10 Best antihistamines of 2025

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Best Choice

1

Claritin
Claritin Allergy Medicine for Adults, 24-Hour Non-Drowsy Loratadine 10mg Pills, Antihistamine, 100 Tablets
Main highlights

24-Hour Non-Drowsy Relief
Provides powerful, all-day allergy relief without causing drowsiness.

Ideal for Seasonal Allergies
Perfect for managing symptoms from pollen, dust, and pet allergens.

Highly Recommended for Spring
Praised for effectiveness during peak allergy seasons like Spring.
9.9

Exceptional

Our Rating

9.7
simple to consume

8.9
worth the money
How do we rank?

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Based on millions of stores and reviews

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Value for Money

2

Allegra
Allegra Adult 24-Hour Allergy Relief Tablets, Non-Drowsy Indoor and Outdoor Allergy Medicine, 180 mg Fexofenadine HCI Antihistamine Pill, 100-Count

20% Off
Main highlights

24-Hour Relief
One tablet provides round-the-clock relief from allergy symptoms.

Versatile Allergy Use
Effective for indoor, outdoor, seasonal, and pet allergies.

Convenience and Availability
Praised for being easy to carry and readily available.
9.8

Exceptional

Our Rating
3

Amazon Basic Care
Amazon Basic Care All Day Allergy, Cetirizine Hydrochloride Tablets, Antihistamine, 10 mg, 365 Count (Packaging may vary)

49% Off
Main highlights

24-Hour Relief
Provides up to 24 hours of temporary relief from allergy symptoms.

Indoor and Outdoor Use
Effective for both indoor and outdoor allergy symptom relief.

Budget-Friendly Alternative
Praised for being a cost-effective alternative to Zyrtec and Allertec.
9.7

Exceptional

Our Rating
4

Amazon Basic Care
Amazon Basic Care Complete Allergy Relief, Diphenhydramine HCl 25 mg, Relieves Symptoms, Antihistamine Tablets, 400 Count
Main highlights

Powerful Allergy Relief
Contains diphenhydramine HCl 25 mg for effective multi-symptom relief.

Nighttime Use
Ideal for nighttime use to relieve allergies and aid sleep.

Highly Praised Sleep Aid
Customers appreciate its effectiveness as a sleep aid.
9.6

Exceptional

Our Rating

9.9
simple to consume

9.7
worth the money

9.3
Flavor
5

Benadryl
Benadryl Ultratabs Antihistamine Allergy Relief Medicine, Diphenhydramine HCl Tablets for Relief of Cold & Allergy Symptoms Such as Sneezing, Runny Nose, & Itchy Eyes & Throat, 100 ct

24% Off
Main highlights

Powerful Allergy Relief
Benadryl Ultratabs provide fast relief from sneezing, runny nose, itchy eyes, and throat.

Ideal for Seasonal Allergies
Perfect for managing symptoms from pollen, dust, mold, and pet dander.

Highly Effective
Customers praise its effectiveness in relieving allergy symptoms quickly.
9.5

Excellent

Our Rating

9.7
simple to consume

9.5
worth the money
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6

ValuMeds
ValuMeds 24-Hour Allergy Medicine (300-Count) Antihistamine for Pollen, Hay Fever, Dry, Itchy Eyes, Allergies | Cetirizine HCl 10mg Caplets, Compare to Zyrtec
Main highlights

24-Hour Allergy Relief
Experience effective, long-lasting relief from allergies with cetirizine hydrochloride.

Ideal for Busy Lifestyles
Non-drowsy formula perfect for work, school, or daily activities.

Highly Rated Value
Customers appreciate the quality and cost-effectiveness compared to brand names.
9.4

Excellent

Our Rating

9.9
simple to consume

9.3
worth the money

9.3
quality of ingredients
7

Benadryl
Benadryl Ultratabs Antihistamine Allergy Relief with Diphenhydramine HCl, 24 Count

23% Off
Main highlights

Powerful Allergy and Cold Relief
Benadryl Ultratabs provide effective relief for allergies and cold symptoms like sneezing, runny nose, and itchy, watery eyes.

Perfect for On-the-Go Use
Compact, easy-to-swallow tablets ideal for travel, fitting easily into purses, carry-ons, or glove compartments.

