10 Best indigestion medications of 2025

Save up to 41% off

Best Choice

1

Iberogast
Iberogast Softgels, Herbal Relief of Stomach Upsets: Occasional Indigestion, Bloating, Gas, Nausea, Upset Stomach; 6-Herb Blend with Iberis Amara, Peppermint, Licorice, Lemon Balm; 30ct
Main highlights

Dual Action Digestive Relief
Iberogast offers clinically proven relief for stomach upsets using a unique 6-herb blend to restore digestive function.

Ideal for On-the-Go Use
Iberogast tablets are versatile and convenient for travel, providing easy digestive support outside the home.

Highly Recommended by Customers
Customers praise Iberogast for its effectiveness and ease of use, with endorsements from healthcare professionals.
Key specs
- Form:Herbal supplement
- Use:Digestive relief
- Active Ingredient:Iberis amara
- Relief Duration:N/A
- Pack Size:N/A
9.7

Exceptional

Our Rating
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Value for Money

2

Pepcid
Pepcid AC Maximum Strength Heartburn Relief Tablets, OTC Medicine Prevents & Relieves Heartburn Due to Acid Indigestion & Sour Stomach, 20mg Famotidine Acid Reducer, Fast-Acting, 50 ct

41% Off
Main highlights

Fast-Acting and Long-Lasting Relief
Pepcid AC provides up to 12-hour relief from heartburn and acid indigestion.

Ideal for Preventative Use
Take 60 minutes before meals to prevent heartburn.

Highly Praised Effectiveness
Customers appreciate the reliable relief from GERD symptoms.
9.6

Exceptional

Our Rating

9.9
simple to consume

9.1
worth the money
3

Amazon Basic Care
Amazon Basic Care Omeprazole Delayed Release Tablets 20 mg, Treats Frequent Heartburn, Acid Reducer, Heartburn Medicine, 42 Count (Pack of 1) (Packaging may vary)
Main highlights

Effective Acid Reduction
Omeprazole 20 mg reduces stomach acid, treating frequent heartburn occurring twice a week or more.

Recommended for Regular Heartburn Sufferers
Ideal for those experiencing heartburn at least twice weekly, requiring a 14-day treatment.

Cost-Effective Prilosec Alternative
Praised for affordability and effectiveness compared to Prilosec, offering great value.
9.4

Excellent

Our Rating

9.9
simple to consume

9.3
Flavor

9.3
worth the money
4

HealthCareAisle
HealthCareAisle Omeprazole 20 mg, 42 Delayed-Release Capsules - Acid Reducer, Treats Frequent Heartburn, 42 Count (Pack of 1)
Main highlights

Effective Heartburn Relief
Omeprazole 20mg capsules provide 24-hour relief from frequent heartburn.

Best for Frequent Heartburn
Ideal for individuals experiencing heartburn 2 or more days a week.

Affordable Alternative
Customers praise its cost-effectiveness compared to brand-name products.
9.1

Excellent

Our Rating
5

Gaviscon
Gaviscon Extra Strength Cherry Chewable Tablet For Fast-Acting Heartburn Relief, 100 Count
Main highlights

Fast and Long-Lasting Relief
Gaviscon Extra Strength Cherry Chewable Tablets provide quick relief from heartburn and acid reflux, lasting for hours when used as directed.

Ideal for Nighttime Use
Perfect for reducing nighttime acid reflux, these tablets help prevent sleep disturbances caused by heartburn.

Highly Praised Flavor
Customers appreciate the pleasant cherry flavor, making it a favored choice among antacid products.
9.0

Excellent

Our Rating

8.7
worth the money

8.2
Flavor
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6

Pepto Bismol
Pepto Bismol Caplets Ultra for Nausea, Heartburn, Indigestion, Upset Stomach, and Diarrhea - 5 Symptom Fast Relief, 24 ct

16% Off
Main highlights

Fast Relief for Five Symptoms
Pepto Bismol Caplets Ultra provide quick relief for nausea, heartburn, indigestion, upset stomach, and diarrhea with a 2X concentrated formula.

Ideal for Travel and Busy Lifestyles
Compact caplets are perfect for travelers and those needing quick relief without carrying liquid bottles.

Highly Praised for Effectiveness
Customers frequently commend the caplets for their fast and effective relief, especially in diverse food environments.
8.9

Very Good

Our Rating

9.3
For traveling

8.7
simple to consume

8.7
worth the money
7

Amazon Basic Care
Amazon Basic Care Maximum Strength Famotidine Tablets 20 mg, Acid Reducer Pills for Heartburn Relief, 200 Count (Packaging may vary)
Main highlights

Effective Heartburn Relief
Contains 20 mg famotidine, reduces heartburn for up to 12 hours.

