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10 Best canker sore medicines of 2026

Save up to 31% off

  • 1

    Abreva 10 Percent Docosanol Cold Sore Treatment, Treats Your Fever Blister in 2.5 Days - 0.07 oz Tube x 2
    Abreva

    Abreva 10 Percent Docosanol Cold Sore Treatment, Treats Your Fever Blister in 2.5 Days - 0.07 oz Tube x 2

    • active ingredients:10% docosanol
    • application:Portable tube
    • usage:Cold sore treatment
    • formula:Docosanol cream
    • weight:1.76 ounces
    9.9
    Exceptional
    Our Rating
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  • 2

    Canker-X Mouth Sore Gel, Fast Pain Relief & Healing for Canker Sores, Cheek Bites and Oral Abrasions, Oral Pain Relief Gel, Benzocaine-Free and Alcohol-Free, Adults and Kids 6+ Years, 0.28 fl oz
    Canker-X

    Canker-X Mouth Sore Gel, Fast Pain Relief & Healing for Canker Sores, Cheek Bites and Oral Abrasions, Oral Pain Relief Gel, Benzocaine-Free and Alcohol-Free, Adults and Kids 6+ Years, 0.28 fl oz

    • Pain Relief:Fast, long-lasting
    • Active Ingredients:Aloe Vera, Sodium Hyaluronate
    • Application Method:Extended nozzle, finger, swab
    • Formulation:Gel
    • Target Area:Mouth sores
    9.6
    Exceptional
    Our Rating

  • 3

    Zilactin-B Fast Acting Canker Sore Treatment - Long Lasting Protection and Oral Pain Relief of Canker Sores, Mouth Sores and Gum Irritations, Made in USA, 0.25oz Gel, Pack of 1
    Zilactin

    Zilactin-B Fast Acting Canker Sore Treatment - Long Lasting Protection and Oral Pain Relief of Canker Sores, Mouth Sores and Gum Irritations, Made in USA, 0.25oz Gel, Pack of 1

    • Pain Relief:Immediate, long lasting
    • Active Ingredients:10% Benzocaine
    • Application Method:Bioadhesive technology
    • Formulation:Proprietary blend
    • Target Area:Mouth, gums
    9.4
    Excellent

  • 4

    Zilactin-B Fast Acting Canker Sore Treatment - Long Lasting Protection and Oral Pain Relief of Canker Sores, Mouth Sores and Gum Irritations, Made in USA, 0.25oz Gel, Pack of 1
    Zilactin

    Zilactin-B Fast Acting Canker Sore Treatment - Long Lasting Protection and Oral Pain Relief of Canker Sores, Mouth Sores and Gum Irritations, Made in USA, 0.25oz Gel, Pack of 1

    • Pain Relief:Immediate, long lasting
    • Active Ingredients:10% Benzocaine
    • Application Method:Bioadhesive technology
    • Formulation:Proprietary blend
    • Target Area:Mouth, gums
    9.2
    Excellent

  • 5

    Orajel 3X for Mouth Sores: Maximum Strength Gel Tube 0.42oz- from #1 Oral Pain Relief Brand
    Orajel

    Orajel 3X for Mouth Sores: Maximum Strength Gel Tube 0.42oz- from #1 Oral Pain Relief Brand

    27% Off
    • Pain Relief:Instant pain relief
    • Active Ingredients:20% Benzocaine
    • Application Method:Gel
    • Formulation:Maximum strength gel
    • Target Area:Mouth
    9.0
    Excellent
    Our Rating
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  • 6

    Orajel 3X for Mouth Sores: Maximum Strength Gel Tube 0.42oz- from #1 Oral Pain Relief Brand
    Orajel

    Orajel 3X for Mouth Sores: Maximum Strength Gel Tube 0.42oz- from #1 Oral Pain Relief Brand

    31% Off
    • Pain Relief:Instant pain relief
    • Active Ingredients:20% Benzocaine
    • Application Method:Gel
    • Formulation:Maximum strength gel
    • Target Area:Mouth
    8.8
    Very Good
    Our Rating

  • 7

    Canker-X Mouth Sore Gel, Fast Pain Relief & Healing for Canker Sores, Cheek Bites and Oral Abrasions, Oral Pain Relief Gel, Benzocaine-Free and Alcohol-Free, Adults and Kids 6+ Years, 0.28 fl oz
    Canker-X

    Canker-X Mouth Sore Gel, Fast Pain Relief & Healing for Canker Sores, Cheek Bites and Oral Abrasions, Oral Pain Relief Gel, Benzocaine-Free and Alcohol-Free, Adults and Kids 6+ Years, 0.28 fl oz

    • Pain Relief:Fast, long-lasting
    • Active Ingredients:Aloe Vera, Sodium Hyaluronate
    • Application Method:Extended nozzle, finger, swab
    • Formulation:Gel
    • Target Area:Mouth sores
    8.5
    Good
    Our Rating

  • 8

    Kank-A Triple Action Gel, 0.42 oz, Maximum Strength Mouth Pain Relief Gel for Canker Sores, Triple Action Treatment, Fast Acting and Long-Lasting Pain Relief, Cools and Soothes Irritation, 0.42 oz
    Kank-A

    Kank-A Triple Action Gel, 0.42 oz, Maximum Strength Mouth Pain Relief Gel for Canker Sores, Triple Action Treatment, Fast Acting and Long-Lasting Pain Relief, Cools and Soothes Irritation, 0.42 oz

    8.3
    Good

  • 9

    Kank-A Triple Action Gel, 0.42 oz, Maximum Strength Mouth Pain Relief Gel for Canker Sores, Triple Action Treatment, Fast Acting and Long-Lasting Pain Relief, Cools and Soothes Irritation, 0.42 oz
    Kank-A

    Kank-A Triple Action Gel, 0.42 oz, Maximum Strength Mouth Pain Relief Gel for Canker Sores, Triple Action Treatment, Fast Acting and Long-Lasting Pain Relief, Cools and Soothes Irritation, 0.42 oz

    14% Off
    8.1
    Good

  • 10

    Anbesol Gel Maximum Strength - Instant Oral Pain Relief for Toothaches, Canker Sores, Sore Gums, Denture Pain - 0.33 oz
    Anbesol

    Anbesol Gel Maximum Strength - Instant Oral Pain Relief for Toothaches, Canker Sores, Sore Gums, Denture Pain - 0.33 oz

    16% Off
    7.9
    Good
    Our Rating