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9 Best topical treatments of 2025

Save up to 37% off
  • Best Choice

    1

    Amazon Basics Flea and Tick Topical Treatment for Small Dogs (5-22 pounds), 6 Count (Previously Solimo)
    Amazon Basics

    Amazon Basics Flea and Tick Topical Treatment for Small Dogs (5-22 pounds), 6 Count (Previously Solimo)

    9.9
    Exceptional
    Our Rating
  • Powerful technology We scan thousands of products and stores, analyzing reviews to find what matters most to users like you
    Careful review Our team ensures quality, value, and fit based on real user feedback
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  • Value for Money

    2

    Frontline Plus Flea and Tick Treatment for Small Dogs Upto 5 to 22 lbs. 3 Treatments
    Frontline

    Frontline Plus Flea and Tick Treatment for Small Dogs Upto 5 to 22 lbs. 3 Treatments

    37% Off
    • Target Weight:5 pounds or more
    • Active Ingredients:fipronil, S-methoprene
    • Application Method:topical
    • Waterproof:Yes
    • Treatment Duration:30 days
    9.6
    Exceptional
    Our Rating

  • 3

    Amazon Basics Flea and Tick Topical Treatment for Medium Dogs (23-44 Pounds), 6 Count (Previously Solimo)
    Amazon Basics

    Amazon Basics Flea and Tick Topical Treatment for Medium Dogs (23-44 Pounds), 6 Count (Previously Solimo)

    9.5
    Excellent
    Our Rating

  • 4

    PetArmor Plus Flea and Tick Prevention for Dogs, Dog Flea and Tick Treatment, 3 Doses, Waterproof Topical, Fast Acting, Small Dogs (5-22 lbs)
    PetArmor

    PetArmor Plus Flea and Tick Prevention for Dogs, Dog Flea and Tick Treatment, 3 Doses, Waterproof Topical, Fast Acting, Small Dogs (5-22 lbs)

    14% Off
    9.4
    Excellent
    Our Rating

  • 5

    Amazon Basics Flea and Tick Topical Treatment for Large Dogs (45-88 pounds), 3 Count (Previously Solimo)
    Amazon Basics

    Amazon Basics Flea and Tick Topical Treatment for Large Dogs (45-88 pounds), 3 Count (Previously Solimo)

    9.3
    Excellent
    Our Rating
  • See Today’s Deals & Prices

  • 6

    Amazon Basics Flea and Tick Topical Treatment for X-Large Dogs (89-132 Pounds), 3 Count (Previously Solimo)
    Amazon Basics

    Amazon Basics Flea and Tick Topical Treatment for X-Large Dogs (89-132 Pounds), 3 Count (Previously Solimo)

    24% Off
    9.2
    Excellent
    Our Rating

  • 7

    Amazon Basics Flea, Tick & Mosquito Topical Treatment for Large Dogs (21-55 pounds), 6 Count (Previously Solimo)
    Amazon Basics

    Amazon Basics Flea, Tick & Mosquito Topical Treatment for Large Dogs (21-55 pounds), 6 Count (Previously Solimo)

    • Target Weight:21-55 pounds
    • Active Ingredients:FiImidacloprid, Permethrin, Pyriproxyfen
    • Application Method:Topical
    • Waterproof:24 hours after application
    • Treatment Duration:Up to 30 days
    9.1
    Excellent
    Our Rating

  • 8

    Amazon Basics Flea and Tick Topical Treatment for Medium Dogs (23-44 Pounds), 3 Count (Previously Solimo)
    Amazon Basics

    Amazon Basics Flea and Tick Topical Treatment for Medium Dogs (23-44 Pounds), 3 Count (Previously Solimo)

    9.0
    Excellent
    Our Rating

  • 9

    Amazon Basics Flea and Tick Topical Treatment for Cats (Over 1.5 Pounds), 6 Count (Previously Solimo)
    Amazon Basics

    Amazon Basics Flea and Tick Topical Treatment for Cats (Over 1.5 Pounds), 6 Count (Previously Solimo)

    8.8
    Very Good
    Our Rating