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10 Best heartburn medicines of 2026
Save up to 28% off
Best Choice1
Amazon One Medical9.9Exceptional
Acid Reflux Treatment & Symptoms | Request prescription for acid reflux medicine, heartburn relief, antacids from an online doctor, NP, or PA
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Value for Money2
Nexium9.7Exceptional
Nexium 24HR Acid Reducer Heartburn Relief Capsules for All-Day and All-Night Protection from Frequent Heartburn, Heartburn Medicine with Esomeprazole Magnesium - 42 Count
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Prilosec9.6Exceptional
Prilosec OTC, Omeprazole 20mg, Heartburn Medicine, Acid Reflux Medicine, 24 Hour Relief, 42 Tablets
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is discontinued by manufacturer:No
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asin:B0000AN9L7
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product dimensions:2.32 x 4.75 x 3.7 inches 2.4 ounces
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date first available:December 1, 2003
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item model number:OTC
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4
Amazon Basic Care9.5Excellent
Amazon Basic Care Maximum Strength Famotidine Tablets 20 mg, Acid Reducer for Heartburn Relief, Prevents & Relieves Acid Indigestion, Heartburn Medicine, 12 Hour Protection, 200 Count
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is discontinued by manufacturer:No
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asin:B074F18H4B
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product dimensions:1.78 x 3.44 x 1.78 inches 2.08 ounces
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date first available:July 28, 2017
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item model number:N/A
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5
C'rcle9.3Excellent
Omeprazole 20mg Bulk 84 ct - Heartburn Medicine Omeprazole Tablets - Acid Reducer Pills for Heartburn Relief and Acid Reflux Medicine - Six 14 Ct Bottles
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is discontinued by manufacturer:N/A
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asin:B08HGS7727
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product dimensions:5.24 x 3.58 x 3.27 inches; 5.29 ounces
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date first available:September 4, 2020
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item model number:N/A
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6
Amazon Basic Care9.2Excellent
Amazon Basic Care Esomeprazole Magnesium Delayed-Release Mini Capsules, 20 mg, Acid Reducer, 24 Hour Heartburn Medicine, 42 Count
28% Off-
is discontinued by manufacturer:N/A
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asin:B08518JGPH
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product dimensions:1.63 x 4.88 x 3.25 inches 2.08 ounces
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date first available:June 1, 2020
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item model number:1024325
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7
Amazon Basic Care9.1Excellent
Amazon Basic Care Esomeprazole Magnesium Delayed Release Capsules, 20 mg, Acid Reducer, 42 Count
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is discontinued by manufacturer:N/A
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asin:B0779CJZ9Q
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product dimensions:1.63 x 4.88 x 3.25 inches; 2.08 ounces
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date first available:November 11, 2017
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item model number:S0062AN
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8
Amazon Basic Care8.9Very Good
Amazon Basic Care Maximum Strength Famotidine Tablets, 20 mg, Acid Reducer for Heartburn Relief, Prevents & Relieves Heartburn, 400 Count Pack
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is discontinued by manufacturer:N/A
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asin:B09NBQ58R5
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product dimensions:3.43 x 1.78 x 3.5 inches 2.43 ounces
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date first available:June 14, 2022
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item model number:N/A
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9
Pepcid8.6Very Good
Pepcid Complete Acid Reducer + Antacid Chewable Tablets, 10mg Famotidine, 800mg Calcium Carbonate & 165mg Magnesium Hydroxide per Heartburn Medicine Tablet, Antacid Chews, Berry Flavored, 70 ct
12% Off
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10
Amazon Basic Care8.4Good
Amazon Basic Care Dual Action Complete, Chewable Acid Reducer Plus Antacid Tablets, Berry Flavor, Heartburn Medicine, Acid Indigestion Relief, 50 Count
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is discontinued by manufacturer:N/A
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asin:B07MJ87WS5
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product dimensions:2.3 x 2.3 x 4.75 inches 0.01 ounces
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date first available:February 4, 2019
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item model number:N/A
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