9 Best otc flea medication for dogs of 2025

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Best Choice

1

Capstar
Capstar(nitenpyram) for Dogs Fast-Acting Oral Flea Treatment for Dogs 2-25 lbs, Vet-Recommended Medication Tablets Start Killing in 30 Minutes, 6 Doses
Main highlights

Fast-Acting Flea Treatment
Capstar nitenpyram starts killing adult fleas in just 30 minutes.

Ideal for Small Dogs and Puppies
Safe for dogs 4 weeks and older, weighing 2-25 pounds.

Convenient No-Prescription Solution
Easy administration with no vet prescription needed, praised by customers.
9.7

Exceptional

Our Rating

8.2
Simple to use

8.0
simple to consume

8.0
Comfort
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Value for Money

2

Frontline
FRONTLINE Plus Flea and Tick Treatment for Large Dogs Up to 45 to 88 lbs. 3 Treatments

11% Off
Main highlights

Comprehensive Flea and Tick Protection
FRONTLINE Plus kills fleas, ticks, larvae, and lice effectively.

Ideal for Large Dogs
Perfect for dogs 45 to 88 lbs., including thick coats.

Waterproof and Long-lasting
Proven waterproof even through creeks and rivers.
9.6

Exceptional

Our Rating

8.0
Simple to use

8.0
Aroma

8.0
Comfort
3

PetArmor
PetArmor CAPACTION (nitenpyram) Oral Flea Treatment for Dogs, Fast Acting Tablets Start Killing Fleas in 30 Minutes, Dogs Over 25 lbs, 6 Doses (Pack of 1) (Packaging May Vary)
Main highlights

Rapid Flea Elimination
Begins killing fleas within 30 minutes with over 90% effectiveness.

Convenient for Large Dogs
Ideal for dogs weighing 25.1 to 200 pounds, no prescription needed.

Customer Praised Fast Action
Highly praised for immediate relief and fast flea reduction.
9.5

Excellent

Our Rating

8.0
Simple to use

8.0
Sheerness

8.0
Aroma
4

FRONTLINE
FRONTLINE Plus Flea and Tick Treatment for Small Dogs Upto 5 to 22 lbs. 3 Treatments

11% Off
Main highlights

Long-Lasting Protection
FRONTLINE Plus offers month-long protection against fleas, ticks, and lice with waterproof, fast-acting formula.

Ideal for Small Dogs
Perfect for dogs 5-22 lbs, ensuring safe and effective flea and tick control.

Highly Effective
Praised for consistent month-long effectiveness, even in challenging environments.
9.2

Excellent

Our Rating

8.2
Simple to take off

8.0
Simple to use

8.0
Aroma
5

Amazon Basics
Amazon Basics Flea and Tick Topical Treatment for Small Dogs (5-22 pounds), 3 Count (Previously Solimo)
Main highlights

Long-Lasting Protection
Provides up to 30 days of flea and tick prevention.

Ideal for Small Dogs
Perfect for small dogs weighing 5-22 pounds.

Easy Application Praised
Users appreciate the easy and quick application process.
9.1

Excellent

Our Rating

8.0
Simple to use

8.0
Aroma

8.0
Comfort
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6

PetArmor
PetArmor Plus Flea and Tick Prevention for Dogs, Dog Flea and Tick Treatment, 3 Doses, Waterproof Topical, Fast Acting, Large Dogs (45-88 lbs)

14% Off
Main highlights

Powerful Flea and Tick Protection
PetArmor Plus offers waterproof, 30-day flea and tick prevention with active ingredients fipronil and S-methoprene.

Ideal for Large Dogs 45-88 lbs
Perfect for large dogs, providing effective pest control and easy application.

Ease of Use Praised by Customers
Users appreciate the simple application process and effective pest control results.
8.8

Very Good

Our Rating

8.2
Simple to use

8.0
Aroma

8.0
Comfort
7

MaxBuddy
Flea and Tick Oral Prevention Support & Treatment for Dogs and Cats – Natural Flea Control with Multivitamin - Supplement Drops for Small and Large Dogs – Made in The USA

20% Off
Main highlights

Comprehensive Flea Tick Protection
Offers daily defense against fleas, ticks, eggs, larvae, and mosquitoes.

Ideal for All Pet Sizes
Perfect for puppies, kittens, and adult pets of any size.

Highly Praised Health Benefits
Customers love the added multivitamins and enzymes for joint and immune support.
8.6

Very Good

Our Rating
8

Amazon Basics
Amazon Basics Flea and Tick Topical Treatment for Large Dogs (45-88 pounds), Unscented, 3 Count (Previously Solimo)
Main highlights

Effective Flea and Tick Protection
Starts eliminating fleas and ticks within 24 hours with Fipronil and s-methoprene.

Ideal for Large Dogs
Perfect for dogs weighing between 45-88 pounds, providing tailored protection.

Cost-Effective Solution
Highly praised for affordability and effectiveness compared to other brands.
8.5

Good

Our Rating

9.9
Precision

8.0
Simple to use

8.0
Aroma
9

K9 Advantix
K9 Advantix II Medium Dog Vet-Recommended Flea, Tick & Mosquito Treatment & Prevention | Dogs 11-20 lbs. | 2-Mo Supply
Main highlights

Quick and Effective Protection
Kills fleas within 12 hours and repels ticks, mosquitoes, and more.

Ideal for Medium-Sized Dogs
Perfect for dogs weighing 11-20 lbs needing comprehensive pest protection.

Customer Satisfaction with Immediate Results
Highly praised for effectively stopping dogs from scratching.
8.3

Good

Our Rating

8.4
Simple to use

8.0
worth the money

8.0
Aroma

9 Best otc flea medication for dogs of 2025

1

Capstar(nitenpyram) for Dogs Fast-Acting Oral Flea Treatment for Dogs 2-25 lbs, Vet-Recommended Medication Tablets Start Killing in 30 Minutes, 6 Doses

8.2

8.0

8.0

How do we rank?

How do we rank?

Analyzing top stores

2

FRONTLINE Plus Flea and Tick Treatment for Large Dogs Up to 45 to 88 lbs. 3 Treatments

8.0

8.0

8.0

3

PetArmor CAPACTION (nitenpyram) Oral Flea Treatment for Dogs, Fast Acting Tablets Start Killing Fleas in 30 Minutes, Dogs Over 25 lbs, 6 Doses (Pack of 1) (Packaging May Vary)

8.0

8.0

8.0

4

FRONTLINE Plus Flea and Tick Treatment for Small Dogs Upto 5 to 22 lbs. 3 Treatments

8.2

8.0

8.0

5

Amazon Basics Flea and Tick Topical Treatment for Small Dogs (5-22 pounds), 3 Count (Previously Solimo)

8.0

8.0

8.0

6

PetArmor Plus Flea and Tick Prevention for Dogs, Dog Flea and Tick Treatment, 3 Doses, Waterproof Topical, Fast Acting, Large Dogs (45-88 lbs)

8.2

8.0

8.0

7

Flea and Tick Oral Prevention Support & Treatment for Dogs and Cats – Natural Flea Control with Multivitamin - Supplement Drops for Small and Large Dogs – Made in The USA

8

Amazon Basics Flea and Tick Topical Treatment for Large Dogs (45-88 pounds), Unscented, 3 Count (Previously Solimo)

9.9

8.0

8.0

9

K9 Advantix II Medium Dog Vet-Recommended Flea, Tick & Mosquito Treatment & Prevention | Dogs 11-20 lbs. | 2-Mo Supply

8.4

8.0

8.0

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