10 Best cold and flu tablets of 2025

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Best Choice

1

Advil
Advil Multi Symptom Cold and Flu Medicine, Cold Medicine for Adults with Ibuprofen, Phenylephrine HCL and Chlorpheniramine Maleate - 50 Coated Tablets
Main highlights

Powerful Multi-Symptom Relief
Combines ibuprofen, phenylephrine, and chlorpheniramine for comprehensive cold and flu symptom management.

Ideal for Cold and Flu Symptoms
Perfect for adults experiencing nasal congestion, sneezing, and body aches.

Praised for Sinus Headache Relief
Highly rated by users for its effectiveness in relieving sinus headaches.
Key specs
- active ingredient:Ibuprofen, Phenylephrine, Chlorpheniramine
- symptom relief:Cold, flu symptoms
- form:Coated tablet
- target age:12 years and older
- package type:Packets
9.9

Exceptional

Our Rating
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Value for Money

2

Amazon Basic Care
Amazon Basic Care Daytime Severe Cold & Flu Relief Caplets, Medication for Severe Cold and Flu Symptoms Like Headache, Fever, Coughing, Chest & Nasal Congestion, Vapor Ice, 24 Count
Main highlights

Key Features
Combines acetaminophen, dextromethorphan, guaifenesin, phenylephrine for comprehensive cold, flu relief. Compares to Vicks DayQuil Severe+ VapoCOOL.

Ideal Use Cases
Effective for daytime relief of severe cold and flu symptoms, including fever, headache, cough, and nasal congestion.

Customer Praise
Users frequently highlight its effectiveness in relieving a wide range of symptoms quickly, appreciating the fast-acting formula.
9.8

Exceptional

Our Rating
3

Amazon Basic Care
Amazon Basic Care Cold and Flu Relief, Daytime and Nighttime Combo Pack Softgels, Powerful Cold Medicine for Day and Night Multi-Symptom Relief, 48 Count(Pack of 1)
Main highlights

Multi-Symptom Relief
Provides effective relief from headache, fever, sore throat, and more.

Day and Night Use
Ideal for continuous relief of cold and flu symptoms.

Quick Action
Praised for fast-acting relief within a few hours.
9.7

Exceptional

Our Rating

9.3
simple to consume

9.3
Flavor

9.1
worth the money
4

Tylenol
Tylenol Cold + Flu Severe Day & Night Caplets Combo Pack for Multi-Symptom Cold & Flu Symptom Relief, Cough, Sore Throat, and Headache Relief, Acetaminophen Pain Reliever, 24 ct

27% Off
Main highlights

Comprehensive Cold Flu Relief
24-count pack offers multi-symptom relief for cold and flu.

Day Night Usage
Ideal for day and night relief with separate formulas.

Highly Praised Value
Customers appreciate the value and effectiveness of the product.
Key specs
- features:Cold & flu relief
- product dimensions:4.52 x 0.78 x 2.95 inches
- active ingredients:Acetaminophen, Phenylephrine HCl
- decongestant:Phenylephrine HCl
- saline solution:N/A
9.5

Excellent

Our Rating
5

Amazon Basic Care
Amazon Basic Care Vapor Ice Day and Night Severe Cold and Flu Relief Caplets, Maximum Strength Medicine, Combo Pack, 48 Count

18% Off
Main highlights

Maximum Strength Multi-Symptom Relief
Provides around-the-clock relief for cold and flu symptoms with a combination of daytime and nighttime caplets.

Ideal for Families and Busy Individuals
Perfect for those needing effective relief during the day and restful sleep at night.

Highly Praised Nighttime Formula
Customers appreciate the nighttime caplets for aiding sleep and symptom relief.
Key specs
- active ingredient:Compare to Vicks DayQuil/NyQuil
- symptom relief:Cold and flu symptoms
- form:Coated caplets
- target age:N/A
- package type:Combination pack
9.3

Excellent

Our Rating

9.3
simple to consume

9.1
worth the money

8.7
Flavor
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6

Tylenol
Tylenol Cold + Flu Severe Medicine Caplets for Cold & Flu Symptom Relief, Fever Reducer, Pain Reliever, Cough Suppressant, Nasal Decongestant & Expectorant with Acetaminophen, 2 pks of 24 ct ea, 48 ct

28% Off
Main highlights

Comprehensive Symptom Relief
Tylenol Cold + Flu Severe Medicine Caplets provide multi-symptom relief for fever, aches, sore throat, congestion, and cough.

Ideal for Cold and Flu Season
Perfect for adults and children 12+ needing relief from severe cold and flu symptoms.

Fast Delivery Praised by Customers
Customers appreciate the quick delivery, often arriving earlier than expected, which is a lifesaver during illness.
Key specs
- active ingredient:Acetaminophen, Dextromethorphan, Phenylephrine, Guaifenesin
- symptom relief:Fever, headache, congestion
- form:Caplets
- target age:12 years and older
- package type:Twin 2 Pack
9.2

Excellent

Our Rating
7

Tylenol
Tylenol Cold + Flu Severe Medicine Caplets for Fever, Pain, Cough & Congestion, 24 ct.

