10 Best heartburn medicines of 2025

Explore top picks

Best Choice

1

Amazon Basic Care
Amazon Basic Care Omeprazole Delayed Release Tablets 20 mg, Acid Reducer, Wildberry Mint Coated Tablet, Heartburn Medicine, 42 Count
Main highlights

24 Hour Heartburn Relief
Provides effective 24-hour relief from frequent heartburn with one daily pill.

Ideal for Frequent Heartburn
Best for individuals experiencing heartburn two or more times a week.

Easy to Swallow
Customers praise the ease of swallowing due to the Wildberry Mint coating.
9.9

Exceptional

Our Rating

9.7
simple to consume

9.1
worth the money

8.9
Flavor
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Analyzing top stores
Value for Money

2

Ohm
Ohm Omeprazole 20mg, 42 Delayed-Release Tablets, Acid Reducer for Frequent Heartburn, 24-Hour Relief Heartburn Medicine, Helps Relieve Stomach & Chest Discomfort (6 Weeks of Supply, 42, Count)
Main highlights

Effective Stomach Acid Reduction
Ohm Omeprazole Tablets provide effective relief from frequent heartburn by reducing stomach acid with delayed-release technology.

Ideal for Regular Use
Perfect for individuals needing consistent heartburn management, offering three 14-day treatment courses in one package.

Easy Swallowing Experience
Customers appreciate the coated tablets for being easier to swallow compared to capsules.
9.8

Exceptional

Our Rating
3

Amazon Basic Care
Amazon Basic Care Maximum Strength Famotidine Tablets 20 mg, Acid Reducer Pills for Heartburn Relief, 200 Count (Packaging may vary)
Main highlights

Effective Heartburn Relief
Contains 20 mg famotidine, reduces heartburn for up to 12 hours.

Ideal for Nighttime Use
Prevents nighttime indigestion when taken before bedtime.

Cost-Effective Alternative
Customers praise value, comparable effectiveness to name brands.
9.7

Exceptional

Our Rating

9.9
simple to consume

9.3
worth the money

9.1
Flavor
4

Amazon Basic Care
Amazon Basic Care Esomeprazole Magnesium Delayed Release Capsules, 20 mg, Acid Reducer, Heartburn Medicine, 42 Count
Main highlights

Effective Acid Reducer
Contains esomeprazole 20 mg, clinically proven to treat frequent heartburn.

Ideal for Frequent Heartburn
Best for those experiencing heartburn 2 or more days a week.

Cost-Effective Alternative
Praised for being as effective as Nexium but more affordable.
9.6

Exceptional

Our Rating

9.5
simple to consume

8.4
worth the money
5

HealthCareAisle
HealthCareAisle Omeprazole 20 mg, 42 Delayed-Release Capsules - Acid Reducer, Treats Frequent Heartburn, 42 Count (Pack of 1)
Main highlights

Effective Heartburn Relief
Omeprazole 20mg capsules provide 24-hour relief from frequent heartburn.

Best for Frequent Heartburn
Ideal for individuals experiencing heartburn 2 or more days a week.

Affordable Alternative
Customers praise its cost-effectiveness compared to brand-name products.
9.3

Excellent

Our Rating
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6

GoodSense
GoodSense Omeprazole Delayed Release Tablets 20 mg, Stomach Acid Reducer for Frequent Heartburn Treatment, 42 Count
Main highlights

Heartburn Treatment Efficiency
Omeprazole 20 mg reduces stomach acid for frequent heartburn relief.

Ideal for Frequent Heartburn
Best for those experiencing heartburn at least twice weekly.

User Satisfaction
Customers praise its consistent effectiveness in heartburn relief.
9.2

Excellent

Our Rating

9.9
simple to consume

9.3
worth the money

9.3
Flavor
7

Pepcid
Pepcid AC Maximum Strength Heartburn Relief Tablets, OTC Medicine Prevents & Relieves Heartburn Due to Acid Indigestion, 20mg Famotidine Acid Reducer, Fast-Acting, 25 Ct
Main highlights

All-Day Night Acid Control
One tablet provides up to 21 hours of acid control.

