10 Best pimple spot treatments of 2025

Save up to 35% off

Best Choice

1

La Roche-Posay
La Roche-Posay Effaclar Adapalene Gel 0.1% Acne Treatment, Retinoid Cream, Acne Medication Gel For Blackheads & Whiteheads, Oil Free, Helps Clear And Prevent Blemishes & Clogged Pores
Main highlights

Prescription Strength Acne Treatment
La Roche-Posay Effaclar Adapalene Gel 0.1% effectively clears and prevents acne and clogged pores with prescription-strength retinoid.

Ideal for Acne and Hyperpigmentation
Best suited for individuals struggling with acne, clogged pores, and hyperpigmentation, delivering noticeable improvements in skin clarity and texture.

Rapid Results Praised by Users
Customers frequently highlight its fast-acting nature, clearing acne and reducing hyperpigmentation within weeks of use.
9.9

Exceptional

Our Rating

9.1
Aroma

8.9
worth the money

8.0
Moisturizing
How do we rank?

Powerful technology We scan thousands of products and stores, analyzing reviews to find what matters most to users like you

Careful review Our team ensures quality, value, and fit based on real user feedback

Trusted insights AI and human analysis guide your decisions, reflecting real user priorities
Real users impact

Thousands of users trust our site daily

Based on millions of stores and reviews

Shoppers influence our rankings
Analyzing top stores
Value for Money

2

Mario Badescu

Mario Badescu AM/PM Blemish Kit, Includes Drying Lotion Spot Treatment with Salicylic Acid and Sulfur (1 Fl Oz) AND Drying Patch Facial Stickers, Invisible Pimple Patches (12 Count)
9.8

Exceptional

Our Rating

9.3
Simple to use

8.0
worth the money

8.0
For Gentle skin
3

AcneFree
AcneFree Terminator 10 Acne Spot Treatment with Benzoyl Peroxide 10% Maximum Strength Acne Cream Treatment, 1 Ounce - Pack Of 1

35% Off
Main highlights

Maximum Strength Benzoyl Peroxide
Contains 10% benzoyl peroxide for effective acne treatment and redness control.

Ideal for Spot Treatment
Best used for treating individual pimples and mild recurring acne.

Convenient Flip-Cap Design
Praised for its easy-to-use flip-cap that prevents loss and simplifies application.
Key specs
- Skin Benefits:Redness Control
- Formulation:Cream
- Skin Type:N/A
- Application Frequency:N/A
- Exfoliation Type:N/A
9.6

Exceptional

Our Rating

9.7
quality of ingredients

8.4
worth the money

8.0
Sheerness
4

Mighty Patch
Mighty Patch™ Original patch from Hero Cosmetics – The #1 Hydrocolloid Acne Pimple Patch for Shrinking Zits and Whiteheads in 1 use; Nighttime Spot Stickers for Face and Skin (36 Count)
Main highlights

Overnight Pimple Treatment
Mighty Patch Original uses hydrocolloid to visibly improve pimples overnight, reducing redness and size.

Best for Night Use
Ideal for overnight use, these patches stay on securely while you sleep.

Customer Praised Adhesion
Customers love the strong adhesion that keeps the patch in place all night.
9.3

Excellent

Our Rating

9.5
Simple to use

9.5
Simple to take off

9.5
Attachment
5

Neutrogena
Neutrogena Rapid Clear Stubborn Acne Spot Treatment Gel, Maximum Strength 10% Benzoyl Peroxide Treatment Medication for Acne Prone Skin, Pimple Cream Reduces Size & Redness in 2 Hours, 1 oz

27% Off
Main highlights

Maximum Strength Benzoyl Peroxide
Contains 10% benzoyl peroxide for rapid acne reduction.

Ideal for Stubborn Acne
Perfect for treating stubborn acne on acne-prone skin.

Quick and Effective Results
Praised for reducing acne size and redness within hours.
9.2

Excellent

Our Rating

8.7
Aroma

8.4
Fashion

8.2
worth the money
See Today’s Deals & Prices
6

Neutrogena
Neutrogena On-The-Spot Acne Spot Treatment Cream with 2.5% Benzoyl Peroxide, Gentle Face Blemish Medicine for Acne-Prone Skin, Vanishing Formula, Clinically Proven Day-1 Results, 0.75-Ounce Tube

31% Off
Main highlights

Effective Acne Treatment with Benzoyl Peroxide
.75-ounce tube with 2.5% benzoyl peroxide fights acne gently.

Ideal for Daily Use on Acne-Prone Skin
Use up to three times daily without over-drying.

Praised for Quick and Visible Results
Customers appreciate its effectiveness and quick results.
Key specs
- Skin Type:All skin types
- Formulation:Cream
- Effects:Fights acne
- Niacinamide:N/A
- Hyaluronic Acid:N/A
9.0

Excellent

Our Rating
7

Differin
Differin Acne Treatment Gel, 30 Day Supply, Retinoid Treatment for Face with 0.1% Adapalene, Gentle Skin Care for Acne Prone Sensitive Skin, 15g Tube (Packaging May Vary)
Main highlights

Effective Acne Treatment
Differin Gel targets clogged pores and inflammation, reducing breakouts and improving skin texture and tone.

