9 Best flea treatments for dogs of 2025

Save up to 14% off

Best Choice

1

K9 Advantix
K9 Advantix II Large Dog Vet-Recommended Flea, Tick & Mosquito Treatment & Prevention | Dogs 21 - 55 lbs. | 4-Mo Supply
Main highlights

30-Day Protection for Dogs 21-55 lbs
K9 Advantix II provides a 30-day treatment and prevention for fleas, ticks, mosquitoes, biting flies, and lice, suitable for dogs weighing 21-55 lbs.

Use Based on Dog's Weight
Ensure to purchase K9 Advantix II according to your dog's weight, not size, for effective flea and tick control. Ideal for suburban and rural areas.

Effective Flea and Tick Repellent
Customers praise K9 Advantix II for its effectiveness in repelling fleas and ticks, with noticeable results within 12 hours and long-lasting protection.
9.8

Exceptional

Our Rating

8.7
Simple to use

8.0
Aroma

8.0
worth the money
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Our rankings are cleverly generated from the algorithmic analysis of thousands of customer reviews about products, brands, merchant’s customer service levels, popularity trends, and more. The rankings reflect our opinion and should be a good starting point for shopping. By purchasing the products we rank, you’ll get the lowest price we found while we may receive a commission at no cost to you, which will help us continue to provide you with value.
Value for Money

2

Frontline
FRONTLINE Plus Flea and Tick Treatment for Large Dogs Up to 45 to 88 lbs. 3 Treatments

11% Off
Main highlights

Comprehensive Flea and Tick Protection
FRONTLINE Plus kills fleas, ticks, larvae, and lice effectively.

Ideal for Large Dogs
Perfect for dogs 45 to 88 lbs., including thick coats.

Waterproof and Long-lasting
Proven waterproof even through creeks and rivers.
9.7

Exceptional

Our Rating

8.0
Simple to use

8.0
Aroma

8.0
Comfort
3

PetArmor
PetArmor Plus Flea and Tick Prevention for Dogs, Dog Flea and Tick Treatment, 3 Doses, Waterproof Topical, Fast Acting, Small Dogs (5-22 lbs)

14% Off
Main highlights

Effective Flea and Tick Protection
PetArmor Plus offers waterproof protection against fleas, ticks, and lice for up to 30 days.

Ideal for Active Dogs
Perfect for dogs 5-22 lbs who frequently go outdoors.

Highly Praised Long-Lasting Formula
Customers appreciate its ability to break the flea cycle and provide lasting protection.
9.6

Exceptional

Our Rating

9.3
Water tight

8.2
Simple to use

8.0
Aroma
4

Amazon Basics
Amazon Brand - Solimo for Dogs Large Dog (45-88 pounds) Flea and Tick Treatment, 6 Doses
Main highlights

Fast-Acting Protection
Starts eliminating fleas and ticks within 24 hours, offering up to 30 days of protection.

Ideal for Large Dogs
Perfect for dogs weighing between 45-88 pounds, ensuring effective flea and tick prevention.

Affordable and Effective
Praised for its cost-effectiveness compared to similar brands like Frontline and Advantix.
9.5

Excellent

Our Rating

9.9
Precision

8.0
Simple to use

8.0
Aroma
5

TTLXBL

Dog Flea and Tick Treatment Chewable 200 Treatment Chews Natural Soft Chew Fleas Ticks Treatment Dog Oral Chewables Support Supplement Pest Defense Breeds and Ages Dogs Chicken Flavor
9.4

Excellent

Our Rating
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6

K9 Advantix
K9 Advantix II XL Dog Vet-Recommended Flea, Tick & Mosquito Treatment & Prevention | Dogs Over 55 lbs. | 1-Mo Supply
Main highlights

Comprehensive Protection
Protects dogs over 55 lbs from fleas, ticks, mosquitoes, biting flies, and lice with a 30-day treatment.

