10 Best antihistamines for adults of 2025

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Best Choice

1

Claritin
Claritin Allergy Medicine for Adults, 24-Hour Non-Drowsy Loratadine 10mg Pills, Antihistamine, 100 Tablets
Main highlights

24-Hour Non-Drowsy Relief
Provides powerful, all-day allergy relief without causing drowsiness.

Ideal for Seasonal Allergies
Perfect for managing symptoms from pollen, dust, and pet allergens.

Highly Recommended for Spring
Praised for effectiveness during peak allergy seasons like Spring.
Key specs
- pack size:100 days
- form:Tablet
- active ingredient:10 milligrams loratadine
- symptom relief:Allergy symptoms
- dosage:N/A
9.9

Exceptional

Our Rating

9.7
simple to consume

8.9
worth the money
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Value for Money

2

Allegra
Allegra Adult 24-Hour Allergy Relief Tablets, Non-Drowsy Indoor and Outdoor Allergy Medicine, 180 mg Fexofenadine HCI Antihistamine Pill, 100-Count

20% Off
Main highlights

24-Hour Relief
One tablet provides round-the-clock relief from allergy symptoms.

Versatile Allergy Use
Effective for indoor, outdoor, seasonal, and pet allergies.

Convenience and Availability
Praised for being easy to carry and readily available.
Key specs
- pack size:100-count
- form:tablet
- active ingredient:fexofenadine HCI
- symptom relief:sneezing, runny nose, itchy eyes
- dosage:24-hour
9.8

Exceptional

Our Rating
3

Amazon Basic Care
Amazon Basic Care All Day Allergy, Cetirizine Hydrochloride Tablets, 10 mg, Antihistamine, 90 Count (Packaging may vary)
Main highlights

24-Hour Allergy Relief
Provides relief from indoor and outdoor allergy symptoms for 24 hours.

Effective for Dermatographism
Ideal for reducing itchiness and hives associated with skin allergies.

Budget-Friendly Alternative
Praised by customers for being a cost-effective substitute for Zyrtec.
9.7

Exceptional

Our Rating
4

Amazon Basic Care
Amazon Basic Care Allergy Relief Diphenhydramine HCl 25 mg, Antihistamine Tablets for Symptoms Due to Hay Fever and Upper Respiratory Allergies, 100 Count
Main highlights

Powerful Antihistamine Relief
Contains 25 mg diphenhydramine HCl for effective multi-symptom allergy relief.

Nighttime Allergy and Cold Relief
Ideal for alleviating symptoms like sneezing and runny nose at night.

Affordable and Effective Sleep Aid
Praised for being a cost-effective alternative to name brands with similar efficacy.
9.6

Exceptional

Our Rating

9.9
simple to consume

9.7
worth the money

9.3
Flavor
5

Benadryl
Benadryl Ultratabs Allergy Relief Medicine, 25 mg Diphenhydramine HCl Antihistamine Tablets For Relief of Cold & Allergy Symptoms Like Sneezing, Runny Nose, & Itchy Eyes & Throat, 100 ct

24% Off
Main highlights

Powerful Allergy Relief
Benadryl Ultratabs provide fast relief from sneezing, runny nose, itchy eyes, and throat.

Ideal for Seasonal Allergies
Perfect for managing symptoms from pollen, dust, mold, and pet dander.

Highly Effective
Customers praise its effectiveness in relieving allergy symptoms quickly.
9.3

Excellent

Our Rating

9.7
simple to consume

9.5
worth the money
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6

MAJOR
Major Allergy Loratadine 10 mg Tablets - Non-Drowsy Allergy Medicine for Adults and Kids Ages 6+ - Promotes 24-Hour Allergy Relief - Daily Allergy Tablets - Antihistamine - 300 Tablets
Main highlights

Large Quantity and Cost Efficiency
300 tablets provide a long-lasting supply, reducing frequent purchases and offering great value for money.

Ideal for Daily Allergy Relief
Perfect for individuals needing consistent allergy management without frequent re-purchasing.

Highly Praised for Affordability
Customers appreciate the significant cost savings compared to national brands.
9.2

Excellent

Our Rating
7

ValuMeds
ValuMeds 24-Hour Allergy Medicine Antihistamine for Pollen, Hay Fever, Dry, Itchy Eyes, Allergies | Cetirizine HCl 10mg Caplets, Compare to Leading Brand (300 Count (Pack of 1))
Main highlights

24-Hour Allergy Relief
Experience effective, long-lasting relief from allergies with cetirizine hydrochloride.

Ideal for Busy Lifestyles
Non-drowsy formula perfect for work, school, or daily activities.

