10 Best flea medicine for cats of 2025

Save up to 22% off

Best Choice

1

NEXTSTAR
NEXTSTAR Flea and Tick Prevention for Cats, Repellent, and Control, Fast Acting Waterproof Topical Drops for Cats Over 3.5 lbs, 6 Month Dose
Main highlights

Fast-Acting 30-Day Protection
NextStar offers a fast-acting, long-lasting topical solution for monthly flea and tick prevention.

Ideal for Busy Pet Owners
No vet visit needed; easy-to-use, waterproof topical for hassle-free protection.

Customer Praise for Effectiveness
Users appreciate the 7-way pest protection and quick action against fleas and ticks.
Key specs
- Application Method:Topical
- Kill Time:15 minutes
- Target Weight:Over 3.5 lbs
- Active Ingredients:N/A
- Duration:30 days
9.8

Exceptional

Our Rating
How do we rank?

Our rankings are cleverly generated from the algorithmic analysis of thousands of customer reviews about products, brands, merchant’s customer service levels, popularity trends, and more. The rankings reflect our opinion and should be a good starting point for shopping. By purchasing the products we rank, you’ll get the lowest price we found while we may receive a commission at no cost to you, which will help us continue to provide you with value.
Value for Money

2

Advecta
Advecta Plus Flea Prevention for Cats, Cat and Kitten Treatment & Control, Small and Large, Fast Acting Waterproof Topical Drops, 6 Month Supply
Main highlights

Fast Acting Flea Treatment
Kills fleas within 12 hours and prevents reinfestation by targeting all life stages.

Ideal for Cat Owners
Perfect for cats and kittens 8 weeks and older needing effective flea control.

Customer Praised Ease of Use
Users appreciate the easy application and waterproof formula for hassle-free protection.
Key specs
- Application Method:Topical
- Kill Time:Within 12 hours
- Target Weight:N/A
- Active Ingredients:Imidacloprid, Pyriproxyfen
- Duration:N/A
9.6

Exceptional

Our Rating
3

Woyamay
Woyamay Flea Treatment for Cats, 200 Treats Flea and Tick Prevention for Cats Chewables, Natural Cat Flea and Tick Treatment Chews Daily Oral Flea Supplement, Kitten Cat Flea Treatment, Chicken Flavor
Main highlights

Natural Ingredients and Safety
Veterinarian-approved chews with coconut oil, flaxseed, and brewer's yeast.

Daily Use for All Cats
Suitable for small, medium, and large cats; ideal for daily protection.

Delicious Chicken Flavor
Customers love the easy administration thanks to the tasty flavor.
Key specs
- Application Method:Oral chews
- Kill Time:N/A
- Target Weight:Small, medium, large cats
- Active Ingredients:Coconut oil, flaxseed, yeast
- Duration:Over 3 months
9.5

Excellent

Our Rating
4

Frontline
FRONTLINE Plus Flea and Tick Treatment for Cats Over 1.5 lbs. 3 Treatments

22% Off
Main highlights

Waterproof Long-Lasting Protection
Frontline Plus offers waterproof, fast-acting flea and tick control for cats over 1.5 lbs.

Ideal for Infestation Prevention
Perfect for preventing flea infestations and protecting against Lyme disease transmission.

Veterinarian Trusted
Praised for its effectiveness and long-standing trust among veterinarians.
9.3

Excellent

Our Rating

8.0
Simple to use

8.0
Aroma

8.0
Simple to take off
5

Amazon Basics
Amazon Basics Flea and Tick Topical Treatment for Cats (over 1.5 lbs), 6 Count (Previously Solimo)
Main highlights

Fast-Acting Protection
Begins eliminating fleas and ticks within 24 hours.

Ideal for Multi-Cat Households
Provides six doses, perfect for homes with multiple cats.

High Customer Satisfaction
Praised for affordability and effectiveness in eliminating fleas.
9.2

Excellent

Our Rating

8.0
Simple to use

8.0
Aroma

8.0
Comfort
See Today’s Deals & Prices
6

Amazon Basics
Amazon Basics Flea Topical for Large Cats (over 9 pounds), 4 Count (Previously Solimo)
Main highlights

Quick Flea Elimination
Amazon Basics Flea Topical starts eliminating fleas within 12 hours.

Ideal for Large Cats
Perfect for cats over 9 pounds, offering effective flea control.

