10 Best antihistamines of 2025

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Best Choice

1

Claritin
Claritin Allergy Medicine for Adults, 24-Hour Non-Drowsy Loratadine 10mg Pills, Antihistamine, 100 Tablets
Main highlights

24-Hour Non-Drowsy Relief
Provides powerful, all-day allergy relief without causing drowsiness.

Ideal for Seasonal Allergies
Perfect for managing symptoms from pollen, dust, and pet allergens.

Highly Recommended for Spring
Praised for effectiveness during peak allergy seasons like Spring.
Key specs
- pack size:100 days
- form:Tablet
- active ingredient:10 milligrams loratadine
- symptom relief:Allergy symptoms
- dosage:N/A
9.9

Exceptional

Our Rating

9.7
simple to consume

8.9
worth the money
How do we rank?

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Based on millions of stores and reviews

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Value for Money

2

Zyrtec
Zyrtec 24 Hour Allergy Relief Tablets, Indoor & Outdoor Allergy Medicine with 10 mg Cetirizine HCl Antihistamine for Allergies, Bundle of one, 30 ct Bottle & Three,1 ct Travel Packs
Main highlights

Powerful 24-Hour Relief
Provides all-day relief from indoor and outdoor allergy symptoms with a single dose.

Versatile Allergy Solution
Ideal for treating allergies caused by dust, mold, pet dander, pollen, weeds, and grasses.

Highly Praised Effectiveness
Customers appreciate its ability to stop itching and provide relief.
9.8

Exceptional

Our Rating
3

Amazon Basic Care
Amazon Basic Care All Day Allergy, Cetirizine Hydrochloride Tablets, 10 mg, Antihistamine, 90 Count (Packaging may vary)
Main highlights

24-Hour Allergy Relief
Provides relief from indoor and outdoor allergy symptoms for 24 hours.

Effective for Dermatographism
Ideal for reducing itchiness and hives associated with skin allergies.

Budget-Friendly Alternative
Praised by customers for being a cost-effective substitute for Zyrtec.
9.7

Exceptional

Our Rating
4

Benadryl
Benadryl Ultratabs Allergy Relief Medicine, 25 mg Diphenhydramine HCl Antihistamine Tablets For Relief of Cold & Allergy Symptoms Like Sneezing, Runny Nose, & Itchy Eyes & Throat, 100 ct

24% Off
Main highlights

Powerful Allergy Relief
Benadryl Ultratabs provide fast relief from sneezing, runny nose, itchy eyes, and throat.

Ideal for Seasonal Allergies
Perfect for managing symptoms from pollen, dust, mold, and pet dander.

Highly Effective
Customers praise its effectiveness in relieving allergy symptoms quickly.
9.4

Excellent

Our Rating

9.7
simple to consume

9.5
worth the money
5

Amazon Basic Care
Amazon Basic Care Complete Allergy Relief, Diphenhydramine HCl 25 mg, Relieves Symptoms, Antihistamine Tablets, 400 Count
Main highlights

Powerful Allergy Relief
Contains diphenhydramine HCl 25 mg for effective multi-symptom relief.

Nighttime Use
Ideal for nighttime use to relieve allergies and aid sleep.

Highly Praised Sleep Aid
Customers appreciate its effectiveness as a sleep aid.
9.3

Excellent

Our Rating

9.9
simple to consume

9.7
worth the money

9.3
Flavor
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6

ValuMeds
ValuMeds 24-Hour Allergy Medicine Antihistamine for Pollen, Hay Fever, Dry, Itchy Eyes, Allergies | Cetirizine HCl 10mg Caplets, Compare to Leading Brand (300 Count (Pack of 1))
Main highlights

24-Hour Allergy Relief
Experience effective, long-lasting relief from allergies with cetirizine hydrochloride.

Ideal for Busy Lifestyles
Non-drowsy formula perfect for work, school, or daily activities.

Highly Rated Value
Customers appreciate the quality and cost-effectiveness compared to brand names.
9.1

Excellent

Our Rating

9.9
simple to consume

9.3
worth the money

9.3
quality of ingredients
7

MAJOR
Major Allergy Loratadine 10 mg Tablets - Non-Drowsy Allergy Medicine for Adults and Kids Ages 6+ - Promotes 24-Hour Allergy Relief - Daily Allergy Tablets - Antihistamine - 300 Tablets
Main highlights

Large Quantity and Cost Efficiency
300 tablets provide a long-lasting supply, reducing frequent purchases and offering great value for money.

