January 1, 2026

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9 Best topical treatments of 2026

Explore top picks

Best Choice

1

TevraPet
TevraPet Activate II Flea and Tick Prevention for Dogs | 4 Count | Extra Large Dogs 55+ lbs | Topical Drops | 4 Months Flea Treatment
Main highlights

Fast Acting Flea and Tick Protection
Activate II uses Imidacloprid, Permethrin, and Pyriproxyfen for quick and effective pest control.

Ideal for Large Dogs
Perfect for extra-large dogs 55+ lbs needing monthly flea and tick prevention.

Easy Application Praised by Users
Customers appreciate the simple application process and effective pest prevention.
9.9

Exceptional

Our Rating

8.2
Simple to use

8.0
worth the money

8.0
Aroma
How do we rank?

Powerful technology We scan thousands of products and stores, analyzing reviews to find what matters most to users like you

Careful review Our team ensures quality, value, and fit based on real user feedback

Trusted insights AI and human analysis guide your decisions, reflecting real user priorities
Real users impact

Thousands of users trust our site daily

Based on millions of stores and reviews

Shoppers influence our rankings
Analyzing top stores
Value for Money

2

PetArmor
PetArmor Plus Flea and Tick Prevention for Dogs, Small Dog Flea and Tick Treatment, 3 Doses, Waterproof Topical, Fast Acting (5-22 lbs)
Main highlights

Effective Flea and Tick Protection
PetArmor Plus offers waterproof protection against fleas, ticks, and lice for up to 30 days.

Ideal for Active Dogs
Perfect for dogs 5-22 lbs who frequently go outdoors.

Highly Praised Long-Lasting Formula
Customers appreciate its ability to break the flea cycle and provide lasting protection.
9.7

Exceptional

Our Rating

9.3
Water tight

8.2
Simple to use

8.0
Aroma
3

Amazon Basics
Amazon Basics Flea and Tick Topical Treatment for Large Dogs (45-88 pounds), 3 Count (Previously Solimo)
Main highlights

Effective Flea and Tick Protection
Starts eliminating fleas and ticks within 24 hours with Fipronil and s-methoprene.

Ideal for Large Dogs
Perfect for dogs weighing between 45-88 pounds, providing tailored protection.

Cost-Effective Solution
Highly praised for affordability and effectiveness compared to other brands.
9.6

Exceptional

Our Rating

9.9
Precision

8.0
Simple to use

8.0
Aroma
4

Amazon Basics
Amazon Basics Flea and Tick Topical Treatment for Small Dogs (5-22 pounds), 6 Count (Previously Solimo)
Main highlights

Quick Flea and Tick Elimination
Starts eliminating fleas and ticks within 24 hours with up to 30 days protection.

Ideal for Small Dogs
Perfect for small dogs weighing 5-22 pounds, providing effective pest control.

Cost-Effective Alternative
Praised for being as effective as high-cost brands like Frontline.
9.5

Excellent

Our Rating

9.9
Precision

8.0
Simple to use

8.0
Aroma
5

Amazon Basics
Amazon Basics Flea and Tick Topical Treatment for Small Dogs (5-22 Pounds), 3 Count (Previously Solimo)
Main highlights

Long-Lasting Protection
Provides up to 30 days of flea and tick prevention.

Ideal for Small Dogs
Perfect for small dogs weighing 5-22 pounds.

Easy Application Praised
Users appreciate the easy and quick application process.
9.4

Excellent

Our Rating

8.0
Simple to use

8.0
Aroma

8.0
Comfort
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6

Amazon Basics
Amazon Basics Flea and Tick Topical Treatment for Medium Dogs (23-44 Pounds), 6 Count (Previously Solimo)
Main highlights

Key Features
Eliminates fleas, ticks within 24 hours, prevents infestations, waterproof, provides 30 days protection. Active ingredients: Fipronil, s-methoprene.

