10 Best sam e supplements of 2025

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Best Choice

1

Pure Encapsulations
Pure Encapsulations SAMe S-Adenosylmethionine 180's - Supports Joint Health & Glutathione Production* - Gluten Free & Non-GMO - 60 Capsules
Main highlights

Methylation and Joint Support
Contains 200 mg SAM-e for methylation, joint comfort, and glutathione production.

Ideal for Joint and Mood Enhancement
Supports joint function, flexibility, and balanced mood for active lifestyle.

Customer Praise for Joint Relief
Praised for relieving joint stiffness and enhancing mood effectively.
9.9

Exceptional

Our Rating
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Value for Money

2

Doctor's BEST
Doctor's Best SAM-e 400 mg, Vegan, Gluten Free, Soy Free, Mood and Joint Support, 60 Enteric Coated Tablets
Main highlights

Mood and Cognitive Health Benefits
Doctors Best SAMe Double Strength enhances mood and promotes cognitive health.

Ideal for Joint and Liver Support
Proven to promote joint comfort, mobility, and supports liver health.

Highly Praised for Joint Relief
Users report significant joint pain relief, especially in hip injuries.
9.8

Exceptional

Our Rating

9.7
quality of ingredients

9.3
worth the money

8.9
simple to consume
3

Nature Made
Nature Made SAM-e Complete 400 mg, Dietary Supplement for Mood Support, 36 Tablets, 36 Day Supply

47% Off
Main highlights

Key Features
Nature Made SAM-e Complete supports healthy mood and joint comfort, gluten-free with no artificial flavors or preservatives.

Ideal Use Cases
Perfect for adults seeking mood enhancement and joint support, especially when taken on an empty stomach with water.

Customer Praise
Most reviews highlight its effectiveness in improving mood and reducing joint discomfort, with high marks for quality and reliability.
9.7

Exceptional

Our Rating

8.4
simple to consume

8.2
worth the money

8.0
pain management
4

Nature's Trove
Nature's Trove SAM-e 400mg 30 Enteric Coated Caplets. Vegan, Kosher, Non-GMO, Soy Free, Gluten Free - Mood and Joint Support - Cold Form Blister Packed.
Main highlights

Premium Quality and Absorption
Natures Trove SAM-e is enteric-coated for optimal absorption and freshness, offering vegan, Kosher, and non-GMO certification.

Mood and Joint Support
Ideal for individuals seeking natural support for mood stabilization and joint flexibility, especially during seasonal changes.

Positive Customer Feedback
Customers praise its effectiveness in improving mood and joint health without causing stomach upset.
9.4

Excellent

Our Rating

9.9
quality of ingredients

9.7
simple to consume

9.5
worth the money
5

NOW Foods
NOW Foods Supplements, SAMe (S-Adenosyl-L-Methionine)200 mg, Nervous System Support*, 60 Veg Capsules

44% Off
Main highlights

Supports Joint and Nervous System Health
NOW Supplements SAMe helps maintain joint health and supports nervous system function, promoting overall well-being.

Ideal for Mood Balance and Stress Management
Perfect for those seeking natural mood enhancement and stress relief without prescription medication side effects.

Highly Praised for Stomach Friendliness
Customers appreciate its gentle formulation, avoiding common digestive issues seen with other brands.
9.1

Excellent

Our Rating
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6

Nutricost
Nutricost SAM-e (S-Adenosyl-L-Methionine) 400mg Per Serving, 60 Servings, 200mg Per Capsule, 120 Capsules - Non-GMO, Gluten Free Same, Vegetarian
Main highlights

High Strength SAMe Formula
400mg of SAMe per serving, ideal for optimal support.

Suitable for Dietary Needs
Non-GMO, gluten-free, vegetarian-friendly; ideal for diverse diets.

Effective for COMP-T Gene Variant
Praised for beneficial effects on COMP-T gene variant issues.
8.9

Very Good

Our Rating
7

NOW Foods
NOW Foods Supplements, SAMe (S-Adenosyl-L-Methionine) 400 mg, Nervous System Support*, 60 Tablets

56% Off
Main highlights

Supports Nervous System and Emotional Well-Being
SAMe is essential for neurotransmitter synthesis, aiding mood and joint health.

Ideal for Pain Relief and Mood Enhancement
Effective for minor aches, mood support, and boosting energy levels.

Praised for Pain Relief and Mood Improvement
Users report significant relief from chronic pain and enhanced mood.
8.8

Very Good

Our Rating

9.9
quality of ingredients

9.7
pain management

9.3
worth the money
8

Jarrow Formulas

Jarrow Formulas® SAMe 200 mg, Supports Joint Health, Liver Function, Brain Metabolism, 60 Tablets, Up To A 60 Day Supply

35% Off
8.7

Very Good

Our Rating
9

Enerlix

1200 MG SAM e Supplement for Brain, Mood, Joint, and Liver, High Absorption SAM-e (S-Adenosyl-L-Methionine) with CoQ10, 5-HTP, Enteric Coated 60 Tablets, Vegan

20% Off
8.4

Good

Our Rating
10

Nature's Trove

SAM-e 200mg Daily Supplement - Vegan, Kosher, Non-GMO, Soy Free, Gluten Free - 60 Enteric Coated Tablets - Cold Form Blister Packed - by Nature’s Trove
8.2

Good

Our Rating

9.5
simple to consume

9.5
worth the money

8.2
pain management

10 Best sam e supplements of 2025

1

Pure Encapsulations SAMe S-Adenosylmethionine 180's - Supports Joint Health & Glutathione Production* - Gluten Free & Non-GMO - 60 Capsules

How do we rank?

How do we rank?

Analyzing top stores

2

Doctor's Best SAM-e 400 mg, Vegan, Gluten Free, Soy Free, Mood and Joint Support, 60 Enteric Coated Tablets

9.7

9.3

8.9

3

Nature Made SAM-e Complete 400 mg, Dietary Supplement for Mood Support, 36 Tablets, 36 Day Supply

8.4

8.2

8.0

4

Nature's Trove SAM-e 400mg 30 Enteric Coated Caplets. Vegan, Kosher, Non-GMO, Soy Free, Gluten Free - Mood and Joint Support - Cold Form Blister Packed.

9.9

9.7

9.5

5

NOW Foods Supplements, SAMe (S-Adenosyl-L-Methionine)200 mg, Nervous System Support*, 60 Veg Capsules

6

Nutricost SAM-e (S-Adenosyl-L-Methionine) 400mg Per Serving, 60 Servings, 200mg Per Capsule, 120 Capsules - Non-GMO, Gluten Free Same, Vegetarian

7

NOW Foods Supplements, SAMe (S-Adenosyl-L-Methionine) 400 mg, Nervous System Support*, 60 Tablets

9.9

9.7

9.3

8

Jarrow Formulas® SAMe 200 mg, Supports Joint Health, Liver Function, Brain Metabolism, 60 Tablets, Up To A 60 Day Supply

9

1200 MG SAM e Supplement for Brain, Mood, Joint, and Liver, High Absorption SAM-e (S-Adenosyl-L-Methionine) with CoQ10, 5-HTP, Enteric Coated 60 Tablets, Vegan

10

SAM-e 200mg Daily Supplement - Vegan, Kosher, Non-GMO, Soy Free, Gluten Free - 60 Enteric Coated Tablets - Cold Form Blister Packed - by Nature’s Trove

9.5

9.5

8.2

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