Our rankings are cleverly generated from the algorithmic analysis of thousands of customer reviews about products, brands, merchant’s customer service levels, popularity trends, and more. The rankings reflect our opinion and should be a good starting point for shopping. By purchasing the products we rank, you’ll get the lowest price we found while we may receive a commission at no cost to you, which will help us continue to provide you with value.
9 Best flea treatment for cats of 2025
- Best Choice
1
FrontlineFRONTLINE Plus Flea and Tick Treatment for Cats Over 1.5 lbs. 3 Treatments
22% OffMain highlights-
Waterproof Long-Lasting Protection
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Ideal for Infestation Prevention
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Veterinarian Trusted
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How do we rank?
Our rankings are cleverly generated from the algorithmic analysis of thousands of customer reviews about products, brands, merchant’s customer service levels, popularity trends, and more. The rankings reflect our opinion and should be a good starting point for shopping. By purchasing the products we rank, you’ll get the lowest price we found while we may receive a commission at no cost to you, which will help us continue to provide you with value.
- Value for Money
2
TevraPetTevraPet Actispot II Flea Treatment for Large Cats 9+ lbs | 6 Doses | Powerful Prevention and Control
Main highlights-
Powerful Flea Treatment
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Ideal for Multi-Cat Homes
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Fast Acting Formula
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3
Amazon BasicsAmazon Basics Flea and Tick Topical Treatment for Cats (over 1.5 lbs), 6 Count (Previously Solimo)
Main highlights-
Fast-Acting Protection
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Ideal for Multi-Cat Households
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High Customer Satisfaction
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4
AdvantageAdvantage II Large Cat Vet-Recommended Flea Treatment & Prevention | Cats Over 9 lbs. | 1-Month Supply
Main highlights-
Comprehensive Flea Protection
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Ideal for Large Cats
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Fast-Acting Formula
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5
ProElobaraFlea and Tick Prevention for Cats & Kittens: Waterproof Topical Cat Flea and Tick Treatment – Fast-Acting & Long-Lasting At Home Flea Control for Cats Over 1.5 lbs and 8 Weeks or Older – 6-Dose Supply
Main highlights-
Fast-Acting and Long-Lasting Protection
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Ideal for Cats with Sensitive Skin
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Easy to Apply
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See Today’s Deals & Prices
6
Amazon BasicsAmazon Basics Flea Topical for Large Cats (over 9 pounds), 4 Count (Previously Solimo)
Main highlights-
Quick Flea Elimination
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Ideal for Large Cats
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Customer Satisfaction Guarantee
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7
AdvantageAdvantage II Small Cat Vet-Recommended Flea Treatment & Prevention | Cats 5-9 lbs. | 1-Month Supply
Main highlights-
Total Flea Protection
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Ideal for Small Cats
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Fast Acting Relief
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8
AdvantageAdvantage Topical Cat Flea Treatment and Prevention for Large Cats Over 9 lbs. | Apply Flea Drops Monthly | 2 Treatments
Main highlights-
Rapid Flea Elimination
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Ideal for Indoor and Outdoor Cats
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Convenient Application
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9
HartzHartz UltraGuard Topical Flea & Tick Prevention for Cats and Kittens - 3 Monthly Treatments
16% OffMain highlights-
Effective Flea and Tick Protection
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Ideal for Cats and Kittens
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Highly Praised for Effectiveness
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