Our rankings are cleverly generated from the algorithmic analysis of thousands of customer reviews about products, brands, merchant’s customer service levels, popularity trends, and more. The rankings reflect our opinion and should be a good starting point for shopping. By purchasing the products we rank, you’ll get the lowest price we found while we may receive a commission at no cost to you, which will help us continue to provide you with value.
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10 Best sedative for dogs of 2025
Save up to 46% off
Best Choice1
Pro Plan Veterinary DietsPurina Pro Plan Veterinary Supplements Calming Care - Calming Dog Supplements - 30 ct. Boxes
Key specs-
Usage:Calming supplement
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Target:Dogs
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Form:Powder
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Active Ingredients:N/A
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Flavor:N/A
9.7Exceptional
Our Rating
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Value for Money2
GOODGROWLIESGOODGROWLIES Melatonin for Dogs to Sleep 6mg - Doggie Sleep Aid Treats - Sleeping Pills for Anxiety - Extra Strength Calming Chews Large & Medium Breed Help Sleep at Night - Made in USA - 120Ct
17% Off9.5Excellent
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3
Vet PromiseAdvanced Calming Chews for Dogs - Hemp Dog Calming Chews - Anxiety Relief with Melatonin - Stress & Separation Anxiety - Sleep Aid + Hip and Joint Supplement Support - Made in USA - 70 Treats
11% Off9.4Excellent
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4
VETIQVetIQ Calming Support Supplement for Dogs, Calming Chews Help Manage Stress and Promote Relaxation, Anxiety Relief for Dogs, Made in The USA, 60 Count
Key specs-
Dimensions:1.5 x 6.18 x 7.75 inches
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Health Benefit:Maintains calmness, promotes relaxation
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Country of Origin:USA
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Formulation:N/A
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Ingredients:N/A
9.3Excellent
Our Rating
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5
ZZTRMYZZTRMY Melatonin for Dogs,Dog Sleep Aid,Calming for Dogs,Promote Relaxation,Reduce Anxiety and Stress,Regulates Sleep Patterns,Promotes Overall Well-Being,Vitamin and Probiotic Enriched Dog Melatonin
9.2Excellent
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6
NaturVetNaturVet Quiet Moments Calming Dog Supplement, Dog Soft Chews with Melatonin to Help Reduce Stress from Storms, The Vet, Fireworks, and Travel, Bacon and Chicken Flavored Pet Supplement, 70 Count Jar
9.1Excellent
Our Rating
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7
Pet Health SolutionsTranQuil-Tabs for Dogs - Contains Chamomile, L-Tryptophan, and Melatonin - Relieves Stress and Tension - Ease Travel and Separation Anxiety - 60 Tabs
Key specs-
Usage:Calming dogs
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Target:Dogs
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Form:Tablets
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Active Ingredients:Chamomile, Passion Flower, Valerian root
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Flavor:Vegetarian beef
9.0Excellent
Our Rating
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8
BARK&SPARKBARK&SPARK Advanced Calming Chews for Dogs - Hemp Chew + Melatonin - Anxiety Relief - Sleep Aid - Relaxing Treats - Stress Relief During Fireworks, Storms, Thunder, Barking - Made in USA - 60Ct
36% Off8.8Very Good
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9
RESCUEBach RESCUE REMEDY PET Dropper 10mL, Natural Stress Relief, Calming for Dogs, Cats, & Other Pets, Homeopathic Flower Essence, Thunder, Fireworks, Travel, Separation, Sedative-Free
8.6Very Good
Our Rating
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10
CHARLIE & BUDDYCharlie & Buddy Hemp Оil for Dogs Cats - Helps Pets with Аnxiеty, Pаin, Strеss, Slееp, Аrthritis, Sеizures Rеlief - Нiр Jоint Hеalth - Cаlming Trеats
46% OffKey specs-
Pet Age:All breeds and sizes
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Function:Relieves anxiety, reduces pain
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Form:Oil
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Ingredients:Omega 3, 6, 9, Vitamin E
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Health Benefits:Anti-inflammatory, mood boost
8.5Good
Our Rating
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