Ideal for Daily Allergy Relief
Perfect for individuals needing consistent allergy management without frequent re-purchasing.

Highly Praised for Affordability
Customers appreciate the significant cost savings compared to national brands.
9.0

Excellent

Our Rating
8

Allegra
Allegra Hives Antihistamine 24-Hour Tablets, Non-Drowsy Hive Reduction and Hive Itch Relief, 180 mg Fexofenadine HCI, 30-Count

12% Off
Main highlights

24-Hour Non-Drowsy Relief
Offers 24-hour relief from hives and itching without causing drowsiness.

Ideal for Chronic Hives
Perfect for individuals with persistent hives seeking effective relief.

Highly Effective for Hives
Praised by users for being the only effective solution for hives.
Key specs
- pack size:30-count
- form:Tablets
- active ingredient:fexofenadine HCI
- symptom relief:Hives and itching
- dosage:One tablet daily
8.8

Very Good

Our Rating

9.7
quality of ingredients

9.3
pain management

8.0
worth the money
9

HealthA2Z
HealthA2Z® Allergy Relief | Loratadine 10mg | Antihistamine | Relief from Itchy Throat, Sneezing, Runny Noses | 24-Hours Allergy Medicine (300 Tablets)

32% Off
Main highlights

24-Hour Non-Drowsy Relief
Provides effective, non-drowsy allergy relief for 24 hours.

Ideal for Daily Allergy Management
Perfect for managing symptoms from pollen, dust, and pets.

Value for Money
Praised for its affordability and quantity compared to brands.
8.5

Good

Our Rating
10

ValuMeds
ValuMeds Allergy Medicine Antihistamine, Diphenhydramine HCl 25 mg | Children and Adults | Relieve Itchy Eyes, Runny Nose, Sneezing (25 mg, 600)
Main highlights

Rapid Allergy Relief
Fast-acting diphenhydramine provides quick relief from itching, sneezing, and runny nose.

Dual Use for Allergies and Sleep
Ideal for those needing allergy relief and restful sleep.

Affordable and Effective
Praised for being as effective as name brands at a lower cost.
8.3

Good

Our Rating

9.9
simple to consume

9.9
worth the money

9.1
Flavor

10 Best antihistamines of 2025

1

Claritin Allergy Medicine for Adults, 24-Hour Non-Drowsy Loratadine 10mg Pills, Antihistamine, 100 Tablets

9.7

8.9

How do we rank?

How do we rank?

Analyzing top stores

2

Zyrtec 24 Hour Allergy Relief Tablets, Indoor & Outdoor Allergy Medicine with 10 mg Cetirizine HCl Antihistamine for Allergies, Bundle of one, 30 ct Bottle & Three,1 ct Travel Packs

3

Amazon Basic Care All Day Allergy, Cetirizine Hydrochloride Tablets, 10 mg, Antihistamine, 90 Count (Packaging may vary)

4

Benadryl Ultratabs Allergy Relief Medicine, 25 mg Diphenhydramine HCl Antihistamine Tablets For Relief of Cold & Allergy Symptoms Like Sneezing, Runny Nose, & Itchy Eyes & Throat, 100 ct

9.7

9.5

5

Amazon Basic Care Complete Allergy Relief, Diphenhydramine HCl 25 mg, Relieves Symptoms, Antihistamine Tablets, 400 Count

9.9

9.7

9.3

6

ValuMeds 24-Hour Allergy Medicine Antihistamine for Pollen, Hay Fever, Dry, Itchy Eyes, Allergies | Cetirizine HCl 10mg Caplets, Compare to Leading Brand (300 Count (Pack of 1))

9.9

9.3

9.3

7

Major Allergy Loratadine 10 mg Tablets - Non-Drowsy Allergy Medicine for Adults and Kids Ages 6+ - Promotes 24-Hour Allergy Relief - Daily Allergy Tablets - Antihistamine - 300 Tablets

8

Allegra Hives Antihistamine 24-Hour Tablets, Non-Drowsy Hive Reduction and Hive Itch Relief, 180 mg Fexofenadine HCI, 30-Count

9.7

9.3

8.0

9

HealthA2Z® Allergy Relief | Loratadine 10mg | Antihistamine | Relief from Itchy Throat, Sneezing, Runny Noses | 24-Hours Allergy Medicine (300 Tablets)

10

ValuMeds Allergy Medicine Antihistamine, Diphenhydramine HCl 25 mg | Children and Adults | Relieve Itchy Eyes, Runny Nose, Sneezing (25 mg, 600)

9.9

9.9

9.1

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