10 Best stress reduction supplements of 2025

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Best Choice

1

LifeSeasons
LifeSeasons Anxie-T - Stress Relief Supplement - Supports Mood & Mental Focus - Feel Calm and Relaxed - Eases Tension & Nervousness - Ashwagandha, Kava Kava, GABA & L-Theanine - 60 Capsules
Main highlights

Stress Relief and Calmness
Anxie-T helps manage stress symptoms, promoting calmness without causing fatigue.

Ideal for Stressful Situations
Perfect for work stress, anxiety management, and focus improvement.

Praised Ingredient Combination
Customers love the blend of L-theanine, Ashwagandha, and GABA.
9.9

Exceptional

Our Rating

9.1
Flavor

8.7
worth the money
How do we rank?

Our rankings are cleverly generated from the algorithmic analysis of thousands of customer reviews about products, brands, merchant’s customer service levels, popularity trends, and more. The rankings reflect our opinion and should be a good starting point for shopping. By purchasing the products we rank, you’ll get the lowest price we found while we may receive a commission at no cost to you, which will help us continue to provide you with value.
Value for Money

2

LES Labs
LES Labs Cortisol Health – Stress Relief, Balanced Cortisol Response, Relaxation & Deep Sleep – Phosphatidylserine, Magnesium, Magnolia Bark, Rhodiola Rosea & Ashwagandha – Non-GMO – 60 Capsules
Main highlights

Natural Stress Relief and Sleep Support
Formulated with natural ingredients to promote relaxation and restful sleep.

Ideal for Stressful Lifestyles
Perfect for individuals experiencing stress and sleep disturbances.

Highly Praised for Sleep Improvement
Customers love its effectiveness in enhancing sleep quality.
9.6

Exceptional

Our Rating

9.5
simple to consume

9.3
quality of ingredients

8.9
quality of sleep
3

OLLY
OLLY Ultra Goodbye Stress Softgels, 60ct
Main highlights

Stress Relief Formula
Blended with GABA, Ashwagandha, L-Theanine, and Lemon Balm for calmness.

Ideal for Corporate Stress
Perfect for professionals needing stress management in high-pressure environments.

Ease of Use
Frequently praised for easy swallowing and quick absorption.
9.3

Excellent

Our Rating

9.3
simple to consume

8.9
Flavor

8.0
worth the money
4

Zenium
Zenium - Relieve Stress, Tension, Worry, Nervousness, & Irritability | Calm The Mind & Body | Ayurvedic | Natural Relief Supplement | Boosts Mood | Ashwagandha, L-Theanine, GABA, Rhodiola |60 Capsules
Main highlights

Natural Stress Relief
Zenium offers plant-based, vegan stress relief with 9+ powerful ingredients like Ashwagandha and GABA.

Ideal for Anxiety and Sleep
Perfect for managing anxiety, improving focus, and enhancing sleep quality.

Calming Without Drowsiness
Users praise its calming effects without causing drowsiness, enhancing focus and serenity.
9.2

Excellent

Our Rating

9.9
worth the money

9.5
simple to consume

9.5
Flavor
5

Nature's Bounty
Nature's Bounty Stress Relief, Ashwagandha KSM-66, Supports Occasional Stress Relief, Dietary Supplement, Tablets, 90 Ct

27% Off
Main highlights

Clinically Studied Ashwagandha KSM-66
Features KSM-66 Ashwagandha, a clinically studied extract for stress relief.

Ideal for Daily Stress Management
Perfect for those seeking natural support for occasional stress.

Praised for Mood Enhancement
Customers love its calming effect and mood improvement.
9.1

Excellent

Our Rating
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6

Integrative Therapeutics
Integrative Therapeutics - Cortisol Manager - Supplement with Ashwagandha and L-Theanine - Supports Relaxation & Calm* - 30 Tablets
Main highlights

Supports Balanced Cortisol Levels
Cortisol Manager tablets aid in maintaining healthy cortisol levels and stress response.

Ideal for Stress and Sleep Issues
Perfect for individuals seeking stress relief and improved sleep quality.

Praised for Sleep Improvement
Customers frequently commend its effectiveness in enhancing sleep patterns.
9.0

Excellent

Our Rating

8.0
quality of sleep

8.0
Precision

8.0
worth the money
7

THORNE
THORNE Adrenal Cortex - Supplement for Cortisol Management - Support Healthy Adrenal Gland Function, Immune System, Stress Management, Fatigue & Metabolism* - 60 Capsules
Main highlights

Adrenal Support and Stress Management
Formulated to nourish adrenal glands, regulate metabolism, and manage stress response.