28% Off
Main highlights

Comprehensive Symptom Relief
Relieves fever, pain, congestion, cough, and loosens mucus.

Ideal for Cold and Flu
Perfect for adults and children 12+ with cold and flu symptoms.

Praised Effectiveness
Customers appreciate its superior efficacy over generic alternatives.
9.1

Excellent

Our Rating

9.9
pain management

9.3
worth the money

8.7
simple to consume
8

Sambucol
Sambucol Cold and Flu Relief Tablets - Homeopathic Cold Medicine, Remedy for Adults, Black Elderberry for Colds, Zinc Remedy - 30 Count

25% Off
Main highlights

Fast Cold and Flu Relief
Quick-dissolving tablets provide fast, temporary relief from cold and flu symptoms.

Ideal for Early Symptom Use
Best used at the first sign of cold or flu symptoms.

Praised for Pleasant Taste
Customers love the grape-like flavor and fast-dissolving nature.
Key specs
- active ingredient:Black Elderberry
- symptom relief:Cold & flu symptoms
- form:Dissolving Tablets
- target age:Whole family
- package type:N/A
8.8

Very Good

Our Rating

9.7
Simple to use

9.7
pain management

9.7
Flavor
9

Amazon Basic Care
Amazon Basic Care Nighttime Cold and Flu Relief Softgels, 6 Hour Cold Medicine, Relieves Major Flu Symptoms So You Can Rest, 48 Count (Pack of 1)
Main highlights

Powerful Nighttime Relief
This cold and flu medicine provides multi-symptom relief of common cold and flu symptoms while you sleep, including pain, fever, cough, and runny nose.

Ideal for Online Purchase
Convenient for those who prefer not to go out when sick. Works effectively and is cost-efficient compared to name brands.

Effective and Affordable
Customers appreciate the effective relief comparable to name brands at a lower cost, with fast delivery being a significant advantage.
Key specs
- active ingredient:acetaminophen, dextromethorphan, doxylamine
- symptom relief:cold, flu, cough
- form:N/A
- target age:N/A
- package type:N/A
8.6

Very Good

Our Rating

9.9
worth the money

9.3
pain management

8.7
simple to consume
10

Advil
Advil Multi Symptom Cold and Flu Medicine, Cold Medicine for Adults with Ibuprofen, Phenylephrine HCL and Chlorpheniramine Maleate - 20 Coated Tablets
Main highlights

Multi-Symptom Relief
Combines Ibuprofen, Phenylephrine, and Chlorpheniramine for comprehensive cold and flu symptom relief.

Ideal for Home Use
Best used when resting at home due to drowsiness.

Customer Favorite
Praised for its effectiveness in relieving multiple cold symptoms.
Key specs
- active ingredient:Ibuprofen, Phenylephrine HCL
- symptom relief:Cold and flu symptoms
- form:Coated tablets
- target age:12 years and older
- package type:Bottle
8.5

Good

Our Rating

10 Best cold and flu tablets of 2025

1

Advil Multi Symptom Cold and Flu Medicine, Cold Medicine for Adults with Ibuprofen, Phenylephrine HCL and Chlorpheniramine Maleate - 50 Coated Tablets

How do we rank?

How do we rank?

Analyzing top stores

2

Amazon Basic Care Daytime Severe Cold & Flu Relief Caplets, Medication for Severe Cold and Flu Symptoms Like Headache, Fever, Coughing, Chest & Nasal Congestion, Vapor Ice, 24 Count

3

Amazon Basic Care Cold and Flu Relief, Daytime and Nighttime Combo Pack Softgels, Powerful Cold Medicine for Day and Night Multi-Symptom Relief, 48 Count(Pack of 1)

9.3

9.3

9.1

4

Tylenol Cold + Flu Severe Day & Night Caplets Combo Pack for Multi-Symptom Cold & Flu Symptom Relief, Cough, Sore Throat, and Headache Relief, Acetaminophen Pain Reliever, 24 ct

5

Amazon Basic Care Vapor Ice Day and Night Severe Cold and Flu Relief Caplets, Maximum Strength Medicine, Combo Pack, 48 Count

9.3

9.1

8.7

6

Tylenol Cold + Flu Severe Medicine Caplets for Cold & Flu Symptom Relief, Fever Reducer, Pain Reliever, Cough Suppressant, Nasal Decongestant & Expectorant with Acetaminophen, 2 pks of 24 ct ea, 48 ct

7

Tylenol Cold + Flu Severe Medicine Caplets for Fever, Pain, Cough & Congestion, 24 ct.

9.9

9.3

8.7

8

Sambucol Cold and Flu Relief Tablets - Homeopathic Cold Medicine, Remedy for Adults, Black Elderberry for Colds, Zinc Remedy - 30 Count

9.7

9.7

9.7

9

Amazon Basic Care Nighttime Cold and Flu Relief Softgels, 6 Hour Cold Medicine, Relieves Major Flu Symptoms So You Can Rest, 48 Count (Pack of 1)

9.9

9.3

8.7

10

Advil Multi Symptom Cold and Flu Medicine, Cold Medicine for Adults with Ibuprofen, Phenylephrine HCL and Chlorpheniramine Maleate - 20 Coated Tablets

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