Ideal for Acne-Prone Skin
Best for those with acne-prone, sensitive skin needing a gentle retinoid treatment.

Praised for Clear Skin
Customers love its ability to keep skin clear and smooth, even with hormonal or diet-related acne.
8.8

Very Good

Our Rating

8.2
worth the money

8.0
Aroma

8.0
Fashion
8

CeraVe
CeraVe Acne Control Gel, 2% Salicylic Acid Treatment With Glycolic Acid + Lactic Acids + Niacniamide, Acne Gel Helps Clear Blemishes Without Over Drying, Alcohol Free & Oil Free, 1.35 Fl Oz

18% Off
Main highlights

Advanced Exfoliation and Hydration
Combines BHA and AHA to clear acne, smooth skin, and maintain moisture.

Ideal for Sensitive and Acne-Prone Skin
Perfect for those seeking gentle yet effective acne treatment.

Unmatched Performance and Affordability
Praised for its effective results and affordable price point.
8.7

Very Good

Our Rating

8.9
worth the money

8.9
For Gentle skin

8.7
Aroma
9

Clean & Clear
Clean & Clear Persa-Gel 10 Oil-Free Acne Spot Treatment with Maximum Strength 10% Benzoyl Peroxide, Topical Pimple Cream & Gel Medication for Face, Fragrance-Free, 1 fl. oz, 4 Pack

25% Off
Main highlights

Maximum Strength Formula
Contains 10% benzoyl peroxide for effective acne treatment.

Ideal for Spot Treatment
Perfect for inflamed acne bumps and quick results.

Highly Praised for Quick Results
Users report visible reduction in acne overnight.
8.6

Very Good

Our Rating
10

Enaskin Naturals

Acne Pimple Spot Treatment Cream: Cystic Hormonal Blackheads Blemish Breakouts for Face, Back and Body - 10% Azelaic Acid & Salicylic Acid - Teens-Adults, 1.8 oz
8.4

Good

Our Rating

10 Best pimple spot treatments of 2025

1

La Roche-Posay Effaclar Adapalene Gel 0.1% Acne Treatment, Retinoid Cream, Acne Medication Gel For Blackheads & Whiteheads, Oil Free, Helps Clear And Prevent Blemishes & Clogged Pores

9.1

8.9

8.0

How do we rank?

How do we rank?

Analyzing top stores

2

Mario Badescu AM/PM Blemish Kit, Includes Drying Lotion Spot Treatment with Salicylic Acid and Sulfur (1 Fl Oz) AND Drying Patch Facial Stickers, Invisible Pimple Patches (12 Count)

9.3

8.0

8.0

3

AcneFree Terminator 10 Acne Spot Treatment with Benzoyl Peroxide 10% Maximum Strength Acne Cream Treatment, 1 Ounce - Pack Of 1

9.7

8.4

8.0

4

Mighty Patch™ Original patch from Hero Cosmetics – The #1 Hydrocolloid Acne Pimple Patch for Shrinking Zits and Whiteheads in 1 use; Nighttime Spot Stickers for Face and Skin (36 Count)

9.5

9.5

9.5

5

Neutrogena Rapid Clear Stubborn Acne Spot Treatment Gel, Maximum Strength 10% Benzoyl Peroxide Treatment Medication for Acne Prone Skin, Pimple Cream Reduces Size & Redness in 2 Hours, 1 oz

8.7

8.4

8.2

6

Neutrogena On-The-Spot Acne Spot Treatment Cream with 2.5% Benzoyl Peroxide, Gentle Face Blemish Medicine for Acne-Prone Skin, Vanishing Formula, Clinically Proven Day-1 Results, 0.75-Ounce Tube

7

Differin Acne Treatment Gel, 30 Day Supply, Retinoid Treatment for Face with 0.1% Adapalene, Gentle Skin Care for Acne Prone Sensitive Skin, 15g Tube (Packaging May Vary)

8.2

8.0

8.0

8

CeraVe Acne Control Gel, 2% Salicylic Acid Treatment With Glycolic Acid + Lactic Acids + Niacniamide, Acne Gel Helps Clear Blemishes Without Over Drying, Alcohol Free & Oil Free, 1.35 Fl Oz

8.9

8.9

8.7

9

Clean & Clear Persa-Gel 10 Oil-Free Acne Spot Treatment with Maximum Strength 10% Benzoyl Peroxide, Topical Pimple Cream & Gel Medication for Face, Fragrance-Free, 1 fl. oz, 4 Pack

10

Acne Pimple Spot Treatment Cream: Cystic Hormonal Blackheads Blemish Breakouts for Face, Back and Body - 10% Azelaic Acid & Salicylic Acid - Teens-Adults, 1.8 oz

Sign up and get exclusive special deals