10 Best antihistamines of 2025

Save up to 32% off

Best Choice

1

Claritin
Claritin Allergy Medicine for Adults, 24-Hour Non-Drowsy Loratadine 10mg Pills, Antihistamine, 100 Tablets
Main highlights

24-Hour Non-Drowsy Relief
Provides powerful, all-day allergy relief without causing drowsiness.

Ideal for Seasonal Allergies
Perfect for managing symptoms from pollen, dust, and pet allergens.

Highly Recommended for Spring
Praised for effectiveness during peak allergy seasons like Spring.
Key specs
- pack size:100 days
- form:Tablet
- active ingredient:10 milligrams loratadine
- symptom relief:Allergy symptoms
- dosage:N/A
9.8

Exceptional

Our Rating

9.7
simple to consume

8.9
worth the money
How do we rank?

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Value for Money

2

Claritin
Claritin Allergy Medicine for Adults, 24-Hour Non-Drowsy Loratadine 10mg Pills, Antihistamine, 30 Tablets + 1ct On-The-Go Relief

14% Off
Main highlights

Powerful 24-Hour Relief
Provides non-drowsy relief for indoor and outdoor allergies.

Ideal for Travelers
Includes 31 tablets, with one conveniently packaged for travel.

Praised for Small Size
Customers appreciate the compact bottle for easy storage and travel.
Key specs
- pack size:31 days
- form:Tablet
- active ingredient:Loratadine 10mg
- symptom relief:Sneezing, runny nose, itchy eyes
- dosage:10mg per tablet
9.6

Exceptional

Our Rating
3

Amazon Basic Care
Amazon Basic Care All Day Allergy, Cetirizine Hydrochloride Tablets, 10 mg, Antihistamine, 90 Count (Packaging may vary)
Main highlights

24-Hour Allergy Relief
Provides relief from indoor and outdoor allergy symptoms for 24 hours.

Effective for Dermatographism
Ideal for reducing itchiness and hives associated with skin allergies.

Budget-Friendly Alternative
Praised by customers for being a cost-effective substitute for Zyrtec.
9.5

Excellent

Our Rating
4

Amazon Basic Care
Amazon Basic Care Complete Allergy Relief, Diphenhydramine HCl 25 mg, Relieves Symptoms, Antihistamine Tablets, 400 Count
Main highlights

Powerful Allergy Relief
Contains diphenhydramine HCl 25 mg for effective multi-symptom relief.

Nighttime Use
Ideal for nighttime use to relieve allergies and aid sleep.

Highly Praised Sleep Aid
Customers appreciate its effectiveness as a sleep aid.
9.4

Excellent

Our Rating

9.9
simple to consume

9.7
worth the money

9.3
Flavor
5

Benadryl
Benadryl Ultratabs Allergy Relief Medicine, 25 mg Diphenhydramine HCl Antihistamine Tablets For Relief of Cold & Allergy Symptoms Like Sneezing, Runny Nose, & Itchy Eyes & Throat, 100 ct

24% Off
Main highlights

Powerful Allergy Relief
Benadryl Ultratabs provide fast relief from sneezing, runny nose, itchy eyes, and throat.

Ideal for Seasonal Allergies
Perfect for managing symptoms from pollen, dust, mold, and pet dander.

Highly Effective
Customers praise its effectiveness in relieving allergy symptoms quickly.
9.1

Excellent

Our Rating

9.7
simple to consume

9.5
worth the money
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6

ValuMeds
ValuMeds 24-Hour Allergy Medicine Antihistamine for Pollen, Hay Fever, Dry, Itchy Eyes, Allergies | Cetirizine HCl 10mg Caplets, Compare to Leading Brand (300 Count (Pack of 1))
Main highlights

24-Hour Allergy Relief
Experience effective, long-lasting relief from allergies with cetirizine hydrochloride.

Ideal for Busy Lifestyles
Non-drowsy formula perfect for work, school, or daily activities.

Highly Rated Value
Customers appreciate the quality and cost-effectiveness compared to brand names.
8.9

Very Good

Our Rating

9.9
simple to consume

9.3
worth the money

9.3
quality of ingredients
7

Allegra
Allegra Hives Antihistamine 24-Hour Tablets, Non-Drowsy Hive Reduction and Hive Itch Relief, 180 mg Fexofenadine HCI, 30-Count

12% Off
Main highlights

24-Hour Non-Drowsy Relief
Offers 24-hour relief from hives and itching without causing drowsiness.

Ideal for Chronic Hives
Perfect for individuals with persistent hives seeking effective relief.

