10 Best topical antimicrobials of 2025

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Best Choice

1

Hibiclens
Hibiclens – Antimicrobial and Antiseptic Soap and Skin Cleanser – 8 oz with Foaming Pump – for Home and Hospital – 4% CHG

22% Off
Main highlights

Advanced Antimicrobial Protection
Hibiclens provides lasting antimicrobial action, killing germs on contact and continuing to protect even after rinsing.

Ideal for Medical and Home Use
Perfect for pre-operative patient bathing and everyday home use to reduce infection risk.

Highly Recommended by Experts
Top choice among pharmacists and dermatologists for antiseptic skin cleansing.
Key specs
- Active Ingredients:Chlorhexidine gluconate
- Type:Antibacterial, antiseptic
- Usage:Pre-operative patient bathing
- Form:Antiseptic skin cleanser
- Application:Foam pump
9.9

Exceptional

Our Rating
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Value for Money

2

Neosporin
Neosporin + Maximum-Strength Pain Relief Dual Action Cream, First Aid Topical Antibiotic and Analgesic Cream for Wound Care of Minor Cuts, Scrapes and Burns, Polymyxin B & Pramoxine HCl, 1 oz

20% Off
Main highlights

24-Hour Infection Protection
Contains neomycin and polymyxin B for continuous infection defense.

Versatile Use for Humans and Pets
Ideal for treating scrapes and wounds on both humans and pets.

Easy Application and Short-term Numbing
Praised for its easy application and immediate, though brief, numbing effect.
Key specs
- Active Ingredients:Neomycin, polymyxin B
- Usage:Infection prevention, pain relief
- Formulation:Ointment
- Packaging:Tube
- Country of Origin:USA
9.8

Exceptional

Our Rating

9.7
Simple to use

9.5
pain management

9.1
worth the money
3

neosporin
Neosporin Original First Aid Antibiotic Ointment with Bacitracin Zinc for Infection Protection, Wound Care Treatment & Scar Appearance Minimizer for Minor Cuts, Scrapes and Burns,.5 oz

27% Off
Main highlights

24-Hour Infection Protection
Neosporin Original provides 24-hour infection protection for minor cuts, scrapes, and burns with its powerful antibiotic formula.

Ideal for Minor Wounds
Perfect for treating minor cuts, scrapes, and burns, ensuring quick and effective healing.

Highly Praised for Effectiveness
Customers frequently praise its effectiveness and ease of use for minor emergencies.
Key specs
- Active Ingredients:neomycin sulfate, bacitracin zinc, polymyxin B
- Usage:Apply 1 to 3 times daily
- Formulation:Ointment
- Packaging:Tube
- Country of Origin:USA
9.7

Exceptional

Our Rating

9.9
For Gentle skin

9.7
Simple to use

9.7
For traveling
4

Thera Care
Thera Care Triple Antibiotic Ointment | First Aid | Infection Prevention and Protection | 1.0 oz | Topical Wound Care for Minor Scrapes and Cuts
Main highlights

Long-lasting Protection
Provides extended protection against infections for minor cuts, scrapes, and burns with antibiotic ointment.

Ideal for Minor Wounds
Perfect for treating minor scrapes, cuts, and fresh piercings, aiding in faster healing.

Highly Praised Effectiveness
Customers commend its efficiency in healing and preventing infections effectively.
Key specs
- Active Ingredients:Bacitracin Zinc
- Type:N/A
- Usage:Treats minor cuts, scrapes
- Form:N/A
- Application:N/A
9.5

Excellent

Our Rating
5

Polysporin
Polysporin First Aid Topical Antibiotic Skin Ointment with Bacitracin Zinc & Polymyxin B Sulfate, for Infection Protection & Wound Care, Neomycin-Free, Travel Size, 0.5 oz

28% Off
Main highlights

Effective Infection Prevention
Combines bacitracin zinc and polymyxin B sulfate for powerful infection protection.

Ideal for Minor Wounds
Best used for cuts, scrapes, burns, and minor wounds.

Rapid Healing
Frequently praised for its fast healing properties in customer reviews.
9.4

Excellent

Our Rating
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6

CareAll
CareAll Triple Antibiotic Ointment (25 Pack), 0.9gr Foil Packet. First Aid Ointment That Prevents Infection in Minor Scrapes, Cuts, and Burns
Main highlights

Antibiotic Ointment Formulation
FIRST AID ANTIBIOTIC OINTMENT for the prevention of infections in minor cuts, scrapes and burns. Formulated to be phthalate-free, paraben-free, dye-free, and fragrance-free.

Ideal for Travel and First Aid Kits
SINGLE USE each 0.9 gram foil packet is easy to dispense. Perfect for travel, glove compartments, first aid kits in homes, cars, workshops, and workplaces.

