10 Best lysine lip balms of 2025

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Best Choice

1

DOCO
DocoShield Lip Balm w/Docosanol and Lysine (3-Pack)
Main highlights

Effective Cold Sore Prevention
This lip balm is highly effective in preventing cold sores, with users reporting significant reduction in outbreaks and faster healing times.

Best for Chapped Lips and Cold Sores
Ideal for individuals with persistent chapped lips and those prone to cold sores, providing both soothing relief and preventative care.

Praised for Healing and Prevention
Customers consistently praise the lip balm for its ability to heal dry, chapped lips quickly and prevent cold sores with regular use.
9.8

Exceptional

Our Rating

9.7
Aroma

9.3
Moisturizing

8.7
For Gentle skin
How do we rank?

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Based on millions of stores and reviews

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Value for Money

2

Basic Brands
Basic Brands - L-Lysine Ointment - 0.875 oz - Lysine Cold Sore Treatment and Blister Relief - Soothes Chapped Lips and Dry Skin – 2-Pack
Main highlights

Lysine Cold Sore Relief
Active lysine helps heal cold sores and blisters.

Ideal for Sensitive Lips
Perfect for chapped lips, dry skin, and minor irritations.

Long-lasting Moisture
Praised for its lasting hydration and soothing effect.
Key specs
- Absorption:Goes on clear
- Form:Ointment
- Quality:No dyes, phthalates
- Functions:Cold sore treatment
- Dosage:N/A
9.6

Exceptional

Our Rating

9.7
Moisturizing

9.5
worth the money

9.3
Flavor
3

Quantum
Quantum Health Lip Clear Lysine+ Cold Sore Treatment Soothe & Moisturize Mouth Sores - L-Lysine Menthol Calendula & Propolis Ointment - Transparent Fever Blister Healing Balm - 0.25 Oz

25% Off
Main highlights

Halve Healing Time
Cut cold sore healing time by 50% with L-Lysine.

Ideal for First Signs
Best used at the first sign of a cold sore.

Rapid Results
Praised for quickly reducing cold sore size and discomfort.
9.5

Excellent

Our Rating

9.3
Moisturizing

9.3
worth the money

8.4
Flavor
4

Quantum Health

Quantum Health SuperLysine+ ColdStick Lip Sunscreen|Soothes and Moisturizes Lips|Softens and Protects from the Sun|Goes on Clear|0.17 Ounce

15% Off
9.4

Excellent

Our Rating
5

Basic Organics
Basic Brands L-Lysine Ointment, Cold Sore Fever Blister Relief, Soothes Chapped Lips and Dry Skin, Goes on Clear, 0.875 oz (Pack of 1)
Main highlights

Cold Sore Prevention and Relief
Contains L-Lysine for effective prevention and relief of lip sores.

Ideal for Sun Exposure and Stress
Perfect for those exposed to sun or stress-induced outbreaks.

Highly Praised for Moisturizing
Customers appreciate its moisturizing effect on chapped lips.
Key specs
- active ingredients:Vitamin A, D, E, Lysine
- application:Goes on clear
- usage:Lip sores, fever blisters
- formula:Gluten Free, No Dyes
- pain relief:Lip sores, fever blisters
9.1

Excellent

Our Rating

9.7
Moisturizing

9.5
quality of ingredients

9.3
pain management
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6

Quantum
Quantum Health Super Lysine+ Coldstick, Tangerine Flavored - Soothes, Moisturizes, Protects Lips, Herbal Lip Balm, Spf 21, 5 Gm
Main highlights

Key Features
SPF 21 protection, hydrates chapped lips, combines honey, echinacea, vitamins, and lysine for fast relief and lip health restoration.

Ideal Use Cases
Perfect for preventing cold sore triggers from sun exposure, healing fever blisters, combating harsh weather effects, and treating dehydration-induced lip dryness.

