July 16, 2025

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10 Best refrigerated probiotics of 2025

Save up to 20% off

Best Choice

1

VSL#3
VSL #3® Probiotics for Digestive Health, IBS & UC Symptoms - 112.5B CFUs, High-Potency, Multi-Strain, Live, Refrigerated Probiotic, Medical Food for Gut Health Support in Men & Women, 120 Capsules
Main highlights

High Potency Probiotics
VSL 3 112.5B high potency probiotic capsules contain 112.5 billion CFU per serving, significantly higher than most other probiotic products.

Ideal for Digestive Health
VSL 3 probiotics for women and men contain 8 complementary strains from 3 different genera to support digestive health and gut health.

Most Praised Feature
Many customers appreciate the effectiveness of VSL 3 in improving digestive issues and its recommendation by gastroenterologists.
Key specs
- Probiotic Strains:8 strains
- Formulation:Capsules
- CFU Amount:112.5 billion
- Prebiotic Type:N/A
- Capsule Size:N/A
9.7

Exceptional

Our Rating

9.9
quality of ingredients

8.0
Temperature control

8.0
worth the money
How do we rank?

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Based on millions of stores and reviews

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Value for Money

2

Visbiome
Visbiome® GI Care - High Potency Probiotic - 112.5 Billion CFU Live Probiotics, Original De Simone Formulation, Made in USA, 60 Capsules.
Main highlights

Powerful Probiotic Blend
Contains 8 clinically-tested strains with 112.5 billion CFU per capsule, designed for optimal gut health in both men and women.

Ideal for Gut Health Maintenance
Best for individuals needing potent probiotics for gut health, supported by over 100 clinical trials and recommended by doctors.

Highly Praised Cold Shipping
Customers appreciate the cold shipping with ice packs and temperature monitoring, ensuring the product arrives in optimal condition.
Key specs
- CFU:112.5 billion
- Form:Capsule
- Strains:8 clinically-tested
- Gluten Free:Yes
- Features:Low-FODMAP, Non-GMO
9.6

Exceptional

Our Rating

9.9
Packaging materials

9.9
Temperature control

9.7
quality of ingredients
3

Florajen
Florajen3 Digestion High Potency Refrigerated Probiotics | Restores Balance in Digestive System | for Antibiotic Side Effects | 60 Capsules
Main highlights

Key Features and Benefits
Allergen-free, non-GMO, and kosher, promoting digestive health with a multiculture blend in GMP-certified facilities.

Ideal Use Cases
Ideal for those with dietary restrictions, and to alleviate digestive upset, especially beneficial following antibiotic use.

Customer Reviews Summary
Most praised for its effectiveness in improving gut health and its ability to alleviate digestive discomfort without causing allergies.
Key specs
- Usage:Digestive health support
- Formulation:Capsules
- Ingredient Type:Lactobacillus acidophilus, Bifidobacterium
- Effect:Restore digestive balance
- Support Type:Digestive
9.5

Excellent

Our Rating

9.3
simple to consume

8.2
Flavor

8.0
worth the money
4

Physician's CHOICE
Physician's CHOICE Probiotics 60 Billion CFU - 10 Strains + Organic Prebiotics - Immune, Digestive & Gut Health - Supports Occasional Constipation, Diarrhea, Gas & Bloating - for Women & Men - 60ct

10% Off
Main highlights

Supports Digestive Health & Gut Balance
The probiotic contains 60 billion CFU and 10 strains to support digestive health and a balanced gut microbiome.

Perfect for Gut Health Challenges
Ideal for managing occasional constipation, diarrhea, gas, and bloating, enhancing gut health.

Improved Digestion & Reduced Bloating
Customers praise its effectiveness in improving digestion and reducing bloating.
Key specs
- Type:General Probiotic
- Usage:Supports digestive health
- Strains:10 diverse strains
- Formulation:Acid-resistant capsules
- Ingredients:Probiotics and prebiotics
9.4

Excellent

Our Rating

9.7
simple to consume

9.5
worth the money

9.5
quality of ingredients
5

Garden of Life
Garden of Life Raw Probiotics for Women and Men with Digestive Enzymes, 100 Billion CFU, Clinically Studied Strains, 30 Capsules
Main highlights

High Potency Probiotic Formula
Contains 100 Billion CFU and 34 strains for optimal gut health.

Convenient for Travel
Shelf-stable, no need for refrigeration, ideal for busy lifestyles.

Clinically Studied Strains
Praised for its effective strains supporting digestive health.
Key specs
- CFU:100 Billion
- Form:Capsule
- Strains:34 Probiotic Strains
- Gluten Free:Yes
- Features:Non-GMO, Enzymes, Vitamins
9.2

Excellent

Our Rating

9.5
simple to consume

9.1
Flavor

8.2
worth the money
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6

Garden of Life
Garden of Life Once Daily Dr. Formulated Probiotics for Women 50 Billion CFU 16 Probiotic Strains with Organic Prebiotics for Digestive, Vaginal & Immune Health, Dairy Free, Shelf Stable 30 Capsules
Main highlights

50 Billion CFU for Digestive and Immune Support
Formulated with 50 Billion CFU and 16 probiotics for optimal digestive and immune health.

Perfect for Women's Health Needs
Designed to support women's digestive, immune, and reproductive health, including maintaining balanced pH levels.

