10 Best indigestion medications of 2025

Save up to 34% off

Best Choice

1

Amazon Basic Care
Amazon Basic Care Esomeprazole Magnesium Delayed Release Capsules, 20 mg, Acid Reducer, Heartburn Medicine, 42 Count
Main highlights

Effective Acid Reducer
Contains esomeprazole 20 mg, clinically proven to treat frequent heartburn.

Ideal for Frequent Heartburn
Best for those experiencing heartburn 2 or more days a week.

Cost-Effective Alternative
Praised for being as effective as Nexium but more affordable.
9.8

Exceptional

Our Rating

9.5
simple to consume

8.4
worth the money
How do we rank?

Powerful technology We scan thousands of products and stores, analyzing reviews to find what matters most to users like you

Careful review Our team ensures quality, value, and fit based on real user feedback

Trusted insights AI and human analysis guide your decisions, reflecting real user priorities
Real users impact

Thousands of users trust our site daily

Based on millions of stores and reviews

Shoppers influence our rankings
Analyzing top stores
Value for Money

2

Amazon Basic Care
Amazon Basic Care Maximum Strength Famotidine Tablets 20 mg, Acid Reducer Pills for Heartburn Relief, 200 Count (Packaging may vary)
Main highlights

Effective Heartburn Relief
Contains 20 mg famotidine, reduces heartburn for up to 12 hours.

Ideal for Nighttime Use
Prevents nighttime indigestion when taken before bedtime.

Cost-Effective Alternative
Customers praise value, comparable effectiveness to name brands.
9.7

Exceptional

Our Rating

9.9
simple to consume

9.3
worth the money

9.1
Flavor
3

HealthCareAisle
HealthCareAisle Omeprazole 20 mg, 42 Delayed-Release Capsules - Acid Reducer, Treats Frequent Heartburn, 42 Count (Pack of 1)
Main highlights

Effective Heartburn Relief
Omeprazole 20mg capsules provide 24-hour relief from frequent heartburn.

Best for Frequent Heartburn
Ideal for individuals experiencing heartburn 2 or more days a week.

Affordable Alternative
Customers praise its cost-effectiveness compared to brand-name products.
9.4

Excellent

Our Rating
4

Amazon Basic Care
Amazon Basic Care Omeprazole Delayed Release Tablets 20 mg, Treats Frequent Heartburn, Acid Reducer, Heartburn Medicine, 42 Count (Pack of 1) (Packaging may vary)

34% Off
Main highlights

Effective Acid Reduction
Omeprazole 20 mg reduces stomach acid, treating frequent heartburn occurring twice a week or more.

Recommended for Regular Heartburn Sufferers
Ideal for those experiencing heartburn at least twice weekly, requiring a 14-day treatment.

Cost-Effective Prilosec Alternative
Praised for affordability and effectiveness compared to Prilosec, offering great value.
9.2

Excellent

Our Rating

9.9
simple to consume

9.3
Flavor

9.3
worth the money
5

Pepto Bismol
Pepto Bismol Chewable Tablets for Nausea, Heartburn, Indigestion, Upset Stomach, and Diarrhea - 5 Symptom Fast Relief, Original Flavor, 48 ct
Main highlights

Five Symptom Relief
Provides fast relief for nausea, heartburn, indigestion, upset stomach, and diarrhea.

Ideal for Travel
Perfect for on-the-go relief, making it travel-friendly.

Praised for Convenience
Customers appreciate its portability and ease of use.
9.1

Excellent

Our Rating

9.9
movability

9.7
Simple to use

9.3
simple to consume
See Today’s Deals & Prices
6

Tagamet
Tagamet HB 200 mg Cimetidine Acid Reducer and Heartburn Relief, 30 Count

32% Off
Main highlights

Effective Heartburn Relief
Tagamet HB 200 provides fast relief and prevention of heartburn and acid indigestion.

Versatile Usage
Ideal for use at mealtime or bedtime to prevent heartburn.