Customer Praise
Highly praised for its effectiveness in quick lip healing, convenient travel-friendly packaging, and the added benefit of sun protection.
8.8

Very Good

Our Rating

9.1
Moisturizing

8.9
Sun protection

8.7
Flavor
7

Quantum

Super Lysine Plus+ ColdStick, SPF 21, Regular 0.18 oz (Pack of 3) by Quantum Research
8.6

Very Good

Our Rating
8

Piping Rock

Piping Rock Lysine Lip Balm | 0.15 oz | Moisturizing and Soothing Ointment | Non GMO, Gluten Free
8.5

Good

Our Rating
9

Herpecin-L
Herpecin L Lip Balm Stick with SPF30 and Lysine; Protects & Treats Cold Sores & Fever Blisters, Chapped Lips, 0.1oz - 2 Pack

28% Off
Main highlights

Cold Sore Relief and Protection
Formulated with lysine and dimethicone, Herpecin L relieves and protects against cold sores and chapped lips.

Ideal for Cold Sore Sufferers
Best used at the onset of cold sores for effective relief and healing.

Highly Effective Sun Protection
Praised for SPF 30 protection, shielding lips from harmful UV rays.
8.4

Good

Our Rating

9.3
Moisturizing

9.3
Sun protection

8.9
worth the money
10

Herpecin-L
Herpecin L Lip Balm Stick; Cold Sore Sun & Fever Blisters and Chapped Lips Relief Lip Balm with SPF30, Lemon Balm, and Lysine, 0.1oz
Main highlights

Cold Sore and Sun Protection
Herpecin L Lip Balm provides relief for cold sores and protects against UV rays with SPF 30.

Ideal for Outdoor Use
Perfect for those needing lip protection from sun exposure and cold sore relief.

Praised for Fast Healing
Customers appreciate its fast action in healing cracked and irritated lips.
Key specs
- active ingredients:Dimethicone, lysine
- application:Lip balm
- usage:Lips, cold sores
- formula:Lysine, vitamins, SPF 30
- pain relief:Cold sores, chapped lips
8.3

Good

Our Rating

9.1
Moisturizing

8.9
worth the money

8.0
Flavor

10 Best lysine lip balms of 2025

1

DocoShield Lip Balm w/Docosanol and Lysine (3-Pack)

9.7

9.3

8.7

How do we rank?

How do we rank?

Analyzing top stores

2

Basic Brands - L-Lysine Ointment - 0.875 oz - Lysine Cold Sore Treatment and Blister Relief - Soothes Chapped Lips and Dry Skin – 2-Pack

9.7

9.5

9.3

3

Quantum Health Lip Clear Lysine+ Cold Sore Treatment Soothe & Moisturize Mouth Sores - L-Lysine Menthol Calendula & Propolis Ointment - Transparent Fever Blister Healing Balm - 0.25 Oz

9.3

9.3

8.4

4

Quantum Health SuperLysine+ ColdStick Lip Sunscreen|Soothes and Moisturizes Lips|Softens and Protects from the Sun|Goes on Clear|0.17 Ounce

5

Basic Brands L-Lysine Ointment, Cold Sore Fever Blister Relief, Soothes Chapped Lips and Dry Skin, Goes on Clear, 0.875 oz (Pack of 1)

9.7

9.5

9.3

6

Quantum Health Super Lysine+ Coldstick, Tangerine Flavored - Soothes, Moisturizes, Protects Lips, Herbal Lip Balm, Spf 21, 5 Gm

9.1

8.9

8.7

7

Super Lysine Plus+ ColdStick, SPF 21, Regular 0.18 oz (Pack of 3) by Quantum Research

8

Piping Rock Lysine Lip Balm | 0.15 oz | Moisturizing and Soothing Ointment | Non GMO, Gluten Free

9

Herpecin L Lip Balm Stick with SPF30 and Lysine; Protects & Treats Cold Sores & Fever Blisters, Chapped Lips, 0.1oz - 2 Pack

9.3

9.3

8.9

10

Herpecin L Lip Balm Stick; Cold Sore Sun & Fever Blisters and Chapped Lips Relief Lip Balm with SPF30, Lemon Balm, and Lysine, 0.1oz

9.1

8.9

8.0

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