Ideal for Large Breeds
Perfect for large dogs needing effective flea and tick prevention without a prescription.

Quick Flea Elimination
Kills fleas within 12 hours of application, praised for fast effectiveness.
9.3

Excellent

Our Rating

8.7
Simple to use

8.0
Water tight

8.0
worth the money
7

FRONTLINE
FRONTLINE Plus Flea and Tick Treatment for Small Dogs Upto 5 to 22 lbs. 3 Treatments

11% Off
Main highlights

Long-Lasting Protection
FRONTLINE Plus offers month-long protection against fleas, ticks, and lice with waterproof, fast-acting formula.

Ideal for Small Dogs
Perfect for dogs 5-22 lbs, ensuring safe and effective flea and tick control.

Highly Effective
Praised for consistent month-long effectiveness, even in challenging environments.
9.0

Excellent

Our Rating

8.2
Simple to take off

8.0
Simple to use

8.0
Aroma
8

Frontline
FRONTLINE Plus Flea and Tick Treatment for Medium Dogs Up to 23 to 44 lbs. 3 Treatments

11% Off
Main highlights

Long-Lasting Protection
FRONTLINE Plus offers a full month of flea and tick protection with a single application.

Ideal for Active Dogs
Perfect for dogs that enjoy outdoor activities or live in flea-prone areas.

Odorless and Quick-Drying
Customers praise its lack of odor and fast drying time, ensuring no mess.
8.9

Very Good

Our Rating

8.2
Simple to use

8.0
Aroma

8.0
Simple to take off
9

TevraPet
Activate II Flea and Tick Prevention for Dogs | 4 Count | Extra Large Dogs 55+ lbs | Topical Drops | 4 Months Flea Treatment
Main highlights

Fast Acting Flea and Tick Protection
Activate II uses Imidacloprid, Permethrin, and Pyriproxyfen for quick and effective pest control.

Ideal for Large Dogs
Perfect for extra-large dogs 55+ lbs needing monthly flea and tick prevention.

Easy Application Praised by Users
Customers appreciate the simple application process and effective pest prevention.
8.8

Very Good

Our Rating

8.2
Simple to use

8.0
worth the money

8.0
Aroma

9 Best flea treatments for dogs of 2025

1

K9 Advantix II Large Dog Vet-Recommended Flea, Tick & Mosquito Treatment & Prevention | Dogs 21 - 55 lbs. | 4-Mo Supply

8.7

8.0

8.0

2

FRONTLINE Plus Flea and Tick Treatment for Large Dogs Up to 45 to 88 lbs. 3 Treatments

8.0

8.0

8.0

3

PetArmor Plus Flea and Tick Prevention for Dogs, Dog Flea and Tick Treatment, 3 Doses, Waterproof Topical, Fast Acting, Small Dogs (5-22 lbs)

9.3

8.2

8.0

4

Amazon Brand - Solimo for Dogs Large Dog (45-88 pounds) Flea and Tick Treatment, 6 Doses

9.9

8.0

8.0

5

Dog Flea and Tick Treatment Chewable 200 Treatment Chews Natural Soft Chew Fleas Ticks Treatment Dog Oral Chewables Support Supplement Pest Defense Breeds and Ages Dogs Chicken Flavor

6

K9 Advantix II XL Dog Vet-Recommended Flea, Tick & Mosquito Treatment & Prevention | Dogs Over 55 lbs. | 1-Mo Supply

8.7

8.0

8.0

7

FRONTLINE Plus Flea and Tick Treatment for Small Dogs Upto 5 to 22 lbs. 3 Treatments

8.2

8.0

8.0

8

FRONTLINE Plus Flea and Tick Treatment for Medium Dogs Up to 23 to 44 lbs. 3 Treatments

8.2

8.0

8.0

9

Activate II Flea and Tick Prevention for Dogs | 4 Count | Extra Large Dogs 55+ lbs | Topical Drops | 4 Months Flea Treatment

8.2

8.0

8.0

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