10 Best anesthetic creams of 2025

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Best Choice

1

Ebanel
Ebanel 5% Lidocaine Numbing Cream, 2-Pack Pain Relief Burn Itch Numb Cream, Maximum Strength Topical Anesthetic with Allantoin, Vitamin E for Local and Anorectal Uses, Hemorrhoid Treatment

20% Off
Main highlights

Maximum Strength Pain Relief
Contains 5% Lidocaine for effective, temporary relief from pain, itching, and discomfort.

Ideal for Tattoos and Hemorrhoids
Perfect for tattoos, hemorrhoid treatment, minor burns, and skin irritations.

Praised for Tattoo Use
Customers love its effectiveness in numbing tattoo areas for a more comfortable experience.
Key specs
- pack size:1.34 ounces
- active ingredients:Lidocaine
- application method:Topical
- usage:Apply before, during treatment
- formulation:Cream
9.8

Exceptional

Our Rating

9.3
Simple to use

8.9
Comfort

8.0
worth the money
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Based on millions of stores and reviews

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Value for Money

2

Nupharmisto

Nupharmisto Numbing Cream Maximum Strength : Long Lasting Numbing Cream with 5x Numbing - Emu Oil and Arnica (60ml)
9.7

Exceptional

Our Rating
3

Ebanel
Ebanel 5% Lidocaine Numbing Cream, Pain Relief Burn Itch Numb Cream, Maximum Strength Topical Anesthetic with Allantoin, Vitamin E for Local and Anorectal Uses, Hemorrhoid Treatment, 1.35 Oz
Main highlights

Fast-Acting Long-Lasting Relief
Ebanel 5 Lidocaine Cream provides quick, enduring numbing for pain relief and itch reduction.

Ideal for Skin Procedures
Perfect for tattoos, microneedling, waxing, and injections, enhancing comfort during sessions.

Highly Praised Numbing Effect
Customers commend its ability to significantly reduce discomfort and improve treatment experience.
9.6

Exceptional

Our Rating

8.9
Simple to use

8.0
Absorbency

8.0
Gentle
4

HealthWise

HealthWise Maximum OTC Strength Lidocaine Cream | Numbs Away Pain | Long-Lasting Relief | Non-Greasy | 2.7 Oz | Unscented Formula | Topical Anesthetic
9.5

Excellent

Our Rating
5

Treatonic

Treatonic Maximum Strength Numbing Cream: Numbing Cream for Discomfort, Burn, Itch & Pain Relief - Fast-Acting, Soothing Topical Anesthetic with Menthol & Emu Oil for Hemorrhoid Treatment – 1.7oz
9.3

Excellent

Our Rating
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6

WELMATE

WELMATE - 5% Lidocaine Numbing Cream, 6oz (170g) - Maximum Strength Lidocaine Cream - Hemorrhoid Relief - External Use Anesthetic, Vitamin E - Child Resistant - Topical Skin Care, HSA & FSA Eligible
9.2

Excellent

Our Rating
7

Curist
Curist 5% Lidocaine Cream Maximum Strength Topical Pain Relief - 6 oz (170 g) XL Tube - Numb Quickly & Effectively Numbing Formulation - (1 Pack - 6 oz Tube)
Main highlights

Maximum Strength Relief
Experience deep pain relief with 5% lidocaine, the strongest OTC formulation.

Versatile Use Cases
Ideal for hemorrhoids, bug bites, rashes, bruises, and more.

Highly Recommended Application
Customers praise its non-greasy, quick-absorbing formula and long-lasting effect.
9.1

Excellent

Our Rating

8.2
pain management

8.0
worth the money
8

HealthWise
HealthWise Lidocaine Plus+ Cream | Numbs Away Pain | | Non-Greasy | 3.0 Oz | 4% OTC Lidocaine + 10% Benzyl Alcohol | Topical Anesthetic
Main highlights

Powerful Pain Relief
Combines 4% lidocaine and 10% benzyl alcohol for effective pain numbing.

Ideal for Muscle and Joint Aches
Perfect for arthritis, backaches, strains, sprains, and bruises.

