9 Best preservative free artificial tears eye drops of 2025

Save up to 44% off

Best Choice

1

Systane
Systane Hydration Multi-Dose Preservative-Free Eye Drops Dry Eye Relief Twin Pack (2x10ml)

27% Off
Main highlights

Fast Hydration and Long-Lasting Relief
Provides quick hydration and sustained relief for dry eyes.

Ideal for Contact Lens Wearers
Safe for use with all contact lenses, perfect for daily wear.

User-Friendly Bottle Design
Customers appreciate the easy-to-use bottle, despite some dispensing issues.
Key specs
- Formula:Contains hyaluronate
- Usage:Safe with contact lenses
- Preservatives:Preservative free
- Hydration:Advanced hydration
- Content:1.45 ounces
9.8

Exceptional

Our Rating

9.3
Moisturizing

8.7
worth the money

8.0
Simple to use
How do we rank?

Powerful technology We scan thousands of products and stores, analyzing reviews to find what matters most to users like you

Careful review Our team ensures quality, value, and fit based on real user feedback

Trusted insights AI and human analysis guide your decisions, reflecting real user priorities
Real users impact

Thousands of users trust our site daily

Based on millions of stores and reviews

Shoppers influence our rankings
Analyzing top stores
Value for Money

2

Systane
Systane COMPLETE PF Multi-Dose Preservative Free Dry Eye Drops 0.34 Fl Oz, 2 count (pack of 1) (Packaging may vary)
Main highlights

Fast Acting Hydration
Nano droplets provide quick and effective moisture for sensitive eyes.

Ideal for Post-Lasik
Recommended for use before and after Lasik surgery for optimal recovery.

Improved Bottle Design
New squeeze bottle retains shape and reduces waste, praised by users.
9.7

Exceptional

Our Rating

9.1
Long life

9.1
Moisturizing

8.2
worth the money
3

Refresh

Refresh Tears PF Preservative-Free Artificial Tears Lubricant Eye Drops, 0.33 fl oz (10 mL)
9.4

Excellent

Our Rating
4

Refresh
Refresh Plus Lubricant Eye Drops, Preservative-Free, 0.01 Fl Oz Single-Use Containers, 50 Count, Packaging May Vary

27% Off
Main highlights

Preservative-Free Formula
Original strength, preservative-free formula that mimics natural tears.

Ideal for Post-Surgery and Dry Eyes
Recommended for use after LASIK and for relieving mild dryness.

Highly Praised Convenience
Single-use vials praised for preventing contamination and ensuring hygiene.
Key specs
- Preservative Free:Yes
- Use Case:After LASIK or surgeries
- Relief Duration:Instantly moisturizes and lubricates
- Eye Comfort:Great for sensitive eyes
- Moisturizing Formula:Original strength, preservative-free
9.3

Excellent

Our Rating

9.5
Simple to use

9.5
Moisturizing

9.3
Comfort
5

TheraTears
TheraTears Dry Eye Therapy Lubricating Eye Drops for Dry Eyes, Preservative Free eye drops, 30 Single-Use Vials

15% Off
Main highlights

Immediate Long-Lasting Relief
TheraTears provides immediate, long-lasting relief from dry eye symptoms with its unique formula.

Ideal After LASIK
Perfect for post-LASIK care, offering gentle hydration and soothing relief.

Praised Reusability
Customers love the reusability of vials, minimizing waste and maximizing value.
Key specs
- Formula:Lubricant eye drops
- Usage:Immediate relief
- Preservatives:Preservative free
- Hydration:Silky hydration
- Content:30 vials
9.1

Excellent

Our Rating

9.9
Simple to use

9.1
Moisturizing

8.9
Comfort
See Today’s Deals & Prices
6

Refresh
Refresh Optive MEGA-3 Lubricant Eye Drops Preservative-Free Artificial Tears, 0.01 fl oz (0.4 mL), 30 Single-Use Containers

18% Off
Main highlights

Fast-Acting Relief
Rapidly comforts dry, irritated eyes with a triple-action formula.