Ideal for Nighttime Use
Prevents nighttime indigestion when taken before bedtime.

Cost-Effective Alternative
Customers praise value, comparable effectiveness to name brands.
8.8

Very Good

Our Rating

9.9
simple to consume

9.3
worth the money

9.1
Flavor
8

Amazon Basic Care
Amazon Basic Care Esomeprazole Magnesium Delayed Release Capsules, 20 mg, Acid Reducer, Heartburn Medicine, 42 Count
Main highlights

Effective Acid Reducer
Contains esomeprazole 20 mg, clinically proven to treat frequent heartburn.

Ideal for Frequent Heartburn
Best for those experiencing heartburn 2 or more days a week.

Cost-Effective Alternative
Praised for being as effective as Nexium but more affordable.
8.7

Very Good

Our Rating

9.5
simple to consume

8.4
worth the money
9

Pepto Bismol
Pepto Bismol Liquid for Nausea, Heartburn, Indigestion, Upset Stomach, and Diarrhea - Fast Relief for 5 Symptoms, Original Flavor, 2x12 oz
Main highlights

Fast Relief for Multiple Symptoms
Pepto Bismol provides quick relief for nausea, heartburn, indigestion, upset stomach, and diarrhea.

Ideal for Quick Stomach Relief
Perfect for anyone needing fast, effective relief from common digestive discomforts.

Trusted Family Classic
Customers appreciate Pepto Bismol's reliability as a classic, effective stomach remedy.
Key specs
- country of origin:USA
- package dimensions:2.63 x 5.25 x 6.88 inches
- discontinued:No
- symptoms relief:Nausea, Heartburn, Indigestion
- dosage form:N/A
8.6

Very Good

Our Rating

9.3
Flavor

9.3
worth the money
10

Glenmark Therapeutics
Glenmark Maximum Strength Famotidine Tablets, 20 mg, Acid Reducer for Heartburn Relief, 200 Count
Main highlights

Effective Acid Reducer
Includes 20 mg of Famotidine for quick heartburn relief.

Ideal for Frequent Heartburn
Perfect for those experiencing frequent heartburn or indigestion.

Highly Praised Affordability
Praised for its cost-effectiveness compared to name brands.
8.5

Good

Our Rating

9.9
simple to consume

9.3
worth the money

10 Best indigestion medications of 2025

1

Iberogast Softgels, Herbal Relief of Stomach Upsets: Occasional Indigestion, Bloating, Gas, Nausea, Upset Stomach; 6-Herb Blend with Iberis Amara, Peppermint, Licorice, Lemon Balm; 30ct

How do we rank?

How do we rank?

Analyzing top stores

2

Pepcid AC Maximum Strength Heartburn Relief Tablets, OTC Medicine Prevents & Relieves Heartburn Due to Acid Indigestion & Sour Stomach, 20mg Famotidine Acid Reducer, Fast-Acting, 50 ct

9.9

9.1

3

Amazon Basic Care Omeprazole Delayed Release Tablets 20 mg, Treats Frequent Heartburn, Acid Reducer, Heartburn Medicine, 42 Count (Pack of 1) (Packaging may vary)

9.9

9.3

9.3

4

HealthCareAisle Omeprazole 20 mg, 42 Delayed-Release Capsules - Acid Reducer, Treats Frequent Heartburn, 42 Count (Pack of 1)

5

Gaviscon Extra Strength Cherry Chewable Tablet For Fast-Acting Heartburn Relief, 100 Count

8.7

8.2

6

Pepto Bismol Caplets Ultra for Nausea, Heartburn, Indigestion, Upset Stomach, and Diarrhea - 5 Symptom Fast Relief, 24 ct

9.3

8.7

8.7

7

Amazon Basic Care Maximum Strength Famotidine Tablets 20 mg, Acid Reducer Pills for Heartburn Relief, 200 Count (Packaging may vary)

9.9

9.3

9.1

8

Amazon Basic Care Esomeprazole Magnesium Delayed Release Capsules, 20 mg, Acid Reducer, Heartburn Medicine, 42 Count

9.5

8.4

9

Pepto Bismol Liquid for Nausea, Heartburn, Indigestion, Upset Stomach, and Diarrhea - Fast Relief for 5 Symptoms, Original Flavor, 2x12 oz

9.3

9.3

10

Glenmark Maximum Strength Famotidine Tablets, 20 mg, Acid Reducer for Heartburn Relief, 200 Count

9.9

9.3

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