10 Best acid reflux medicines of 2025

Save up to 22% off

Best Choice

1

Amazon Basic Care

Amazon Basic Care Maximum Strength Famotidine Tablets Acid Reducer for Heartburn Relief, 20 mg, 400 Count Pack

16% Off
9.8

Exceptional

Our Rating
How do we rank?

Powerful technology We scan thousands of products and stores, analyzing reviews to find what matters most to users like you

Careful review Our team ensures quality, value, and fit based on real user feedback

Trusted insights AI and human analysis guide your decisions, reflecting real user priorities
Real users impact

Thousands of users trust our site daily

Based on millions of stores and reviews

Shoppers influence our rankings
Analyzing top stores
Value for Money

2

Amazon Basic Care
Amazon Basic Care Esomeprazole Magnesium Delayed Release Capsules, 20 mg, Acid Reducer, Heartburn Medicine, 42 Count
Main highlights

Effective Acid Reducer
Contains esomeprazole 20 mg, clinically proven to treat frequent heartburn.

Ideal for Frequent Heartburn
Best for those experiencing heartburn 2 or more days a week.

Cost-Effective Alternative
Praised for being as effective as Nexium but more affordable.
9.7

Exceptional

Our Rating

9.5
simple to consume

8.4
worth the money
3

Amazon Basic Care
Amazon Basic Care Omeprazole Delayed Release Tablets 20 mg, Treats Frequent Heartburn, Acid Reducer, Heartburn Medicine, 42 Count (Pack of 1) (Packaging may vary)
Main highlights

Effective Acid Reduction
Omeprazole 20 mg reduces stomach acid, treating frequent heartburn occurring twice a week or more.

Recommended for Regular Heartburn Sufferers
Ideal for those experiencing heartburn at least twice weekly, requiring a 14-day treatment.

Cost-Effective Prilosec Alternative
Praised for affordability and effectiveness compared to Prilosec, offering great value.
9.5

Excellent

Our Rating

9.9
simple to consume

9.3
Flavor

9.3
worth the money
4

Amazon Basic Care
Amazon Basic Care Maximum Strength Famotidine Tablets 20 mg, Acid Reducer Pills for Heartburn Relief, 200 Count (Packaging may vary)
Main highlights

Effective Heartburn Relief
Contains 20 mg famotidine, reduces heartburn for up to 12 hours.

Ideal for Nighttime Use
Prevents nighttime indigestion when taken before bedtime.

Cost-Effective Alternative
Customers praise value, comparable effectiveness to name brands.
9.4

Excellent

Our Rating

9.9
simple to consume

9.3
worth the money

9.1
Flavor
5

Amazon Basic Care
Amazon Basic Care Maximum Strength Famotidine Tablets 20 mg, Acid Reducer for Heartburn Relief, 50 Count

22% Off
Main highlights

Effective Acid Reduction
Contains 20 mg of famotidine, an H2-blocker for heartburn relief lasting up to 12 hours.

Ideal for Preemptive Use
Prevents heartburn when taken 10 to 60 minutes before meals.

Customer Satisfaction for Value
Praised for quality and value, comparable to name brands.
Key specs
- Form:Tablets
- Relief Duration:Up to 12 hours
- Use:Heartburn relief
- Active Ingredient:20 mg famotidine
- Pack Size:N/A
9.3

Excellent

Our Rating

9.9
simple to consume

9.3
worth the money

9.1
Flavor
See Today’s Deals & Prices
6

TIME-CAP LABS, INC.
Timely Acid Reducer Famotidine 20mg - Anatcid Acid Reflux Medicine for Heartburn Relief and Acid Indigestion Symptoms - 200 Tablets
Main highlights

Effective Heartburn Relief
Timely Acid Reducer provides maximum strength relief by reducing stomach acid, allowing you to enjoy meals without discomfort.

Long-Lasting Use
Ideal for those needing extended relief, with effects lasting up to 12 hours, perfect for day-long comfort.

Great Value for Money
Customers appreciate the cost-effectiveness, offering national brand equivalency at a fraction of the price.
Key specs
- Form:Tablet
- Relief Duration:Up to 12 hours
- Use:Heartburn relief
- Active Ingredient:Famotidine
- Pack Size:200-count
9.2

Excellent

Our Rating
7

Pepcid
Pepcid AC Maximum Strength Heartburn Relief Tablets, OTC Medicine Prevents & Relieves Heartburn Due to Acid Indigestion, 20mg Famotidine Acid Reducer, Fast-Acting, 25 Ct
Main highlights

All-Day Night Acid Control
One tablet provides up to 21 hours of acid control.

