9 Best flea tick and mosquito for dogs of 2025

Save up to 11% off

Best Choice

1

Frontline
FRONTLINE Plus Flea and Tick Treatment for Large Dogs Up to 45 to 88 lbs. 3 Treatments

11% Off
Main highlights

Comprehensive Flea and Tick Protection
FRONTLINE Plus kills fleas, ticks, larvae, and lice effectively.

Ideal for Large Dogs
Perfect for dogs 45 to 88 lbs., including thick coats.

Waterproof and Long-lasting
Proven waterproof even through creeks and rivers.
9.9

Exceptional

Our Rating

8.0
Simple to use

8.0
Aroma

8.0
Comfort
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Value for Money

2

Amazon Basics

Amazon Basics Flea, Tick & Mosquito Topical Treatment for Small Dogs (4-10 pounds), 6 Count (Previously Solimo)
9.7

Exceptional

Our Rating
3

Amazon Basics
Amazon Basics Flea, Tick & Mosquito Topical Treatment for X-Large Dogs (over 55 pounds), 6 Count (Previously Solimo)
Main highlights

Key Features
Eliminates fleas, ticks within 24 hours, offers 30 days protection, waterproof, active ingredients kill various pests without expiry.

Ideal Use Cases
Best for extra large dogs over 55 pounds, suitable for all water activities and environments with high flea and tick infestations.

Customer Reviews
Most praised for its effectiveness in pest elimination, ease of application, and long-lasting protection without irritation to pets.
9.6

Exceptional

Our Rating

8.7
Simple to use

8.0
Aroma

8.0
Flavor
4

Amazon Basics
Amazon Basics Flea, Tick & Mosquito Topical Treatment for Large Dogs (21-55 pounds), 6 Count (Previously Solimo)
Main highlights

Fast Acting Protection
Starts eliminating fleas and ticks within 24 hours, providing up to 30 days of protection.

Ideal for Prevention
Best used consistently monthly to prevent flea infestations in large dogs.

Cost Effective Solution
Praised for affordability compared to other flea and tick treatments.
9.5

Excellent

Our Rating

8.0
Simple to use

8.0
Aroma

8.0
Long life
5

Amazon Basics
Amazon Basics Flea, Tick & Mosquito Topical Treatment for Medium Dogs (11-20 pounds), 6 Count (Previously Solimo)
Main highlights

Key Features
Starts eliminating fleas, ticks within 24 hours, up to 30 days protection. Waterproof post 24 hours, contains FiImidacloprid, Permethrin, Pyriproxyfen.

Ideal Use Cases
Perfect for medium dogs (11-20 pounds) engaging in water activities or in areas prone to fleas, ticks, mosquitos, biting flies, and chewing lice.

Customer Praise
Most reviews highlight the effectiveness in flea and tick prevention and appreciate the satisfaction guarantee for peace of mind.
9.4

Excellent

Our Rating

8.2
Simple to use

8.2
Flavor

8.0
Comfort
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6

K9 Advantix
K9 Advantix II XL Dog Vet-Recommended Flea, Tick & Mosquito Treatment & Prevention | Dogs Over 55 lbs. | 1-Mo Supply
Main highlights

Comprehensive Protection
Protects dogs over 55 lbs from fleas, ticks, mosquitoes, biting flies, and lice with a 30-day treatment.

Ideal for Large Breeds
Perfect for large dogs needing effective flea and tick prevention without a prescription.

Quick Flea Elimination
Kills fleas within 12 hours of application, praised for fast effectiveness.
9.3

Excellent

Our Rating

8.7
Simple to use

8.0
Water tight

8.0
worth the money
7

K9 Advantix
K9 Advantix II Large Dog Vet-Recommended Flea, Tick & Mosquito Treatment & Prevention | Dogs 21-55 lbs. | 2-Mo Supply
Main highlights

Comprehensive Protection
Protects dogs 21-55 lbs. from fleas, ticks, mosquitoes, biting flies and lice.

Ideal for Active Dogs
Perfect for dogs that spend time outdoors in mosquito-prone areas.

Highly Praised Mosquito Repellent
Customers appreciate its effectiveness in repelling mosquitoes, reducing heartworm risk.
9.1

Excellent

Our Rating

8.7
Simple to use

8.0
Aroma

8.0
Comfort
8

Vet's Best
Vet's Best Flea and Tick Yard and Dog Kennel Spray, Mosquito Repellent with Certified Natural Oils, Plant Safe with Ready-to-Use Hose Attachment, Flea and Tick Prevention for Dogs, 32 oz
Main highlights

Natural Ingredients Safe for Pets
Utilizes certified natural plant-based oils, ensuring safety for pets and family.

Ideal for Yard and Kennel Use
Perfect for treating lawns, kennels, and patios with ease.

Easy Application Praised by Users
Customers love the simple hose attachment for quick, hassle-free application.
8.8

Very Good

Our Rating

8.4
Simple to use

8.4
Aroma

8.0
worth the money
9

K9 Advantix

K9 Advantix Flea, Tick & Mosquito Prevention for Dogs 21-55 lbs. | Flea Drops for Large Dogs | Apply Monthly | 2 Treatments
8.7

Very Good

Our Rating

9.9
Simple to use

9.3
worth the money

9 Best flea tick and mosquito for dogs of 2025

1

FRONTLINE Plus Flea and Tick Treatment for Large Dogs Up to 45 to 88 lbs. 3 Treatments

8.0

8.0

8.0

2

Amazon Basics Flea, Tick & Mosquito Topical Treatment for Small Dogs (4-10 pounds), 6 Count (Previously Solimo)

3

Amazon Basics Flea, Tick & Mosquito Topical Treatment for X-Large Dogs (over 55 pounds), 6 Count (Previously Solimo)

8.7

8.0

8.0

4

Amazon Basics Flea, Tick & Mosquito Topical Treatment for Large Dogs (21-55 pounds), 6 Count (Previously Solimo)

8.0

8.0

8.0

5

Amazon Basics Flea, Tick & Mosquito Topical Treatment for Medium Dogs (11-20 pounds), 6 Count (Previously Solimo)

8.2

8.2

8.0

6

K9 Advantix II XL Dog Vet-Recommended Flea, Tick & Mosquito Treatment & Prevention | Dogs Over 55 lbs. | 1-Mo Supply

8.7

8.0

8.0

7

K9 Advantix II Large Dog Vet-Recommended Flea, Tick & Mosquito Treatment & Prevention | Dogs 21-55 lbs. | 2-Mo Supply

8.7

8.0

8.0

8

Vet's Best Flea and Tick Yard and Dog Kennel Spray, Mosquito Repellent with Certified Natural Oils, Plant Safe with Ready-to-Use Hose Attachment, Flea and Tick Prevention for Dogs, 32 oz

8.4

8.4

8.0

9

K9 Advantix Flea, Tick & Mosquito Prevention for Dogs 21-55 lbs. | Flea Drops for Large Dogs | Apply Monthly | 2 Treatments

9.9

9.3

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