10 Best fever blister medications of 2025

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Best Choice

1

Abreva
Abreva 10 Percent Docosanol Cold Sore Treatment, Treats Your Fever Blister in 2.5 Days - 0.07 oz Tube x 2

20% Off
Main highlights

Fast Healing with Docosanol
Contains 10% docosanol to shorten cold sore duration to 2.5 days.

Ideal for On-the-Go Treatment
Portable tube design perfect for quick, discreet application.

Highly Praised for Effectiveness
Users appreciate fast results and healing of cracked lips.
Key specs
- pain relief:Tingling, pain, burning, itching
- application:Portable tube
- usage:Cold sore treatment
- weight:1.76 ounces
- formula:Docosanol cream
9.8

Exceptional

Our Rating

8.7
worth the money

8.4
Flavor
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Value for Money

2

TARO

TARO Cold Sore & Fever Blister Treatment - Fast-Acting Docosanol 10% Cream - Cold Sore & Fever Blister Treatment for Lips, Anti-Itch Formula for Effective Relief and Healing - 0.07 oz (2 Pack)
9.7

Exceptional

Our Rating
3

Campho-Phenique
Campho Phenique Cold Sore and Fever Blister Treatment for Lips, Maximum Strength Provides Instant Relief, Helps Prevent Infection To Promote Healing, Original Gel Formula, 0.23 Oz
Main highlights

Pain and Itch Relief
Specially formulated to instantly relieve pain and itch from cold sores and fever blisters.

Versatile Use
Ideal for treating cold sores, fever blisters, insect bites, and minor sunburns.

Quick Healing
Praised for its ability to speed up healing and provide immediate relief.
Key specs
- pain relief:Instantly relieves pain & itch
- application:For adults and children 2 years and over
- usage:For cold sores/fever blisters
- weight:0.23 ounces
- formula:Specially formulated
9.5

Excellent

Our Rating

9.3
worth the money

8.0
Flavor
4

TARO
TARO Cold Sore & Fever Blister Treatment - Fast-Acting Docosanol 10% Cream - Cold Sore & Fever Blister Treatment for Lips, Anti-Itch Formula for Effective Relief and Healing - 0.07 oz (1 Pack)
Main highlights

Effective Cold Sore Treatment
Docosanol cream effectively treats cold sores, shortening healing time and symptom duration.

Ideal for Immediate Relief
Perfect for those seeking quick relief from cold sore symptoms on face or lips.

Affordable Alternative
Praised for cost-effectiveness, offering same active ingredient as name brands.
Key specs
- pain relief:Shortens healing time
- application:Face or lips
- usage:Treats cold sores
- weight:0.07 ounces
- formula:Cream 10%
9.4

Excellent

Our Rating
5

Quantum Health
Quantum Health Lip Clear Lysine+ Cold Sore Treatment Soothe & Moisturize Mouth Sores - L-Lysine Menthol Calendula & Propolis Ointment - Transparent Fever Blister Healing Balm - 0.25 Oz

25% Off
Main highlights

Halve Healing Time
Cut cold sore healing time by 50% with L-Lysine.

Ideal for First Signs
Best used at the first sign of a cold sore.

Rapid Results
Praised for quickly reducing cold sore size and discomfort.
9.3

Excellent

Our Rating

9.3
Moisturizing

9.3
worth the money

8.4
Flavor
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6

Abreva
Abreva Cold Sore Treatment Rapid Pain Relief Cream - 1 Tube, 3 Grams
Main highlights

Rapid Symptom Relief
Shortens duration of tingling, pain, burning, and itching for quick comfort.

Convenient On-the-Go Use
Ideal for busy individuals needing fast and easy application.

Highly Praised Effectiveness
Customers frequently highlight its immediate and noticeable relief.
Key specs
- pain relief:Shortens duration
- application:Tube form
- usage:Tingling, pain, burning relief
- weight:0.11 ounces
- formula:N/A
9.1

Excellent

Our Rating
7

Mederma
Mederma Fever Blister Discreet Healing Patch - A Patch That Protects and Conceals Cold Sores - 15 Count
Main highlights

Fast Healing Hydrocolloid Gel
Ultra-thin hydrocolloid gel accelerates healing and prevents scabbing.

Discreet Social Use
Ideal for social settings, conceals cold sores effectively.