Customer Satisfaction Guarantee
Customers appreciate its effectiveness and affordability compared to name brands.
9.1

Excellent

Our Rating

8.2
Simple to use

8.0
Aroma

8.0
worth the money
7

TevraPet
TevraPet Actispot II Flea Treatment for Large Cats 9+ lbs | 6 Doses | Powerful Prevention and Control
Main highlights

Powerful Flea Treatment
Kills fleas, eggs, and larvae for 30 days.

Ideal for Multi-Cat Homes
Effective for large cats, requires separation post-application.

Fast Acting Formula
Begins killing fleas within 24 hours, praised by users.
8.8

Very Good

Our Rating

8.4
Simple to use

8.0
worth the money

8.0
Comfort
8

ProElobara
Flea and Tick Prevention for Cats & Kittens: Waterproof Topical Cat Flea and Tick Treatment – Fast-Acting & Long-Lasting At Home Flea Control for Cats Over 1.5 lbs and 8 Weeks or Older – 6-Dose Supply
Main highlights

Fast-Acting and Long-Lasting Protection
Provides up to 30 days of continuous protection against fleas and ticks.

Ideal for Cats with Sensitive Skin
Safe and gentle formula suitable for all cats, including kittens and seniors.

Easy to Apply
Topical treatment applied to shoulder blades, praised for ease of use.
8.7

Very Good

Our Rating
9

Amazon Basics
Amazon Basics Topical Flea Treatment for Medium Cats (5-9 Pounds), 4 Count (Previously Solimo)
Main highlights

Fast Flea Elimination
Begins killing fleas within 12 hours, providing quick relief.

Ideal for Small Cats
Perfect for cats weighing 5-9 pounds, ensuring safe use.

Customer Praised Effectiveness
Highly effective in keeping cats flea-free for 30 days.
8.5

Good

Our Rating

8.2
Comfort

8.0
Simple to use

8.0
worth the money
10

PetArmor
PetArmor CAPACTION (nitenpyram) Oral Flea Treatment for Cats, Fast Acting Tablets Start Killing Fleas in 30 Minutes, Cats 2-25 lbs, 6 Doses
Main highlights

Fast-Acting Flea Treatment
Begins killing fleas within 30 minutes of administration.

Versatile for Cat Sizes
Suitable for cats weighing 2 to 25 pounds.

Proven Customer Satisfaction
Highly praised for visible flea reduction and ease of use.
8.4

Good

Our Rating

8.4
Simple to use

8.0
Comfort

8.0
worth the money

10 Best flea medicine for cats of 2025

1

NEXTSTAR Flea and Tick Prevention for Cats, Repellent, and Control, Fast Acting Waterproof Topical Drops for Cats Over 3.5 lbs, 6 Month Dose

2

Advecta Plus Flea Prevention for Cats, Cat and Kitten Treatment & Control, Small and Large, Fast Acting Waterproof Topical Drops, 6 Month Supply

3

Woyamay Flea Treatment for Cats, 200 Treats Flea and Tick Prevention for Cats Chewables, Natural Cat Flea and Tick Treatment Chews Daily Oral Flea Supplement, Kitten Cat Flea Treatment, Chicken Flavor

4

FRONTLINE Plus Flea and Tick Treatment for Cats Over 1.5 lbs. 3 Treatments

8.0

8.0

8.0

5

Amazon Basics Flea and Tick Topical Treatment for Cats (over 1.5 lbs), 6 Count (Previously Solimo)

8.0

8.0

8.0

6

Amazon Basics Flea Topical for Large Cats (over 9 pounds), 4 Count (Previously Solimo)

8.2

8.0

8.0

7

TevraPet Actispot II Flea Treatment for Large Cats 9+ lbs | 6 Doses | Powerful Prevention and Control

8.4

8.0

8.0

8

Flea and Tick Prevention for Cats & Kittens: Waterproof Topical Cat Flea and Tick Treatment – Fast-Acting & Long-Lasting At Home Flea Control for Cats Over 1.5 lbs and 8 Weeks or Older – 6-Dose Supply

9

Amazon Basics Topical Flea Treatment for Medium Cats (5-9 Pounds), 4 Count (Previously Solimo)

8.2

8.0

8.0

10

PetArmor CAPACTION (nitenpyram) Oral Flea Treatment for Cats, Fast Acting Tablets Start Killing Fleas in 30 Minutes, Cats 2-25 lbs, 6 Doses

8.4

8.0

8.0

Similar products on Amazon

Advantage II Small Cat Vet-Recommended Flea Treatment & Prevention | Cats 5-9 lbs. | 1-Month Supply

$16.98

Hartz UltraGuard Topical Flea & Tick Prevention for Cats and Kittens - 3 Monthly Treatments

$5.44

Sign up and get exclusive special deals