10 Best fissures creams of 2025

Save up to 22% off

Best Choice

1

Doctor Butler's
Doctor Butler's Advanced Hemorrhoid & Fissure Ointment – Lidocaine Hemorrhoid Treatment and Fissure Treatment Extra Strength Formula, Heals and Provides Fast Pain and Itch Relief* (1.5 oz.)
Main highlights

Fast Relief with Lidocaine
Provides quick pain and itch relief using lidocaine and organic ingredients.

Ideal for Pain and Itch Relief
Best for immediate relief of hemorrhoid-related pain and itching.

Praised for Effectiveness Over Brands
Customers appreciate its effectiveness over other popular brands like Preparation H.
Key specs
- active ingredients:Lidocaine, organic herbs
- application method:Topical
- usage:Hemorrhoid and fissure treatment
- formulation:Ointment
- pain relief:Numbing cream for hemorrhoids
9.8

Exceptional

Our Rating

8.7
Gentle

8.4
Comfort

8.0
worth the money
How do we rank?

Powerful technology We scan thousands of products and stores, analyzing reviews to find what matters most to users like you

Careful review Our team ensures quality, value, and fit based on real user feedback

Trusted insights AI and human analysis guide your decisions, reflecting real user priorities
Real users impact

Thousands of users trust our site daily

Based on millions of stores and reviews

Shoppers influence our rankings
Analyzing top stores
Value for Money

2

Doctor Butler's
Doctor Butler’s Hemorrhoid & Fissure Ointment – Hemorrhoid Treatment and Hemorrhoid Cream with Lidocaine and Phenylephrine HCI for Fast Acting Relief of Pain, Swelling, Discomfort, and Itching (1 oz.)
Main highlights

Fast Acting Relief
Doctor Butler's cream offers rapid relief from hemorrhoid pain, swelling, and itching with Lidocaine and Phenylephrine.

Pregnancy-Friendly Use
Ideal for pregnant women seeking safe and effective hemorrhoid relief.

Customer Praised Effectiveness
Highly praised for its quick relief and long-lasting effects in severe cases.
9.7

Exceptional

Our Rating

8.7
Gentle

8.2
pain management

8.0
worth the money
3

Doctor Butler's
Doctor Butler's Hemorrhoid & Fissure Cream – Instant Pain Relief Hemorrhoid Treatment with Lidocaine, Fast Acting Hemorrhoid Cream for Relief from External Itching and Burning (1 oz.)
Main highlights

Quick Pain Relief with Lidocaine
Doctor Butler's cream offers fast-acting relief from pain and discomfort using lidocaine.

Ideal for Hemorrhoids and Fissures
Designed for individuals suffering from external hemorrhoids and fissures needing immediate relief.

Effective Soothing and Numbing
Customers praise its ability to soothe and numb effectively, providing much-needed comfort.
Key specs
- active ingredients:Lidocaine
- application method:Topical
- usage:Hemorrhoid treatment
- formulation:Cream
- pain relief:Topical pain relief
9.6

Exceptional

Our Rating
4

REVIVOL-XR
REVIVOL-XR Advanced Hemorrhoid Treatment. 5% Lidocaine + Shrinks + Protects Skin + Aloe + Witch Hazel + Botanicals, External & Internal Use. Most Complete OTC Ointment & Fissure Cream, USA Made.

22% Off
Main highlights

Rapid Relief and Protection
Combines 5% Lidocaine and 0.25% Phenylephrine for fast pain, itch, and swelling relief with protective hydration.

Ideal for Hemorrhoid Discomfort
Perfect for those seeking immediate relief from hemorrhoid-related pain, itch, and swelling.

Customer Praised Ease of Use
Aloe-infused formula praised for cooling effect and easy application.
Key specs
- active ingredients:Lidocaine, Phenylephrine HCl
- application method:Apply thin layer
- usage:Skin-soothing, itch relief
- formulation:Cream
- pain relief:Lidocaine for discomfort
9.4

Excellent

Our Rating
5

Reejoys
Reejoys Hemorrhoid Cream Treatment– Fissure Ointment Fast Relief & Healing Hemorrhoid Cream Ointment for Hemorrhoids & Fissures, Soothing Treatment Formula (0.7 oz)

20% Off
Main highlights

Powerful Formula with Natural Ingredients
Combines natural herbs and doctor-recommended ingredients for effective hemorrhoid relief.

Ideal for Quick Relief and Healing
Designed for fast relief from pain, burning, and itching, reducing swelling efficiently.

Highly Praised for Instant Comfort
Users appreciate the immediate discomfort relief and improved healing process.
Key specs
- active ingredients:Natural herbs
- application method:External use only
- usage:Twice a day
- formulation:Cream
- pain relief:Pain, Burning & Itching
9.3

Excellent

Our Rating

9.9
Simple to use

9.7
Gentle

9.7
pain management
See Today’s Deals & Prices
6

Preparation H
Preparation H Hemorrhoid Symptom Treatment Cream (0.9 Ounce Tube), Maximum Strength Multi-Symptom Pain Relief with Aloe
Main highlights

Maximum Strength Relief
Provides rapid relief from pain, burning, itching, and discomfort.

Ideal for External Symptoms
Best used for external hemorrhoid symptom relief and tissue shrinking.

