10 Best cold sore treatments of 2025

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1

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Abreva
Abreva 10 Percent Docosanol Cold Sore Treatment, Treats Your Fever Blister in 2.5 Days - 0.07 oz Tube x 2

22% Off
Main highlights

Fast Healing with Docosanol
Contains 10% docosanol to shorten cold sore duration to 2.5 days.

Ideal for On-the-Go Treatment
Portable tube design perfect for quick, discreet application.

Highly Praised for Effectiveness
Users appreciate fast results and healing of cracked lips.
Key specs
- weight:1.76 ounces
- pain relief:Tingling, pain, burning, itching
- dimensions:1.71 x 5.1 x 5.5 inches
- application:Portable tube
- usage:Cold sore treatment
9.9

Exceptional

Our Rating

8.7
worth the money

8.4
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Value for Money

2

Orajel
Orajel Touch Free Cold Sore Treatment .12oz, Liquid Formula, Provides Immediate & Targeted Pain Relief, Bonus Size, 6 Applicators.
Main highlights

Touch-Free Application
Unique applicator prevents direct contact, ensuring hygienic and precise treatment application.

Ideal for Quick Relief
Perfect for immediate pain and itch relief from cold sores.

Praised Numbing Effect
Customers appreciate the numbing sensation that reduces discomfort and aids healing.
Key specs
- weight:0.86 ounces
- pain relief:Numbs pain and itching
- dimensions:4.75 x 3.75 x 1 inches
- application:Touch-free applicator
- usage:Cold sore treatment
9.8

Exceptional

Our Rating

8.9
Comfort

8.2
worth the money
3

Mederma
Mederma Fever Blister Discreet Healing Patch - A Patch That Protects and Conceals Cold Sores - 15 Count

28% Off
Main highlights

Fast Healing Hydrocolloid Gel
Ultra-thin hydrocolloid gel accelerates healing and prevents scabbing.

Discreet Social Use
Ideal for social settings, conceals cold sores effectively.

Pain and Itch Relief
Eliminates pain and itchiness, enhancing comfort during healing.
Key specs
- weight:0.63 ounces
- pain relief:Relieve pain
- dimensions:6.1 x 4.3 x 0.8 inches
- application:N/A
- usage:N/A
9.7

Exceptional

Our Rating

8.7
Comfort

8.4
Simple to use

8.4
Sheerness
4

Campho-Phenique
Campho Phenique Cold Sore and Fever Blister Treatment for Lips, Maximum Strength Provides Instant Relief, Helps Prevent Infection To Promote Healing, Original Gel Formula, 0.23 Oz

52% Off
Main highlights

Pain and Itch Relief
Specially formulated to instantly relieve pain and itch from cold sores and fever blisters.

Versatile Use
Ideal for treating cold sores, fever blisters, insect bites, and minor sunburns.

Quick Healing
Praised for its ability to speed up healing and provide immediate relief.
Key specs
- weight:0.23 ounces
- pain relief:Instantly relieves pain & itch
- dimensions:0.75 x 3.31 x 4.09 inches
- application:For adults and children 2 years and over
- usage:For cold sores/fever blisters
9.5

Excellent

Our Rating

9.3
worth the money

8.0
Flavor
5

Quantum Health
Quantum Health Lip Clear Lysine+ Cold Sore Treatment Soothe & Moisturize Mouth Sores - L-Lysine Menthol Calendula & Propolis Ointment - Transparent Fever Blister Healing Balm - 0.25 Oz

25% Off
Main highlights

Halve Healing Time
Cut cold sore healing time by 50% with L-Lysine.

Ideal for First Signs
Best used at the first sign of a cold sore.

Rapid Results
Praised for quickly reducing cold sore size and discomfort.
9.4

Excellent

Our Rating

9.3
Moisturizing

9.3
worth the money

8.4
Flavor
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6

TARO

Taro Fever Blister & Cold Sore Treatment, Docosanol 10% Cream, 0.07 Oz (2 Tube), Fast-Acting Anti Itch Cream, Cold Sore & Fever Blister Prevention
9.3

Excellent

Our Rating
7

Abreva
Abreva 10 Percent Docosanol Cold Sore Treatment, Treats Your Fever Blister in 2.5 Days - 0.07 oz Pump

37% Off
Main highlights

Rapid Healing Formula
Abreva contains 10% docosanol, proven to heal cold sores in 2.5 days.