Highly Praised Portability
Customers appreciate the convenient packaging that makes it easy to carry and access the tablets whenever needed.
9.3

Excellent

Our Rating
8

MAJOR
Major Allergy Loratadine 10 mg Tablets - Non-Drowsy Allergy Medicine for Adults and Kids Ages 6+ - Promotes 24-Hour Allergy Relief - Daily Allergy Tablets - Antihistamine - 300 Tablets
Main highlights

Large Quantity and Cost Efficiency
300 tablets provide a long-lasting supply, reducing frequent purchases and offering great value for money.

Ideal for Daily Allergy Relief
Perfect for individuals needing consistent allergy management without frequent re-purchasing.

Highly Praised for Affordability
Customers appreciate the significant cost savings compared to national brands.
9.2

Excellent

Our Rating
9

HealthA2Z
HealthA2Z® Allergy Relief | Loratadine 10mg | Antihistamine | Non-Drowsy | Relief from Itchy Throat, Sneezing, Runny Noses | 24-Hours Allergy Medicine (300 Tablets)

10% Off
Main highlights

24-Hour Non-Drowsy Relief
Provides effective, non-drowsy allergy relief for 24 hours.

Ideal for Daily Allergy Management
Perfect for managing symptoms from pollen, dust, and pets.

Value for Money
Praised for its affordability and quantity compared to brands.
9.1

Excellent

Our Rating
10

GenCare
GenCare - Cetirizine HCL 10 mg (200 Caplets) - 24 Hour Allergy Relief Pills - Non Drowsy Generic OTC Allergy Medication - Antihistamine Medicine for Sneezing, Runny Nose & Itchy Eyes - Generic Zyrtec
Main highlights

24 Hour Non Drowsy Relief
Provides full-day relief from allergies without causing drowsiness.

Effective for Indoor and Outdoor Allergies
Ideal for hay fever, pollen, dust, pet dander, and seasonal allergies.

Comparable to Brand Name Effectiveness
Praised for being as effective as brand-name allergy medications.
9.0

Excellent

Our Rating

9.7
simple to consume

9.5
worth the money

10 Best antihistamines of 2025

1

Claritin Allergy Medicine for Adults, 24-Hour Non-Drowsy Loratadine 10mg Pills, Antihistamine, 100 Tablets

9.7

8.9

How do we rank?

How do we rank?

Analyzing top stores

2

Allegra Adult 24-Hour Allergy Relief Tablets, Non-Drowsy Indoor and Outdoor Allergy Medicine, 180 mg Fexofenadine HCI Antihistamine Pill, 100-Count

3

Amazon Basic Care All Day Allergy, Cetirizine Hydrochloride Tablets, Antihistamine, 10 mg, 365 Count (Packaging may vary)

4

Amazon Basic Care Complete Allergy Relief, Diphenhydramine HCl 25 mg, Relieves Symptoms, Antihistamine Tablets, 400 Count

9.9

9.7

9.3

5

Benadryl Ultratabs Antihistamine Allergy Relief Medicine, Diphenhydramine HCl Tablets for Relief of Cold & Allergy Symptoms Such as Sneezing, Runny Nose, & Itchy Eyes & Throat, 100 ct

9.7

9.5

6

ValuMeds 24-Hour Allergy Medicine (300-Count) Antihistamine for Pollen, Hay Fever, Dry, Itchy Eyes, Allergies | Cetirizine HCl 10mg Caplets, Compare to Zyrtec

9.9

9.3

9.3

7

Benadryl Ultratabs Antihistamine Allergy Relief with Diphenhydramine HCl, 24 Count

8

Major Allergy Loratadine 10 mg Tablets - Non-Drowsy Allergy Medicine for Adults and Kids Ages 6+ - Promotes 24-Hour Allergy Relief - Daily Allergy Tablets - Antihistamine - 300 Tablets

9

HealthA2Z® Allergy Relief | Loratadine 10mg | Antihistamine | Non-Drowsy | Relief from Itchy Throat, Sneezing, Runny Noses | 24-Hours Allergy Medicine (300 Tablets)

10

GenCare - Cetirizine HCL 10 mg (200 Caplets) - 24 Hour Allergy Relief Pills - Non Drowsy Generic OTC Allergy Medication - Antihistamine Medicine for Sneezing, Runny Nose & Itchy Eyes - Generic Zyrtec

9.7

9.5

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