8 Best flea meds for dogs of 2025

Save up to 22% off

Best Choice

1

K9 Advantix
K9 Advantix II Large Dog Vet-Recommended Flea, Tick & Mosquito Treatment & Prevention | Dogs 21 - 55 lbs. | 4-Mo Supply
Main highlights

30-Day Protection for Dogs 21-55 lbs
K9 Advantix II provides a 30-day treatment and prevention for fleas, ticks, mosquitoes, biting flies, and lice, suitable for dogs weighing 21-55 lbs.

Use Based on Dog's Weight
Ensure to purchase K9 Advantix II according to your dog's weight, not size, for effective flea and tick control. Ideal for suburban and rural areas.

Effective Flea and Tick Repellent
Customers praise K9 Advantix II for its effectiveness in repelling fleas and ticks, with noticeable results within 12 hours and long-lasting protection.
9.8

Exceptional

Our Rating

8.7
Simple to use

8.0
Aroma

8.0
worth the money
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Value for Money

2

Capstar
Capstar for Dogs (nitenpyram), Fast-Acting Oral Flea Treatment for Dogs Over 25+ lbs, Vet-Recommended Flea Medication Tablets Start Killing in 30 Minutes, 6 Doses
Main highlights

Fast-Acting Relief
Capstar nitenpyram starts killing adult fleas in just 30 minutes.

Ideal for Quick Reinfestation Control
Perfect for dogs over 25 lbs needing fast flea treatment.

Convenient Oral Administration
Praised for easy, mess-free administration without vet prescription.
Key specs
- Dog Weight Range:25.1-125 pounds
- Form:Oral
- Flea Action:Starts killing fleas in 30 minutes
- Active Ingredient:nitenpyram
- Dosage:57 mg
9.6

Exceptional

Our Rating

8.2
Simple to use

8.0
simple to consume

8.0
Aroma
3

PetArmor
PetArmor CAPACTION (nitenpyram) Oral Flea Treatment for Dogs, Fast Acting Tablets Start Killing Fleas in 30 Minutes, Dogs Over 25 lbs, 6 Doses
Main highlights

Rapid Flea Elimination
Begins killing fleas within 30 minutes with over 90% effectiveness.

Convenient for Large Dogs
Ideal for dogs weighing 25.1 to 200 pounds, no prescription needed.

Customer Praised Fast Action
Highly praised for immediate relief and fast flea reduction.
9.3

Excellent

Our Rating

8.0
Simple to use

8.0
Sheerness

8.0
Aroma
4

Frontline
FRONTLINE Plus Flea and Tick Treatment for Large Dogs Up to 45 to 88 lbs. 3 Treatments

22% Off
Main highlights

Comprehensive Flea and Tick Protection
FRONTLINE Plus kills fleas, ticks, larvae, and lice effectively.

Ideal for Large Dogs
Perfect for dogs 45 to 88 lbs., including thick coats.

Waterproof and Long-lasting
Proven waterproof even through creeks and rivers.
9.2

Excellent

Our Rating

8.0
Simple to use

8.0
Aroma

8.0
Comfort
5

K9 Advantix
K9 Advantix II XL Dog Vet-Recommended Flea, Tick & Mosquito Treatment & Prevention | Dogs Over 55 lbs. | 2-Mo Supply
Main highlights

Comprehensive Protection
Protects dogs over 55 lbs from fleas, ticks, mosquitoes, biting flies, and lice with a 30-day treatment.

Ideal for Double Coated Breeds
Effective for breeds with dense coats like Siberian Huskies, ensuring thorough pest control.

Fast Acting and Mess-Free
Kills fleas within 12 hours without the need for a bath, praised for ease of use and effectiveness.
Key specs
- Target Weight:Over 55 lbs
- Application Method:Topical
- Waterproof:Yes, after 24 hours
- Treatment Duration:30-day
- Protection Type:Fleas, ticks, mosquitoes
9.1

Excellent

Our Rating

9.9
Aroma

8.7
Simple to use

8.0
Water tight
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6

Amazon Basics
Amazon Basics Flea and Tick Topical Treatment for Large Dogs (45-88 pounds), 3 Count (Previously Solimo)
Main highlights

Effective Flea and Tick Protection
Starts eliminating fleas and ticks within 24 hours with Fipronil and s-methoprene.

Ideal for Large Dogs
Perfect for dogs weighing between 45-88 pounds, providing tailored protection.

Cost-Effective Solution
Highly praised for affordability and effectiveness compared to other brands.
9.0

Excellent

Our Rating

9.9
Precision

8.0
Simple to use

8.0
Aroma
7

K9 Advantix
K9 Advantix II Large Dog Vet-Recommended Flea, Tick & Mosquito Treatment & Prevention | Dogs 21-55 lbs. | 1-Mo Supply
Main highlights

Kills and Repels Fleas Quickly
Vet-recommended formula kills fleas within 12 hours and repels pests on contact.

Ideal for Active Dogs
Perfect for dogs weighing 21-55 lbs, especially those frequently outdoors.

Mosquito Repellent Praised
Customers appreciate its effectiveness in repelling mosquitoes, reducing heartworm risk.
8.8

Very Good

Our Rating

8.7
Simple to use

8.0
Aroma

8.0
Comfort
8

Amazon Basics
Amazon Basics Flea and Tick Topical Treatment for Small Dogs (5-22 Pounds), 3 Count (Previously Solimo)

18% Off
Main highlights

Long-Lasting Protection
Provides up to 30 days of flea and tick prevention.

Ideal for Small Dogs
Perfect for small dogs weighing 5-22 pounds.

Easy Application Praised
Users appreciate the easy and quick application process.
8.7

Very Good

Our Rating

8.0
Simple to use

8.0
Aroma

8.0
Comfort

8 Best flea meds for dogs of 2025

1

K9 Advantix II Large Dog Vet-Recommended Flea, Tick & Mosquito Treatment & Prevention | Dogs 21 - 55 lbs. | 4-Mo Supply

8.7

8.0

8.0

How do we rank?

How do we rank?

Analyzing top stores

2

Capstar for Dogs (nitenpyram), Fast-Acting Oral Flea Treatment for Dogs Over 25+ lbs, Vet-Recommended Flea Medication Tablets Start Killing in 30 Minutes, 6 Doses

8.2

8.0

8.0

3

PetArmor CAPACTION (nitenpyram) Oral Flea Treatment for Dogs, Fast Acting Tablets Start Killing Fleas in 30 Minutes, Dogs Over 25 lbs, 6 Doses

8.0

8.0

8.0

4

FRONTLINE Plus Flea and Tick Treatment for Large Dogs Up to 45 to 88 lbs. 3 Treatments

8.0

8.0

8.0

5

K9 Advantix II XL Dog Vet-Recommended Flea, Tick & Mosquito Treatment & Prevention | Dogs Over 55 lbs. | 2-Mo Supply

9.9

8.7

8.0

6

Amazon Basics Flea and Tick Topical Treatment for Large Dogs (45-88 pounds), 3 Count (Previously Solimo)

9.9

8.0

8.0

7

K9 Advantix II Large Dog Vet-Recommended Flea, Tick & Mosquito Treatment & Prevention | Dogs 21-55 lbs. | 1-Mo Supply

8.7

8.0

8.0

8

Amazon Basics Flea and Tick Topical Treatment for Small Dogs (5-22 Pounds), 3 Count (Previously Solimo)

8.0

8.0

8.0

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