Non-Greasy Formula Praised
Customers love the smooth, non-greasy application.
Key specs
- Package Type:Tube
- Active Ingredients:Lidocaine, Benzyl Alcohol
- Application Method:Apply directly to skin
- Formulation:Non-greasy cream
- Target Area:Muscles and joints
8.9

Very Good

Our Rating
9

Clinical Resolution
Clinical Resolution Numb Master 5% Lidocaine Numbing Cream for Pain Relief, Topical Anesthetic Burn Itch Cream Maximum Strength, Fast Acting Hemorrhoid Treatment with Vitamin E and Aloe, 1.25 Oz
Main highlights

Key Features
Provides quick, long-lasting numbing relief. Non-oily, water-based, safe for all skin types. Doctor recommended, cruelty-free, made in the USA.

Ideal Use Cases
Perfect for relieving pain, itching, and discomfort from anorectal disorders and inflammation. Suitable for minor skin irritations.

Customer Reviews
Most praised for its fast-acting relief, effectiveness, and ease of application without leaving a greasy residue.
8.7

Very Good

Our Rating

8.0
Gentle

8.0
worth the money

8.0
pain management
10

Aspercreme
Aspercreme Lidocaine Pain Relief Cream Soothes Aggravated Nerves, Numbing Topical Analgesic with Max-Strength 4% Lidocaine & Moisturizing Aloe, 4.3 Oz.

34% Off
Main highlights

Fast-Acting Numbing Relief
Contains 4% lidocaine for quick, effective pain relief.

Ideal for Joint and Muscle Pain
Perfect for arthritis, backaches, sprains, and strains.

Praised for Ease of Use
Customers love its ease of application and effectiveness.
Key specs
- Package Type:Bottle
- Active Ingredients:4% Lidocaine
- Application Method:Topical
- Formulation:Cream
- Target Area:Joints & Muscles
8.4

Good

Our Rating

8.4
worth the money

8.4
pain management

10 Best anesthetic creams of 2025

1

Ebanel 5% Lidocaine Numbing Cream, 2-Pack Pain Relief Burn Itch Numb Cream, Maximum Strength Topical Anesthetic with Allantoin, Vitamin E for Local and Anorectal Uses, Hemorrhoid Treatment

9.3

8.9

8.0

How do we rank?

How do we rank?

Analyzing top stores

2

Nupharmisto Numbing Cream Maximum Strength : Long Lasting Numbing Cream with 5x Numbing - Emu Oil and Arnica (60ml)

3

Ebanel 5% Lidocaine Numbing Cream, Pain Relief Burn Itch Numb Cream, Maximum Strength Topical Anesthetic with Allantoin, Vitamin E for Local and Anorectal Uses, Hemorrhoid Treatment, 1.35 Oz

8.9

8.0

8.0

4

HealthWise Maximum OTC Strength Lidocaine Cream | Numbs Away Pain | Long-Lasting Relief | Non-Greasy | 2.7 Oz | Unscented Formula | Topical Anesthetic

5

Treatonic Maximum Strength Numbing Cream: Numbing Cream for Discomfort, Burn, Itch & Pain Relief - Fast-Acting, Soothing Topical Anesthetic with Menthol & Emu Oil for Hemorrhoid Treatment – 1.7oz

6

WELMATE - 5% Lidocaine Numbing Cream, 6oz (170g) - Maximum Strength Lidocaine Cream - Hemorrhoid Relief - External Use Anesthetic, Vitamin E - Child Resistant - Topical Skin Care, HSA & FSA Eligible

7

Curist 5% Lidocaine Cream Maximum Strength Topical Pain Relief - 6 oz (170 g) XL Tube - Numb Quickly & Effectively Numbing Formulation - (1 Pack - 6 oz Tube)

8.2

8.0

8

HealthWise Lidocaine Plus+ Cream | Numbs Away Pain | | Non-Greasy | 3.0 Oz | 4% OTC Lidocaine + 10% Benzyl Alcohol | Topical Anesthetic

9

Clinical Resolution Numb Master 5% Lidocaine Numbing Cream for Pain Relief, Topical Anesthetic Burn Itch Cream Maximum Strength, Fast Acting Hemorrhoid Treatment with Vitamin E and Aloe, 1.25 Oz

8.0

8.0

8.0

10

Aspercreme Lidocaine Pain Relief Cream Soothes Aggravated Nerves, Numbing Topical Analgesic with Max-Strength 4% Lidocaine & Moisturizing Aloe, 4.3 Oz.

8.4

8.4

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