10 Best heartburn medicines of 2026

Save up to 32% off

1

Amazon Basic Care
Amazon Basic Care Esomeprazole Magnesium Delayed Release Capsules, 20 mg, Acid Reducer, Heartburn Medicine, 42 Count
Main highlights

Effective Acid Reducer
Contains esomeprazole 20 mg, clinically proven to treat frequent heartburn.

Ideal for Frequent Heartburn
Best for those experiencing heartburn 2 or more days a week.

Cost-Effective Alternative
Praised for being as effective as Nexium but more affordable.
9.9

Exceptional

Our Rating

9.5
simple to consume

8.4
worth the money
How do we rank?

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Careful review Our team ensures quality, value, and fit based on real user feedback

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Based on millions of stores and reviews

Shoppers influence our rankings
Analyzing top stores
2

Amazon Basic Care
Amazon Basic Care Esomeprazole Magnesium Delayed Release Capsules, 20 mg, Acid Reducer, Heartburn Medicine, 42 Count
Main highlights

Effective Acid Reducer
Contains esomeprazole 20 mg, clinically proven to treat frequent heartburn.

Ideal for Frequent Heartburn
Best for those experiencing heartburn 2 or more days a week.

Cost-Effective Alternative
Praised for being as effective as Nexium but more affordable.
9.8

Exceptional

Our Rating

9.5
simple to consume

8.4
worth the money
3

Amazon Basic Care
Amazon Basic Care Omeprazole Delayed Release Tablets 20 mg, Treats Frequent Heartburn, Acid Reducer, Heartburn Medicine, 42 Count (Pack of 1) (Packaging may vary)
Main highlights

Effective Acid Reduction
Omeprazole 20 mg reduces stomach acid, treating frequent heartburn occurring twice a week or more.

Recommended for Regular Heartburn Sufferers
Ideal for those experiencing heartburn at least twice weekly, requiring a 14-day treatment.

Cost-Effective Prilosec Alternative
Praised for affordability and effectiveness compared to Prilosec, offering great value.
9.6

Exceptional

Our Rating

9.9
simple to consume

9.3
Flavor

9.3
worth the money
4

Amazon Basic Care
Amazon Basic Care Omeprazole Delayed Release Tablets 20 mg, Treats Frequent Heartburn, Acid Reducer, Heartburn Medicine, 42 Count (Pack of 1) (Packaging may vary)
Main highlights

Effective Acid Reduction
Omeprazole 20 mg reduces stomach acid, treating frequent heartburn occurring twice a week or more.

Recommended for Regular Heartburn Sufferers
Ideal for those experiencing heartburn at least twice weekly, requiring a 14-day treatment.

Cost-Effective Prilosec Alternative
Praised for affordability and effectiveness compared to Prilosec, offering great value.
9.4

Excellent

Our Rating

9.9
simple to consume

9.3
Flavor

9.3
worth the money
5

Amazon Basic Care
Amazon Basic Care Maximum Strength Famotidine Tablets 20 mg, Acid Reducer Pills for Heartburn Relief, 200 Count (Packaging may vary)

15% Off
Main highlights

Effective Heartburn Relief
Contains 20 mg famotidine, reduces heartburn for up to 12 hours.

Ideal for Nighttime Use
Prevents nighttime indigestion when taken before bedtime.

Cost-Effective Alternative
Customers praise value, comparable effectiveness to name brands.
9.3

Excellent

Our Rating

9.9
simple to consume

9.3
worth the money

9.1
Flavor
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6

Amazon Basic Care
Amazon Basic Care Maximum Strength Famotidine Tablets 20 mg, Acid Reducer Pills for Heartburn Relief, 200 Count (Packaging may vary)

19% Off
Main highlights

Effective Heartburn Relief
Contains 20 mg famotidine, reduces heartburn for up to 12 hours.

Ideal for Nighttime Use
Prevents nighttime indigestion when taken before bedtime.

Cost-Effective Alternative
Customers praise value, comparable effectiveness to name brands.
9.2

Excellent

Our Rating

9.9
simple to consume

9.3
worth the money

9.1
Flavor
7

Ohm
Ohm Omeprazole 20mg, 42 Delayed-Release Tablets, Acid Reducer for Frequent Heartburn, 24-Hour Relief Heartburn Medicine, Helps Relieve Stomach & Chest Discomfort (6 Weeks of Supply, 42, Count)

28% Off
Main highlights

Effective Stomach Acid Reduction
Ohm Omeprazole Tablets provide effective relief from frequent heartburn by reducing stomach acid with delayed-release technology.

Ideal for Regular Use
Perfect for individuals needing consistent heartburn management, offering three 14-day treatment courses in one package.

