10 Best cold sore treatments of 2025

Save up to 25% off

Best Choice

1

Mederma
Mederma Cold Sore Discreet Healing Patch - Hydrocolloid Gel for Fast Healing, Relieves Pain, Redness & Swelling, Conceals Cold Sores (30 Patches)
Main highlights

Fast Healing and Pain Relief
FAST HEALING ultra-thin Hydrocolloid Gel provides a moist environment to help: relieve pain, reduce the blistering and prevent scabbing.

Ideal for Cold Sore Management
TO HELP REDUCE Redness, Swelling, Tingling, Itching & Burning of the cold sore. Acts as a protective barrier to help reduce contamination.

Highly Praised for Discreet Appearance
DISCREET translucent patch blends in with the skin and instantly hides cold sores. Easy to apply and stays in place for up to 12 hours.
Key specs
- weight:1.76 ounces
- formula:Hydrocolloid Gel
- pain relief:Relieve pain, reduce blistering
- dimensions:6.13 x 4.25 x 1.5 inches
- application:Easy to apply
9.8

Exceptional

Our Rating
How do we rank?

Powerful technology We scan thousands of products and stores, analyzing reviews to find what matters most to users like you

Careful review Our team ensures quality, value, and fit based on real user feedback

Trusted insights AI and human analysis guide your decisions, reflecting real user priorities
Real users impact

Thousands of users trust our site daily

Based on millions of stores and reviews

Shoppers influence our rankings
Analyzing top stores
Value for Money

2

Abreva
Abreva 10 Percent Docosanol Cold Sore Treatment, Treats Your Fever Blister in 2.5 Days - 0.07 oz Tube x 2

20% Off
Main highlights

Fast Healing with Docosanol
Contains 10% docosanol to shorten cold sore duration to 2.5 days.

Ideal for On-the-Go Treatment
Portable tube design perfect for quick, discreet application.

Highly Praised for Effectiveness
Users appreciate fast results and healing of cracked lips.
Key specs
- weight:1.76 ounces
- formula:Docosanol cream
- pain relief:Tingling, pain, burning, itching
- dimensions:1.71 x 5.1 x 5.5 inches
- application:Portable tube
9.7

Exceptional

Our Rating

8.7
worth the money

8.4
Flavor
3

Campho-Phenique
Campho Phenique Cold Sore and Fever Blister Treatment for Lips, Maximum Strength Provides Instant Relief, Helps Prevent Infection To Promote Healing, Original Gel Formula, 0.23 Oz
Main highlights

Pain and Itch Relief
Specially formulated to instantly relieve pain and itch from cold sores and fever blisters.

Versatile Use
Ideal for treating cold sores, fever blisters, insect bites, and minor sunburns.

Quick Healing
Praised for its ability to speed up healing and provide immediate relief.
Key specs
- weight:0.23 ounces
- formula:Specially formulated
- pain relief:Instantly relieves pain & itch
- dimensions:0.75 x 3.31 x 4.09 inches
- application:For adults and children 2 years and over
9.5

Excellent

Our Rating

9.3
worth the money

8.0
Flavor
4

Mederma
Mederma Fever Blister Discreet Healing Patch - A Patch That Protects and Conceals Cold Sores - 15 Count
Main highlights

Fast Healing Hydrocolloid Gel
Ultra-thin hydrocolloid gel accelerates healing and prevents scabbing.

Discreet Social Use
Ideal for social settings, conceals cold sores effectively.

Pain and Itch Relief
Eliminates pain and itchiness, enhancing comfort during healing.
Key specs
- weight:0.63 ounces
- formula:Ultra-thin Hydrocolloid
- pain relief:Relieve pain
- dimensions:6.1 x 4.3 x 0.8 inches
- application:N/A
9.4

Excellent

Our Rating

8.7
Comfort

8.4
Simple to use

8.4
Sheerness
5

Abreva
Abreva 10 Percent Docosanol Cold Sore Treatment, Treats Your Fever Blister in 2.5 Days - 0.07 oz Pump

18% Off
Main highlights

Rapid Healing Formula
Abreva contains 10% docosanol, proven to heal cold sores in 2.5 days.

Ideal for Early Treatment
Best used at the first sign of a cold sore for maximum effectiveness.

Highly Effective
Customers frequently praise its fast action and reliability against cold sores.
9.1

Excellent

Our Rating

8.2
Sheerness

8.0
worth the money

8.0
Long life
See Today’s Deals & Prices
6

Quantum Health
Quantum Health Lip Clear Lysine+ Cold Sore Treatment Soothe & Moisturize Mouth Sores - L-Lysine Menthol Calendula & Propolis Ointment - Transparent Fever Blister Healing Balm - 0.25 Oz

25% Off
Main highlights

Halve Healing Time
Cut cold sore healing time by 50% with L-Lysine.

Ideal for First Signs
Best used at the first sign of a cold sore.