Ideal for Quick Relief
Effective when taken 10 minutes before meals.

Praised for Fast-Acting Relief
Customers love its quick action against heartburn.
8.9

Very Good

Our Rating

9.9
simple to consume

9.7
pain management

9.1
worth the money
8

Glenmark Therapeutics
Glenmark Maximum Strength Famotidine Tablets, 20 mg, Acid Reducer for Heartburn Relief, 200 Count
Main highlights

Effective Acid Reducer
Includes 20 mg of Famotidine for quick heartburn relief.

Ideal for Frequent Heartburn
Perfect for those experiencing frequent heartburn or indigestion.

Highly Praised Affordability
Praised for its cost-effectiveness compared to name brands.
8.8

Very Good

Our Rating

9.9
simple to consume

9.3
worth the money
9

Amazon Basic Care
Amazon Basic Care Omeprazole Delayed Release Tablets 20 mg, Acid Reducer, 14 Count (Packaging may vary)
Main highlights

Effective Acid Reducer
Contains omeprazole 20 mg, a PPI that reduces stomach acid.

Frequent Heartburn Treatment
Best for treating heartburn occurring 2+ times a week.

Great Value
Praised for cost-effectiveness compared to similar products.
8.7

Very Good

Our Rating

9.3
simple to consume

9.3
worth the money

9.1
Flavor
10

Ohm
Ohm Omeprazole 20mg, 42 Delayed-Release Tablets, Acid Reducer for Frequent Heartburn, 24-Hour Relief Heartburn Medicine, Helps Relieve Stomach & Chest Discomfort (6 Weeks of Supply, 42, Count)

20% Off
Main highlights

Effective Stomach Acid Reduction
Ohm Omeprazole Tablets provide effective relief from frequent heartburn by reducing stomach acid with delayed-release technology.

Ideal for Regular Use
Perfect for individuals needing consistent heartburn management, offering three 14-day treatment courses in one package.

Easy Swallowing Experience
Customers appreciate the coated tablets for being easier to swallow compared to capsules.
8.6

Very Good

Our Rating

10 Best acid reflux medicines of 2025

1

Amazon Basic Care Maximum Strength Famotidine Tablets Acid Reducer for Heartburn Relief, 20 mg, 400 Count Pack

How do we rank?

How do we rank?

Analyzing top stores

2

Amazon Basic Care Esomeprazole Magnesium Delayed Release Capsules, 20 mg, Acid Reducer, Heartburn Medicine, 42 Count

9.5

8.4

3

Amazon Basic Care Omeprazole Delayed Release Tablets 20 mg, Treats Frequent Heartburn, Acid Reducer, Heartburn Medicine, 42 Count (Pack of 1) (Packaging may vary)

9.9

9.3

9.3

4

Amazon Basic Care Maximum Strength Famotidine Tablets 20 mg, Acid Reducer Pills for Heartburn Relief, 200 Count (Packaging may vary)

9.9

9.3

9.1

5

Amazon Basic Care Maximum Strength Famotidine Tablets 20 mg, Acid Reducer for Heartburn Relief, 50 Count

9.9

9.3

9.1

6

Timely Acid Reducer Famotidine 20mg - Anatcid Acid Reflux Medicine for Heartburn Relief and Acid Indigestion Symptoms - 200 Tablets

7

Pepcid AC Maximum Strength Heartburn Relief Tablets, OTC Medicine Prevents & Relieves Heartburn Due to Acid Indigestion, 20mg Famotidine Acid Reducer, Fast-Acting, 25 Ct

9.9

9.7

9.1

8

Glenmark Maximum Strength Famotidine Tablets, 20 mg, Acid Reducer for Heartburn Relief, 200 Count

9.9

9.3

9

Amazon Basic Care Omeprazole Delayed Release Tablets 20 mg, Acid Reducer, 14 Count (Packaging may vary)

9.3

9.3

9.1

10

Ohm Omeprazole 20mg, 42 Delayed-Release Tablets, Acid Reducer for Frequent Heartburn, 24-Hour Relief Heartburn Medicine, Helps Relieve Stomach & Chest Discomfort (6 Weeks of Supply, 42, Count)

Sign up and get exclusive special deals