Customer Praise for Reliability
Highly praised for consistent relief and effectiveness over substitutes and generics.
9.0

Excellent

Our Rating

9.7
simple to consume

9.1
worth the money
7

Pepto Bismol
Pepto Bismol Liquid for Nausea, Heartburn, Indigestion, Upset Stomach, and Diarrhea - Fast Relief for 5 Symptoms, Original Flavor, 2x12 oz
Main highlights

Fast Relief for Multiple Symptoms
Pepto Bismol provides quick relief for nausea, heartburn, indigestion, upset stomach, and diarrhea.

Ideal for Quick Stomach Relief
Perfect for anyone needing fast, effective relief from common digestive discomforts.

Trusted Family Classic
Customers appreciate Pepto Bismol's reliability as a classic, effective stomach remedy.
8.9

Very Good

Our Rating

9.3
Flavor

9.3
worth the money
8

TUMS
TUMS Chewy Bites Antacid Tablets for Chewable Heartburn Relief and Acid Indigestion Relief, Assorted Berries - 60 Count
Main highlights

Instant Relief and Portability
TUMS Chewy Bites provide fast heartburn relief and are portable.

Ideal for Busy Lifestyles
Perfect for those needing quick, convenient acid relief anytime.

Taste and Texture Satisfaction
Customers love the pleasant taste and easy chewability.
8.7

Very Good

Our Rating

9.5
simple to consume

9.3
Flavor

9.1
pain management
9

Mylanta

Mylanta Heartburn and Gas Relief, Liquid Antacid, Classic Flavor, 12 Fluid Ounce
8.6

Very Good

Our Rating
10

Pepto Bismol
Pepto Bismol Caplets Ultra for Nausea, Heartburn, Indigestion, Upset Stomach, and Diarrhea - 5 Symptom Fast Relief, 24 ct

16% Off
Main highlights

Fast Relief for Five Symptoms
Pepto Bismol Caplets Ultra provide quick relief for nausea, heartburn, indigestion, upset stomach, and diarrhea with a 2X concentrated formula.

Ideal for Travel and Busy Lifestyles
Compact caplets are perfect for travelers and those needing quick relief without carrying liquid bottles.

Highly Praised for Effectiveness
Customers frequently commend the caplets for their fast and effective relief, especially in diverse food environments.
8.5

Good

Our Rating

9.3
For traveling

8.7
simple to consume

8.7
worth the money

10 Best indigestion medications of 2025

1

Amazon Basic Care Esomeprazole Magnesium Delayed Release Capsules, 20 mg, Acid Reducer, Heartburn Medicine, 42 Count

9.5

8.4

How do we rank?

How do we rank?

Analyzing top stores

2

Amazon Basic Care Maximum Strength Famotidine Tablets 20 mg, Acid Reducer Pills for Heartburn Relief, 200 Count (Packaging may vary)

9.9

9.3

9.1

3

HealthCareAisle Omeprazole 20 mg, 42 Delayed-Release Capsules - Acid Reducer, Treats Frequent Heartburn, 42 Count (Pack of 1)

4

Amazon Basic Care Omeprazole Delayed Release Tablets 20 mg, Treats Frequent Heartburn, Acid Reducer, Heartburn Medicine, 42 Count (Pack of 1) (Packaging may vary)

9.9

9.3

9.3

5

Pepto Bismol Chewable Tablets for Nausea, Heartburn, Indigestion, Upset Stomach, and Diarrhea - 5 Symptom Fast Relief, Original Flavor, 48 ct

9.9

9.7

9.3

6

Tagamet HB 200 mg Cimetidine Acid Reducer and Heartburn Relief, 30 Count

9.7

9.1

7

Pepto Bismol Liquid for Nausea, Heartburn, Indigestion, Upset Stomach, and Diarrhea - Fast Relief for 5 Symptoms, Original Flavor, 2x12 oz

9.3

9.3

8

TUMS Chewy Bites Antacid Tablets for Chewable Heartburn Relief and Acid Indigestion Relief, Assorted Berries - 60 Count

9.5

9.3

9.1

9

Mylanta Heartburn and Gas Relief, Liquid Antacid, Classic Flavor, 12 Fluid Ounce

10

Pepto Bismol Caplets Ultra for Nausea, Heartburn, Indigestion, Upset Stomach, and Diarrhea - 5 Symptom Fast Relief, 24 ct

9.3

8.7

8.7

Sign up and get exclusive special deals