10 Best spot acne treatments of 2025

Save up to 31% off

Best Choice

1

La Roche-Posay
La Roche-Posay Effaclar Adapalene Gel 0.1% Acne Treatment, Retinoid Cream, Acne Medication Gel For Blackheads & Whiteheads, Oil Free, Helps Clear And Prevent Blemishes & Clogged Pores
Main highlights

Prescription Strength Acne Treatment
La Roche-Posay Effaclar Adapalene Gel 0.1% effectively clears and prevents acne and clogged pores with prescription-strength retinoid.

Ideal for Acne and Hyperpigmentation
Best suited for individuals struggling with acne, clogged pores, and hyperpigmentation, delivering noticeable improvements in skin clarity and texture.

Rapid Results Praised by Users
Customers frequently highlight its fast-acting nature, clearing acne and reducing hyperpigmentation within weeks of use.
9.9

Exceptional

Our Rating

9.1
Aroma

8.9
worth the money

8.0
Moisturizing
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Value for Money

2

Murad
Murad Rapid Relief Acne Spot Treatment – Acne Control Max Strength 2% Salicylic Acid Invisible Gel Spot Solution for Fast Acne Relief - Reduces Blemish Size and Redness Within 4 Hours, 0.5 Oz
Main highlights

Fast Acne Relief with Science-Backed Formula
Murad Rapid Relief Acne Spot Treatment offers fast acne relief using 2% salicylic acid, scientifically proven for effectiveness.

Ideal for On-the-Spot Application
Best used for targeted acne treatment, apply directly to blemishes for quick results.

Smooth Skin Finish Praised by Users
Users love that it leaves skin feeling smooth without dryness, a standout feature.
9.8

Exceptional

Our Rating
3

AcneFree
AcneFree Terminator 10 Acne Spot Treatment with Benzoyl Peroxide 10% Maximum Strength Acne Cream Treatment, 1 Ounce - Pack Of 1

31% Off
Main highlights

Maximum Strength Benzoyl Peroxide
Contains 10% benzoyl peroxide for effective acne treatment and redness control.

Ideal for Spot Treatment
Best used for treating individual pimples and mild recurring acne.

Convenient Flip-Cap Design
Praised for its easy-to-use flip-cap that prevents loss and simplifies application.
Key specs
- Skin Benefits:Redness Control
- Formulation:Cream
- Skin Type:N/A
- Application Frequency:N/A
- Exfoliation Type:N/A
9.6

Exceptional

Our Rating

9.7
quality of ingredients

8.4
worth the money

8.0
Sheerness
4

Mighty Patch
Mighty Patch™ Original patch from Hero Cosmetics - Hydrocolloid Acne Pimple Patch for Covering Zits and Blemishes in Face and Skin, Vegan-friendly and Not Tested on Animals (36 Count)
Main highlights

Overnight Pimple Treatment
Mighty Patch Original uses hydrocolloid to visibly improve pimples overnight, reducing redness and size.

Best for Night Use
Ideal for overnight use, these patches stay on securely while you sleep.

Customer Praised Adhesion
Customers love the strong adhesion that keeps the patch in place all night.
9.5

Excellent

Our Rating

9.5
Simple to use

9.5
Simple to take off

9.5
Attachment
5

Neutrogena
Neutrogena On-The-Spot Acne Spot Treatment with 2.5% Benzoyl Peroxide Acne Treatment Medication to Treat Face Acne, Gentle Benzoyl Peroxide Pimple Cream for Acne Prone Skin Care,.75 oz

31% Off
Main highlights

Effective Acne Treatment with Benzoyl Peroxide
.75-ounce tube with 2.5% benzoyl peroxide fights acne gently.

Ideal for Daily Use on Acne-Prone Skin
Use up to three times daily without over-drying.

Praised for Quick and Visible Results
Customers appreciate its effectiveness and quick results.
Key specs
- Skin Type:All skin types
- Formulation:Cream
- Effects:Fights acne
- Niacinamide:N/A
- Hyaluronic Acid:N/A
9.4

Excellent

Our Rating
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6

Neutrogena
Neutrogena Rapid Clear Stubborn Acne Spot Treatment Gel with Maximum Strength 10% Benzoyl Peroxide Acne Treatment Medication, Pimple Cream for Acne Prone Skin Care, 1 oz

27% Off
Main highlights

Maximum Strength Benzoyl Peroxide
Contains 10% benzoyl peroxide for rapid acne reduction.

Ideal for Stubborn Acne
Perfect for treating stubborn acne on acne-prone skin.

Quick and Effective Results
Praised for reducing acne size and redness within hours.
9.2

Excellent

Our Rating

8.7
Aroma

8.4
Fashion

8.2
worth the money
7

Differin
Differin Acne Treatment Gel, 30 Day Supply, Retinoid Treatment for Face with 0.1% Adapalene, Gentle Skin Care for Acne Prone Sensitive Skin, 15g Tube (Packaging May Vary)
Main highlights

Effective Acne Treatment
Differin Gel targets clogged pores and inflammation, reducing breakouts and improving skin texture and tone.

