Our rankings are generated through the algorithmic analysis of thousands of customer reviews about products, brands, merchant customer service levels, popularity trends, and more. We use advanced technology, including AI, to help process and organize this information at scale, supporting our analysis with greater speed and consistency. The rankings reflect our opinion and should be a good starting point for shopping.
Advertising Disclosure
10 Best rls supplements of 2026
Explore top picks
Best Choice1
Hyland's9.6Exceptional
Hyland's Restful Legs PM Tablets, Nighttime Formula so You Can Sleep, 50ct
-
asin:B07F4CPP7C
-
product dimensions:1.38 x 2.75 x 4 inches; 0.8 ounces
-
date first available:June 26, 2018
-
item model number:HYRLPM-T50
-
best sellers rank:#3 in Single Homeopathic Remedies
-
-
Powerful technology We scan thousands of products and stores, analyzing reviews to find what matters most to users like you
Careful review Our team ensures quality, value, and fit based on real user feedback
Trusted insights AI and human analysis guide your decisions, reflecting real user prioritiesReal users impact
Thousands of users trust our site daily- Based on millions of stores and reviews
- Shoppers influence our rankings
Value for Money2
Calm Legs9.4Excellent
Calm Legs Natural for Natural Itching, Crawling, Tingling and Agitated Leg with Iron, Magnesium, and Valerian Root (60 Tablets)…
-
package dimensions:4.29 x 2.2 x 2.2 inches 0.39 ounces
-
asin:B09K4KX8DP
-
date first available:October 25, 2021
-
manufacturer:Biomedical Research Laboratories
-
3
Hyland's9.2Excellent
Hyland's Restful Legs Tablets, for Itching, Crawling, Tingling Relief, 50ct
-
is discontinued by manufacturer:No
-
product dimensions:4 x 2.75 x 1.38 inches; 0.8 ounces
-
asin:B00DQK9E5I
-
date first available:March 8, 2011
-
department:All Ages
-
4
Real Science Nutrition9.1Excellent
Real Science LegEase Miracle – All Natural Restless Legs Syndrome Relief & Leg Cramp Supplement with Vitamins C, D, K, B6, B12 + Nitric Oxide Support – Sleep & Circulation Aid – Made in USA, 60 Caps
-
5
Pure Encapsulations9.0Excellent
Pure Encapsulations OptiFerin-C, 60 Capsules
-
asin:B08LNRHMSX
-
product dimensions:3.5 x 1.9 x 1.6 inches 1.4 ounces
-
date first available:October 22, 2020
-
item model number:OF26
-
manufacturer:Pure Encapsulations
-
-
See Today’s Deals & Prices
6
Approved Science8.7Very Good
Approved Science Restlex for Restless Legs – Magnesium Glycinate for Calm Legs and Restful Legs – Natural Itching, Crawling, and Tingling in Feet and Legs - Calm, Restful Sleep Support - 1 Month
-
Magnesium Glycinate Blend:420 mg
-
L-theanine:200 mg
-
B Vitamins:Included
-
Capsule Count:60
-
Vitamin E:Included
-
7
MagniLife8.4Good
MagniLife Relaxing Legs Sublingual Tablets, 125 Count, Quick-Dissolving Homeopathic Pain Reliever & Nighttime Sleep Aid, Helps Calm Restless Legs, Discomfort & Sleepless Tossing
-
is discontinued by manufacturer:No
-
package dimensions:5.2 x 2.13 x 2.13 inches; 1.45 ounces
-
asin:B01JA13W54
-
date first available:August 1, 2016
-
best sellers rank:#16 in Joint & Muscle Pain Relief Medications
-
8
Hyland's8.3Good
Hyland's Restful Legs PM, Nighttime Formula, Calms Agitated Legs so You Can Sleep, 50 Quick Dissolving Tablets (Pack of 2)
-
asin:B07LCX9RPZ
-
product dimensions:4 x 4 x 8 inches 2.56 ounces
-
date first available:December 14, 2018
-
item model number:N/A
-
best sellers rank:N/A
-
9
SaltWrap8.2Good
SaltWrap Mag R&R Nighttime Muscle Cramp Relief, 90 Caps
-
is discontinued by manufacturer:No
-
package dimensions:4.21 x 2.18 x 2.16 inches; 2.89 ounces
-
asin:B01BRKA2YU
-
date first available:February 14, 2016
-
best sellers rank:N/A
-
10
HERBALICIOUS8.1Good
Quinine Liquid Extract 2oz – Restless Legs Syndrome Relief & Leg Cramps PM Nighttime Cramp Relief – All-Natural Cinchona Officinalis Bark Tincture for Cramp Defense, Digestive Health & Immune Support
-
package dimensions:5.08 x 1.85 x 1.77 inches 4.97 ounces
-
asin:B098B3JJ6H
-
date first available:June 30, 2021
-
manufacturer:HERBALICIOUS LLC
-
country of origin:USA
-