Ideal for Quick Relief
Effective when taken 10 minutes before meals.

Praised for Fast-Acting Relief
Customers love its quick action against heartburn.
8.9

Very Good

Our Rating

9.9
simple to consume

9.7
pain management

9.1
worth the money
8

Amazon Basic Care
Amazon Basic Care Heartburn & Gas SuperChews Chewable Tablets, Mixed Berry, 82 Count (Previously SoundHealth)
Main highlights

Fast-Acting Relief
Provides quick relief from heartburn, gas, sour stomach, and bloating.

Ideal for Cost-Conscious Users
Offers the same benefits as name brands at a lower cost.

Flavor and Texture
Praised for its candy-like flavor and convenient chewable form.
8.7

Very Good

Our Rating

9.1
Flavor

8.9
worth the money

8.4
Comfort
9

Glenmark Therapeutics
Glenmark Maximum Strength Famotidine Tablets, 20 mg, Acid Reducer for Heartburn Relief, 200 Count
Main highlights

Effective Acid Reducer
Includes 20 mg of Famotidine for quick heartburn relief.

Ideal for Frequent Heartburn
Perfect for those experiencing frequent heartburn or indigestion.

Highly Praised Affordability
Praised for its cost-effectiveness compared to name brands.
8.6

Very Good

Our Rating

9.9
simple to consume

9.3
worth the money
10

Glenmark Therapeutics
Glenmark Maximum Strength Famotidine Tablets, 20 mg, Acid Reducer for Heartburn Relief, 200 Count
Main highlights

Effective Acid Reducer
Includes 20 mg of Famotidine for quick heartburn relief.

Ideal for Frequent Heartburn
Perfect for those experiencing frequent heartburn or indigestion.

Highly Praised Affordability
Praised for its cost-effectiveness compared to name brands.
8.5

Good

Our Rating

9.9
simple to consume

9.3
worth the money

10 Best heartburn medicines of 2025

1

Amazon Basic Care Omeprazole Delayed Release Tablets 20 mg, Acid Reducer, Wildberry Mint Coated Tablet, Heartburn Medicine, 42 Count

9.7

9.1

8.9

How do we rank?

How do we rank?

Analyzing top stores

2

Ohm Omeprazole 20mg, 42 Delayed-Release Tablets, Acid Reducer for Frequent Heartburn, 24-Hour Relief Heartburn Medicine, Helps Relieve Stomach & Chest Discomfort (6 Weeks of Supply, 42, Count)

3

Amazon Basic Care Maximum Strength Famotidine Tablets 20 mg, Acid Reducer Pills for Heartburn Relief, 200 Count (Packaging may vary)

9.9

9.3

9.1

4

Amazon Basic Care Esomeprazole Magnesium Delayed Release Capsules, 20 mg, Acid Reducer, Heartburn Medicine, 42 Count

9.5

8.4

5

HealthCareAisle Omeprazole 20 mg, 42 Delayed-Release Capsules - Acid Reducer, Treats Frequent Heartburn, 42 Count (Pack of 1)

6

GoodSense Omeprazole Delayed Release Tablets 20 mg, Stomach Acid Reducer for Frequent Heartburn Treatment, 42 Count

9.9

9.3

9.3

7

Pepcid AC Maximum Strength Heartburn Relief Tablets, OTC Medicine Prevents & Relieves Heartburn Due to Acid Indigestion, 20mg Famotidine Acid Reducer, Fast-Acting, 25 Ct

9.9

9.7

9.1

8

Amazon Basic Care Heartburn & Gas SuperChews Chewable Tablets, Mixed Berry, 82 Count (Previously SoundHealth)

9.1

8.9

8.4

9

Glenmark Maximum Strength Famotidine Tablets, 20 mg, Acid Reducer for Heartburn Relief, 200 Count

9.9

9.3

10

Glenmark Maximum Strength Famotidine Tablets, 20 mg, Acid Reducer for Heartburn Relief, 200 Count

9.9

9.3

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