Ideal Use Cases
Perfect for medium dogs (23-44 pounds) engaging in water activities or exposed to wet conditions, ensuring continuous protection.

Customer Reviews Summary
Highly praised for its effectiveness in flea and tick prevention and the convenience of a 30-day protection period.
9.3

Excellent

Our Rating

9.9
Precision

8.2
Simple to use

8.0
Comfort
7

Amazon Basics
Amazon Basics Flea and Tick Topical Treatment for Medium Dogs (23-44 Pounds), 3 Count (Previously Solimo)
Main highlights

Fast_Effective_Protection
Starts eliminating fleas and ticks within 24 hours, providing up to 30 days of protection.

Ideal_for_Cost-Conscious_Owners
Perfect for medium dogs (23-44 lbs), offering affordable, long-lasting flea and tick prevention.

Comparable_to_Premium_Brands
Praised for effectiveness and ease of use, comparable to more expensive brands.
9.2

Excellent

Our Rating

9.9
Precision

8.0
Simple to use

8.0
Aroma
8

Amazon Basics
Amazon Basics Flea and Tick Topical Treatment for Large Dogs (45-88 lbs), Unscented, 6 Count (Previously Solimo)
Main highlights

Fast-Acting Protection
Starts eliminating fleas and ticks within 24 hours, offering up to 30 days of protection.

Ideal for Large Dogs
Perfect for dogs weighing between 45-88 pounds, ensuring effective flea and tick prevention.

Affordable and Effective
Praised for its cost-effectiveness compared to similar brands like Frontline and Advantix.
9.1

Excellent

Our Rating

9.9
Precision

8.0
Simple to use

8.0
Aroma
9

Amazon Basics
Amazon Basics Flea and Tick Topical Treatment for X-Large Dogs (89-132 Pounds), 3 Count (Previously Solimo)
Main highlights

Fast-Acting Formula
Begins eliminating fleas and ticks within 24 hours, providing rapid relief.

Ideal for Large Dogs
Perfect for X-Large dogs weighing 89-132 lbs, offering tailored protection.

Value for Money
Praised for affordability and effectiveness, suitable for budget-conscious pet owners.
9.0

Excellent

Our Rating

8.0
Simple to use

8.0
Aroma

8.0
Comfort

9 Best topical treatments of 2026

1

TevraPet Activate II Flea and Tick Prevention for Dogs | 4 Count | Extra Large Dogs 55+ lbs | Topical Drops | 4 Months Flea Treatment

8.2

8.0

8.0

How do we rank?

How do we rank?

Analyzing top stores

2

PetArmor Plus Flea and Tick Prevention for Dogs, Small Dog Flea and Tick Treatment, 3 Doses, Waterproof Topical, Fast Acting (5-22 lbs)

9.3

8.2

8.0

3

Amazon Basics Flea and Tick Topical Treatment for Large Dogs (45-88 pounds), 3 Count (Previously Solimo)

9.9

8.0

8.0

4

Amazon Basics Flea and Tick Topical Treatment for Small Dogs (5-22 pounds), 6 Count (Previously Solimo)

9.9

8.0

8.0

5

Amazon Basics Flea and Tick Topical Treatment for Small Dogs (5-22 Pounds), 3 Count (Previously Solimo)

8.0

8.0

8.0

6

Amazon Basics Flea and Tick Topical Treatment for Medium Dogs (23-44 Pounds), 6 Count (Previously Solimo)

9.9

8.2

8.0

7

Amazon Basics Flea and Tick Topical Treatment for Medium Dogs (23-44 Pounds), 3 Count (Previously Solimo)

9.9

8.0

8.0

8

Amazon Basics Flea and Tick Topical Treatment for Large Dogs (45-88 lbs), Unscented, 6 Count (Previously Solimo)

9.9

8.0

8.0

9

Amazon Basics Flea and Tick Topical Treatment for X-Large Dogs (89-132 Pounds), 3 Count (Previously Solimo)

8.0

8.0

8.0

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