Pain and Itch Relief
Eliminates pain and itchiness, enhancing comfort during healing.
Key specs
- pain relief:Relieve pain
- application:N/A
- usage:N/A
- weight:0.63 ounces
- formula:Ultra-thin Hydrocolloid
9.0

Excellent

Our Rating

8.7
Comfort

8.4
Simple to use

8.4
Sheerness
8

Zilactin
Zilactin Early Relief Cold Sore Treatment - Fast Relief of Cold Sores and Fever Blisters, Made in USA, 0.25oz Gel, Pack of 1
Main highlights

Fast Relief with Unique Formula
Zilactin provides targeted treatment with 10% Benzyl Alcohol for quick relief of cold sores.

Ideal for Cold Sores and Fever Blisters
Best used for immediate relief and protection against cold sores and fever blisters.

Praised for Effectiveness
Customers highlight its superior performance compared to other treatments.
Key specs
- Active Ingredients:10% Benzyl Alcohol
- Application Method:Single application
- Duration of Relief:Up to 6 hours
- Formulation:Unique Formula
- Target Area:Cold sores, fever blisters
8.9

Very Good

Our Rating
9

Acculip
Acculip Cold Sore Patch Lysine Cold Sore Treatment for Lips, Lysine Lip Balm Alternative for Cold Sore Relief, Medicated Fever Blister Cold Sore Patch, L-lysine Cold Sore Treatment, FSA Eligible
Main highlights

Fast Healing with Added Ingredients
Hydrocolloid patch with lysine, zinc, and calendula promotes quick healing of cold sores.

Ideal for Discreet Cold Sore Treatment
Perfect for hiding and healing cold sores, even under makeup.

Highly Praised for Travel Convenience
Thin, travel-friendly patches with resealable packaging praised by customers.
Key specs
- pain relief:Hydrate and heal
- application:Lip patches
- usage:Cold sore treatment
- weight:N/A
- formula:Hydrocolloid patch
8.6

Very Good

Our Rating
10

Herpecin-L
Herpecin-L Pain Relief Treatment for Cold Sores and Fever Blisters, with Lidocaine, numbs Pain and Itch, Protects Against Infection, 0.15 oz

23% Off
Main highlights

Instant Pain Relief
Triple Action treatment numbs pain & itch, protects, and moisturizes.

Ideal for Cold Sores
Best used at the onset of cold sores or fever blisters.

Praised Lidocaine Effect
Customers love the immediate pain relief without numbing the entire lip.
Key specs
- pain relief:Numbs pain & itch
- application:Spot treatment
- usage:Cold sore treatment
- weight:0.1 ounces
- formula:Triple Action
8.5

Good

Our Rating

9.9
pain management

9.3
Moisturizing

8.9
Aroma

10 Best fever blister medications of 2025

1

Abreva 10 Percent Docosanol Cold Sore Treatment, Treats Your Fever Blister in 2.5 Days - 0.07 oz Tube x 2

8.7

8.4

How do we rank?

How do we rank?

Analyzing top stores

2

TARO Cold Sore & Fever Blister Treatment - Fast-Acting Docosanol 10% Cream - Cold Sore & Fever Blister Treatment for Lips, Anti-Itch Formula for Effective Relief and Healing - 0.07 oz (2 Pack)

3

Campho Phenique Cold Sore and Fever Blister Treatment for Lips, Maximum Strength Provides Instant Relief, Helps Prevent Infection To Promote Healing, Original Gel Formula, 0.23 Oz

9.3

8.0

4

TARO Cold Sore & Fever Blister Treatment - Fast-Acting Docosanol 10% Cream - Cold Sore & Fever Blister Treatment for Lips, Anti-Itch Formula for Effective Relief and Healing - 0.07 oz (1 Pack)

5

Quantum Health Lip Clear Lysine+ Cold Sore Treatment Soothe & Moisturize Mouth Sores - L-Lysine Menthol Calendula & Propolis Ointment - Transparent Fever Blister Healing Balm - 0.25 Oz

9.3

9.3

8.4

6

Abreva Cold Sore Treatment Rapid Pain Relief Cream - 1 Tube, 3 Grams

7

Mederma Fever Blister Discreet Healing Patch - A Patch That Protects and Conceals Cold Sores - 15 Count

8.7

8.4

8.4

8

Zilactin Early Relief Cold Sore Treatment - Fast Relief of Cold Sores and Fever Blisters, Made in USA, 0.25oz Gel, Pack of 1

9

Acculip Cold Sore Patch Lysine Cold Sore Treatment for Lips, Lysine Lip Balm Alternative for Cold Sore Relief, Medicated Fever Blister Cold Sore Patch, L-lysine Cold Sore Treatment, FSA Eligible

10

Herpecin-L Pain Relief Treatment for Cold Sores and Fever Blisters, with Lidocaine, numbs Pain and Itch, Protects Against Infection, 0.15 oz

9.9

9.3

8.9

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