Ideal for Acne-Prone Skin
Best for those with acne-prone, sensitive skin needing a gentle retinoid treatment.

Praised for Clear Skin
Customers love its ability to keep skin clear and smooth, even with hormonal or diet-related acne.
9.0

Excellent

Our Rating

8.2
worth the money

8.0
Aroma

8.0
Fashion
8

Clean & Clear
Clean & Clear, Persa-Gel 10 Acne Spot Treatment, Maximum Strength, 1 Oz

25% Off
Main highlights

Maximum Strength Formula
Contains 10% benzoyl peroxide for effective acne treatment.

Ideal for Spot Treatment
Perfect for inflamed acne bumps and quick results.

Highly Praised for Quick Results
Users report visible reduction in acne overnight.
8.9

Very Good

Our Rating
9

CeraVe
CeraVe Acne Control Gel, 2% Salicylic Acid Treatment With Glycolic Acid + Lactic Acids + Niacniamide, Acne Gel Helps Clear Blemishes Without Over Drying, Alcohol Free & Oil Free, 1.35 Fl Oz

18% Off
Main highlights

Advanced Exfoliation and Hydration
Combines BHA and AHA to clear acne, smooth skin, and maintain moisture.

Ideal for Sensitive and Acne-Prone Skin
Perfect for those seeking gentle yet effective acne treatment.

Unmatched Performance and Affordability
Praised for its effective results and affordable price point.
8.8

Very Good

Our Rating

8.9
worth the money

8.9
For Gentle skin

8.7
Aroma
10

Rael
Rael Pimple Patches, Miracle Invisible Spot Cover - Hydrocolloid Acne Patch, Treatment for Breakouts, Absorbs Zits & Blemish, Korean Skin Care, 2 Sizes (96 Count)
Main highlights

Gentle_Effective_Care
Made with medical-grade hydrocolloid, non-drying, hypoallergenic.

Ideal_for_Acne_and_Blemishes
Perfect for pimples, blemishes, and bug bites; two sizes available.

Highly_Praised_Invisibility
Clear, matte finish blends with all skin tones.
Key specs
- Function:Draws out pus
- Skin Type:All skin tones
- Usage:All day, night
- Form:Patch
- Size:10mm and 12mm
8.6

Very Good

Our Rating

9.5
Simple to take off

9.5
Attachment

9.3
For Gentle skin

10 Best spot acne treatments of 2025

1

La Roche-Posay Effaclar Adapalene Gel 0.1% Acne Treatment, Retinoid Cream, Acne Medication Gel For Blackheads & Whiteheads, Oil Free, Helps Clear And Prevent Blemishes & Clogged Pores

9.1

8.9

8.0

How do we rank?

How do we rank?

Analyzing top stores

2

Murad Rapid Relief Acne Spot Treatment – Acne Control Max Strength 2% Salicylic Acid Invisible Gel Spot Solution for Fast Acne Relief - Reduces Blemish Size and Redness Within 4 Hours, 0.5 Oz

3

AcneFree Terminator 10 Acne Spot Treatment with Benzoyl Peroxide 10% Maximum Strength Acne Cream Treatment, 1 Ounce - Pack Of 1

9.7

8.4

8.0

4

Mighty Patch™ Original patch from Hero Cosmetics - Hydrocolloid Acne Pimple Patch for Covering Zits and Blemishes in Face and Skin, Vegan-friendly and Not Tested on Animals (36 Count)

9.5

9.5

9.5

5

Neutrogena On-The-Spot Acne Spot Treatment with 2.5% Benzoyl Peroxide Acne Treatment Medication to Treat Face Acne, Gentle Benzoyl Peroxide Pimple Cream for Acne Prone Skin Care,.75 oz

6

Neutrogena Rapid Clear Stubborn Acne Spot Treatment Gel with Maximum Strength 10% Benzoyl Peroxide Acne Treatment Medication, Pimple Cream for Acne Prone Skin Care, 1 oz

8.7

8.4

8.2

7

Differin Acne Treatment Gel, 30 Day Supply, Retinoid Treatment for Face with 0.1% Adapalene, Gentle Skin Care for Acne Prone Sensitive Skin, 15g Tube (Packaging May Vary)

8.2

8.0

8.0

8

Clean & Clear, Persa-Gel 10 Acne Spot Treatment, Maximum Strength, 1 Oz

9

CeraVe Acne Control Gel, 2% Salicylic Acid Treatment With Glycolic Acid + Lactic Acids + Niacniamide, Acne Gel Helps Clear Blemishes Without Over Drying, Alcohol Free & Oil Free, 1.35 Fl Oz

8.9

8.9

8.7

10

Rael Pimple Patches, Miracle Invisible Spot Cover - Hydrocolloid Acne Patch, Treatment for Breakouts, Absorbs Zits & Blemish, Korean Skin Care, 2 Sizes (96 Count)

9.5

9.5

9.3

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