Easy Swallowing Experience
Customers appreciate the coated tablets for being easier to swallow compared to capsules.
9.1

Excellent

Our Rating
8

Ohm
Ohm Omeprazole 20mg, 42 Delayed-Release Tablets, Acid Reducer for Frequent Heartburn, 24-Hour Relief Heartburn Medicine, Helps Relieve Stomach & Chest Discomfort (6 Weeks of Supply, 42, Count)

32% Off
Main highlights

Effective Stomach Acid Reduction
Ohm Omeprazole Tablets provide effective relief from frequent heartburn by reducing stomach acid with delayed-release technology.

Ideal for Regular Use
Perfect for individuals needing consistent heartburn management, offering three 14-day treatment courses in one package.

Easy Swallowing Experience
Customers appreciate the coated tablets for being easier to swallow compared to capsules.
9.0

Excellent

Our Rating
9

Amazon Basic Care
Amazon Basic Care Maximum Strength Famotidine Tablets 20 mg, Acid Reducer for Heartburn Relief, 50 Count

18% Off
Main highlights

Effective Acid Reduction
Contains 20 mg of famotidine, an H2-blocker for heartburn relief lasting up to 12 hours.

Ideal for Preemptive Use
Prevents heartburn when taken 10 to 60 minutes before meals.

Customer Satisfaction for Value
Praised for quality and value, comparable to name brands.
Key specs
- Form:Tablets
- Relief Duration:Up to 12 hours
- Use:Heartburn relief
- Active Ingredient:20 mg famotidine
- Dosage:20 mg
8.9

Very Good

Our Rating

9.9
simple to consume

9.3
worth the money

9.1
Flavor
10

Amazon Basic Care
Amazon Basic Care Maximum Strength Famotidine Tablets 20 mg, Acid Reducer for Heartburn Relief, 50 Count

22% Off
Main highlights

Effective Acid Reduction
Contains 20 mg of famotidine, an H2-blocker for heartburn relief lasting up to 12 hours.

Ideal for Preemptive Use
Prevents heartburn when taken 10 to 60 minutes before meals.

Customer Satisfaction for Value
Praised for quality and value, comparable to name brands.
Key specs
- Form:Tablets
- Relief Duration:Up to 12 hours
- Use:Heartburn relief
- Active Ingredient:20 mg famotidine
- Dosage:20 mg
8.8

Very Good

Our Rating

9.9
simple to consume

9.3
worth the money

9.1
Flavor

10 Best heartburn medicines of 2026

1

Amazon Basic Care Esomeprazole Magnesium Delayed Release Capsules, 20 mg, Acid Reducer, Heartburn Medicine, 42 Count

9.5

8.4

How do we rank?

How do we rank?

Analyzing top stores

2

Amazon Basic Care Esomeprazole Magnesium Delayed Release Capsules, 20 mg, Acid Reducer, Heartburn Medicine, 42 Count

9.5

8.4

3

Amazon Basic Care Omeprazole Delayed Release Tablets 20 mg, Treats Frequent Heartburn, Acid Reducer, Heartburn Medicine, 42 Count (Pack of 1) (Packaging may vary)

9.9

9.3

9.3

4

Amazon Basic Care Omeprazole Delayed Release Tablets 20 mg, Treats Frequent Heartburn, Acid Reducer, Heartburn Medicine, 42 Count (Pack of 1) (Packaging may vary)

9.9

9.3

9.3

5

Amazon Basic Care Maximum Strength Famotidine Tablets 20 mg, Acid Reducer Pills for Heartburn Relief, 200 Count (Packaging may vary)

9.9

9.3

9.1

6

Amazon Basic Care Maximum Strength Famotidine Tablets 20 mg, Acid Reducer Pills for Heartburn Relief, 200 Count (Packaging may vary)

9.9

9.3

9.1

7

Ohm Omeprazole 20mg, 42 Delayed-Release Tablets, Acid Reducer for Frequent Heartburn, 24-Hour Relief Heartburn Medicine, Helps Relieve Stomach & Chest Discomfort (6 Weeks of Supply, 42, Count)

8

Ohm Omeprazole 20mg, 42 Delayed-Release Tablets, Acid Reducer for Frequent Heartburn, 24-Hour Relief Heartburn Medicine, Helps Relieve Stomach & Chest Discomfort (6 Weeks of Supply, 42, Count)

9

Amazon Basic Care Maximum Strength Famotidine Tablets 20 mg, Acid Reducer for Heartburn Relief, 50 Count

9.9

9.3

9.1

10

Amazon Basic Care Maximum Strength Famotidine Tablets 20 mg, Acid Reducer for Heartburn Relief, 50 Count

9.9

9.3

9.1

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