Ideal for On-the-Go
Single-use vials are convenient for travel and frequent use.

Praised for Immediate Relief
Customers love the quick relief from dryness and irritation.
9.0

Excellent

Our Rating

9.9
Simple to use

9.3
Moisturizing

8.9
Long life
7

Systane
Systane Ultra Multi-Dose Preservative-Free Eye Drops Twin Pack (2x10ml)

23% Off
Main highlights

Preservative-Free Hydration
Fast-acting hydration with a preservative-free formula for sensitive eyes, providing lasting dry eye relief.

Ideal for Screen Users
Perfect for users experiencing dry eyes from prolonged screen time or contact lens wear.

Highly Effective Relief
Customers praise its effectiveness in soothing dry and irritated eyes despite the bottle design.
Key specs
- Preservative Free:Preservative-Free
- Use Case:dry eye symptom relief
- Relief Duration:lasting dry eye relief
- Eye Comfort:for sensitive eyes
- Moisturizing Formula:Moisture rich formula
8.9

Very Good

Our Rating
8

TheraTears

TheraTears Dry Eye Therapy Lubricating Eye Drops for Dry Eyes, 1 Fl Oz Twin Pack, (2 x 30mL Bottles)

18% Off
8.7

Very Good

Our Rating

9.9
Comfort

9.5
Simple to use

9.1
Moisturizing
9

TheraTears
TheraTears Extra Dry Eye Therapy Preservative-Free Lubricating Eye Drops for Dry Eyes, 30 Single-Use Vials

44% Off
Main highlights

Extraordinary Hydration Relief
Provides up to 12 hours of hydrating comfort for extra dry eyes.

Ideal for Sensitive Eyes
Perfect for users needing preservative-free, single-use vials for freshness.

Highly Praised Moisturizing Formula
Customers love the non-stinging, long-lasting moisture and ease of use.
Key specs
- Formula:5 vital electrolytes
- Usage:Extra dry eyes
- Preservatives:Preservative free
- Hydration:12 Hours of Hydrating Comfort
- Content:Preservative free
8.6

Very Good

Our Rating

9.9
Moisturizing

9.7
Simple to use

9.5
Packaging materials

9 Best preservative free artificial tears eye drops of 2025

1

Systane Hydration Multi-Dose Preservative-Free Eye Drops Dry Eye Relief Twin Pack (2x10ml)

9.3

8.7

8.0

How do we rank?

How do we rank?

Analyzing top stores

2

Systane COMPLETE PF Multi-Dose Preservative Free Dry Eye Drops 0.34 Fl Oz, 2 count (pack of 1) (Packaging may vary)

9.1

9.1

8.2

3

Refresh Tears PF Preservative-Free Artificial Tears Lubricant Eye Drops, 0.33 fl oz (10 mL)

4

Refresh Plus Lubricant Eye Drops, Preservative-Free, 0.01 Fl Oz Single-Use Containers, 50 Count, Packaging May Vary

9.5

9.5

9.3

5

TheraTears Dry Eye Therapy Lubricating Eye Drops for Dry Eyes, Preservative Free eye drops, 30 Single-Use Vials

9.9

9.1

8.9

6

Refresh Optive MEGA-3 Lubricant Eye Drops Preservative-Free Artificial Tears, 0.01 fl oz (0.4 mL), 30 Single-Use Containers

9.9

9.3

8.9

7

Systane Ultra Multi-Dose Preservative-Free Eye Drops Twin Pack (2x10ml)

8

TheraTears Dry Eye Therapy Lubricating Eye Drops for Dry Eyes, 1 Fl Oz Twin Pack, (2 x 30mL Bottles)

9.9

9.5

9.1

9

TheraTears Extra Dry Eye Therapy Preservative-Free Lubricating Eye Drops for Dry Eyes, 30 Single-Use Vials

9.9

9.7

9.5

Sign up and get exclusive special deals