10 Best antihistamine nasal sprays of 2025

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Best Choice

1

Astepro

Astepro Nasal Spray and Tissue Bundle, 24-Hour Allergy Relief, Steroid-Free, Nasal Congestion, Runny & Itchy Nose, 200 Metered Sprays (Packaging May Vary)
9.8

Exceptional

Our Rating
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Value for Money

2

Flonase
Flonase Allergy Relief Nasal Spray, 24-Hour Non-Drowsy Multi-Symptom Relief 144 Sprays, Bonus Pack of Tissues
Main highlights

24-Hour Non-Drowsy Relief
Flonase provides 24-hour non-drowsy relief for nasal congestion, runny nose, and itchy eyes.

Year-Round Allergy Protection
Ideal for indoor and outdoor allergies, including pollen, mold, and pet dander.

Highly Effective Performance
Customers praise its effectiveness despite occasional spray clogging issues.
9.5

Excellent

Our Rating

9.3
Gentle

9.1
worth the money
3

Amazon Basic Care
Amazon Basic Care 24-Hour Allergy Relief Nasal Spray, Fluticasone Propionate (Glucocorticoid), 50 mcg, Full Prescription Strength, Non-Drowsy, 0.62 fl oz (Pack of 1)

10% Off
Main highlights

24-Hour Non-Drowsy Relief
Provides effective allergy symptom relief for up to 24 hours without causing drowsiness.

Ideal for Various Allergens
Perfect for combating indoor, outdoor, and pet allergens with ease.

Comparable to Flonase Quality
Customers praise its effectiveness and quality, comparable to Flonase.
Key specs
- symptom relief:Allergy symptoms
- form:Nasal spray
- dosage:50 mcg per spray
- pack size:N/A
- active ingredient:Fluticasone Propionate, 50 mcg
9.4

Excellent

Our Rating

9.5
Simple to use

9.1
worth the money

8.2
Flavor
4

Flonase
Flonase Allergy Relief Nasal Spray, 24 Hour Non Drowsy Allergy Medicine, Metered Nasal Spray - 72 Sprays - Fall and Seasonal Allergy Relief
Main highlights

24 Hour Non-Drowsy Relief
Flonase provides 24-hour non-drowsy relief from allergy symptoms, including congestion, sneezing, and itchy eyes.

Ideal for Seasonal and Year-Round Allergies
Perfect for managing seasonal and year-round indoor and outdoor allergies effectively.

Highly Praised for Effectiveness
Customers frequently praise Flonase for its quick and effective relief from allergy symptoms.
Key specs
- symptom relief:Runny nose, sneezing, itchy eyes
- form:Nasal spray
- dosage:One to two sprays
- pack size:72-spray bottle
- active ingredient:Fluticasone propionate
9.3

Excellent

Our Rating

9.7
Comfort

9.1
Simple to use

8.2
worth the money
5

Nasonex
Nasonex 24HR Allergy Nasal Spray, Allergy + Congestion, Non-Drowsy Relief in Full Prescription Strength, 120 Spray

26% Off
Main highlights

Full Prescription Strength Relief
Experience full prescription strength allergy and congestion relief with Nasonex, now available over the counter for easy access.

Ideal for Severe Allergy Sufferers
Perfect for those with severe allergies, providing 24-hour relief from nasal congestion, runny nose, sneezing, and itchy nose without drowsiness.

Praised for No Lingering Smell
Customers appreciate that Nasonex does not leave a lingering smell, unlike other nasal sprays like Flonase, making it more pleasant to use.
Key specs
- symptom relief:Allergy, congestion
- form:Nasal Spray
- dosage:N/A
- pack size:N/A
- active ingredient:N/A
9.2

Excellent

Our Rating

9.9
Aroma

9.7
Simple to use

9.3
worth the money
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6

HealthA2Z
HealthA2Z® Fluticasone Propionate Nasal Spray | 50 mcg per Spray | 24 Hour Allergy Relief | 72 Sprays | 0.38 fl oz. (11.1mL) (0.38 fl oz. (Pack of 1))
Main highlights

Effective Allergy Relief
Provides 24-hour relief from nasal congestion, runny nose, and sneezing with 50 mcg of fluticasone propionate per spray.

Ideal for Daily Use
Perfect for individuals seeking consistent relief from common allergy symptoms, suitable for everyday use.

Comparable to Name Brands
Customers praise its effectiveness, noting no difference from more expensive name brands.
9.1

Excellent

Our Rating
7

Amazon Basic Care
Amazon Basic Care 24 Hour Allergy Nasal Spray, Triamcinolone Acetonide 55 mcg per spray, Allergy Medicine, Non-Drowsy, 0.57 fl oz (Pack of 1)
Main highlights

Key Features and Benefits
24-hour relief, compares to Nasacort Allergy 24HR, effective against nasal congestion, runny nose, sneezing, itchy nose, non-drowsy formula.