Ideal for Early Treatment
Best used at the first sign of a cold sore for maximum effectiveness.

Highly Effective
Customers frequently praise its fast action and reliability against cold sores.
9.0

Excellent

Our Rating

8.2
Sheerness

8.0
worth the money

8.0
Long life
8

Abreva
Abreva Cold Sore Treatment Rapid Pain Relief Cream - 1 Tube, 3 Grams
Main highlights

Rapid Symptom Relief
Shortens duration of tingling, pain, burning, and itching for quick comfort.

Convenient On-the-Go Use
Ideal for busy individuals needing fast and easy application.

Highly Praised Effectiveness
Customers frequently highlight its immediate and noticeable relief.
Key specs
- weight:0.11 ounces
- pain relief:Shortens duration
- dimensions:5.08 x 3.96 x 1.06 inches
- application:Tube form
- usage:Tingling, pain, burning relief
8.8

Very Good

Our Rating
9

Orajel
Orajel Moisturelock Cold Sore Symptom Treatment, Cream 0.105 oz (Packaging May Vary)

36% Off
Main highlights

Instant Pain Relief
Orajel Moisturelock provides immediate relief with maximum strength benzocaine.

Ideal for Quick Cold Sore Treatment
Best used at the onset of cold sore symptoms for fast action.

Praised for Effective Numbing
Customers love its ability to numb pain and reduce swelling quickly.
Key specs
- weight:0.11 ounces
- pain relief:Maximum strength benzocaine
- dimensions:3.63 x 0.75 x 4.75 inches
- application:Moisturelock cream
- usage:Instant Pain Relief
8.6

Very Good

Our Rating

9.9
Comfort

9.3
pain management

9.1
worth the money
10

Wellness Basics
Wellness Basics Docosanol Cream 10% | Cold Sore Treatment | Shortens Healing Time | 0.07oz - 1 Tube
Main highlights

Fast Healing Formula
Docosanol 10 Cream shortens cold sore healing time and symptoms.

Ideal for Early Treatment
Apply at first signs to tackle cold sores promptly.

Affordable Brand Alternative
Praised for being as effective as name brands but cheaper.
Key specs
- weight:1.13 ounces
- pain relief:Shortens healing time
- dimensions:4.92 x 4.65 x 1.3 inches
- application:Apply at first signs
- usage:Treats cold sores
8.5

Good

Our Rating

10 Best cold sore treatments of 2025

1

Abreva 10 Percent Docosanol Cold Sore Treatment, Treats Your Fever Blister in 2.5 Days - 0.07 oz Tube x 2

8.7

8.4

How do we rank?

How do we rank?

Analyzing top stores

2

Orajel Touch Free Cold Sore Treatment .12oz, Liquid Formula, Provides Immediate & Targeted Pain Relief, Bonus Size, 6 Applicators.

8.9

8.2

3

Mederma Fever Blister Discreet Healing Patch - A Patch That Protects and Conceals Cold Sores - 15 Count

8.7

8.4

8.4

4

Campho Phenique Cold Sore and Fever Blister Treatment for Lips, Maximum Strength Provides Instant Relief, Helps Prevent Infection To Promote Healing, Original Gel Formula, 0.23 Oz

9.3

8.0

5

Quantum Health Lip Clear Lysine+ Cold Sore Treatment Soothe & Moisturize Mouth Sores - L-Lysine Menthol Calendula & Propolis Ointment - Transparent Fever Blister Healing Balm - 0.25 Oz

9.3

9.3

8.4

6

Taro Fever Blister & Cold Sore Treatment, Docosanol 10% Cream, 0.07 Oz (2 Tube), Fast-Acting Anti Itch Cream, Cold Sore & Fever Blister Prevention

7

Abreva 10 Percent Docosanol Cold Sore Treatment, Treats Your Fever Blister in 2.5 Days - 0.07 oz Pump

8.2

8.0

8.0

8

Abreva Cold Sore Treatment Rapid Pain Relief Cream - 1 Tube, 3 Grams

9

Orajel Moisturelock Cold Sore Symptom Treatment, Cream 0.105 oz (Packaging May Vary)

9.9

9.3

9.1

10

Wellness Basics Docosanol Cream 10% | Cold Sore Treatment | Shortens Healing Time | 0.07oz - 1 Tube

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