10 Best canker sore medicines of 2025

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Best Choice

1

Durham's Bee Farm, Inc.
Durham's Bee Farm, Inc. Canker-Rid® - Get Immediate Relief and Heal Canker Sores - Restore Your Quality of Life Today
Main highlights

Immediate Pain Relief and Healing
Canker-Rid provides instant pain relief and accelerates healing for canker sores, restoring comfort and quality of life.

Best for Severe Canker Sores
Ideal for individuals suffering from severe canker sores, offering effective treatment where other remedies fail.

Highly Praised for Effectiveness
Customers frequently praise its ability to prevent canker sores from developing and reduce healing time significantly.
9.7

Exceptional

Our Rating

9.3
pain management

9.1
worth the money

9.1
Long life
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Value for Money

2

Dentemp
Dentemp Canker Cover - Canker Sore Medicine Pain Reliever (8 Count) - Canker Sore Treatment to Relieve Canker Pain, Mouth Sores & Mouth Irritation - Fast Acting Canker Sore Relief Tablets for Adults
Main highlights

Fast Pain Relief and Protection
Dentemp Canker Cover offers quick pain relief and forms a protective barrier over canker sores.

Ideal for Active Lifestyles
Perfect for those needing relief while on-the-go, even during meals.

Long-Lasting Relief Praised by Users
Customers love the 12-hour soothing effect and ease of use.
Key specs
- Pain Relief:Immediate pain relief
- Active Ingredients:Menthol
- Application Method:Place on sore
- Duration of Relief:12 hours
- Formulation:Mint-flavored patches
9.6

Exceptional

Our Rating
3

Zilactin
Zilactin-B Fast Acting Canker Sore Treatment - Long Lasting Protection and Oral Pain Relief of Canker Sores, Mouth Sores and Gum Irritations, Made in USA, 0.25oz Gel, Pack of 1
Main highlights

Immediate and Long-Lasting Relief
Zilactin-B provides fast, enduring pain relief for canker and mouth sores with its broad-spectrum formula.

Ideal for Daily Use
Perfect for those suffering from recurring mouth sores, gum irritations, or canker sores needing consistent relief.

Highly Praised Bioadhesive Technology
Customers love the 6-hour protection allowing pain-free eating and drinking.
Key specs
- Pain Relief:Immediate, long lasting
- Active Ingredients:10% Benzocaine
- Application Method:Bioadhesive technology
- Duration of Relief:Up to 6 hours
- Formulation:Proprietary blend
9.4

Excellent

Our Rating
4

Anbesol
Anbesol Maximum Strength Oral Pain Relief Gel, Instant Pain Relief For Toothache Pain, Canker Sores, Sore Gums, Mouth Sores, Denture Pain, and Aligner Pain, ADA Accepted, 0.33 oz (packaging may vary)

15% Off
Main highlights

Instant Oral Pain Relief
Formulated with Benzocaine for fast, temporary relief from mouth pain.

Ideal for Various Oral Pains
Effective for toothaches, canker sores, sore gums, and more.

Praised for Quick Numbing
Customers appreciate its immediate numbing effect for pain relief.
9.3

Excellent

Our Rating

8.9
worth the money

8.4
pain management

8.0
Flavor
5

DenTek
DenTek Canker Relief Sore Patch Relieves Canker Pain, 6 Count (Pack of 1)

39% Off
Main highlights

Pain Relief and Healing
DenTek Canker Relief Patches provide fast pain relief and promote healing.

Ideal for Oral Irritations
Best for canker sores, small oral wounds, and irritation from braces.

Praised for Comfort
Users love the comfort provided by flexible and ultrathin patches.
9.2

Excellent

Our Rating

8.0
Flavor

8.0
pain management

8.0
Attachment
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6

Boiron
Boiron Borax 30C Homeopathic Medicine for Canker Sores - 80 Pellets
Main highlights

Effective Relief for Canker Sores
Homeopathic medicine that relieves canker sores with natural substances.

Ideal for First Sign of Symptoms
Take at the first sign of symptoms for best results.

Highly Praised for Pain Relief
Customers appreciate its effectiveness in relieving mouth sore pain.
8.9

Very Good

Our Rating
7

Kank-A
Kank-A Triple Action Gel, 0.42 oz, Maximum Strength Mouth Pain Relief Gel for Canker Sores, Triple Action Treatment, Fast Acting and Long-Lasting Pain Relief, Cools and Soothes Irritation, 0.42 oz
Main highlights

Pain Relief and Healing
Kank-A Triple Action Gel provides maximum strength pain relief and aids in healing.

Ideal for Canker Sores
Perfect for treating canker sores, mouth sores, and minor oral injuries.

