10 Best medicine for cold sores of 2025

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Best Choice

1

Clear Probiotics
Lysine Cold Sore Treatment for Lips with Pre-Probiotics & VIT C | 1 Month Supply | Supercharged Lysine Capsules with Rhamnosus & Acidophilus for Cold Sores Relief, Skin + Gut Health & Immune Support
Main highlights

Cold Sore Prevention
Probiotic blend with lysine and vitamin C prevents outbreaks.

Ideal for Cold Sore Sufferers
Perfect for those experiencing recurring cold sores and skin issues.

Customer Praised Effectiveness
Highly effective in reducing cold sore frequency and severity.
Key specs
- weight:2.08 ounces
- dimensions:2.1 x 2.1 x 3.6 inches
- application:Oral
- usage:Prevent cold sores
- formula:Vegan, Non-GMO
9.8

Exceptional

Our Rating
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Value for Money

2

Abreva
Abreva 10 Percent Docosanol Cold Sore Treatment, Treats Your Fever Blister in 2.5 Days - 0.07 oz Tube x 2

20% Off
Main highlights

Fast Healing with Docosanol
Contains 10% docosanol to shorten cold sore duration to 2.5 days.

Ideal for On-the-Go Treatment
Portable tube design perfect for quick, discreet application.

Highly Praised for Effectiveness
Users appreciate fast results and healing of cracked lips.
Key specs
- weight:1.76 ounces
- dimensions:1.71 x 5.1 x 5.5 inches
- application:Portable tube
- usage:Cold sore treatment
- formula:Docosanol cream
9.7

Exceptional

Our Rating

8.7
worth the money

8.4
Flavor
3

Mederma
Mederma Fever Blister Discreet Healing Patch - A Patch That Protects and Conceals Cold Sores - 15 Count
Main highlights

Fast Healing Hydrocolloid Gel
Ultra-thin hydrocolloid gel accelerates healing and prevents scabbing.

Discreet Social Use
Ideal for social settings, conceals cold sores effectively.

Pain and Itch Relief
Eliminates pain and itchiness, enhancing comfort during healing.
Key specs
- weight:0.63 ounces
- dimensions:6.1 x 4.3 x 0.8 inches
- application:N/A
- usage:N/A
- formula:Ultra-thin Hydrocolloid
9.6

Exceptional

Our Rating

8.7
Comfort

8.4
Simple to use

8.4
Sheerness
4

Campho-Phenique
Campho Phenique Cold Sore and Fever Blister Treatment for Lips, Maximum Strength Provides Instant Relief, Helps Prevent Infection To Promote Healing, Original Gel Formula, 0.23 Oz

52% Off
Main highlights

Pain and Itch Relief
Specially formulated to instantly relieve pain and itch from cold sores and fever blisters.

Versatile Use
Ideal for treating cold sores, fever blisters, insect bites, and minor sunburns.

Quick Healing
Praised for its ability to speed up healing and provide immediate relief.
Key specs
- weight:0.23 ounces
- dimensions:0.75 x 3.31 x 4.09 inches
- application:For adults and children 2 years and over
- usage:For cold sores/fever blisters
- formula:Specially formulated
9.4

Excellent

Our Rating

9.3
worth the money

8.0
Flavor
5

Abreva
Abreva Cold Sore Treatment Rapid Pain Relief Cream - 1 Tube, 3 Grams

16% Off
Main highlights

Rapid Symptom Relief
Shortens duration of tingling, pain, burning, and itching for quick comfort.

Convenient On-the-Go Use
Ideal for busy individuals needing fast and easy application.

Highly Praised Effectiveness
Customers frequently highlight its immediate and noticeable relief.
Key specs
- weight:0.11 ounces
- dimensions:5.08 x 3.96 x 1.06 inches
- application:Tube form
- usage:Tingling, pain, burning relief
- formula:N/A
9.2

Excellent

Our Rating
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6

TARO

Taro Cold Sore & Fever Blister Treatment - Fast-Acting Docosanol 10% Cream - Cold Sore & Fever Blister Treatment for Lips, Anti-Itch Formula for Effective Relief and Healing - 0.07 oz (2 Tube)

20% Off
9.1

Excellent

Our Rating
7

TARO
TARO Cold Sore & Fever Blister Treatment - Fast-Acting Docosanol 10% Cream - Cold Sore & Fever Blister Treatment for Lips, Anti-Itch Formula for Effective Relief and Healing - 0.07 oz (1 Tube)
Main highlights

Effective Cold Sore Treatment
Docosanol cream effectively treats cold sores, shortening healing time and symptom duration.