Highly Rated Value
Customers appreciate the quality and cost-effectiveness compared to brand names.
9.0

Excellent

Our Rating

9.9
simple to consume

9.3
worth the money

9.3
quality of ingredients
8

Allegra
Allegra Hives Antihistamine 24-Hour Tablets, Non-Drowsy Hive Reduction and Hive Itch Relief, 180 mg Fexofenadine HCI, 30-Count

10% Off
Main highlights

24-Hour Non-Drowsy Relief
Offers 24-hour relief from hives and itching without causing drowsiness.

Ideal for Chronic Hives
Perfect for individuals with persistent hives seeking effective relief.

Highly Effective for Hives
Praised by users for being the only effective solution for hives.
Key specs
- pack size:30-count
- form:Tablets
- active ingredient:fexofenadine HCI
- symptom relief:Hives and itching
- dosage:One tablet daily
8.8

Very Good

Our Rating

9.7
quality of ingredients

9.3
pain management

8.0
worth the money
9

Zyrtec
Zyrtec 24 Hour Allergy Relief Liquid Gels, Antihistamine Capsules with Cetirizine HCl Allergy Medicine for All-Day Relief from Runny Nose, Sneezing, Itchy Eyes & More, 40 Count

17% Off
Main highlights

24-Hour Relief with Cetirizine Hydrochloride
Provides all-day relief from runny nose, sneezing, and itchy eyes.

Ideal for Indoor and Outdoor Allergies
Treats allergies caused by dust, mold, pet dander, pollen, and grasses.

Fast-Acting and Non-Drowsy Formula
Praised for being reliable and not causing drowsiness.
8.5

Good

Our Rating

9.9
simple to consume

9.1
worth the money
10

Claritin
Claritin Allergy Medicine for Adults, 24-Hour Non-Drowsy Loratadine 10mg Pills, Antihistamine, 30 Tablets + 1ct On-The-Go Relief

14% Off
Main highlights

Powerful 24-Hour Relief
Provides non-drowsy relief for indoor and outdoor allergies.

Ideal for Travelers
Includes 31 tablets, with one conveniently packaged for travel.

Praised for Small Size
Customers appreciate the compact bottle for easy storage and travel.
Key specs
- pack size:31 days
- form:Tablet
- active ingredient:Loratadine 10mg
- symptom relief:Sneezing, runny nose, itchy eyes
- dosage:10mg per tablet
8.3

Good

Our Rating

10 Best antihistamines for adults of 2025

1

Claritin Allergy Medicine for Adults, 24-Hour Non-Drowsy Loratadine 10mg Pills, Antihistamine, 100 Tablets

9.7

8.9

How do we rank?

How do we rank?

Analyzing top stores

2

Allegra Adult 24-Hour Allergy Relief Tablets, Non-Drowsy Indoor and Outdoor Allergy Medicine, 180 mg Fexofenadine HCI Antihistamine Pill, 100-Count

3

Amazon Basic Care All Day Allergy, Cetirizine Hydrochloride Tablets, 10 mg, Antihistamine, 90 Count (Packaging may vary)

4

Amazon Basic Care Allergy Relief Diphenhydramine HCl 25 mg, Antihistamine Tablets for Symptoms Due to Hay Fever and Upper Respiratory Allergies, 100 Count

9.9

9.7

9.3

5

Benadryl Ultratabs Allergy Relief Medicine, 25 mg Diphenhydramine HCl Antihistamine Tablets For Relief of Cold & Allergy Symptoms Like Sneezing, Runny Nose, & Itchy Eyes & Throat, 100 ct

9.7

9.5

6

Major Allergy Loratadine 10 mg Tablets - Non-Drowsy Allergy Medicine for Adults and Kids Ages 6+ - Promotes 24-Hour Allergy Relief - Daily Allergy Tablets - Antihistamine - 300 Tablets

7

ValuMeds 24-Hour Allergy Medicine Antihistamine for Pollen, Hay Fever, Dry, Itchy Eyes, Allergies | Cetirizine HCl 10mg Caplets, Compare to Leading Brand (300 Count (Pack of 1))

9.9

9.3

9.3

8

Allegra Hives Antihistamine 24-Hour Tablets, Non-Drowsy Hive Reduction and Hive Itch Relief, 180 mg Fexofenadine HCI, 30-Count

9.7

9.3

8.0

9

Zyrtec 24 Hour Allergy Relief Liquid Gels, Antihistamine Capsules with Cetirizine HCl Allergy Medicine for All-Day Relief from Runny Nose, Sneezing, Itchy Eyes & More, 40 Count

9.9

9.1

10

Claritin Allergy Medicine for Adults, 24-Hour Non-Drowsy Loratadine 10mg Pills, Antihistamine, 30 Tablets + 1ct On-The-Go Relief

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