Customer Praised Effectiveness
Highly praised for its fast-acting and effective pain relief.
8.7

Very Good

Our Rating
8

Oracoat
OraCoat CankerMelts Sore Treatment - Stick-On Pain Relief Melts for Fast Acting Relief Inside Mouth with Benzocaine, Hyaluronic Acid & Vitamin B12, Pack of 20
Main highlights

Long Lasting Relief
Provides fast and prolonged pain relief with vitamin B12 for healing.

Best for Gum Line Sores
Designed for canker sores, mouth sores, and gum irritations.

Minty Taste and Numbing Effect
Customers praise its minty flavor and effective numbing sensation.
Key specs
- application:Stick-on melt form
- usage:Canker sores, mouth sores
- weight:0.63 ounces
- pain relief:Fast and long lasting
- dimensions:2.5 x 3.75 x 4 inches
8.6

Very Good

Our Rating
9

Campho-Phenique
Campho Phenique Cold Sore and Fever Blister Treatment for Lips, Maximum Strength Provides Instant Relief, Helps Prevent Infection To Promote Healing, Original Gel Formula, 0.23 Oz

52% Off
Main highlights

Pain and Itch Relief
Specially formulated to instantly relieve pain and itch from cold sores and fever blisters.

Versatile Use
Ideal for treating cold sores, fever blisters, insect bites, and minor sunburns.

Quick Healing
Praised for its ability to speed up healing and provide immediate relief.
Key specs
- application:For adults and children 2 years and over
- usage:For cold sores/fever blisters
- weight:0.23 ounces
- pain relief:Instantly relieves pain & itch
- dimensions:0.75 x 3.31 x 4.09 inches
8.4

Good

Our Rating

9.3
worth the money

8.0
Flavor
10

Muspyn
Red Cross Canker Sore Medication - 0.25 Oz (Packaging May Vary)

19% Off
Main highlights

Long Lasting Pain Relief
Red Cross Canker Sore Medication provides extended relief from mouth and gum irritation.

Ideal for Persistent Sores
Perfect for those needing stable protection against recurring mouth sores.

Highly Praised Adhesion
Customers love its ability to stick and stay on dry skin.
Key specs
- application:Forms protective layer
- usage:Canker sore relief
- weight:0.25 ounces
- pain relief:Mouth and gum irritation
- dimensions:4.17 x 3.58 x 0.59 inches
8.3

Good

Our Rating

9.7
pain management

8.0
Long life

8.0
Flavor

10 Best canker sore medicines of 2025

1

Durham's Bee Farm, Inc. Canker-Rid® - Get Immediate Relief and Heal Canker Sores - Restore Your Quality of Life Today

9.3

9.1

9.1

How do we rank?

How do we rank?

Analyzing top stores

2

Dentemp Canker Cover - Canker Sore Medicine Pain Reliever (8 Count) - Canker Sore Treatment to Relieve Canker Pain, Mouth Sores & Mouth Irritation - Fast Acting Canker Sore Relief Tablets for Adults

3

Zilactin-B Fast Acting Canker Sore Treatment - Long Lasting Protection and Oral Pain Relief of Canker Sores, Mouth Sores and Gum Irritations, Made in USA, 0.25oz Gel, Pack of 1

4

Anbesol Maximum Strength Oral Pain Relief Gel, Instant Pain Relief For Toothache Pain, Canker Sores, Sore Gums, Mouth Sores, Denture Pain, and Aligner Pain, ADA Accepted, 0.33 oz (packaging may vary)

8.9

8.4

8.0

5

DenTek Canker Relief Sore Patch Relieves Canker Pain, 6 Count (Pack of 1)

8.0

8.0

8.0

6

Boiron Borax 30C Homeopathic Medicine for Canker Sores - 80 Pellets

7

Kank-A Triple Action Gel, 0.42 oz, Maximum Strength Mouth Pain Relief Gel for Canker Sores, Triple Action Treatment, Fast Acting and Long-Lasting Pain Relief, Cools and Soothes Irritation, 0.42 oz

8

OraCoat CankerMelts Sore Treatment - Stick-On Pain Relief Melts for Fast Acting Relief Inside Mouth with Benzocaine, Hyaluronic Acid & Vitamin B12, Pack of 20

9

Campho Phenique Cold Sore and Fever Blister Treatment for Lips, Maximum Strength Provides Instant Relief, Helps Prevent Infection To Promote Healing, Original Gel Formula, 0.23 Oz

9.3

8.0

10

Red Cross Canker Sore Medication - 0.25 Oz (Packaging May Vary)

9.7

8.0

8.0

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