Ideal Use Cases
Ideal for adults and children aged 2+ experiencing symptoms of hay fever or upper respiratory allergies seeking all-day relief.

Customer Reviews Highlight
Most praised for its effectiveness in providing quick, long-lasting relief from severe allergy symptoms without causing drowsiness.
9.0

Excellent

Our Rating

8.9
Simple to use

8.4
worth the money

8.0
Flavor
8

Astepro

Astepro Allergy Nasal Spray, 24-Hour Allergy Relief, Steroid-Free Antihistamine, 60 Metered Sprays
8.9

Very Good

Our Rating

8.0
worth the money

8.0
Flavor
9

Vicks
Vicks Sinex SEVERE Allergy & Sinus Nasal Spray, Original Ultra Fine Mist, Decongestant Medicine, Relief from Nasal Congestion due to Cold or Allergy, Sinus Pressure Relief, 265 Sprays x 2

14% Off
Main highlights

12-Hour Relief from Congestion
Provides instant, long-lasting relief from nasal congestion and sinus pressure for up to 12 hours.

Ideal for Cold and Allergy Season
Perfect for treating severe sinus congestion and pressure from colds or allergies.

Instant Effectiveness Praised by Users
Highly rated for its immediate effectiveness in clearing nasal passages.
8.7

Very Good

Our Rating

9.5
Simple to use

9.3
Moisturizing

9.1
worth the money
10

NasalCrom
NasalCrom Nasal Spray Allergy Symptom Controller | 200 Sprays | .88 FL OZ
Main highlights

Key Features
Non-drowsy, non-habit forming allergy relief with 200 sprays; steroid-free and safe for children ages two and up.

Ideal Use Cases
Perfect for preventing and controlling nasal allergy symptoms like runny, itchy nose and sneezing, especially in high-allergen environments.

Customer Praise
Most reviews highlight its effectiveness in allergy relief without causing drowsiness or jitters, making it a top choice for daily use.
Key specs
- symptom relief:Allergy symptoms relief
- form:N/A
- dosage:N/A
- pack size:200 sprays
- active ingredient:N/A
8.6

Very Good

Our Rating

9.5
Simple to use

8.9
worth the money

8.4
Flavor

10 Best antihistamine nasal sprays of 2025

1

Astepro Nasal Spray and Tissue Bundle, 24-Hour Allergy Relief, Steroid-Free, Nasal Congestion, Runny & Itchy Nose, 200 Metered Sprays (Packaging May Vary)

How do we rank?

How do we rank?

Analyzing top stores

2

Flonase Allergy Relief Nasal Spray, 24-Hour Non-Drowsy Multi-Symptom Relief 144 Sprays, Bonus Pack of Tissues

9.3

9.1

3

Amazon Basic Care 24-Hour Allergy Relief Nasal Spray, Fluticasone Propionate (Glucocorticoid), 50 mcg, Full Prescription Strength, Non-Drowsy, 0.62 fl oz (Pack of 1)

9.5

9.1

8.2

4

Flonase Allergy Relief Nasal Spray, 24 Hour Non Drowsy Allergy Medicine, Metered Nasal Spray - 72 Sprays - Fall and Seasonal Allergy Relief

9.7

9.1

8.2

5

Nasonex 24HR Allergy Nasal Spray, Allergy + Congestion, Non-Drowsy Relief in Full Prescription Strength, 120 Spray

9.9

9.7

9.3

6

HealthA2Z® Fluticasone Propionate Nasal Spray | 50 mcg per Spray | 24 Hour Allergy Relief | 72 Sprays | 0.38 fl oz. (11.1mL) (0.38 fl oz. (Pack of 1))

7

Amazon Basic Care 24 Hour Allergy Nasal Spray, Triamcinolone Acetonide 55 mcg per spray, Allergy Medicine, Non-Drowsy, 0.57 fl oz (Pack of 1)

8.9

8.4

8.0

8

Astepro Allergy Nasal Spray, 24-Hour Allergy Relief, Steroid-Free Antihistamine, 60 Metered Sprays

8.0

8.0

9

Vicks Sinex SEVERE Allergy & Sinus Nasal Spray, Original Ultra Fine Mist, Decongestant Medicine, Relief from Nasal Congestion due to Cold or Allergy, Sinus Pressure Relief, 265 Sprays x 2

9.5

9.3

9.1

10

NasalCrom Nasal Spray Allergy Symptom Controller | 200 Sprays | .88 FL OZ

9.5

8.9

8.4

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