Praised for Gut Health Benefits
Customers frequently commend its impact on gut health and overall well-being.
9.1

Excellent

Our Rating

9.1
simple to consume

8.9
worth the money

8.9
quality of ingredients
7

Triquetra Health
Flora Biome - Live Probiotic, Prebiotic, & Postbiotic – Organic Live-Culture – 10 Probiotic Strains, 18 Fermented Herbs - Complete Gut Health & Microbiome Optimizer (16 oz)
Main highlights

Key Features and Benefits
Delivers 50 Billion CFU live-culture probiotics with 19 fermented herbs for complete gut health, using nature`s acid-resistant delivery system.

Ideal Use Cases
Optimal for enhancing digestion, boosting energy and brain function, and supporting weight management through a balanced inner microbiome.

Customer Reviews Highlight
Most praised for significantly improving gut health and digestion, with noticeable benefits in energy and overall well-being.
Key specs
- Probiotic Strains:10 probiotic strains
- Formulation:Liquid
- CFU Amount:50 Billion CFU
- Prebiotic Type:19 fermented herbs
- Capsule Size:N/A
9.0

Excellent

Our Rating

8.0
worth the money

8.0
Flavor
8

Florajen

Florajen Acidophilus High Potency Refrigerated Supports Overall Health, 20 Billion CFUs for Potent Probiotic Benefits, Unflavored, 60 Count
8.9

Very Good

Our Rating
9

Vitalitown
VITALITOWN Probiotics 120 Billion CFUs | 36 Strains, with Prebiotics & Digestive Enzymes for Men Women | Shelf Stable | Digestive Health & Immune Support | Vegan, Non-GMO | 30 Delayed Release Veg Caps

20% Off
Main highlights

High CFU Count and Strain Variety
Vitalitown Probiotics offer 120 Billion CFUs and 36 strains, supporting diverse gut health needs.

Digestive and Immune Support
Ideal for those seeking enhanced digestive health and immune system support.

Effective Digestive Relief
Customers frequently praise its immediate impact on digestive issues.
Key specs
- Type:Capsule
- Usage:Digestive & Immune Support
- Strains:36 Strains
- Formulation:Probiotics + Prebiotics + Enzymes
- Ingredients:Vegan, No GMOs, Gluten-Free
8.8

Very Good

Our Rating

9.9
simple to consume

9.9
worth the money

9.7
quality of ingredients
10

Wholesome Wellness
Wholesome Wellness Organic Raw Probiotics 100 Billion CFU, Dr Formulated for Women and Men, Complete Adult Supplement with Prebiotics and Digestive Enzymes; 30 Capsules, Shelf Stable

14% Off
Main highlights

High Potency Probiotic
Contains 100 Billion CFUs and 34 strains per serving for optimal gut health.

Ideal for Adults
Designed for both men and women, ensuring comprehensive digestive support.

Ease of Use
Praised for being potent and easy to take daily.
Key specs
- Type:Capsules
- Usage:Once daily
- Strains:34 Strains
- Formulation:Dr Formulated
- Ingredients:Lactobacillus, Bifidobacterium
8.7

Very Good

Our Rating

9.7
simple to consume

9.7
worth the money

9.5
Flavor

10 Best refrigerated probiotics of 2025

1

VSL #3® Probiotics for Digestive Health, IBS & UC Symptoms - 112.5B CFUs, High-Potency, Multi-Strain, Live, Refrigerated Probiotic, Medical Food for Gut Health Support in Men & Women, 120 Capsules

9.9

8.0

8.0

How do we rank?

How do we rank?

Analyzing top stores

2

Visbiome® GI Care - High Potency Probiotic - 112.5 Billion CFU Live Probiotics, Original De Simone Formulation, Made in USA, 60 Capsules.

9.9

9.9

9.7

3

Florajen3 Digestion High Potency Refrigerated Probiotics | Restores Balance in Digestive System | for Antibiotic Side Effects | 60 Capsules

9.3

8.2

8.0

4

Physician's CHOICE Probiotics 60 Billion CFU - 10 Strains + Organic Prebiotics - Immune, Digestive & Gut Health - Supports Occasional Constipation, Diarrhea, Gas & Bloating - for Women & Men - 60ct

9.7

9.5

9.5

5

Garden of Life Raw Probiotics for Women and Men with Digestive Enzymes, 100 Billion CFU, Clinically Studied Strains, 30 Capsules

9.5

9.1

8.2

6

Garden of Life Once Daily Dr. Formulated Probiotics for Women 50 Billion CFU 16 Probiotic Strains with Organic Prebiotics for Digestive, Vaginal & Immune Health, Dairy Free, Shelf Stable 30 Capsules

9.1

8.9

8.9

7

Flora Biome - Live Probiotic, Prebiotic, & Postbiotic – Organic Live-Culture – 10 Probiotic Strains, 18 Fermented Herbs - Complete Gut Health & Microbiome Optimizer (16 oz)

8.0

8.0

8

Florajen Acidophilus High Potency Refrigerated Supports Overall Health, 20 Billion CFUs for Potent Probiotic Benefits, Unflavored, 60 Count

9

VITALITOWN Probiotics 120 Billion CFUs | 36 Strains, with Prebiotics & Digestive Enzymes for Men Women | Shelf Stable | Digestive Health & Immune Support | Vegan, Non-GMO | 30 Delayed Release Veg Caps

9.9

9.9

9.7

10

Wholesome Wellness Organic Raw Probiotics 100 Billion CFU, Dr Formulated for Women and Men, Complete Adult Supplement with Prebiotics and Digestive Enzymes; 30 Capsules, Shelf Stable

9.7

9.7

9.5

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