Highly Recommended Brand
Praised for being the go-to brand for effective hemorrhoid relief.
Key specs
- active ingredients:pramoxine, vitamin E, aloe
- application method:topical
- usage:external hemorrhoid symptoms
- formulation:cream
- pain relief:hemorrhoid pain relief
9.1

Excellent

Our Rating

9.1
Simple to use

9.1
pain management

8.9
worth the money
7

Bloop
Bloop Maximum Strength Advanced Anorectal Fissure Recovery - Brazilian Superfruit & Plant-Based Oils | Effective for Acute, Chronic Fissures & Pain | Contains 5% Lidocaine
Main highlights

Powerful Relief with Lidocaine
Bloop Anorectal Fissure Healing Cream offers swift relief and healing with 5% Lidocaine and Amazon Superfruits.

Ideal for Acute and Chronic Fissures
Perfect for those suffering from acute or chronic anorectal fissures, ensuring comfort and protection against recurrence.

Luxurious Feel and Fast Relief
Customers praise its quick relief, silky texture, and natural scent from superfruit and plant-based oils.
Key specs
- active ingredients:Amazon Superfruits, Lidocaine
- application method:Topical
- usage:Anorectal fissure healing
- formulation:Cream
- pain relief:Anal fissure relief
9.0

Excellent

Our Rating
8

THENA Natural Wellness
Intense Hemorrhoid Treatment 100% Natural Hemorrhoid Cream & Fissure Ointment Control Organic Lavender Arnica Witch Hazel Fast Healing Maximum Strength, Best with Thena Sitz Bath Soak for Women Men
Main highlights

Natural Healing Ingredients
Formulated with organic herbs and essential oils for healing.

Ideal for Postpartum Use
Perfect for pregnant or postpartum moms for relief and recovery.

Gentle and Effective Relief
Praised for being gentle, effective, and non-stinging by users.
Key specs
- Type:Gentle & fast-acting
- Effectiveness:Intensive preventive care
- Formulation:Plant-based healing properties
- Ingredients:Organic St. John's Wort
- Safety:No side effects
8.9

Very Good

Our Rating

9.7
Simple to use

9.1
Aroma

8.7
materials Quality
9

Emisun

Hemorrhoid & Fissure Ointment, Hemorrhoidal treatment for Fast Acting Relief of Swelling, itching, Burning, Hemorrhoid Treatment and Hemorrhoid Cream with Lidocaine 4% and Phenylephrine HCI - 1.5 oz
8.8

Very Good

Our Rating
10

ishancare
Hemorrhoid Cream, Hemorrhoid & Fissure Treatment Ointment Extra Strength, Relief Anal Pain, Itching, Bleeding, Swelling, Discomfort, Natural Herbs Fast Acting Ingredients, Contains Vitamin E
Main highlights

Immediate Relief and Healing
Hemorrhoid cream offers fast relief from pain, itching, and swelling.

Ideal for Various Lifestyles
Suitable for elderly, sedentary, or those with irregular bowel habits.

Praised for Fast-Acting Results
Customers appreciate the rapid effectiveness in reducing discomfort.
8.7

Very Good

Our Rating

10 Best fissures creams of 2025

1

Doctor Butler's Advanced Hemorrhoid & Fissure Ointment – Lidocaine Hemorrhoid Treatment and Fissure Treatment Extra Strength Formula, Heals and Provides Fast Pain and Itch Relief* (1.5 oz.)

8.7

8.4

8.0

How do we rank?

How do we rank?

Analyzing top stores

2

Doctor Butler’s Hemorrhoid & Fissure Ointment – Hemorrhoid Treatment and Hemorrhoid Cream with Lidocaine and Phenylephrine HCI for Fast Acting Relief of Pain, Swelling, Discomfort, and Itching (1 oz.)

8.7

8.2

8.0

3

Doctor Butler's Hemorrhoid & Fissure Cream – Instant Pain Relief Hemorrhoid Treatment with Lidocaine, Fast Acting Hemorrhoid Cream for Relief from External Itching and Burning (1 oz.)

4

REVIVOL-XR Advanced Hemorrhoid Treatment. 5% Lidocaine + Shrinks + Protects Skin + Aloe + Witch Hazel + Botanicals, External & Internal Use. Most Complete OTC Ointment & Fissure Cream, USA Made.

5

Reejoys Hemorrhoid Cream Treatment– Fissure Ointment Fast Relief & Healing Hemorrhoid Cream Ointment for Hemorrhoids & Fissures, Soothing Treatment Formula (0.7 oz)

9.9

9.7

9.7

6

Preparation H Hemorrhoid Symptom Treatment Cream (0.9 Ounce Tube), Maximum Strength Multi-Symptom Pain Relief with Aloe

9.1

9.1

8.9

7

Bloop Maximum Strength Advanced Anorectal Fissure Recovery - Brazilian Superfruit & Plant-Based Oils | Effective for Acute, Chronic Fissures & Pain | Contains 5% Lidocaine

8

Intense Hemorrhoid Treatment 100% Natural Hemorrhoid Cream & Fissure Ointment Control Organic Lavender Arnica Witch Hazel Fast Healing Maximum Strength, Best with Thena Sitz Bath Soak for Women Men

9.7

9.1

8.7

9

Hemorrhoid & Fissure Ointment, Hemorrhoidal treatment for Fast Acting Relief of Swelling, itching, Burning, Hemorrhoid Treatment and Hemorrhoid Cream with Lidocaine 4% and Phenylephrine HCI - 1.5 oz

10

Hemorrhoid Cream, Hemorrhoid & Fissure Treatment Ointment Extra Strength, Relief Anal Pain, Itching, Bleeding, Swelling, Discomfort, Natural Herbs Fast Acting Ingredients, Contains Vitamin E

Sign up and get exclusive special deals