Our rankings are cleverly generated from the algorithmic analysis of thousands of customer reviews about products, brands, merchant’s customer service levels, popularity trends, and more. The rankings reflect our opinion and should be a good starting point for shopping. By purchasing the products we rank, you’ll get the lowest price we found while we may receive a commission at no cost to you, which will help us continue to provide you with value.
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10 Best otc muscle relaxers of 2025
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1
Dee Cee LaboratoriesDee Cee Labs Formula 303 Maximum Strength All-Natural Relaxant Tablets, 250 Tablets; All-Natural Relaxant containing Magnesium for Sore Muscles, Passion Flower, and Valerian Root
Main highlights-
Natural Ingredients for Relaxation
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Ideal for Muscle and Stress Relief
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Effective Sciatic Pain Relief
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2
AleveAleve Back & Muscle Pain Relief Naproxen Sodium Tablets, Pain Reliever & Fever Reducer, Medicine for Body , 250 Count
12% OffMain highlights-
12-Hour Pain Relief
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Ideal for Back Pain
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Quick Pain Relief
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3
Oregon's Wild HarvestOregon's Wild Harvest Muscle Relax Organic Herbal Supplement Vegan Capsules with Valerian, Hops and Skullcap
25% OffMain highlights-
Vegan Organic Formula
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Ideal for Relaxation
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Highly Effective for Cramps
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4
TylenolTylenol 8 Hour Acetaminophen 650 mg Extended Release Caplets, Fast Acting Bi-Layer Design, Quick & Long Lasting Pain Relief for Muscle, Joint, Back & Arthritis Aches, Fever Reducer, 100 Count
24% OffMain highlights-
Extended_Release for Long-Lasting Relief
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Ideal for Muscle and Joint Pain
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Highly Recommended for Pain Relief
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5
ecostream Naturalsecostream Naturals Relaxant - Muscle Relax 24/7 - Large 2,300 Milligram Day/Night Use Capsules Maximum Strength Support - with Valerian, Passion Flower, Magnesium
Main highlights-
Natural Relaxant Ingredients
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Ideal for Restlessness Relief
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Praised for Muscle Relaxation
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7
PercogesicPercogesic Backache Relief Pain Reliever, Maximum Strength, 48 Tablets
Main highlights-
Fast Acting Formula
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Ideal for Back and Muscle Pain
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Customer Praised Effectiveness
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8
MediNaturaBHI Spasm Natural Relaxer Relief for Menstrual Cramps, Bloating, Aches & Muscle Spasms 5 Active Homeopathic Ingredients Naturally Soothe Whole Body Discomfort for Women - 100 Tablets
Main highlights-
Fast Relief from PMS and Cramps
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Versatile Use for Various Spasms
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Customer Praised Effectiveness
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9
BoironBoiron Arnicare Tablets for Pain Relief from Muscle Pain, Joint Soreness, Swelling from Injury or Bruises - 60 Count
15% OffMain highlights-
NSAID-Free Natural Relief
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Ideal for Everyday Aches
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Highly Praised for Bruising
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10
AdvilAdvil Dual Action Back Pain Caplets Delivers 125mg Ibuprofen and 250mg Acetaminophen Per Dose for 8 Hours of Back Pain Relief - 144 Count
Main highlights-
Dual Pain Relief Formula
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Versatile Pain Relief
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Convenience and Trust
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