Highly Effective for Hives
Praised by users for being the only effective solution for hives.
Key specs
- pack size:30-count
- form:Tablets
- active ingredient:fexofenadine HCI
- symptom relief:Hives and itching
- dosage:One tablet daily
8.7

Very Good

Our Rating

9.7
quality of ingredients

9.3
pain management

8.0
worth the money
8

MAJOR
Major Allergy Loratadine 10 mg Tablets - Non-Drowsy Allergy Medicine for Adults and Kids Ages 6+ - Promotes 24-Hour Allergy Relief - Daily Allergy Tablets - Antihistamine - 300 Tablets
Main highlights

Large Quantity and Cost Efficiency
300 tablets provide a long-lasting supply, reducing frequent purchases and offering great value for money.

Ideal for Daily Allergy Relief
Perfect for individuals needing consistent allergy management without frequent re-purchasing.

Highly Praised for Affordability
Customers appreciate the significant cost savings compared to national brands.
8.6

Very Good

Our Rating
9

ValuMeds
ValuMeds Allergy Medicine Antihistamine, Diphenhydramine HCl 25 mg | Children and Adults | Relieve Itchy Eyes, Runny Nose, Sneezing (25 mg, 600)
Main highlights

Rapid Allergy Relief
Fast-acting diphenhydramine provides quick relief from itching, sneezing, and runny nose.

Dual Use for Allergies and Sleep
Ideal for those needing allergy relief and restful sleep.

Affordable and Effective
Praised for being as effective as name brands at a lower cost.
8.4

Good

Our Rating

9.9
simple to consume

9.9
worth the money

9.1
Flavor
10

HealthA2Z
HealthA2Z® Allergy Relief | Loratadine 10mg | Antihistamine | Relief from Itchy Throat, Sneezing, Runny Noses | 24-Hours Allergy Medicine (300 Tablets)

32% Off
Main highlights

24-Hour Non-Drowsy Relief
Provides effective, non-drowsy allergy relief for 24 hours.

Ideal for Daily Allergy Management
Perfect for managing symptoms from pollen, dust, and pets.

Value for Money
Praised for its affordability and quantity compared to brands.
8.1

Good

Our Rating

10 Best antihistamines of 2025

1

Claritin Allergy Medicine for Adults, 24-Hour Non-Drowsy Loratadine 10mg Pills, Antihistamine, 100 Tablets

9.7

8.9

How do we rank?

How do we rank?

Analyzing top stores

2

Claritin Allergy Medicine for Adults, 24-Hour Non-Drowsy Loratadine 10mg Pills, Antihistamine, 30 Tablets + 1ct On-The-Go Relief

3

Amazon Basic Care All Day Allergy, Cetirizine Hydrochloride Tablets, 10 mg, Antihistamine, 90 Count (Packaging may vary)

4

Amazon Basic Care Complete Allergy Relief, Diphenhydramine HCl 25 mg, Relieves Symptoms, Antihistamine Tablets, 400 Count

9.9

9.7

9.3

5

Benadryl Ultratabs Allergy Relief Medicine, 25 mg Diphenhydramine HCl Antihistamine Tablets For Relief of Cold & Allergy Symptoms Like Sneezing, Runny Nose, & Itchy Eyes & Throat, 100 ct

9.7

9.5

6

ValuMeds 24-Hour Allergy Medicine Antihistamine for Pollen, Hay Fever, Dry, Itchy Eyes, Allergies | Cetirizine HCl 10mg Caplets, Compare to Leading Brand (300 Count (Pack of 1))

9.9

9.3

9.3

7

Allegra Hives Antihistamine 24-Hour Tablets, Non-Drowsy Hive Reduction and Hive Itch Relief, 180 mg Fexofenadine HCI, 30-Count

9.7

9.3

8.0

8

Major Allergy Loratadine 10 mg Tablets - Non-Drowsy Allergy Medicine for Adults and Kids Ages 6+ - Promotes 24-Hour Allergy Relief - Daily Allergy Tablets - Antihistamine - 300 Tablets

9

ValuMeds Allergy Medicine Antihistamine, Diphenhydramine HCl 25 mg | Children and Adults | Relieve Itchy Eyes, Runny Nose, Sneezing (25 mg, 600)

9.9

9.9

9.1

10

HealthA2Z® Allergy Relief | Loratadine 10mg | Antihistamine | Relief from Itchy Throat, Sneezing, Runny Noses | 24-Hours Allergy Medicine (300 Tablets)

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