Convenient Single Use Packets
Customers frequently praise the convenience of the single-use packets, noting they are perfect for travel, first aid kits, and on-the-go situations.
Key specs
- Active Ingredients:Bacitracin Zinc, Neomycin, Polymyxin B
- Type:Single use
- Usage:First aid antibiotic
- Form:Ointment
- Application:Minor cuts, scrapes, burns
9.3

Excellent

Our Rating

9.9
movability

9.9
dispense easily

9.7
worth the money
7

A+D

A+D Antimicrobial Hydrogel Spray – with Hypochlorous Acid, Removes Germs, Helps Heal Rashes & Irritations, Reduces Itch & Pain, Alcohol-Free, Non-Sting Formula, Safe for All Ages, 4oz
9.2

Excellent

Our Rating
8

Globe
Globe Triple Antibiotic Ointment 1.0 oz (4 Pack), First Aid Ointment for Minor Scrapes, Cuts, and Burns to Help Prevent Infection, Compare to The Active Ingredients of The Leading Brand.

43% Off
Main highlights

Infection Protection
Provides 24-hour protection against infections in minor cuts, scrapes, and burns.

First Aid Essential
Ideal for first aid kits and treating minor injuries at home or on the go.

Customer Praised Value
Praised for identical ingredients and effectiveness as leading brands at a lower price.
Key specs
- Active Ingredients:Neomycin, Bacitracin, Polymyxin
- Type:N/A
- Usage:First aid for cuts
- Form:N/A
- Application:N/A
9.0

Excellent

Our Rating

9.7
Simple to use

9.5
worth the money
9

Bactine
Bactine MAX Antibiotic + Pain Relieving Ointment - Antibiotic Ointment with Lidocaine - Pain + Itch Relief for Minor Cuts & Scrapes & Burns - Lidocaine Numbing Cream - 0.5oz
Main highlights

Pain_Itch_Relief_and_Germ_Protection
Bactine MAX combines pain relief and germ protection with lidocaine and Bacitracin.

Ideal_for_First_Aid_Kits
Perfect for treating minor cuts, burns, and bug bites quickly.

Highly_Praised_Quick_Soothing_Effect
Customers love its fast-acting relief and smooth application.
Key specs
- Active Ingredients:Bacitracin, Lidocaine
- Usage:Pain and itch relief
- Formulation:Ointment
- Packaging:Tube
- Country of Origin:N/A
8.9

Very Good

Our Rating
10

CareAll

CareAll Triple Antibiotic Ointment 1.0 oz (3 Pack), First Aid Ointment for Minor Cuts, Scrapes, and Burns to Help Prevent Infection, Compare to The Active Ingredients of Leading Brands
8.8

Very Good

Our Rating

10 Best topical antimicrobials of 2025

1

Hibiclens – Antimicrobial and Antiseptic Soap and Skin Cleanser – 8 oz with Foaming Pump – for Home and Hospital – 4% CHG

How do we rank?

How do we rank?

Analyzing top stores

2

Neosporin + Maximum-Strength Pain Relief Dual Action Cream, First Aid Topical Antibiotic and Analgesic Cream for Wound Care of Minor Cuts, Scrapes and Burns, Polymyxin B & Pramoxine HCl, 1 oz

9.7

9.5

9.1

3

Neosporin Original First Aid Antibiotic Ointment with Bacitracin Zinc for Infection Protection, Wound Care Treatment & Scar Appearance Minimizer for Minor Cuts, Scrapes and Burns,.5 oz

9.9

9.7

9.7

4

Thera Care Triple Antibiotic Ointment | First Aid | Infection Prevention and Protection | 1.0 oz | Topical Wound Care for Minor Scrapes and Cuts

5

Polysporin First Aid Topical Antibiotic Skin Ointment with Bacitracin Zinc & Polymyxin B Sulfate, for Infection Protection & Wound Care, Neomycin-Free, Travel Size, 0.5 oz

6

CareAll Triple Antibiotic Ointment (25 Pack), 0.9gr Foil Packet. First Aid Ointment That Prevents Infection in Minor Scrapes, Cuts, and Burns

9.9

9.9

9.7

7

A+D Antimicrobial Hydrogel Spray – with Hypochlorous Acid, Removes Germs, Helps Heal Rashes & Irritations, Reduces Itch & Pain, Alcohol-Free, Non-Sting Formula, Safe for All Ages, 4oz

8

Globe Triple Antibiotic Ointment 1.0 oz (4 Pack), First Aid Ointment for Minor Scrapes, Cuts, and Burns to Help Prevent Infection, Compare to The Active Ingredients of The Leading Brand.

9.7

9.5

9

Bactine MAX Antibiotic + Pain Relieving Ointment - Antibiotic Ointment with Lidocaine - Pain + Itch Relief for Minor Cuts & Scrapes & Burns - Lidocaine Numbing Cream - 0.5oz

10

CareAll Triple Antibiotic Ointment 1.0 oz (3 Pack), First Aid Ointment for Minor Cuts, Scrapes, and Burns to Help Prevent Infection, Compare to The Active Ingredients of Leading Brands

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