Ideal for Stress and Fatigue
Best for individuals experiencing stress, fatigue, or seeking energy boost.

Praised for Motivation Boost
Customers frequently praise increased motivation and energy levels.
8.8

Very Good

Our Rating

9.9
Flavor

9.1
simple to consume

8.9
worth the money
8

Futurebiotics
Futurebiotics Ashwagandha Extra Strength Stress & Mood Support with BioPerine - Non GMO Formula, 100 Vegetarian Capsules
Main highlights

Extra Strength Adaptogenic Support
Futurebiotics Ashwagandha provides 150mg 20:1 extract for stress adaptation.

Ideal for Stress and Mood Management
Helps maintain healthy cortisol levels and supports positive mood.

Highly Praised for Easy Consumption
Small, easy-to-swallow capsules praised for aiding stress relief.
Key specs
- Gluten-Free:Yes
- Ingredients:Ashwagandha, BioPerine
- Non-GMO:Yes
- Potency:Extra Strength
- Dosage:150mg 20:1 extract
8.7

Very Good

Our Rating
9

NUTRAHARMONY

Stress Relief Support 500 mg - Relax, Calm & Sleep Support - Stress Gummies with L-Theanine | GABA | Ashwagandha | 5-HTP | Vitamin B6 & Magnesium - Sugar-Free, Vegan, Mixed Berry Flavor - 60 Gummies
8.6

Very Good

Our Rating
10

Boiron
Boiron StressCalm for Relief of Stress, Anxiousness, Nervousness, Irritability, and Fatigue - 60 Count

29% Off
Main highlights

Plant-Powered Stress Relief
StressCalm utilizes plant-based ingredients to alleviate stress symptoms like nervousness and fatigue without causing drowsiness.

Convenient On-the-Go Use
Ideal for adults and children over 12, these meltaway tablets are perfect for home, work, or travel.

Non-Drowsy Effectiveness
Customers appreciate the non-drowsy formula, allowing relaxation without sedation.
8.4

Good

Our Rating

8.0
Flavor

8.0
worth the money

10 Best stress reduction supplements of 2025

1

LifeSeasons Anxie-T - Stress Relief Supplement - Supports Mood & Mental Focus - Feel Calm and Relaxed - Eases Tension & Nervousness - Ashwagandha, Kava Kava, GABA & L-Theanine - 60 Capsules

9.1

8.7

2

LES Labs Cortisol Health – Stress Relief, Balanced Cortisol Response, Relaxation & Deep Sleep – Phosphatidylserine, Magnesium, Magnolia Bark, Rhodiola Rosea & Ashwagandha – Non-GMO – 60 Capsules

9.5

9.3

8.9

3

OLLY Ultra Goodbye Stress Softgels, 60ct

9.3

8.9

8.0

4

Zenium - Relieve Stress, Tension, Worry, Nervousness, & Irritability | Calm The Mind & Body | Ayurvedic | Natural Relief Supplement | Boosts Mood | Ashwagandha, L-Theanine, GABA, Rhodiola |60 Capsules

9.9

9.5

9.5

5

Nature's Bounty Stress Relief, Ashwagandha KSM-66, Supports Occasional Stress Relief, Dietary Supplement, Tablets, 90 Ct

6

Integrative Therapeutics - Cortisol Manager - Supplement with Ashwagandha and L-Theanine - Supports Relaxation & Calm* - 30 Tablets

8.0

8.0

8.0

7

THORNE Adrenal Cortex - Supplement for Cortisol Management - Support Healthy Adrenal Gland Function, Immune System, Stress Management, Fatigue & Metabolism* - 60 Capsules

9.9

9.1

8.9

8

Futurebiotics Ashwagandha Extra Strength Stress & Mood Support with BioPerine - Non GMO Formula, 100 Vegetarian Capsules

9

Stress Relief Support 500 mg - Relax, Calm & Sleep Support - Stress Gummies with L-Theanine | GABA | Ashwagandha | 5-HTP | Vitamin B6 & Magnesium - Sugar-Free, Vegan, Mixed Berry Flavor - 60 Gummies

10

Boiron StressCalm for Relief of Stress, Anxiousness, Nervousness, Irritability, and Fatigue - 60 Count

8.0

8.0

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