Our rankings are cleverly generated from the algorithmic analysis of thousands of customer reviews about products, brands, merchant’s customer service levels, popularity trends, and more. The rankings reflect our opinion and should be a good starting point for shopping. By purchasing the products we rank, you’ll get the lowest price we found while we may receive a commission at no cost to you, which will help us continue to provide you with value.
Advertising Disclosure
10 Best acid reflux medicines of 2025
Explore up to 34% off
- Best Choice
1
Clicked 6 times in the last monthAmazon Basic CareAmazon Basic Care Esomeprazole Magnesium Delayed-Release Mini Capsules, 20 mg, Acid Reducer, 24 Hour Heartburn Medicine, 42 Count
- Curious about how we select the top products for you? Explore How It Works
- Value for Money
2
OhmOhm Omeprazole Tablets, Delayed-Release Tablets, 20mg Acid Reducer, 42 Tablets
3
Amazon Basic CareAmazon Basic Care Omeprazole Delayed Release Tablets 20 mg, Treats Frequent Heartburn, Acid Reducer, Heartburn Medicine, 42 Count (Pack of 1) (Packaging may vary)
34% Off4
Amazon Basic CareAmazon Basic Care Maximum Strength Famotidine Tablets 20 mg, Acid Reducer Pills for Heartburn Relief, 200 Count (Packaging may vary)
5
HealthCareAisleHealthCareAisle Omeprazole 20 mg, 42 Delayed-Release Capsules - Acid Reducer, Treats Frequent Heartburn, 42 Count (Pack of 1)
-
See Today’s Deals & Prices
6
CuristCurist Famotidine 20mg Bulk Pack (300 Count Tablets) Acid Reflux Medicine for Heartburn Relief - OTC Maximum Strength Stomach Acid Reducer - Anti Acid Relief Tablets for Indigestion Heartburn Relief
28% Off7
Amazon Basic CareAmazon Basic Care Esomeprazole Magnesium Delayed Release Capsules, 20 mg, Acid Reducer, Heartburn Medicine, 42 Count
20% Off8
Glenmark TherapeuticsGlenmark Maximum Strength Famotidine Tablets, 20 mg, Acid Reducer for Heartburn Relief, 200 Count
9
TUMSTUMS Chewy Bites Antacid Tablets for Chewable Heartburn Relief and Acid Indigestion Relief, Assorted Berries - 60 Count
10
TIME-CAP LABS, INC.Timely Acid Reducer Famotidine 20mg - Compare to the active ingredient in Maximum Strength Pepcid AC - Acid Reflux Medicine for Heartburn Relief and Acid Indigestion Symptoms - 200 Tablets