Ideal for Immediate Relief
Perfect for those seeking quick relief from cold sore symptoms on face or lips.

Affordable Alternative
Praised for cost-effectiveness, offering same active ingredient as name brands.
Key specs
- weight:0.07 ounces
- dimensions:2.36 x 0.79 x 2.36 inches
- application:Face or lips
- usage:Treats cold sores
- formula:Cream 10%
9.0

Excellent

Our Rating
8

Quantum Health
Quantum Health Lip Clear Lysine+ Cold Sore Treatment Soothe & Moisturize Mouth Sores - L-Lysine Menthol Calendula & Propolis Ointment - Transparent Fever Blister Healing Balm - 0.25 Oz

25% Off
Main highlights

Halve Healing Time
Cut cold sore healing time by 50% with L-Lysine.

Ideal for First Signs
Best used at the first sign of a cold sore.

Rapid Results
Praised for quickly reducing cold sore size and discomfort.
8.9

Very Good

Our Rating

9.3
Moisturizing

9.3
worth the money

8.4
Flavor
9

Lyranda
Lyranda® - Lysine Cold Sore Treatment - Chewable L-Lysine Tablets - Faster Absorption and Better Hygiene
Main highlights

Fast Absorption for Quick Relief
Chewable tablets ensure faster absorption of L-Lysine, promoting quicker relief from cold sore symptoms.

Ideal for Cold Sore Prevention
Perfect for individuals seeking a convenient and effective way to prevent and manage cold sores.

Highly Praised for Convenience
Customers appreciate the individually wrapped, portable, and easy-to-chew tablets.
Key specs
- Absorption:Faster absorption
- Form:Chewable Tablets
- Quality:High-quality, non-GMO
- Functions:Supports Immune Health
- Dosage:1000mg
8.8

Very Good

Our Rating
10

Wellness Basics
Wellness Basics Docosanol Cream 10% | Cold Sore Treatment | Shortens Healing Time | 0.07oz - 1 Tube
Main highlights

Fast Healing Formula
Docosanol 10 Cream shortens cold sore healing time and symptoms.

Ideal for Early Treatment
Apply at first signs to tackle cold sores promptly.

Affordable Brand Alternative
Praised for being as effective as name brands but cheaper.
Key specs
- weight:1.13 ounces
- dimensions:4.92 x 4.65 x 1.3 inches
- application:Apply at first signs
- usage:Treats cold sores
- formula:Non-prescription
8.7

Very Good

Our Rating

10 Best medicine for cold sores of 2025

1

Lysine Cold Sore Treatment for Lips with Pre-Probiotics & VIT C | 1 Month Supply | Supercharged Lysine Capsules with Rhamnosus & Acidophilus for Cold Sores Relief, Skin + Gut Health & Immune Support

How do we rank?

How do we rank?

Analyzing top stores

2

Abreva 10 Percent Docosanol Cold Sore Treatment, Treats Your Fever Blister in 2.5 Days - 0.07 oz Tube x 2

8.7

8.4

3

Mederma Fever Blister Discreet Healing Patch - A Patch That Protects and Conceals Cold Sores - 15 Count

8.7

8.4

8.4

4

Campho Phenique Cold Sore and Fever Blister Treatment for Lips, Maximum Strength Provides Instant Relief, Helps Prevent Infection To Promote Healing, Original Gel Formula, 0.23 Oz

9.3

8.0

5

Abreva Cold Sore Treatment Rapid Pain Relief Cream - 1 Tube, 3 Grams

6

Taro Cold Sore & Fever Blister Treatment - Fast-Acting Docosanol 10% Cream - Cold Sore & Fever Blister Treatment for Lips, Anti-Itch Formula for Effective Relief and Healing - 0.07 oz (2 Tube)

7

TARO Cold Sore & Fever Blister Treatment - Fast-Acting Docosanol 10% Cream - Cold Sore & Fever Blister Treatment for Lips, Anti-Itch Formula for Effective Relief and Healing - 0.07 oz (1 Tube)

8

Quantum Health Lip Clear Lysine+ Cold Sore Treatment Soothe & Moisturize Mouth Sores - L-Lysine Menthol Calendula & Propolis Ointment - Transparent Fever Blister Healing Balm - 0.25 Oz

9.3

9.3

8.4

9

Lyranda® - Lysine Cold Sore Treatment - Chewable L-Lysine Tablets - Faster Absorption and Better Hygiene

10

Wellness Basics Docosanol Cream 10% | Cold Sore Treatment | Shortens Healing Time | 0.07oz - 1 Tube

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