Rapid Results
Praised for quickly reducing cold sore size and discomfort.
9.0

Excellent

Our Rating

9.3
Moisturizing

9.3
worth the money

8.4
Flavor
7

TARO
TARO Cold Sore & Fever Blister Treatment - Fast-Acting Docosanol 10% Cream - Cold Sore & Fever Blister Treatment for Lips, Anti-Itch Formula for Effective Relief and Healing - 0.07 oz (1 Pack)
Main highlights

Effective Cold Sore Treatment
Docosanol cream effectively treats cold sores, shortening healing time and symptom duration.

Ideal for Immediate Relief
Perfect for those seeking quick relief from cold sore symptoms on face or lips.

Affordable Alternative
Praised for cost-effectiveness, offering same active ingredient as name brands.
Key specs
- weight:0.07 ounces
- formula:Cream 10%
- pain relief:Shortens healing time
- dimensions:2.36 x 0.79 x 2.36 inches
- application:Face or lips
8.9

Very Good

Our Rating
8

Orajel
Orajel Moisturelock Cold Sore Symptom Treatment, Cream 0.105 oz (Packaging May Vary)
Main highlights

Instant Pain Relief
Orajel Moisturelock provides immediate relief with maximum strength benzocaine.

Ideal for Quick Cold Sore Treatment
Best used at the onset of cold sore symptoms for fast action.

Praised for Effective Numbing
Customers love its ability to numb pain and reduce swelling quickly.
Key specs
- weight:0.11 ounces
- formula:Skin Protectant
- pain relief:Maximum strength benzocaine
- dimensions:3.63 x 0.75 x 4.75 inches
- application:Moisturelock cream
8.7

Very Good

Our Rating

9.9
Comfort

9.3
pain management

9.1
worth the money
9

Orajel
Orajel Touch Free Cold Sore Treatment .12oz, Liquid Formula, Provides Immediate & Targeted Pain Relief, Bonus Size, 6 Applicators.
Main highlights

Touch-Free Application
Unique applicator prevents direct contact, ensuring hygienic and precise treatment application.

Ideal for Quick Relief
Perfect for immediate pain and itch relief from cold sores.

Praised Numbing Effect
Customers appreciate the numbing sensation that reduces discomfort and aids healing.
Key specs
- weight:0.86 ounces
- formula:Disinfects, quick drying
- pain relief:Numbs pain and itching
- dimensions:4.75 x 3.75 x 1 inches
- application:Touch-free applicator
8.6

Very Good

Our Rating

8.9
Comfort

8.2
worth the money
10

Abreva
Abreva Cream

14% Off
Main highlights

Portable Relief for Cold Sores
Abreva Docosanol 10% Cream provides temporary relief from cold sore symptoms in a portable, easy-to-apply tube.

Ideal for On-the-Go Use
Perfect for those who frequently experience cold sores and need quick relief anytime, anywhere.

Highly Praised for Quick Relief
Customers appreciate its effectiveness in reducing cold sore duration and symptoms when applied at the first sign.
8.5

Good

Our Rating

10 Best cold sore treatments of 2025

1

Mederma Cold Sore Discreet Healing Patch - Hydrocolloid Gel for Fast Healing, Relieves Pain, Redness & Swelling, Conceals Cold Sores (30 Patches)

How do we rank?

How do we rank?

Analyzing top stores

2

Abreva 10 Percent Docosanol Cold Sore Treatment, Treats Your Fever Blister in 2.5 Days - 0.07 oz Tube x 2

8.7

8.4

3

Campho Phenique Cold Sore and Fever Blister Treatment for Lips, Maximum Strength Provides Instant Relief, Helps Prevent Infection To Promote Healing, Original Gel Formula, 0.23 Oz

9.3

8.0

4

Mederma Fever Blister Discreet Healing Patch - A Patch That Protects and Conceals Cold Sores - 15 Count

8.7

8.4

8.4

5

Abreva 10 Percent Docosanol Cold Sore Treatment, Treats Your Fever Blister in 2.5 Days - 0.07 oz Pump

8.2

8.0

8.0

6

Quantum Health Lip Clear Lysine+ Cold Sore Treatment Soothe & Moisturize Mouth Sores - L-Lysine Menthol Calendula & Propolis Ointment - Transparent Fever Blister Healing Balm - 0.25 Oz

9.3

9.3

8.4

7

TARO Cold Sore & Fever Blister Treatment - Fast-Acting Docosanol 10% Cream - Cold Sore & Fever Blister Treatment for Lips, Anti-Itch Formula for Effective Relief and Healing - 0.07 oz (1 Pack)

8

Orajel Moisturelock Cold Sore Symptom Treatment, Cream 0.105 oz (Packaging May Vary)

9.9

9.3

9.1

9

Orajel Touch Free Cold Sore Treatment .12oz, Liquid Formula, Provides Immediate & Targeted Pain Relief, Bonus Size, 6 Applicators.

8.9

8.2

10

Abreva Cream

Sign up and get exclusive special deals