our Rating
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6

GenCare
GenCare - Headache Relief Acetaminophen with Aspirin (NSAID) & Caffeine (300 Caplets) Value Pack | Head Pain, Muscle Aches, Back Pain & Body | Generic ExcedrEn Extra Strength

20% Off
Main highlights

Fast_Effective_Headache_Relief
Contains 250mg Acetaminophen, 250mg Aspirin, 65mg Caffeine for quick, extended pain relief.

Versatile_Pain_Relief_Use
Ideal for headaches, muscle aches, toothaches, menstrual cramps, and arthritis.

Cost-Effective_Generic_Option
Praised for effectiveness matching brand names like Tylenol, at a lower cost.
Key specs
- form:Caplet
- active ingredient:Acetaminophen, Aspirin, Caffeine
- pain relief:Headaches, muscle aches
- dosing instructions:2 caplets every 6 hours
- age suitability:12 years and older
8.9

Very Good

Our Rating

8.9
worth the money

8.0
Flavor
7

TIME-CAP LABS, INC.
TIME-CAP LABS, INC. Timely Extra Strength Headache Relief - Acetaminophen with Aspirin & Caffeine (200 Caplets) - Headache, Migraine & Back and Body Pain & Muscle Aches - Extra Strength - Made in USA
Main highlights

Triple-Action Synergy
Combines Acetaminophen, Aspirin, and Caffeine for effective headache relief.

Ideal for Fast Relief
Perfect for those needing quick relief from headaches and pain.

Comparable to Excedrin
Praised for effectiveness similar to Excedrin by users.
Key specs
- form:Caplets
- active ingredient:Acetaminophen, Aspirin, Caffeine
- pain relief:Effective for headaches
- dosing instructions:200 caplets per bottle
- age suitability:N/A
8.8

Very Good

Our Rating
8

Motrin
Motrin IB Migraine Relief Liquid Gel Capsules with 200 mg Ibuprofen per Capsule, Fast & Effective Migraine Headache Medicine with NSAID Pain Reliever Ibuprofen, Caffeine-Free, 80 ct
Main highlights

Key Features and Benefits
Fast, effective migraine relief with 200mg ibuprofen per liquid gel. Caffeine-free and dye-free for adults 18+. Safe when used as directed.

Ideal Use Cases
Best for adults seeking relief from migraine headaches, including symptoms of nausea, photophobia, and phonophobia, without the use of caffeine or dyes.

Customer Reviews Highlight
Most praised for its rapid relief from severe migraine pain, making it a go-to choice for sufferers needing quick, effective symptom management.
Key specs
- dosage:200 mg per capsule
- pack size:80-count bottle
- active ingredient:Ibuprofen
- formulation:Liquid Gel Capsules
- safety features:Caffeine-free & dye-free
8.7

Very Good

Our Rating
9

Amazon Basic Care
Amazon Basic Care Headache Relief Geltabs, 80 Count
Main highlights

Effective Pain Relief Combination
Combines acetaminophen, aspirin, and caffeine for headache and arthritis relief.

Ideal for Quick Headache Relief
Best used for rapid relief from headaches and minor aches.

Easy to Swallow Gel Tabs
Praised for easy swallowing and effectiveness compared to name brands.
8.5

Good

Our Rating

9.7
simple to consume

9.7
worth the money
10

ValuMeds

ValuMeds Extra-Strength Headache & Migraine Relief | Acetaminophen, Aspirin (NSAID) 250mg, Caffeine 65mg | Generic Pain Reliever for Migraine, Arthritis, Muscle & Joint Pain | 300 Caplets
8.3

Good

Our Rating

9.1
worth the money

9.1
pain management

8.0
Flavor

10 Best migraine medicines of 2025

1

Excedrin Migraine Relief Caplets to Alleviate Migraine Symptoms - 200 Count

9.9

9.3

8.7

How do we rank?

How do we rank?

Analyzing top stores

2

Amazon Basic Care Migraine Relief, Acetaminophen, Aspirin (NSAID) and Caffeine Tablets, Headache Pain Reliever/Pain Reliever Aid, 200 Count

9.5

9.5

9.3

3

Excedrin Migraine Relief Caplets for Migraine Symptoms, Acetaminophen 250mg, Aspirin 250mg, Caffeine 65mg, Pain Reliever, 24 Count

9.7

9.3

4

Excedrin Migraine Relief Caplets for Migraine Symptoms, Acetaminophen 250mg, Aspirin 250mg, Caffeine 65mg, Pain Reliever, 100 Count

5

Amazon Basic Care Migraine Relief Geltabs to Alleviate Migraine Symptoms, Acetaminophen, Aspirin (NSAID) and Caffeine, 80 Count

6

GenCare - Headache Relief Acetaminophen with Aspirin (NSAID) & Caffeine (300 Caplets) Value Pack | Head Pain, Muscle Aches, Back Pain & Body | Generic ExcedrEn Extra Strength

8.9

8.0

7

TIME-CAP LABS, INC. Timely Extra Strength Headache Relief - Acetaminophen with Aspirin & Caffeine (200 Caplets) - Headache, Migraine & Back and Body Pain & Muscle Aches - Extra Strength - Made in USA

8

Motrin IB Migraine Relief Liquid Gel Capsules with 200 mg Ibuprofen per Capsule, Fast & Effective Migraine Headache Medicine with NSAID Pain Reliever Ibuprofen, Caffeine-Free, 80 ct

9

Amazon Basic Care Headache Relief Geltabs, 80 Count

9.7

9.7

10

ValuMeds Extra-Strength Headache & Migraine Relief | Acetaminophen, Aspirin (NSAID) 250mg, Caffeine 65mg | Generic Pain Reliever for Migraine, Arthritis, Muscle & Joint Pain | 300 Caplets

9.1

9.1

8.0

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